AIMTo evaluate intra-session repeatability and reproducibility of optical quality parameters measured at objective and subjective best focuses in a double-pass system.METHODSThirty Chinese healthy adults (19 to 40 yea...AIMTo evaluate intra-session repeatability and reproducibility of optical quality parameters measured at objective and subjective best focuses in a double-pass system.METHODSThirty Chinese healthy adults (19 to 40 years old) meeting our inclusion criterion were enrolled in the study. After a basic eye examination, two methods of optical quality measurement, based on subjective and objective best focuses were performed using the Optical Quality Analysis System (OQAS) with an artificial pupil diameter of 4.0 mm.RESULTSWith each method, three consecutive measurements of the following parameters: the modulation transfer function cutoff frequency (MTF<sub>cutoff</sub>), the Strehl<sup>2D</sup> ratio, the OQAS values (OVs) at contrasts of 100%, 20%, 9% and the objective scatter index (OSI) were performed by an experienced examiner. The repeatability of each method was evaluated by the repeatability limit (RL) and the coefficient of repeatability (COR). Reproducibility of the two methods was evaluated by intra-class correlation coefficient (ICC) and the 95% limits of agreement (Bland and Altman analysis). Thirty subjects, seven females and twenty three males, of whom 15 right eyes and 15 left eyes were selected randomly for recruitment in the study. The RLs (percentage) for the six parameters measured at objective focus and subjective focus ranged from 8.44% to 15.13% and 10.85% to 16.26%, respectively. The CORs for the two measurement methods ranged from 8.27% to 14.83% and 10.63% to 15.93%, respectively. With regard to reproducibility, the ICCs for the six parameters of OQAS ranged from 0.024 to 0.276. The 95% limits of agreement obtained for the six parameters (in comparison of the two methods) ranged from -0.57 to 42.18 (MTF<sub>cutoff</sub>), -0.01 to 0.23 (Strehl<sup>2D</sup> ratio), -0.02 to 1.40 (OV<sub>100%</sub>), -0.10 to 1.75 (OV<sub>20%</sub>), -0.14 to 1.80 (OV<sub>9%</sub>) and -1.46 to 0.18 (OSI).CONCLUSIONMeasurements provided by OQAS with either method showed a good repeatability. However, the results obtained from the two different measurement methods showed a poor reproducibility. These findings suggest that it might be best to evaluate patients' optical quality by OQAS using the best focus as chosen automatically by the instrument.展开更多
AIM:To evaluate the effect of low-degree astigmatism on objective visual quality through the Optical Quality Analysis System(OQAS).METHODS:This study enrolled 46 participants(aged 23 to 30y,90 eyes)with normal or corr...AIM:To evaluate the effect of low-degree astigmatism on objective visual quality through the Optical Quality Analysis System(OQAS).METHODS:This study enrolled 46 participants(aged 23 to 30y,90 eyes)with normal or corrected-to-normal vision.The cylindrical lenses(0,0.5,0.75,1.0,and 1.25 D)were placed at the axial direction(180°,45°,90°,and 135°)in front of the eyes with the best correction to form 16 types of regular low-degree astigmatism.OQAS was used to detect the objective visual quality,recorded as the objective scattering index(OSI),OQAS values at contrasts of 100%,20%,and 9%predictive visual acuity(OV100%,OV20%,and OV9%),modulation transfer function cut-off(MTFcut-off)and Strehl ratio(SR).The mixed effect linear model was used to compare objective visual quality differences between groups and examine associations between astigmatic magnitude and objective visual quality parameters.RESULTS:Apparent negative relationships between the magnitude of low astigmatism and objective visual quality were observed.The increase of OSI per degree of astigmatism at 180°,45°,90°,and 135°axis were 0.38(95%CI:0.35,0.42),0.50(95%CI:0.46,0.53),0.49(95%CI:0.45,0.54)and 0.37(95%CI:0.34,0.41),respectively.The decrease of MTFcut-off per degree of astigmatism at 180°,45°,90°,and 135°axis were-10.30(95%CI:-11.43,-9.16),-12.73(95%CI:-13.62,-11.86),-12.75(95%CI:-13.79,-11.70),and-9.97(95%CI:-10.92,-9.03),respectively.At the same astigmatism degree,OSI at 45°and 90°axis were higher than that at 0°and 135°axis,while MTFcut-off were lower.CONCLUSION:Low astigmatism of only 0.50 D can significantly reduce the objective visual quality.展开更多
AIM:To evaluate the accuracy of spherical equivalent(SE) estimates of a double-pass system and to compare it with retinoscopy,subjective refraction and a table mounted autorefractor.METHODS:Non-cycloplegic refraction ...AIM:To evaluate the accuracy of spherical equivalent(SE) estimates of a double-pass system and to compare it with retinoscopy,subjective refraction and a table mounted autorefractor.METHODS:Non-cycloplegic refraction was performed on 125 eyes of 65 healthy adults(age 23.5±3.0 years) from October 2010 to January 2011 using retinoscopy,subjective refraction,autorefraction(Auto kerato refractometer TOPCON KR-8100,Japan) and a double pass system(Optical Quality Analysis System,OQAS,Visiometrics S.L.,Spain).Nine consecutive measurements with the double-pass system were performed on a subgroup of 22 eyes to assess repeatability.To evaluate the trueness of the OQAS instrument,the SE laboratory bias between the double pass system and the other techniques was calculated.RESULTS:The SE mean coefficient of repeatability obtained was 0.22D.Significant correlations could be established between the OQAS and the SE obtained with retinoscopy(r=0.956,P【0.001),subjective refraction(r=0.955,P【0.001) and autorefraction(r=0.957,P【0.001).The differences in SE between the double-pass system and the other techniques were significant(P【0.001),but lacked clinical relevance except for retinoscopy;Retinoscopy gave more hyperopic values than the double-pass system-0.51±0.50D as well as the subjective refraction-0.23±0.50D;More myopic values were achieved by means of autorefraction 0.24±0.49D. CONCLUSION:The double-pass system provides accurate and reliable estimates of the SE that can be used for clinical studies.This technique can determine the correct focus position to assess the ocular optical quality.However,it has a relatively small measuring range in comparison with autorefractors(-8.00 to +5.00D),and requires prior information on the refractive state of the patient.展开更多
目的:评价近视患者接受飞秒LASIK术后早期的综合视觉质量,探讨双通道系统(OQAS)在视觉质量评估中的应用价值。方法:选取我院2014-09/2015-09进行飞秒LASIK手术近视患者48例96眼,使用OQAS检查,记录患者术前、术后1wk,1、3mo共四个时间点...目的:评价近视患者接受飞秒LASIK术后早期的综合视觉质量,探讨双通道系统(OQAS)在视觉质量评估中的应用价值。方法:选取我院2014-09/2015-09进行飞秒LASIK手术近视患者48例96眼,使用OQAS检查,记录患者术前、术后1wk,1、3mo共四个时间点的斯特列尔比(Strehl ratio,SR),调制传递函数截止空间频率(modulation transfer function cutoff frequency,MTF cutoff)、眼内客观散射指数(objective scattering index,OSI)三个指标,并从客观方面分析和评价患者手术前后早期的视觉质量。结果:术后3mo的MTF截止空间频率优于术前,OSI在术后1wk和1mo均比术前高,差异有统计学意义(P<0.05),但术后3mo恢复至术前水平。利用Pearson线性相关对SR、OSI与MTF截止空间频率进行相关性分析,发现SR、OSI两者皆与MTF截止空间频率具有显著的相关性(P<0.05)。结论:飞秒LASIK术后视力恢复快,其有效性和安全性良好,MIT截止空间频率、SR、OSI检查结果可作为综合指标来评价临床患者术后的视觉质量。展开更多
目的利用视觉质量分析系统对翼状胬肉切除前后患者的客观光学质量变化进行分析。方法选取我院2016年9月至2017年5月在武汉大学人民医院眼科中心确诊为单眼翼状胬肉并且进行翼状胬肉切除伴自体结膜瓣移植手术患者20例20眼,根据翼状胬肉...目的利用视觉质量分析系统对翼状胬肉切除前后患者的客观光学质量变化进行分析。方法选取我院2016年9月至2017年5月在武汉大学人民医院眼科中心确诊为单眼翼状胬肉并且进行翼状胬肉切除伴自体结膜瓣移植手术患者20例20眼,根据翼状胬肉尺寸大小分为小胬肉组10例10眼和大胬肉组10例10眼,采用双通道视觉质量分析系统Ⅱ进行视觉质量检测,记录健康眼及患眼术前、术后1个月、3个月的调制传递函数截止频率(modulation transfer function cut off,MTF_(cutoff))、斯特列尔比(Strehl ratio,SR)、基础客观散射指数及总客观散射指数值,通过计算得出泪膜客观散射指数(tear film objective scatter index,TF-OSI)。结果与术前相比,两组中患眼术后3个月MTF_(cutoff)、SR均升高,TF-OSI降低,差异均有统计学意义(均为P<0.05),而术前与术后1个月相比两组三项视觉质量参数无明显统计学差异(均为P>0.05)。两组之间的视觉质量参数相比,只有术后3个月的MTF_(cutoff)、SR、TF-OSI比较差异具有统计学意义(均为P<0.05),术前与术后1个月的视觉质量参数均无统计学意义(均为P>0.05)。两组中健康眼与患眼术前相比MTF_(cutoff)、SR、TF-OSI均有统计学意义(均为P<0.05)。结论翼状胬肉会影响视觉质量及泪膜功能,早期手术切除能够带来改善,但这种改善可能出现在术后较长的一段时间内。利用视觉质量分析系统Ⅱ可以对手术前后的结果进行客观分析,MTF_(cutoff)、SR、TF-OSI可作为综合指标来评价临床上翼状胬肉患者的视觉质量。展开更多
目的:通过双通道客观视觉质量分析系统Ⅱ(OQASⅡ)评价有晶状体眼后房型人工晶状体(ICL)植入术对高度近视的临床疗效。方法:选取2017-12/2018-12安徽医科大学第一附属医院收治的高度近视患者26例52眼,所有患者均行ICL植入术。随访获取所...目的:通过双通道客观视觉质量分析系统Ⅱ(OQASⅡ)评价有晶状体眼后房型人工晶状体(ICL)植入术对高度近视的临床疗效。方法:选取2017-12/2018-12安徽医科大学第一附属医院收治的高度近视患者26例52眼,所有患者均行ICL植入术。随访获取所有患者术前BCVA以及术前和术后1wk,1、3mo的UCVA、客观散射指数(OSI)、调制传递函数(MTF)、斯特列尔比(SR)和100%、20%及9%的模拟对比度视力(Predicted VA)等一系列参数。结果:与术前BCVA相比,术后1wk,1、3mo UCVA情况均优于术前且日渐改善(P<0.01)。与术前OSI、MTF、SR和Predicted VA 100%、20%及9%相比,术后1wk,1、3mo情况均好转(P<0.01)。结论:ICL植入术能够有效地矫正高度近视,提高裸眼视力。通过OQASⅡ分析,ICL植入术后OSI比术前减小,术后的MTF、SR和Predicted VA 100%、20%及9%比术前均有提高,高度近视患者视觉质量得到良好的改善。展开更多
文摘AIMTo evaluate intra-session repeatability and reproducibility of optical quality parameters measured at objective and subjective best focuses in a double-pass system.METHODSThirty Chinese healthy adults (19 to 40 years old) meeting our inclusion criterion were enrolled in the study. After a basic eye examination, two methods of optical quality measurement, based on subjective and objective best focuses were performed using the Optical Quality Analysis System (OQAS) with an artificial pupil diameter of 4.0 mm.RESULTSWith each method, three consecutive measurements of the following parameters: the modulation transfer function cutoff frequency (MTF<sub>cutoff</sub>), the Strehl<sup>2D</sup> ratio, the OQAS values (OVs) at contrasts of 100%, 20%, 9% and the objective scatter index (OSI) were performed by an experienced examiner. The repeatability of each method was evaluated by the repeatability limit (RL) and the coefficient of repeatability (COR). Reproducibility of the two methods was evaluated by intra-class correlation coefficient (ICC) and the 95% limits of agreement (Bland and Altman analysis). Thirty subjects, seven females and twenty three males, of whom 15 right eyes and 15 left eyes were selected randomly for recruitment in the study. The RLs (percentage) for the six parameters measured at objective focus and subjective focus ranged from 8.44% to 15.13% and 10.85% to 16.26%, respectively. The CORs for the two measurement methods ranged from 8.27% to 14.83% and 10.63% to 15.93%, respectively. With regard to reproducibility, the ICCs for the six parameters of OQAS ranged from 0.024 to 0.276. The 95% limits of agreement obtained for the six parameters (in comparison of the two methods) ranged from -0.57 to 42.18 (MTF<sub>cutoff</sub>), -0.01 to 0.23 (Strehl<sup>2D</sup> ratio), -0.02 to 1.40 (OV<sub>100%</sub>), -0.10 to 1.75 (OV<sub>20%</sub>), -0.14 to 1.80 (OV<sub>9%</sub>) and -1.46 to 0.18 (OSI).CONCLUSIONMeasurements provided by OQAS with either method showed a good repeatability. However, the results obtained from the two different measurement methods showed a poor reproducibility. These findings suggest that it might be best to evaluate patients' optical quality by OQAS using the best focus as chosen automatically by the instrument.
文摘AIM:To evaluate the effect of low-degree astigmatism on objective visual quality through the Optical Quality Analysis System(OQAS).METHODS:This study enrolled 46 participants(aged 23 to 30y,90 eyes)with normal or corrected-to-normal vision.The cylindrical lenses(0,0.5,0.75,1.0,and 1.25 D)were placed at the axial direction(180°,45°,90°,and 135°)in front of the eyes with the best correction to form 16 types of regular low-degree astigmatism.OQAS was used to detect the objective visual quality,recorded as the objective scattering index(OSI),OQAS values at contrasts of 100%,20%,and 9%predictive visual acuity(OV100%,OV20%,and OV9%),modulation transfer function cut-off(MTFcut-off)and Strehl ratio(SR).The mixed effect linear model was used to compare objective visual quality differences between groups and examine associations between astigmatic magnitude and objective visual quality parameters.RESULTS:Apparent negative relationships between the magnitude of low astigmatism and objective visual quality were observed.The increase of OSI per degree of astigmatism at 180°,45°,90°,and 135°axis were 0.38(95%CI:0.35,0.42),0.50(95%CI:0.46,0.53),0.49(95%CI:0.45,0.54)and 0.37(95%CI:0.34,0.41),respectively.The decrease of MTFcut-off per degree of astigmatism at 180°,45°,90°,and 135°axis were-10.30(95%CI:-11.43,-9.16),-12.73(95%CI:-13.62,-11.86),-12.75(95%CI:-13.79,-11.70),and-9.97(95%CI:-10.92,-9.03),respectively.At the same astigmatism degree,OSI at 45°and 90°axis were higher than that at 0°and 135°axis,while MTFcut-off were lower.CONCLUSION:Low astigmatism of only 0.50 D can significantly reduce the objective visual quality.
基金Spanish Ministry of Education and Science(No.DPI2008-06455-C02-01)European Union and the Spanish Agency for International Cooperation(AECI)(No.D/030286/10)
文摘AIM:To evaluate the accuracy of spherical equivalent(SE) estimates of a double-pass system and to compare it with retinoscopy,subjective refraction and a table mounted autorefractor.METHODS:Non-cycloplegic refraction was performed on 125 eyes of 65 healthy adults(age 23.5±3.0 years) from October 2010 to January 2011 using retinoscopy,subjective refraction,autorefraction(Auto kerato refractometer TOPCON KR-8100,Japan) and a double pass system(Optical Quality Analysis System,OQAS,Visiometrics S.L.,Spain).Nine consecutive measurements with the double-pass system were performed on a subgroup of 22 eyes to assess repeatability.To evaluate the trueness of the OQAS instrument,the SE laboratory bias between the double pass system and the other techniques was calculated.RESULTS:The SE mean coefficient of repeatability obtained was 0.22D.Significant correlations could be established between the OQAS and the SE obtained with retinoscopy(r=0.956,P【0.001),subjective refraction(r=0.955,P【0.001) and autorefraction(r=0.957,P【0.001).The differences in SE between the double-pass system and the other techniques were significant(P【0.001),but lacked clinical relevance except for retinoscopy;Retinoscopy gave more hyperopic values than the double-pass system-0.51±0.50D as well as the subjective refraction-0.23±0.50D;More myopic values were achieved by means of autorefraction 0.24±0.49D. CONCLUSION:The double-pass system provides accurate and reliable estimates of the SE that can be used for clinical studies.This technique can determine the correct focus position to assess the ocular optical quality.However,it has a relatively small measuring range in comparison with autorefractors(-8.00 to +5.00D),and requires prior information on the refractive state of the patient.
文摘目的:评价近视患者接受飞秒LASIK术后早期的综合视觉质量,探讨双通道系统(OQAS)在视觉质量评估中的应用价值。方法:选取我院2014-09/2015-09进行飞秒LASIK手术近视患者48例96眼,使用OQAS检查,记录患者术前、术后1wk,1、3mo共四个时间点的斯特列尔比(Strehl ratio,SR),调制传递函数截止空间频率(modulation transfer function cutoff frequency,MTF cutoff)、眼内客观散射指数(objective scattering index,OSI)三个指标,并从客观方面分析和评价患者手术前后早期的视觉质量。结果:术后3mo的MTF截止空间频率优于术前,OSI在术后1wk和1mo均比术前高,差异有统计学意义(P<0.05),但术后3mo恢复至术前水平。利用Pearson线性相关对SR、OSI与MTF截止空间频率进行相关性分析,发现SR、OSI两者皆与MTF截止空间频率具有显著的相关性(P<0.05)。结论:飞秒LASIK术后视力恢复快,其有效性和安全性良好,MIT截止空间频率、SR、OSI检查结果可作为综合指标来评价临床患者术后的视觉质量。
文摘目的利用视觉质量分析系统对翼状胬肉切除前后患者的客观光学质量变化进行分析。方法选取我院2016年9月至2017年5月在武汉大学人民医院眼科中心确诊为单眼翼状胬肉并且进行翼状胬肉切除伴自体结膜瓣移植手术患者20例20眼,根据翼状胬肉尺寸大小分为小胬肉组10例10眼和大胬肉组10例10眼,采用双通道视觉质量分析系统Ⅱ进行视觉质量检测,记录健康眼及患眼术前、术后1个月、3个月的调制传递函数截止频率(modulation transfer function cut off,MTF_(cutoff))、斯特列尔比(Strehl ratio,SR)、基础客观散射指数及总客观散射指数值,通过计算得出泪膜客观散射指数(tear film objective scatter index,TF-OSI)。结果与术前相比,两组中患眼术后3个月MTF_(cutoff)、SR均升高,TF-OSI降低,差异均有统计学意义(均为P<0.05),而术前与术后1个月相比两组三项视觉质量参数无明显统计学差异(均为P>0.05)。两组之间的视觉质量参数相比,只有术后3个月的MTF_(cutoff)、SR、TF-OSI比较差异具有统计学意义(均为P<0.05),术前与术后1个月的视觉质量参数均无统计学意义(均为P>0.05)。两组中健康眼与患眼术前相比MTF_(cutoff)、SR、TF-OSI均有统计学意义(均为P<0.05)。结论翼状胬肉会影响视觉质量及泪膜功能,早期手术切除能够带来改善,但这种改善可能出现在术后较长的一段时间内。利用视觉质量分析系统Ⅱ可以对手术前后的结果进行客观分析,MTF_(cutoff)、SR、TF-OSI可作为综合指标来评价临床上翼状胬肉患者的视觉质量。
文摘目的:通过双通道客观视觉质量分析系统Ⅱ(OQASⅡ)评价有晶状体眼后房型人工晶状体(ICL)植入术对高度近视的临床疗效。方法:选取2017-12/2018-12安徽医科大学第一附属医院收治的高度近视患者26例52眼,所有患者均行ICL植入术。随访获取所有患者术前BCVA以及术前和术后1wk,1、3mo的UCVA、客观散射指数(OSI)、调制传递函数(MTF)、斯特列尔比(SR)和100%、20%及9%的模拟对比度视力(Predicted VA)等一系列参数。结果:与术前BCVA相比,术后1wk,1、3mo UCVA情况均优于术前且日渐改善(P<0.01)。与术前OSI、MTF、SR和Predicted VA 100%、20%及9%相比,术后1wk,1、3mo情况均好转(P<0.01)。结论:ICL植入术能够有效地矫正高度近视,提高裸眼视力。通过OQASⅡ分析,ICL植入术后OSI比术前减小,术后的MTF、SR和Predicted VA 100%、20%及9%比术前均有提高,高度近视患者视觉质量得到良好的改善。
