Benefiting from the widespread potential applications in the era of the Internet of Thing and metaverse,triboelectric and piezoelectric nanogenerators(TENG&PENG)have attracted considerably increasing attention.The...Benefiting from the widespread potential applications in the era of the Internet of Thing and metaverse,triboelectric and piezoelectric nanogenerators(TENG&PENG)have attracted considerably increasing attention.Their outstanding characteristics,such as self-powered ability,high output performance,integration compatibility,cost-effectiveness,simple configurations,and versatile operation modes,could effectively expand the lifetime of vastly distributed wearable,implantable,and environmental devices,eventually achieving self-sustainable,maintenance-free,and reliable systems.However,current triboelectric/piezoelectric based active(i.e.self-powered)sensors still encounter serious bottlenecks in continuous monitoring and multimodal applications due to their intrinsic limitations of monomodal kinetic response and discontinuous transient output.This work systematically summarizes and evaluates the recent research endeavors to address the above challenges,with detailed discussions on the challenge origins,designing strategies,device performance,and corresponding diverse applications.Finally,conclusions and outlook regarding the research gap in self-powered continuous multimodal monitoring systems are provided,proposing the necessity of future research development in this field.展开更多
The insensitive munitions compound nitroguanidine(NQ)is used by the U.S.Army to avoid unintended explosions.However,NQ also represents an emerging contaminant whose environmental emissions can cause toxicity toward aq...The insensitive munitions compound nitroguanidine(NQ)is used by the U.S.Army to avoid unintended explosions.However,NQ also represents an emerging contaminant whose environmental emissions can cause toxicity toward aquatic organisms,indicating the need for effective remediation strategies.Thus,we investigated the feasibility of treating water contaminated with NQ in continuous-flow columns packed with zero-valent iron(ZVI)or iron sulfide(FeS).Initially,the impact of pH on NQ transformation by ZVI or FeS was evaluated in batch experiments.The pseudo first-order rate constant for NQ transformation(k_(1,NQ))by ZVI was 8-10 times higher at pH 3.0 compared to pH 5.5 and 7.0,whereas similar k_(1,NQ)values were obtained for FeS at pH 5.5-10.0.Based on these findings,the influent p H fed to the ZVIand Fe S-packed columns was adjusted to 3.0 and 5.5,respectively.Both reactors transformed NQ into nitrosoguanidine(Nso Q).Further transformation of Nso Q by ZVI produced aminoguanidine,guanidine,and cyanamide,whereas Nso Q transformation by Fe S produced guanidine,ammonium,and traces of urea.ZVI outperformed Fe S as a reactive material to remove NQ.The ZVI-packed column effectively removed NQ below detection even after 45 d of operation(490 pore volumes,PV).In contrast,NQ breakthrough(removal efficiency<85%)was observed after 18 d(180 PV)in the Fe S-packed column.The high NQ removal efficiency and long service life of the ZVI-packed column(>490 PV)suggest that the technology is a promising approach for NQ treatment in packed-bed reactors and in situ remediation.展开更多
Objective:To evaluate the effectiveness of continuous nursing interventions in elderly patients with COPD in the stable phase and frailty.Methods:Sixty elderly patients with COPD in the stable phase and frailty,treate...Objective:To evaluate the effectiveness of continuous nursing interventions in elderly patients with COPD in the stable phase and frailty.Methods:Sixty elderly patients with COPD in the stable phase and frailty,treated between January 2024 and August 2024,were selected as the study subjects.Patients were randomly divided into two groups(30 each)using a drawing method.Patients who drew a black token were assigned to the intervention group and received continuous nursing interventions,while those who drew a red token were assigned to the nursing group and received standard nursing care.The quality of care between the groups was compared.Results:Pulmonary function indicators in the intervention group were significantly better than those in the nursing group(P<0.05).Immune function in the intervention group was also significantly higher than in the nursing group(P<0.05).Before the intervention,there was no significant difference in self-care ability between the two groups(P>0.05).However,post-intervention,both groups showed improved self-care abilities,with the intervention group scoring significantly higher than the nursing group(P<0.05).Similarly,before the intervention,there was no significant difference in quality-of-life scores(P>0.05),but post-intervention,both groups exhibited increased scores,with the intervention group outperforming the nursing group significantly(P<0.05).Conclusion:Continuous nursing interventions significantly improve outcomes in elderly patients with COPD in the stable phase and frailty,warranting broader implementation.展开更多
Objective:To explore nursing measures for elderly patients with chronic obstructive pulmonary disease(COPD)and analyze the effect of continuous nursing pathways on improving the accuracy of aerosol use.Methods:From Ap...Objective:To explore nursing measures for elderly patients with chronic obstructive pulmonary disease(COPD)and analyze the effect of continuous nursing pathways on improving the accuracy of aerosol use.Methods:From April 2023 to April 2024,76 elderly COPD patients admitted to our hospital were randomly selected for nursing research.They were divided into two groups using a computer double-blind method,with 38 patients in each group.The control group received routine nursing,while the observation group applied the continuous nursing pathway.The nursing effects of the two groups were investigated and compared,including(1)aerosol accuracy;(2)cardiopulmonary function;(3)subjective well-being and self-care ability;(4)quality of life;and(5)nursing satisfaction.Results:Compared with the control group,the observation group had a significantly higher accuracy rate of aerosol use(P<0.05).Before nursing,there were no significant differences in cardiopulmonary function indicators,MUNSH scores,and ESCA scores between the two groups(P>0.05).After nursing,the patient's cardiopulmonary function improved significantly,and their subjective well-being and self-care ability increased.The observation group was significantly better than the control group in all the above indicators(P<0.05).The quality of life scores of the observation group were significantly higher than those of the control group(P<0.05).Conclusion:In the nursing of elderly patients with chronic obstructive pulmonary disease,the application of the continuous nursing pathway can effectively improve the accuracy of aerosol use and improve patients'cardiopulmonary function.展开更多
BACKGROUND Radical gastrectomy(RGE)for gastric carcinoma(GC)has exerted definite therapeutic efficacy in treating patients with GC.However,a notable risk of postoperative complications(POCs)persists among middle-aged ...BACKGROUND Radical gastrectomy(RGE)for gastric carcinoma(GC)has exerted definite therapeutic efficacy in treating patients with GC.However,a notable risk of postoperative complications(POCs)persists among middle-aged and elderly patients with compromised physiological functions.Hence,developing and implementing reliable nursing interventions to optimize the comprehensive management of these patients is deemed imperative.AIM To analyze the association of multi-channel continuous nursing intervention with POCs,negative emotions(NEs),and quality of life(QoL)of patients undergoing RGE for GC.METHODS This retrospective study selected 99 patients who underwent RGE for GC in our hospital from May 2020 to May 2023.Participants were categorized into the control(n=49 cases)and research groups(n=50 cases)receiving routine and multi-channel continuous nursing care,respectively.Comparative analysis involved data on postoperative rehabilitation(time to first anal exhaust,oral feeding and ambulation,and hospital stay),complications(nausea and vomiting,delayed gastric emptying,and abdominal distension),NEs[Self-rating Anxiety(SAS)/Depression Scale(SDS)],treatment compliance,self-efficacy,and QoL[World Health Organization QoL Brief Version(WHOQOL-BREF)].RESULTS Compared to the control group,the research group demonstrated earlier first postoperative anal exhaust,oral feeding,and ambulation,shorter hospital stay,lower POC rate,and more reduced SAS and SDS scores postintervention,which was significantly lower than the baseline.The treatment compliance scores were significantly higher in the research group than in the control group in terms of medication adherence,daily exercise,reasonable diet,and regular review.Further,the research group demonstrated increased self-efficacy scores in terms of positive attitude,self-stress relief,and self-decision-making,as well as the overall score postintervention,which were higher than the control group.Moreover,the research group reported notably higher WHOQOL-BREF scores in domains such as physiology,psychology,social relations,and environment.CONCLUSION Multi-channel continuous nursing intervention prevents POCs in patients undergoing RGE for GC as well as significantly alleviates patients’NEs and boosts their QoL.展开更多
The aim of the study is to investigate the impact of the buffer groove structure on the pressure of continuous rotation electro-hydraulic servo motor.The mathematical model of the motor valve plate with triangular gro...The aim of the study is to investigate the impact of the buffer groove structure on the pressure of continuous rotation electro-hydraulic servo motor.The mathematical model of the motor valve plate with triangular groove and U-groove structure is established firstly,and the structure size of the two buffer grooves with better pressure drop effect is obtained by Matlab.Secondly,an established pressure gradient model is developed for the sealed canisters for electric motors using a combined groove structure.The bird swarm optimization algorithm is used to obtain the optimal dimensions for the combined depth and angle of the pressure groove.The flow field in the motor seal chamber is simulated and calculated by Fluent.This study compared the pressure field distributions in the motors sealing chamber using triangular and combined groove structures.It investigated the combined grooves effect on the pressure impact during the commutation of a continuously rotating electro-hydraulic servo motor.It is found that the combined groove structure has a positive impact on reducing the pressure impact.The results indicate that the combined groove structure significantly enhances the efficiency of mitigating pressure shocks when the motor switches between high-and low-pressure chambers.展开更多
The objective of this research is to assess the seismic behavior of the continuous T-beam bridge located at Kulungou in Xinjiang.In addition to traditional static and modal analyses,this study introduces a novel appro...The objective of this research is to assess the seismic behavior of the continuous T-beam bridge located at Kulungou in Xinjiang.In addition to traditional static and modal analyses,this study introduces a novel approach by comprehensively examining the performance of the bridge during construction stages,under ultimate load capacities and seismic load.Compliance with regulatory standards is verified by the static analysis,which also yields a thorough comprehension of stress distribution across various stages of construction.By unveiling the initial 100 vibration modes,the modal analysis has significantly enhanced our comprehension and established a robust basis for the ensuing seismic analysis.A distinctive aspect of this research is its comprehensive exploration of the bridge’s seismic behavior under E1 and E2 earthquake excitations.Under E1 earthquake excitation,the response spectrum analysis confirms the adequacy of the bridge piers’strength according to seismic design criteria,whereas the time-history analysis conducted under E2 ground motion reveals the bridge’s robust resistance to strong earthquakes.This study also undertakes a comparative assessment of the seismic behavior of the bridge,contrasting its performance with lead-rubber bearings against that with high-damping rubber bearings.According to the study’s findings,both types of bearings demonstrate their efficacy in mitigating seismic responses,thereby emphasizing their potential as innovative approaches to enhance the resilience of bridges.A notable contribution of this research lies in its assessment of seismic performance indicators,namely hysteresis curves,backbone curves,and ductility coefficients,utilizing Pushover analysis.By conducting a thorough evaluation,a more profound insight into the seismic performance of bridge piers is gained.In conclusion,the study explores how earthquake wave intensity and aftershocks affect the seismic response of bridge piers,showing a substantial increase in seismic response with intensifying wave magnitude and the potential for aftershocks to aggravate damage to compromised structures.The importance of incorporating these factors in the seismic design and retrofitting of bridges is underscored by these discoveries.This study,in its entirety,proposes a fresh and comprehensive methodology to assess the seismic performance of continuous T-beam bridges,furnishing valuable perspectives and innovative remedies to augment the seismic resilience of bridges in earthquake-prone zones.展开更多
This study analyzed the therapeutic effects of continuous ambulatory peritoneal dialysis(CAPD)and automated peritoneal dialysis(APD)on patients with end-stage renal disease.Fifty patients admitted between January 2024...This study analyzed the therapeutic effects of continuous ambulatory peritoneal dialysis(CAPD)and automated peritoneal dialysis(APD)on patients with end-stage renal disease.Fifty patients admitted between January 2024 and December 2024 were randomly assigned to two groups,with the observation group receiving APD and the reference group receiving CAPD.Renal function indicators,nutritional indicators,mineral metabolism,urine volume,and ultrafiltration volume changes were compared between the two groups.After treatment,the observation group showed lower renal function indicators,higher nutritional indicators,and better mineral metabolism levels compared to the reference group(P<0.05).While there was no significant difference in urine volume between the two groups(P>0.05),the observation group demonstrated superior ultrafiltration volume(P<0.05).These findings suggest that APD offers better clinical outcomes than CAPD by improving renal function,nutritional status,mineral metabolism regulation,and ultrafiltration efficiency in patients with end-stage renal disease.展开更多
The application of liquid core reduction(LCR)technology in thin slab continuous casting can refine the internal microstruc-tures of slabs and improve their production efficiency.To avoid crack risks caused by large de...The application of liquid core reduction(LCR)technology in thin slab continuous casting can refine the internal microstruc-tures of slabs and improve their production efficiency.To avoid crack risks caused by large deformation during the LCR process and to minimize the thickness of the slab in bending segments,the maximum theoretical reduction amount and the corresponding reduction scheme for the LCR process must be determined.With SPA-H weathering steel as a specific research steel grade,the distributions of tem-perature and deformation fields of a slab with the LCR process were analyzed using a three-dimensional thermal-mechanical finite ele-ment model.High-temperature tensile tests were designed to determine the critical strain of corner crack propagation and intermediate crack initiation with various strain rates and temperatures,and a prediction model of the critical strain for two typical cracks,combining the effects of strain rate and temperature,was proposed by incorporating the Zener-Hollomon parameter.The crack risks with different LCR schemes were calculated using the crack risk prediction model,and the maximum theoretical reduction amount for the SPA-H slab with a transverse section of 145 mm×1600 mm was 41.8 mm,with corresponding reduction amounts for Segment 0 to Segment 4 of 15.8,7.3,6.5,6.4,and 5.8 mm,respectively.展开更多
In natural language processing(NLP),managing multiple downstream tasks through fine-tuning pre-trained models often requires maintaining separate task-specific models,leading to practical inefficiencies.To address thi...In natural language processing(NLP),managing multiple downstream tasks through fine-tuning pre-trained models often requires maintaining separate task-specific models,leading to practical inefficiencies.To address this challenge,we introduce AdaptForever,a novel approach that enables continuous mastery of NLP tasks through the integration of elastic and mutual learning strategies with a stochastic expert mechanism.Our method freezes the pre-trained model weights while incorporating adapters enhanced with mutual learning capabilities,facilitating effective knowledge transfer from previous tasks to new ones.By combining Elastic Weight Consolidation(EWC)for knowledge preservation with specialized regularization terms,AdaptForever successfully maintains performance on earlier tasks while acquiring new capabilities.Experimental results demonstrate that AdaptForever achieves superior performance across a continuous sequence of NLP tasks compared to existing parameter-efficient methods,while effectively preventing catastrophic forgetting and enabling positive knowledge transfer between tasks.展开更多
Objective:To analyze the nursing effect of implementing continuous nursing combined with knowledge,attitude,and practice(KAP)intervention under the guidance of interactive goal-setting theory for patients with gestati...Objective:To analyze the nursing effect of implementing continuous nursing combined with knowledge,attitude,and practice(KAP)intervention under the guidance of interactive goal-setting theory for patients with gestational diabetes mellitus(GDM).Methods:A total of 68 patients with GDM who were admitted to the hospital between December 2021 and December 2023 were selected and randomly divided into two groups using a random number table.The combined group(34 cases)received continuous nursing combined with KAP intervention under the premise of interactive goal-setting theory,while the conventional group(34 cases)received routine nursing care.Blood glucose control,health behavior scores,and other indicators were compared between the two groups.Results:After nursing,the blood glucose level in the combined group was lower than that in the conventional group,and the scores for health behavior and self-management ability were higher than those in the conventional group(P<0.05).Conclusion:Combined nursing can improve blood glucose control in patients with GDM,standardize their health behaviors,and cultivate their self-management skills.展开更多
BACKGROUND Despite sharing similar pathogenic factors,cancer and coronary heart disease(CHD)occur in comparable populations at similar ages and possess similar susceptibility factors.Consequently,it is increasingly co...BACKGROUND Despite sharing similar pathogenic factors,cancer and coronary heart disease(CHD)occur in comparable populations at similar ages and possess similar susceptibility factors.Consequently,it is increasingly commonplace for patients to experience the simultaneous occurrence of cancer and CHD,a trend that is steadily rising.AIM To determine the impacts of continuing care on lung cancer patients with CHD following percutaneous coronary intervention(PCI).METHODS There were 94 lung cancer patients with CHD following PCI who were randomly assigned to the intervention group(n=38)and the control group(n=41).In the intervention group,continuing care was provided,while in the control group,routine care was provided.An evaluation of cardiac and pulmonary function,medication compliance,a 6-min walk test,and patient quality of life was performed.RESULTS Differences between the two groups were significant in left ventricular ejection fraction,6-min walk test,oxygen uptake,quality of life and medication compliance(P<0.05).In comparison with the control group,the enhancement in the intervention group was more significant.The intervention group had more patients with high medication compliance than the control group,with a statistically significant difference(P<0.05).CONCLUSION After undergoing PCI,lung patients with CHD could benefit from continued care in terms of cardiac and pulmonary function,medications compliance,and quality of life.展开更多
Vertically oriented carbon structures constructed from low-dimen-sional carbon materials are ideal frameworks for high-performance thermal inter-face materials(TIMs).However,improving the interfacial heat-transfer eff...Vertically oriented carbon structures constructed from low-dimen-sional carbon materials are ideal frameworks for high-performance thermal inter-face materials(TIMs).However,improving the interfacial heat-transfer efficiency of vertically oriented carbon structures is a challenging task.Herein,an orthotropic three-dimensional(3D)hybrid carbon network(VSCG)is fabricated by depositing vertically aligned carbon nanotubes(VACNTs)on the surface of a horizontally oriented graphene film(HOGF).The interfacial interaction between the VACNTs and HOGF is then optimized through an annealing strategy.After regulating the orientation structure of the VACNTs and filling the VSCG with polydimethylsi-loxane(PDMS),VSCG/PDMS composites with excellent 3D thermal conductive properties are obtained.The highest in-plane and through-plane thermal conduc-tivities of the composites are 113.61 and 24.37 W m^(-1)K^(-1),respectively.The high contact area of HOGF and good compressibility of VACNTs imbue the VSCG/PDMS composite with low thermal resistance.In addition,the interfacial heat-transfer efficiency of VSCG/PDMS composite in the TIM performance was improved by 71.3%compared to that of a state-of-the-art thermal pad.This new structural design can potentially realize high-performance TIMs that meet the need for high thermal conductivity and low contact thermal resistance in interfacial heat-transfer processes.展开更多
Managing diabetes during pregnancy is challenging,given the significant risk it poses for both maternal and foetal health outcomes.While traditional methods involve capillary self-monitoring of blood glucose level mon...Managing diabetes during pregnancy is challenging,given the significant risk it poses for both maternal and foetal health outcomes.While traditional methods involve capillary self-monitoring of blood glucose level monitoring and periodic HbA1c tests,the advent of continuous glucose monitoring(CGM)systems has revolutionized the approach.These devices offer a safe and reliable means of tracking glucose levels in real-time,benefiting both women with diabetes during pregnancy and the healthcare providers.Moreover,CGM systems have shown a low rate of side effects and high feasibility when used in pregnancies complicated by diabetes,especially when paired with continuous subcutaneous insulin infusion pump as hybrid closed loop device.Such a combined approach has been demonstrated to improve overall blood sugar control,lessen the occurrence of preeclampsia and neonatal hypoglycaemia,and minimize the duration of neonatal intensive care unit stays.This paper aims to offer a comprehensive evaluation of CGM metrics specifically tailored for pregnancies impacted by type 1 diabetes mellitus.展开更多
Diabetic kidney disease(DKD)is a common complication of diabetes mellitus that contributes to the risk of end-stage kidney disease(ESKD).Wide glycemic var-iations,such as hypoglycemia and hyperglycemia,are broadly fou...Diabetic kidney disease(DKD)is a common complication of diabetes mellitus that contributes to the risk of end-stage kidney disease(ESKD).Wide glycemic var-iations,such as hypoglycemia and hyperglycemia,are broadly found in diabetic patients with DKD and especially ESKD,as a result of impaired renal metabolism.It is essential to monitor glycemia for effective management of DKD.Hemoglobin A1c(HbA1c)has long been considered as the gold standard for monitoring glycemia for>3 months.However,assessment of HbA1c has some bias as it is susceptible to factors such as anemia and liver or kidney dysfunction.Continuous glucose monitoring(CGM)has provided new insights on glycemic assessment and management.CGM directly measures glucose level in interstitial fluid,reports real-time or retrospective glucose concentration,and provides multiple glycemic metrics.It avoids the pitfalls of HbA1c in some contexts,and may serve as a precise alternative to estimation of mean glucose and glycemic variability.Emerging studies have demonstrated the merits of CGM for precise monitoring,which allows fine-tuning of glycemic management in diabetic patients.Therefore,CGM technology has the potential for better glycemic monitoring in DKD patients.More research is needed to explore its application and management in different stages of DKD,including hemodialysis,peritoneal dialysis and kidney transplantation.展开更多
BACKGROUND There are relatively few studies on continuing care of coronary heart disease(CHD),and its research value needs to be further clarified.AIM To investigate the effect of continuous nursing on treatment compl...BACKGROUND There are relatively few studies on continuing care of coronary heart disease(CHD),and its research value needs to be further clarified.AIM To investigate the effect of continuous nursing on treatment compliance and side effect management in patients with CHD.METHODS This is a retrospective study with patients from January 2021 to 2023.The study was divided into two groups with 30 participants in each group.Self-rating anxiety scale(SAS)and Self-rating depression scale(SDS)were used to assess patients'anxiety and depression,and medical coping questionnaire was used to assess patients'coping styles.The pelvic floor dysfunction questionnaire(PFDI-20)was used to assess the status of pelvic floor function,including bladder symptoms,intestinal symptoms,and pelvic symptoms.RESULTS SAS score decreased from 57.33±3.01before treatment to 41.33±3.42 after treatment,SDS score decreased from 50.40±1.45 to 39.47±1.57.The decrease of these two indexes was statistically significant(P<0.05).PFDI-20 scores decreased from the mean 16.83±1.72 before treatment to 10.47±1.3the mean after treatment,which was statistically significant(P<0.05).CONCLUSION The results of this study indicate that pioneering research in continuous care of CHD has a positive impact on improving patients'treatment compliance,reducing anxiety and depression levels,and improving coping styles and pelvic floor functional status.展开更多
Upper gastrointestinal bleeding (UGIB) presents as a prevalent clinical challenge, with annual incidence rates ranging from 80 to 150 cases per 100,000 individuals. Guidelines for managing patients with UGIB due to bl...Upper gastrointestinal bleeding (UGIB) presents as a prevalent clinical challenge, with annual incidence rates ranging from 80 to 150 cases per 100,000 individuals. Guidelines for managing patients with UGIB due to bleeding ulcers recommend a continuous infusion of proton pump inhibitors (PPI). However, studies comparing intermittent dosing of PPI therapy show that this regimen achieves similar clinical benefits. If the clinical efficacy remains equivalent, intermittent dosing will be more cost-effective for patients and the health care system. Our research study aims to analyze the comparative effectiveness of intermittent versus continuous PPI therapy after endoscopic treatment in patients with UGIB, focusing on such endpoints as rebleeding risk at 3-and 7-day mortality rates. Methods: Resources searched included MEDLINE, EMBASE, PUBMED, and the Cochrane Central Register of Controlled Trials databases from January 2010 through December 2023 with the inclusion of meta-analysis, systematic review, review, or ACG guideline recommendations. Results of the analysis show how recommendations regarding high vs. low PPI regimen changed over time: from no difference in regimen in 2010 to recommending continuous regimen in 2012 to declaring insufficient evidence between choosing one regimen over another in 2013 to determine that both regimens were comparable to each other in 2014-2018 and finally to recommending both regimens in 2021. To conclude, our review shows that in patients with bleeding ulcers and high-risk endoscopic findings, intermittent PPI therapy is non-inferior to continuous PPI infusion for three days, seven days bleeding risk or mortality rates;however, it remains challenging to determine the most optimal intermittent regimen due to heterogeneity of RCTs included in meta-analyses, and further trials will need to be performed.展开更多
The security performance of cloud services is a key factor influencing users’selection of Cloud Service Providers(CSPs).Continuous monitoring of the security status of cloud services is critical.However,existing rese...The security performance of cloud services is a key factor influencing users’selection of Cloud Service Providers(CSPs).Continuous monitoring of the security status of cloud services is critical.However,existing research lacks a practical framework for such ongoing monitoring.To address this gap,this paper proposes the first NonCollaborative Container-Based Cloud Service Operation State Continuous Monitoring Framework(NCCMF),based on relevant standards.NCCMF operates without the CSP’s collaboration by:1)establishing a scalable supervisory index system through the identification of security responsibilities for each role,and 2)designing a Continuous Metrics Supervision Protocol(CMA)to automate the negotiation of supervisory metrics.The framework also outlines the supervision process for cloud services across different deployment models.Experimental results demonstrate that NCCMF effectively monitors the operational state of two real-world IoT(Internet of Things)cloud services,with an average supervision error of less than 15%.展开更多
Dynamic control is essential to guarantee the stable performance of continuous chromatography.AutoMAb dynamic control strategy has been developed to ensure a consistent protein load in twincolumn CaptureSMB continuous...Dynamic control is essential to guarantee the stable performance of continuous chromatography.AutoMAb dynamic control strategy has been developed to ensure a consistent protein load in twincolumn CaptureSMB continuous capture by integrating the UV signal of breakthrough.In this study,the process risk of CaptureSMB continuous capture under AutoMAb control towards the feedstock variations was assessed by a mechanistic model developed by us.The effects of target protein and impurities under the variation range of±10 mAU·min^(-1) on load amount,protein loss,process productivity,and resin capacity utilization were investigated.The results showed that the CaptureSMB process could be successfully controlled by AutoMAb towards increased or slightly decreased concentration of feedstock.However,the load process would be out of control with drastically decreased target protein or impurities,and the decreased impurities would lead to protein loss.It was found that AutoMAb control would cause 44.7%non-operational areas and 18.3%protein loss areas in the variation range of±10 mAU·min^(-1).To improve the stability of the CaptureSMB process,a modified AutoMAb control that would stop the load procedure when the absolute value of the integral area reached the preset value,was proposed to reduce the risk of protein loss and the non-operational area.展开更多
A wavelet based identification method for linear time-varying systems is presented,and the ridge and skeleton of the continuous wavelet transform of free response is used to extract time-varying parameters. The stiffn...A wavelet based identification method for linear time-varying systems is presented,and the ridge and skeleton of the continuous wavelet transform of free response is used to extract time-varying parameters. The stiffness and damping coefficients of single-degree-of—freedom systems,frequencies and damping ratios of multi-degree-of-freedom systems are estimated without any prior information of systems. The proposed method is applied to linear time-varying systems with both abrupt and smooth variation parameters. Gaussian white noise is added to the response to test the anti-noise performance of the algorithm. The simulation results show that the proposed method is capable of accurately tracking the variation of the systems.展开更多
基金supported by the National Key R&D Program of China(Grant Nos.2022YFB3603403,2021YFB3600502)the National Natural Science Foundation of China(Grant Nos.62075040,62301150)+3 种基金the Southeast University Interdisciplinary Research Program for Young Scholars(2024FGC1007)the Start-up Research Fund of Southeast University(RF1028623164)the Nanjing Science and Technology Innovation Project for Returned Overseas Talent(4206002302)the Fundamental Research Funds for the Central Universities(2242024K40015).
文摘Benefiting from the widespread potential applications in the era of the Internet of Thing and metaverse,triboelectric and piezoelectric nanogenerators(TENG&PENG)have attracted considerably increasing attention.Their outstanding characteristics,such as self-powered ability,high output performance,integration compatibility,cost-effectiveness,simple configurations,and versatile operation modes,could effectively expand the lifetime of vastly distributed wearable,implantable,and environmental devices,eventually achieving self-sustainable,maintenance-free,and reliable systems.However,current triboelectric/piezoelectric based active(i.e.self-powered)sensors still encounter serious bottlenecks in continuous monitoring and multimodal applications due to their intrinsic limitations of monomodal kinetic response and discontinuous transient output.This work systematically summarizes and evaluates the recent research endeavors to address the above challenges,with detailed discussions on the challenge origins,designing strategies,device performance,and corresponding diverse applications.Finally,conclusions and outlook regarding the research gap in self-powered continuous multimodal monitoring systems are provided,proposing the necessity of future research development in this field.
基金financially supported by the Strategic Environmental Research and Development Program(Grant No.ER19-1075)。
文摘The insensitive munitions compound nitroguanidine(NQ)is used by the U.S.Army to avoid unintended explosions.However,NQ also represents an emerging contaminant whose environmental emissions can cause toxicity toward aquatic organisms,indicating the need for effective remediation strategies.Thus,we investigated the feasibility of treating water contaminated with NQ in continuous-flow columns packed with zero-valent iron(ZVI)or iron sulfide(FeS).Initially,the impact of pH on NQ transformation by ZVI or FeS was evaluated in batch experiments.The pseudo first-order rate constant for NQ transformation(k_(1,NQ))by ZVI was 8-10 times higher at pH 3.0 compared to pH 5.5 and 7.0,whereas similar k_(1,NQ)values were obtained for FeS at pH 5.5-10.0.Based on these findings,the influent p H fed to the ZVIand Fe S-packed columns was adjusted to 3.0 and 5.5,respectively.Both reactors transformed NQ into nitrosoguanidine(Nso Q).Further transformation of Nso Q by ZVI produced aminoguanidine,guanidine,and cyanamide,whereas Nso Q transformation by Fe S produced guanidine,ammonium,and traces of urea.ZVI outperformed Fe S as a reactive material to remove NQ.The ZVI-packed column effectively removed NQ below detection even after 45 d of operation(490 pore volumes,PV).In contrast,NQ breakthrough(removal efficiency<85%)was observed after 18 d(180 PV)in the Fe S-packed column.The high NQ removal efficiency and long service life of the ZVI-packed column(>490 PV)suggest that the technology is a promising approach for NQ treatment in packed-bed reactors and in situ remediation.
文摘Objective:To evaluate the effectiveness of continuous nursing interventions in elderly patients with COPD in the stable phase and frailty.Methods:Sixty elderly patients with COPD in the stable phase and frailty,treated between January 2024 and August 2024,were selected as the study subjects.Patients were randomly divided into two groups(30 each)using a drawing method.Patients who drew a black token were assigned to the intervention group and received continuous nursing interventions,while those who drew a red token were assigned to the nursing group and received standard nursing care.The quality of care between the groups was compared.Results:Pulmonary function indicators in the intervention group were significantly better than those in the nursing group(P<0.05).Immune function in the intervention group was also significantly higher than in the nursing group(P<0.05).Before the intervention,there was no significant difference in self-care ability between the two groups(P>0.05).However,post-intervention,both groups showed improved self-care abilities,with the intervention group scoring significantly higher than the nursing group(P<0.05).Similarly,before the intervention,there was no significant difference in quality-of-life scores(P>0.05),but post-intervention,both groups exhibited increased scores,with the intervention group outperforming the nursing group significantly(P<0.05).Conclusion:Continuous nursing interventions significantly improve outcomes in elderly patients with COPD in the stable phase and frailty,warranting broader implementation.
文摘Objective:To explore nursing measures for elderly patients with chronic obstructive pulmonary disease(COPD)and analyze the effect of continuous nursing pathways on improving the accuracy of aerosol use.Methods:From April 2023 to April 2024,76 elderly COPD patients admitted to our hospital were randomly selected for nursing research.They were divided into two groups using a computer double-blind method,with 38 patients in each group.The control group received routine nursing,while the observation group applied the continuous nursing pathway.The nursing effects of the two groups were investigated and compared,including(1)aerosol accuracy;(2)cardiopulmonary function;(3)subjective well-being and self-care ability;(4)quality of life;and(5)nursing satisfaction.Results:Compared with the control group,the observation group had a significantly higher accuracy rate of aerosol use(P<0.05).Before nursing,there were no significant differences in cardiopulmonary function indicators,MUNSH scores,and ESCA scores between the two groups(P>0.05).After nursing,the patient's cardiopulmonary function improved significantly,and their subjective well-being and self-care ability increased.The observation group was significantly better than the control group in all the above indicators(P<0.05).The quality of life scores of the observation group were significantly higher than those of the control group(P<0.05).Conclusion:In the nursing of elderly patients with chronic obstructive pulmonary disease,the application of the continuous nursing pathway can effectively improve the accuracy of aerosol use and improve patients'cardiopulmonary function.
文摘BACKGROUND Radical gastrectomy(RGE)for gastric carcinoma(GC)has exerted definite therapeutic efficacy in treating patients with GC.However,a notable risk of postoperative complications(POCs)persists among middle-aged and elderly patients with compromised physiological functions.Hence,developing and implementing reliable nursing interventions to optimize the comprehensive management of these patients is deemed imperative.AIM To analyze the association of multi-channel continuous nursing intervention with POCs,negative emotions(NEs),and quality of life(QoL)of patients undergoing RGE for GC.METHODS This retrospective study selected 99 patients who underwent RGE for GC in our hospital from May 2020 to May 2023.Participants were categorized into the control(n=49 cases)and research groups(n=50 cases)receiving routine and multi-channel continuous nursing care,respectively.Comparative analysis involved data on postoperative rehabilitation(time to first anal exhaust,oral feeding and ambulation,and hospital stay),complications(nausea and vomiting,delayed gastric emptying,and abdominal distension),NEs[Self-rating Anxiety(SAS)/Depression Scale(SDS)],treatment compliance,self-efficacy,and QoL[World Health Organization QoL Brief Version(WHOQOL-BREF)].RESULTS Compared to the control group,the research group demonstrated earlier first postoperative anal exhaust,oral feeding,and ambulation,shorter hospital stay,lower POC rate,and more reduced SAS and SDS scores postintervention,which was significantly lower than the baseline.The treatment compliance scores were significantly higher in the research group than in the control group in terms of medication adherence,daily exercise,reasonable diet,and regular review.Further,the research group demonstrated increased self-efficacy scores in terms of positive attitude,self-stress relief,and self-decision-making,as well as the overall score postintervention,which were higher than the control group.Moreover,the research group reported notably higher WHOQOL-BREF scores in domains such as physiology,psychology,social relations,and environment.CONCLUSION Multi-channel continuous nursing intervention prevents POCs in patients undergoing RGE for GC as well as significantly alleviates patients’NEs and boosts their QoL.
基金Supported by the National Natural Science Foundation of China(No.52375037)the Masters Innovation Project of Beijing University of Civil Engineering and Architecture(No.PG2024142)+1 种基金the Outstanding Youth of Pyramid Talent Training Project of Beijing University of Civil Engineering and Architecture(No.GDRC20220801)the Breeding Program Funding of Beijing University of Civil Engineering and Architecture(No.X24026).
文摘The aim of the study is to investigate the impact of the buffer groove structure on the pressure of continuous rotation electro-hydraulic servo motor.The mathematical model of the motor valve plate with triangular groove and U-groove structure is established firstly,and the structure size of the two buffer grooves with better pressure drop effect is obtained by Matlab.Secondly,an established pressure gradient model is developed for the sealed canisters for electric motors using a combined groove structure.The bird swarm optimization algorithm is used to obtain the optimal dimensions for the combined depth and angle of the pressure groove.The flow field in the motor seal chamber is simulated and calculated by Fluent.This study compared the pressure field distributions in the motors sealing chamber using triangular and combined groove structures.It investigated the combined grooves effect on the pressure impact during the commutation of a continuously rotating electro-hydraulic servo motor.It is found that the combined groove structure has a positive impact on reducing the pressure impact.The results indicate that the combined groove structure significantly enhances the efficiency of mitigating pressure shocks when the motor switches between high-and low-pressure chambers.
基金Supported by the Scientific and Technological Research and Development Program of Xinjiang Transportation Investment(Group)Co.,Ltd.:XJJTZKX-FWCG-202312-0456。
文摘The objective of this research is to assess the seismic behavior of the continuous T-beam bridge located at Kulungou in Xinjiang.In addition to traditional static and modal analyses,this study introduces a novel approach by comprehensively examining the performance of the bridge during construction stages,under ultimate load capacities and seismic load.Compliance with regulatory standards is verified by the static analysis,which also yields a thorough comprehension of stress distribution across various stages of construction.By unveiling the initial 100 vibration modes,the modal analysis has significantly enhanced our comprehension and established a robust basis for the ensuing seismic analysis.A distinctive aspect of this research is its comprehensive exploration of the bridge’s seismic behavior under E1 and E2 earthquake excitations.Under E1 earthquake excitation,the response spectrum analysis confirms the adequacy of the bridge piers’strength according to seismic design criteria,whereas the time-history analysis conducted under E2 ground motion reveals the bridge’s robust resistance to strong earthquakes.This study also undertakes a comparative assessment of the seismic behavior of the bridge,contrasting its performance with lead-rubber bearings against that with high-damping rubber bearings.According to the study’s findings,both types of bearings demonstrate their efficacy in mitigating seismic responses,thereby emphasizing their potential as innovative approaches to enhance the resilience of bridges.A notable contribution of this research lies in its assessment of seismic performance indicators,namely hysteresis curves,backbone curves,and ductility coefficients,utilizing Pushover analysis.By conducting a thorough evaluation,a more profound insight into the seismic performance of bridge piers is gained.In conclusion,the study explores how earthquake wave intensity and aftershocks affect the seismic response of bridge piers,showing a substantial increase in seismic response with intensifying wave magnitude and the potential for aftershocks to aggravate damage to compromised structures.The importance of incorporating these factors in the seismic design and retrofitting of bridges is underscored by these discoveries.This study,in its entirety,proposes a fresh and comprehensive methodology to assess the seismic performance of continuous T-beam bridges,furnishing valuable perspectives and innovative remedies to augment the seismic resilience of bridges in earthquake-prone zones.
文摘This study analyzed the therapeutic effects of continuous ambulatory peritoneal dialysis(CAPD)and automated peritoneal dialysis(APD)on patients with end-stage renal disease.Fifty patients admitted between January 2024 and December 2024 were randomly assigned to two groups,with the observation group receiving APD and the reference group receiving CAPD.Renal function indicators,nutritional indicators,mineral metabolism,urine volume,and ultrafiltration volume changes were compared between the two groups.After treatment,the observation group showed lower renal function indicators,higher nutritional indicators,and better mineral metabolism levels compared to the reference group(P<0.05).While there was no significant difference in urine volume between the two groups(P>0.05),the observation group demonstrated superior ultrafiltration volume(P<0.05).These findings suggest that APD offers better clinical outcomes than CAPD by improving renal function,nutritional status,mineral metabolism regulation,and ultrafiltration efficiency in patients with end-stage renal disease.
基金supported by the National Natural Science Foundation of China(No.52474355)the Liaoning Province Science and Technology Plan Joint Program(Key Research and Development Program Project),China(Nos.2022JH25/10200003 and 2023JH2/101800058).
文摘The application of liquid core reduction(LCR)technology in thin slab continuous casting can refine the internal microstruc-tures of slabs and improve their production efficiency.To avoid crack risks caused by large deformation during the LCR process and to minimize the thickness of the slab in bending segments,the maximum theoretical reduction amount and the corresponding reduction scheme for the LCR process must be determined.With SPA-H weathering steel as a specific research steel grade,the distributions of tem-perature and deformation fields of a slab with the LCR process were analyzed using a three-dimensional thermal-mechanical finite ele-ment model.High-temperature tensile tests were designed to determine the critical strain of corner crack propagation and intermediate crack initiation with various strain rates and temperatures,and a prediction model of the critical strain for two typical cracks,combining the effects of strain rate and temperature,was proposed by incorporating the Zener-Hollomon parameter.The crack risks with different LCR schemes were calculated using the crack risk prediction model,and the maximum theoretical reduction amount for the SPA-H slab with a transverse section of 145 mm×1600 mm was 41.8 mm,with corresponding reduction amounts for Segment 0 to Segment 4 of 15.8,7.3,6.5,6.4,and 5.8 mm,respectively.
基金supported by the National Key R&D Program of China(No.2023YFB3308601)Sichuan Science and Technology Program(2024NSFJQ0035,2024NSFSC0004)the Talents by Sichuan provincial Party Committee Organization Department.
文摘In natural language processing(NLP),managing multiple downstream tasks through fine-tuning pre-trained models often requires maintaining separate task-specific models,leading to practical inefficiencies.To address this challenge,we introduce AdaptForever,a novel approach that enables continuous mastery of NLP tasks through the integration of elastic and mutual learning strategies with a stochastic expert mechanism.Our method freezes the pre-trained model weights while incorporating adapters enhanced with mutual learning capabilities,facilitating effective knowledge transfer from previous tasks to new ones.By combining Elastic Weight Consolidation(EWC)for knowledge preservation with specialized regularization terms,AdaptForever successfully maintains performance on earlier tasks while acquiring new capabilities.Experimental results demonstrate that AdaptForever achieves superior performance across a continuous sequence of NLP tasks compared to existing parameter-efficient methods,while effectively preventing catastrophic forgetting and enabling positive knowledge transfer between tasks.
文摘Objective:To analyze the nursing effect of implementing continuous nursing combined with knowledge,attitude,and practice(KAP)intervention under the guidance of interactive goal-setting theory for patients with gestational diabetes mellitus(GDM).Methods:A total of 68 patients with GDM who were admitted to the hospital between December 2021 and December 2023 were selected and randomly divided into two groups using a random number table.The combined group(34 cases)received continuous nursing combined with KAP intervention under the premise of interactive goal-setting theory,while the conventional group(34 cases)received routine nursing care.Blood glucose control,health behavior scores,and other indicators were compared between the two groups.Results:After nursing,the blood glucose level in the combined group was lower than that in the conventional group,and the scores for health behavior and self-management ability were higher than those in the conventional group(P<0.05).Conclusion:Combined nursing can improve blood glucose control in patients with GDM,standardize their health behaviors,and cultivate their self-management skills.
文摘BACKGROUND Despite sharing similar pathogenic factors,cancer and coronary heart disease(CHD)occur in comparable populations at similar ages and possess similar susceptibility factors.Consequently,it is increasingly commonplace for patients to experience the simultaneous occurrence of cancer and CHD,a trend that is steadily rising.AIM To determine the impacts of continuing care on lung cancer patients with CHD following percutaneous coronary intervention(PCI).METHODS There were 94 lung cancer patients with CHD following PCI who were randomly assigned to the intervention group(n=38)and the control group(n=41).In the intervention group,continuing care was provided,while in the control group,routine care was provided.An evaluation of cardiac and pulmonary function,medication compliance,a 6-min walk test,and patient quality of life was performed.RESULTS Differences between the two groups were significant in left ventricular ejection fraction,6-min walk test,oxygen uptake,quality of life and medication compliance(P<0.05).In comparison with the control group,the enhancement in the intervention group was more significant.The intervention group had more patients with high medication compliance than the control group,with a statistically significant difference(P<0.05).CONCLUSION After undergoing PCI,lung patients with CHD could benefit from continued care in terms of cardiac and pulmonary function,medications compliance,and quality of life.
基金financially supported by the National Natural Science Foundation of China(Grant Nos.52130303,52327802,52303101,52173078,51973158)the China Postdoctoral Science Foundation(2023M732579)+2 种基金Young Elite Scientists Sponsorship Program by CAST(No.2022QNRC001)National Key R&D Program of China(No.2022YFB3805702)Joint Funds of Ministry of Education(8091B032218).
文摘Vertically oriented carbon structures constructed from low-dimen-sional carbon materials are ideal frameworks for high-performance thermal inter-face materials(TIMs).However,improving the interfacial heat-transfer efficiency of vertically oriented carbon structures is a challenging task.Herein,an orthotropic three-dimensional(3D)hybrid carbon network(VSCG)is fabricated by depositing vertically aligned carbon nanotubes(VACNTs)on the surface of a horizontally oriented graphene film(HOGF).The interfacial interaction between the VACNTs and HOGF is then optimized through an annealing strategy.After regulating the orientation structure of the VACNTs and filling the VSCG with polydimethylsi-loxane(PDMS),VSCG/PDMS composites with excellent 3D thermal conductive properties are obtained.The highest in-plane and through-plane thermal conduc-tivities of the composites are 113.61 and 24.37 W m^(-1)K^(-1),respectively.The high contact area of HOGF and good compressibility of VACNTs imbue the VSCG/PDMS composite with low thermal resistance.In addition,the interfacial heat-transfer efficiency of VSCG/PDMS composite in the TIM performance was improved by 71.3%compared to that of a state-of-the-art thermal pad.This new structural design can potentially realize high-performance TIMs that meet the need for high thermal conductivity and low contact thermal resistance in interfacial heat-transfer processes.
文摘Managing diabetes during pregnancy is challenging,given the significant risk it poses for both maternal and foetal health outcomes.While traditional methods involve capillary self-monitoring of blood glucose level monitoring and periodic HbA1c tests,the advent of continuous glucose monitoring(CGM)systems has revolutionized the approach.These devices offer a safe and reliable means of tracking glucose levels in real-time,benefiting both women with diabetes during pregnancy and the healthcare providers.Moreover,CGM systems have shown a low rate of side effects and high feasibility when used in pregnancies complicated by diabetes,especially when paired with continuous subcutaneous insulin infusion pump as hybrid closed loop device.Such a combined approach has been demonstrated to improve overall blood sugar control,lessen the occurrence of preeclampsia and neonatal hypoglycaemia,and minimize the duration of neonatal intensive care unit stays.This paper aims to offer a comprehensive evaluation of CGM metrics specifically tailored for pregnancies impacted by type 1 diabetes mellitus.
基金Supported by Natural Science Foundation of Zhejiang Province,No.LY23H050005and Zhejiang Medical Technology Project,No.2022RC009.
文摘Diabetic kidney disease(DKD)is a common complication of diabetes mellitus that contributes to the risk of end-stage kidney disease(ESKD).Wide glycemic var-iations,such as hypoglycemia and hyperglycemia,are broadly found in diabetic patients with DKD and especially ESKD,as a result of impaired renal metabolism.It is essential to monitor glycemia for effective management of DKD.Hemoglobin A1c(HbA1c)has long been considered as the gold standard for monitoring glycemia for>3 months.However,assessment of HbA1c has some bias as it is susceptible to factors such as anemia and liver or kidney dysfunction.Continuous glucose monitoring(CGM)has provided new insights on glycemic assessment and management.CGM directly measures glucose level in interstitial fluid,reports real-time or retrospective glucose concentration,and provides multiple glycemic metrics.It avoids the pitfalls of HbA1c in some contexts,and may serve as a precise alternative to estimation of mean glucose and glycemic variability.Emerging studies have demonstrated the merits of CGM for precise monitoring,which allows fine-tuning of glycemic management in diabetic patients.Therefore,CGM technology has the potential for better glycemic monitoring in DKD patients.More research is needed to explore its application and management in different stages of DKD,including hemodialysis,peritoneal dialysis and kidney transplantation.
文摘BACKGROUND There are relatively few studies on continuing care of coronary heart disease(CHD),and its research value needs to be further clarified.AIM To investigate the effect of continuous nursing on treatment compliance and side effect management in patients with CHD.METHODS This is a retrospective study with patients from January 2021 to 2023.The study was divided into two groups with 30 participants in each group.Self-rating anxiety scale(SAS)and Self-rating depression scale(SDS)were used to assess patients'anxiety and depression,and medical coping questionnaire was used to assess patients'coping styles.The pelvic floor dysfunction questionnaire(PFDI-20)was used to assess the status of pelvic floor function,including bladder symptoms,intestinal symptoms,and pelvic symptoms.RESULTS SAS score decreased from 57.33±3.01before treatment to 41.33±3.42 after treatment,SDS score decreased from 50.40±1.45 to 39.47±1.57.The decrease of these two indexes was statistically significant(P<0.05).PFDI-20 scores decreased from the mean 16.83±1.72 before treatment to 10.47±1.3the mean after treatment,which was statistically significant(P<0.05).CONCLUSION The results of this study indicate that pioneering research in continuous care of CHD has a positive impact on improving patients'treatment compliance,reducing anxiety and depression levels,and improving coping styles and pelvic floor functional status.
文摘Upper gastrointestinal bleeding (UGIB) presents as a prevalent clinical challenge, with annual incidence rates ranging from 80 to 150 cases per 100,000 individuals. Guidelines for managing patients with UGIB due to bleeding ulcers recommend a continuous infusion of proton pump inhibitors (PPI). However, studies comparing intermittent dosing of PPI therapy show that this regimen achieves similar clinical benefits. If the clinical efficacy remains equivalent, intermittent dosing will be more cost-effective for patients and the health care system. Our research study aims to analyze the comparative effectiveness of intermittent versus continuous PPI therapy after endoscopic treatment in patients with UGIB, focusing on such endpoints as rebleeding risk at 3-and 7-day mortality rates. Methods: Resources searched included MEDLINE, EMBASE, PUBMED, and the Cochrane Central Register of Controlled Trials databases from January 2010 through December 2023 with the inclusion of meta-analysis, systematic review, review, or ACG guideline recommendations. Results of the analysis show how recommendations regarding high vs. low PPI regimen changed over time: from no difference in regimen in 2010 to recommending continuous regimen in 2012 to declaring insufficient evidence between choosing one regimen over another in 2013 to determine that both regimens were comparable to each other in 2014-2018 and finally to recommending both regimens in 2021. To conclude, our review shows that in patients with bleeding ulcers and high-risk endoscopic findings, intermittent PPI therapy is non-inferior to continuous PPI infusion for three days, seven days bleeding risk or mortality rates;however, it remains challenging to determine the most optimal intermittent regimen due to heterogeneity of RCTs included in meta-analyses, and further trials will need to be performed.
基金supported in part by the Intelligent Policing and National Security Risk Management Laboratory 2023 Opening Project(No.ZHKFYB2304)the Fundamental Research Funds for the Central Universities(Nos.SCU2023D008,2023SCU12129)+2 种基金the Natural Science Foundation of Sichuan Province(No.2024NSFSC1449)the Science and Engineering Connotation Development Project of Sichuan University(No.2020SCUNG129)the Key Laboratory of Data Protection and Intelligent Management(Sichuan University),Ministry of Education.
文摘The security performance of cloud services is a key factor influencing users’selection of Cloud Service Providers(CSPs).Continuous monitoring of the security status of cloud services is critical.However,existing research lacks a practical framework for such ongoing monitoring.To address this gap,this paper proposes the first NonCollaborative Container-Based Cloud Service Operation State Continuous Monitoring Framework(NCCMF),based on relevant standards.NCCMF operates without the CSP’s collaboration by:1)establishing a scalable supervisory index system through the identification of security responsibilities for each role,and 2)designing a Continuous Metrics Supervision Protocol(CMA)to automate the negotiation of supervisory metrics.The framework also outlines the supervision process for cloud services across different deployment models.Experimental results demonstrate that NCCMF effectively monitors the operational state of two real-world IoT(Internet of Things)cloud services,with an average supervision error of less than 15%.
基金supported by the Zhejiang Key Science and Technology Project(2023C03116)National Natural Science Foundation of China(22078286)National Key Research and Development Program of China(2021YFE0113300).
文摘Dynamic control is essential to guarantee the stable performance of continuous chromatography.AutoMAb dynamic control strategy has been developed to ensure a consistent protein load in twincolumn CaptureSMB continuous capture by integrating the UV signal of breakthrough.In this study,the process risk of CaptureSMB continuous capture under AutoMAb control towards the feedstock variations was assessed by a mechanistic model developed by us.The effects of target protein and impurities under the variation range of±10 mAU·min^(-1) on load amount,protein loss,process productivity,and resin capacity utilization were investigated.The results showed that the CaptureSMB process could be successfully controlled by AutoMAb towards increased or slightly decreased concentration of feedstock.However,the load process would be out of control with drastically decreased target protein or impurities,and the decreased impurities would lead to protein loss.It was found that AutoMAb control would cause 44.7%non-operational areas and 18.3%protein loss areas in the variation range of±10 mAU·min^(-1).To improve the stability of the CaptureSMB process,a modified AutoMAb control that would stop the load procedure when the absolute value of the integral area reached the preset value,was proposed to reduce the risk of protein loss and the non-operational area.
文摘A wavelet based identification method for linear time-varying systems is presented,and the ridge and skeleton of the continuous wavelet transform of free response is used to extract time-varying parameters. The stiffness and damping coefficients of single-degree-of—freedom systems,frequencies and damping ratios of multi-degree-of-freedom systems are estimated without any prior information of systems. The proposed method is applied to linear time-varying systems with both abrupt and smooth variation parameters. Gaussian white noise is added to the response to test the anti-noise performance of the algorithm. The simulation results show that the proposed method is capable of accurately tracking the variation of the systems.
