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A Double Sensitive Fault Detection Filter for Positive Markovian Jump Systems With A Hybrid Event-Triggered Mechanism
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作者 Junfeng Zhang Baozhu Du +1 位作者 Suhuan Zhang Shihong Ding 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第11期2298-2315,共18页
This paper is concerned with the double sensitive fault detection filter for positive Markovian jump systems. A new hybrid adaptive event-triggered mechanism is proposed by introducing a non-monotonic adaptive law. A ... This paper is concerned with the double sensitive fault detection filter for positive Markovian jump systems. A new hybrid adaptive event-triggered mechanism is proposed by introducing a non-monotonic adaptive law. A linear adaptive event-triggered threshold is established by virtue of 1-norm inequality.Under such a triggering strategy, the original system can be transformed into an interval uncertain system. By using a stochastic copositive Lyapunov function, an asynchronous fault detection filter is designed for positive Markovian jump systems(PMJSs) in terms of linear programming. The presented filter satisfies both L_-gain(?_-gain) fault sensitivity and L_1(?_1)internal differential privacy sensitivity. The proposed approach is also extended to the discrete-time case. Finally, two examples are provided to illustrate the effectiveness of the proposed design. 展开更多
关键词 Fault detection filter hybrid event-triggered mechanism positive Markovian jump systems(PMJSs) sensitivity
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Distributed Fixed-Time Optimal Energy Management for Microgrids Based on a Dynamic Event-Triggered Mechanism
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作者 Feisheng Yang Jiaming Liu Xiaohong Guan 《IEEE/CAA Journal of Automatica Sinica》 CSCD 2024年第12期2396-2407,共12页
The article investigates the optimal energy management(OEM)problem for microgrids.To figure out the problem in fixed time and alleviate communication load with limited resources,this article devises a novel fixed-time... The article investigates the optimal energy management(OEM)problem for microgrids.To figure out the problem in fixed time and alleviate communication load with limited resources,this article devises a novel fixed-time stability lemma and an event-triggered(ET)fixed-time distributed OEM approach.Using Lyapunov stability theory,the distributed approach has been proven to converge in fixed time and the upper bound on convergence time can be derived without dependence on the initial states.The dynamic ET method is raised to dynamically adjust the triggering threshold and reduce communication redundancy.In addition,Zeno behavior is avoided.Simulations are given to show the effectiveness and advantage of the designed distributed OEM method. 展开更多
关键词 Distributed optimization dynamic event-triggered(ET)mechanism fixed-time consensus MICROGRID optimal energy management(OEM)
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Event-triggered mechanism based robust fault-tolerant control for networked wind energy conversion system 被引量:1
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作者 Zhihong Huo Chang Xu 《Global Energy Interconnection》 EI CAS CSCD 2022年第1期55-65,共11页
In this paper,a novel robust fault-tolerant control scheme based on event-triggered communication mechanism for a variable-speed wind energy conversion system(WECS)with sensor and actuator failures is proposed.The non... In this paper,a novel robust fault-tolerant control scheme based on event-triggered communication mechanism for a variable-speed wind energy conversion system(WECS)with sensor and actuator failures is proposed.The nonlinear WECS with event-triggered mechanism is modeled based on the Takagi-Sugeno(T-S)fuzzy model.By Lyapunov stability theory,the parameter expression of the proposed robust fault-tolerant controller with event-triggered mechanisms is proposed based on a feasible solution of linear matrix inequalities.Compared with the existing WECS fault-tolerant control methods,the proposed scheme significantly reduces the pressure of network packet transmission and improves the robustness and reliability of the WECS.Considering a doubly-fed variable speed constant frequency wind turbine,the eventtriggered mechanism based fault-tolerant control for WECS is analyzed considering system model uncertainty.Numerical simulation results demonstrate that the proposed scheme is feasible and effective. 展开更多
关键词 event-triggered mechanism(ETM) Wind energy conversion system(WECS) Fault-tolerant control(FTC) Takagi-sugeno(T-S)fuzzy model
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Region coverage control for multiple stratospheric airships with combined self-/event-triggered mechanism 被引量:1
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作者 Yi-fei Zhang Ming Zhu +1 位作者 Tian Chen Ze-wei Zheng 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2023年第6期254-268,共15页
The region coverage control problem of multiple stratospheric airships system is firstly addressed in this paper.Towards it,we propose a two-layer control framework with the artificial potential field(APF)-based regio... The region coverage control problem of multiple stratospheric airships system is firstly addressed in this paper.Towards it,we propose a two-layer control framework with the artificial potential field(APF)-based region coverage control law and the adaptive tracking control law.The APF-based region coverage control law ensures the coverage task is achieved until every single stratospheric airship ends up performing station keeping where near the respective global minimum point,in which an innovative solution to the local minimum problem is put forward.The adaptive tracking control law is designed to realize motion control using tracking the desired velocity and angular velocity given by coverage control law,with the consideration of several practical control problems as unknown individual differences and external disturbances.To save resources,the combined self-/event-triggered mechanism designed therein significantly reduces the times of state information transmission and control law calculation.The effectiveness of the proposed control framework is verified through simulations. 展开更多
关键词 Formation coverage control Combined self-/event-triggered control Improved artificial potential field
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Neural-based prescribed-time consensus control for multiagent systems via dynamic memory event-triggered mechanism
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作者 Xiaohong ZHENG Hui MA +1 位作者 Qi ZHOU Hongyi LI 《Science China(Technological Sciences)》 2025年第3期217-227,共11页
This work investigates the implementation of distributed prescribed-time neural network(NN)control for nonlinear multiagent systems(MASs)using a dynamic memory event-triggered mechanism(DMETM).First,it introduces a co... This work investigates the implementation of distributed prescribed-time neural network(NN)control for nonlinear multiagent systems(MASs)using a dynamic memory event-triggered mechanism(DMETM).First,it introduces a composite learning technique in NN control.This method leverages the prediction error within the NN update law to enhance the accuracy of the unknown nonlinearity estimation.Subsequently,by introducing a time-varying transformation,the study establishes a distributed prescribed-time control algorithm.The notable feature of this algorithm is its ability to predetermine the convergence time independently of initial conditions or control parameters.Moreover,the DMETM is established to reduce the actuation frequency of the controller.Unlike the conventional memoryless dynamic event-triggered mechanism,the DMETM incorporates a memory term to further increase triggering intervals.Utilizing a distributed estimator for the leader,the DMETM-based NN prescribed-time controller is designed in a fully distributed manner,which guarantees that all signals in the closed-loop system remain bounded within the prescribed time.Finally,simulation results are presented to validate the effectiveness of the proposed algorithm. 展开更多
关键词 consensus control composite learning control dynamic memory event-triggered control prescribed-time control multiagent systems(MASs)
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Recursive filtering of multi-rate cyber-physical systems with unknown inputs under adaptive event-triggered mechanisms
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作者 Ying SUN Miaomiao FU +1 位作者 Jingyang MAO Guoliang WEI 《Frontiers of Information Technology & Electronic Engineering》 SCIE EI CSCD 2024年第2期250-259,共10页
Cyber-physical systems(CPSs)take on the characteristics of both multiple rates of information collection and processing and the dependency on information exchanges.The purpose of this paper is to develop a joint recur... Cyber-physical systems(CPSs)take on the characteristics of both multiple rates of information collection and processing and the dependency on information exchanges.The purpose of this paper is to develop a joint recursive filtering scheme that estimates both unknown inputs and system states for multi-rate CPSs with unknown inputs.In cyberspace,the information transmission between the local joint filter and the sensors is governed by an adaptive event-triggered strategy.Furthermore,the desired parameters of joint filters are determined by a set of algebraic matrix equations in a recursive way,and a sufficient condition verifying the boundedness of filtering error covariance is found by resorting to some algebraic operation.A state fusion estimation scheme that uses local state estimation is proposed based on the covariance intersection(CI)based fusion conception.Lastly,an illustrative example demonstrates the effectiveness of the proposed adaptive event-triggered recursive filtering algorithm. 展开更多
关键词 Cyber-physical systems MULTI-RATE Joint recursive filtering Adaptive event-triggered mechanisms Unknown inputs
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Fractional Order Iteration for Gradient Descent Method Based on Event-Triggered Mechanism
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作者 LU Jiajie WANG Yong FAN Yuan 《Journal of Systems Science & Complexity》 SCIE EI CSCD 2023年第5期1927-1948,共22页
In this work,a novel gradient descent method based on event-triggered strategy has been proposed,which involves integer and fractional order iteration.Firstly,the convergence of integer order iterative optimization me... In this work,a novel gradient descent method based on event-triggered strategy has been proposed,which involves integer and fractional order iteration.Firstly,the convergence of integer order iterative optimization method and the stability of its associated system with integrator dynamics are linked.Based on this result,a fractional order iteration approach has been developed by modelling the system with fractional order dynamics.Secondly,to reduce the comsumption of computation,a feedback based event-triggered mechanism has been introduced to the gradient descent method.The convergence of this new event-triggered optimization algorithm is guaranteed by using a Lyapunov method,and Zeno behavior is proved to be avoided simultaneously.Lastly,the effectiveness and advantages of the proposed algorithms are verified by numerical simulations. 展开更多
关键词 event-triggered mechanism fractional order iteration gradient descent Zeno behavior
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Input-Output Finite-Time Guaranteed Cost Control for Time-Varying Systems Based on an Aperiodic Adaptive Event-Triggered Mechanism
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作者 CHEN Menghua WANG Yunming WANG Xinping 《Journal of Systems Science & Complexity》 SCIE EI CSCD 2023年第3期1070-1088,共19页
This paper is concerned with the problem of input-output finite-time guaranteed cost control for a kind of time-varying systems(TVSs).To reduce the transmission burden,an aperiodic-sampling-based event-triggered mecha... This paper is concerned with the problem of input-output finite-time guaranteed cost control for a kind of time-varying systems(TVSs).To reduce the transmission burden,an aperiodic-sampling-based event-triggered mechanism is proposed with an adaptive law.And a time-varying Lyapunov functional involving some time-dependent piecewise matrices is designed.Input-output finite-time stability(IO-FTS)conditions are presented for the closed-loop system.By resorting to properties of the matrix polynomial,input-output finite-time stabilization criterions are further derived by recursive linear matrix inequalities.And the sampled-data static output feedback controller can be obtained.In addition,the corresponding optimization problem about minimum values of both the guaranteed cost bound and system output norm are established.Finally,a spring-mass-damper system illustrates the effectiveness and superiority. 展开更多
关键词 Aperiodic-sampling-based adaptive event-triggered mechanism guaranteed cost control input-output finite-time stability time-varying system
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Non-fragile reliable control for positive Markovian jump systems based on event-triggered mechanism
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作者 Yinggang Feng Junfeng Zhang +1 位作者 Shuo Li Shizhou Fu 《Journal of Control and Decision》 EI 2021年第4期431-443,共13页
This paper is concerned with the non-fragile reliable control of positive Markovian jump systems with actuator saturation based on event-triggered mechanism.First,an event-triggering condition is given in the form of ... This paper is concerned with the non-fragile reliable control of positive Markovian jump systems with actuator saturation based on event-triggered mechanism.First,an event-triggering condition is given in the form of 1-norm.Using a stochastic co-positive Lyapunov function,a design approach is proposed for the non-fragile controller gain and the corresponding auxiliary feedback gain.Under the designed controller,the closed-loop system is positive and stochastically stable even if actuator faults occur.A cone is constructed as the invariant set of the systems.All conditions are solvable in terms of linear programming.Finally,two examples are provided to verify the effectiveness of the obtained results. 展开更多
关键词 Non-fragile reliable control event-triggered mechanism positive Markovian systems linear programming
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Contribution of mechanical forces to structural synaptic plasticity:insights from 3D cellular motility mechanisms
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作者 Rita O.Teodoro Mafalda Ribeiro Ramos Lara Carvalho 《Neural Regeneration Research》 SCIE CAS 2025年第7期1995-1996,共2页
Cells,tissues,and organs are constantly subjected to the action of mechanical forces from the extracellular environment-and the nervous system is no exception.Cell-intrinsic properties such as membrane lipid compositi... Cells,tissues,and organs are constantly subjected to the action of mechanical forces from the extracellular environment-and the nervous system is no exception.Cell-intrinsic properties such as membrane lipid composition,abundance of mechanosensors,and cytoskeletal dynamics make cells more or less likely to sense these forces.Intrinsic and extrinsic cues are integrated by cells and this combined information determines the rate and dynamics of membrane protrusion growth or retraction(Yamada and Sixt,2019).Cell protrusions are extensions of the plasma membrane that play crucial roles in diverse contexts such as cell migration and neuronal synapse formation.In the nervous system,neurons are highly dynamic cells that can change the size and number of their pre-and postsynaptic elements(called synaptic boutons and dendritic spines,respectively),in response to changes in the levels of synaptic activity through a process called plasticity.Synaptic plasticity is a hallmark of the nervous system and is present throughout our lives,being required for functions like memory formation or the learning of new motor skills(Minegishi et al.,2023;Pillai and Franze,2024). 展开更多
关键词 PLASTICITY STRUCTURAL mechanismS
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Depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite
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作者 Feng Zhang Chenyang Zhang +5 位作者 Linlin Wu Wei Sun Hongliang Zhang Jianhua Chen Yong Pei Songjiang Li 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS 2025年第2期335-345,共11页
The depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite still lacked in-depth insight.Therefore,the depression mechanism of sulfite ... The depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite still lacked in-depth insight.Therefore,the depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite was further systematically investigated with experiments and density functional theory(DFT)calculations.The X-ray photoelectric spectroscopy(XPS)results,DFT calculation results,and frontier molecular orbital analysis indicated that sulfite ions were difficult to be adsorbed on sphalerite surface,suggesting that sulfite ions achieved depression effects on sphalerite through other non-adsorption mechanisms.First,the oxygen content in the surface of sphalerite treated with sulfite ions in creased,which enhanced the hydrophilicity of the sphalerite and further increased the difference in hydrophilicity between sphalerite and galena.Then,sulfite ions were chelated with lead ions to form PbSO_(3)in solution.The hydrophilic PbSO_(3)was more easily adsorbed on sphalerite than galena.The interaction between sulfite ions and lead ions could effectively inhibit the activation of sphalerite.In addition the UV spectrum showed that after adding sulfite ions,the peak of perxanthate in the sphalerite treated xanthate solution was significantly stronger than that in the galena with xanthate solution,indicating that xanthate interacted more readily with sulfite ions and oxygen mo lecules within the sphalerite system,leading to the formation of perxanthate.However,sulfite ions hardly depressed the flotation of ga lena and could promote the flotation of galena to some extent.This study deepened the understanding of the depression mechanism o sulfite ions on sphalerite and Pb^(2+)activated sphalerite. 展开更多
关键词 SPHALERITE GALENA sulfite ion density functional theory depression mechanism
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Mechanism for Hydrothermal-carbothermal Synthesis of AlN Nanopowders
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作者 FENG Guanzheng YANG Jian +3 位作者 ZHOU Du CHEN Qiming XU Wentao ZHOU Youfu 《无机材料学报》 北大核心 2025年第1期104-110,I0009-I0011,共10页
Currently,the carbothermal reduction-nitridation(CRN)process is the predominant method for preparing aluminum nitride(AlN)powder.Although AlN powder prepared by CRN process exhibits high purity and excellent sintering... Currently,the carbothermal reduction-nitridation(CRN)process is the predominant method for preparing aluminum nitride(AlN)powder.Although AlN powder prepared by CRN process exhibits high purity and excellent sintering activity,it also presents challenges such as the necessity for high reaction temperatures and difficulties in achieving uniform mixing of its raw materials.This study presents a comprehensive investigation into preparation process of AlN nanopowders using a combination of hydrothermal synthesis and CRN.In the hydrothermal reaction,a homogeneous composite precursor consisting of carbon and boehmite(γ-AlOOH)is synthesized at 200℃using aluminum nitrate as the aluminum source,sucrose as the carbon source,and urea as the precipitant.During the hydrothermal process,the precursor develops a core-shell structure,with boehmite tightly coated with carbon(γ-AlOOH@C)due to electrostatic attraction.Compared with conventional precursor,the hydrothermal hybrid offers many advantages,such as ultrafine particles,uniform particle size distribution,good dispersion,high reactivity,and environmental friendliness.The carbon shell enhances thermodynamic stability of γ-Al_(2)O_(3) compared to the corundum phase(α-Al_(2)O_(3))by preventing the loss of the surface area in alumina.This stability enables γ-Al_(2)O_(3) to maintain high reactivity during CRN process,which initiates at 1300℃,and concludes at 1400℃.The underlying mechanisms are substantiated through experiments and thermodynamic calculations.This research provides a robust theoretical and experimental foundation for the hydrothermal combined carbothermal preparation of non-oxide ceramic nanopowders. 展开更多
关键词 aluminum nitride carbothermal reduction-nitridation mechanism hydrothermal synthesis PRECURSOR
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Decoding molecular mechanisms:brain aging and Alzheimer's disease
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作者 Mahnoor Hayat Rafay Ali Syed +9 位作者 Hammad Qaiser Mohammad Uzair Khalid Al-Regaiey Roaa Khallaf Lubna Abdullah Mohammed Albassam Imdad Kaleem Xueyi Wang Ran Wang Mehwish SBhatti Shahid Bashir 《Neural Regeneration Research》 SCIE CAS 2025年第8期2279-2299,共21页
The complex morphological,anatomical,physiological,and chemical mechanisms within the aging brain have been the hot topic of research for centuries.The aging process alters the brain structure that affects functions a... The complex morphological,anatomical,physiological,and chemical mechanisms within the aging brain have been the hot topic of research for centuries.The aging process alters the brain structure that affects functions and cognitions,but the worsening of such processes contributes to the pathogenesis of neurodegenerative disorders,such as Alzheimer's disease.Beyond these observable,mild morphological shifts,significant functional modifications in neurotransmission and neuronal activity critically influence the aging brain.Understanding these changes is important for maintaining cognitive health,especially given the increasing prevalence of age-related conditions that affect cognition.This review aims to explore the age-induced changes in brain plasticity and molecular processes,differentiating normal aging from the pathogenesis of Alzheimer's disease,thereby providing insights into predicting the risk of dementia,particularly Alzheimer's disease. 展开更多
关键词 Alzheimer’s disease brain aging cognitive health DEMENTIA molecular mechanisms neuronal activity NEUROPLASTICITY NEUROTRANSMISSION
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An Iterated Greedy Algorithm with Memory and Learning Mechanisms for the Distributed Permutation Flow Shop Scheduling Problem
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作者 Binhui Wang Hongfeng Wang 《Computers, Materials & Continua》 SCIE EI 2025年第1期371-388,共18页
The distributed permutation flow shop scheduling problem(DPFSP)has received increasing attention in recent years.The iterated greedy algorithm(IGA)serves as a powerful optimizer for addressing such a problem because o... The distributed permutation flow shop scheduling problem(DPFSP)has received increasing attention in recent years.The iterated greedy algorithm(IGA)serves as a powerful optimizer for addressing such a problem because of its straightforward,single-solution evolution framework.However,a potential draw-back of IGA is the lack of utilization of historical information,which could lead to an imbalance between exploration and exploitation,especially in large-scale DPFSPs.As a consequence,this paper develops an IGA with memory and learning mechanisms(MLIGA)to efficiently solve the DPFSP targeted at the mini-malmakespan.InMLIGA,we incorporate a memory mechanism to make a more informed selection of the initial solution at each stage of the search,by extending,reconstructing,and reinforcing the information from previous solutions.In addition,we design a twolayer cooperative reinforcement learning approach to intelligently determine the key parameters of IGA and the operations of the memory mechanism.Meanwhile,to ensure that the experience generated by each perturbation operator is fully learned and to reduce the prior parameters of MLIGA,a probability curve-based acceptance criterion is proposed by combining a cube root function with custom rules.At last,a discrete adaptive learning rate is employed to enhance the stability of the memory and learningmechanisms.Complete ablation experiments are utilized to verify the effectiveness of the memory mechanism,and the results show that this mechanism is capable of improving the performance of IGA to a large extent.Furthermore,through comparative experiments involving MLIGA and five state-of-the-art algorithms on 720 benchmarks,we have discovered that MLI-GA demonstrates significant potential for solving large-scale DPFSPs.This indicates that MLIGA is well-suited for real-world distributed flow shop scheduling. 展开更多
关键词 Distributed permutation flow shop scheduling MAKESPAN iterated greedy algorithm memory mechanism cooperative reinforcement learning
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Joint Feature Encoding and Task Alignment Mechanism for Emotion-Cause Pair Extraction
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作者 Shi Li Didi Sun 《Computers, Materials & Continua》 SCIE EI 2025年第1期1069-1086,共18页
With the rapid expansion of social media,analyzing emotions and their causes in texts has gained significant importance.Emotion-cause pair extraction enables the identification of causal relationships between emotions... With the rapid expansion of social media,analyzing emotions and their causes in texts has gained significant importance.Emotion-cause pair extraction enables the identification of causal relationships between emotions and their triggers within a text,facilitating a deeper understanding of expressed sentiments and their underlying reasons.This comprehension is crucial for making informed strategic decisions in various business and societal contexts.However,recent research approaches employing multi-task learning frameworks for modeling often face challenges such as the inability to simultaneouslymodel extracted features and their interactions,or inconsistencies in label prediction between emotion-cause pair extraction and independent assistant tasks like emotion and cause extraction.To address these issues,this study proposes an emotion-cause pair extraction methodology that incorporates joint feature encoding and task alignment mechanisms.The model consists of two primary components:First,joint feature encoding simultaneously generates features for emotion-cause pairs and clauses,enhancing feature interactions between emotion clauses,cause clauses,and emotion-cause pairs.Second,the task alignment technique is applied to reduce the labeling distance between emotion-cause pair extraction and the two assistant tasks,capturing deep semantic information interactions among tasks.The proposed method is evaluated on a Chinese benchmark corpus using 10-fold cross-validation,assessing key performance metrics such as precision,recall,and F1 score.Experimental results demonstrate that the model achieves an F1 score of 76.05%,surpassing the state-of-the-art by 1.03%.The proposed model exhibits significant improvements in emotion-cause pair extraction(ECPE)and cause extraction(CE)compared to existing methods,validating its effectiveness.This research introduces a novel approach based on joint feature encoding and task alignment mechanisms,contributing to advancements in emotion-cause pair extraction.However,the study’s limitation lies in the data sources,potentially restricting the generalizability of the findings. 展开更多
关键词 Emotion-cause pair extraction interactive information enhancement joint feature encoding label consistency task alignment mechanisms
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Pyroptosis,ferroptosis,and autophagy in spinal cord injury:regulatory mechanisms and therapeutic targets
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作者 Qingcong Zheng Du Wang +1 位作者 Rongjie Lin Weihong Xu 《Neural Regeneration Research》 SCIE CAS 2025年第10期2787-2806,共20页
Regulated cell death is a form of cell death that is actively controlled by biomolecules.Several studies have shown that regulated cell death plays a key role after spinal cord injury.Pyroptosis and ferroptosis are ne... Regulated cell death is a form of cell death that is actively controlled by biomolecules.Several studies have shown that regulated cell death plays a key role after spinal cord injury.Pyroptosis and ferroptosis are newly discovered types of regulated cell deaths that have been shown to exacerbate inflammation and lead to cell death in damaged spinal cords.Autophagy,a complex form of cell death that is interconnected with various regulated cell death mechanisms,has garnered significant attention in the study of spinal cord injury.This injury triggers not only cell death but also cellular survival responses.Multiple signaling pathways play pivotal roles in influencing the processes of both deterioration and repair in spinal cord injury by regulating pyroptosis,ferroptosis,and autophagy.Therefore,this review aims to comprehensively examine the mechanisms underlying regulated cell deaths,the signaling pathways that modulate these mechanisms,and the potential therapeutic targets for spinal cord injury.Our analysis suggests that targeting the common regulatory signaling pathways of different regulated cell deaths could be a promising strategy to promote cell survival and enhance the repair of spinal cord injury.Moreover,a holistic approach that incorporates multiple regulated cell deaths and their regulatory pathways presents a promising multi-target therapeutic strategy for the management of spinal cord injury. 展开更多
关键词 AUTOPHAGY cell death ferroptosis INFLAMMATION pathological mechanisms PYROPTOSIS regulated cell death regulatory pathways spinal cord injury therapeutic targets
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Molecular Mechanisms of the CIRBP Family in Tumors: Current Status and Future Perspectives
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作者 Yu Cai Tingting Wang Yuan Zhan 《Journal of Cancer Therapy》 2025年第2期63-76,共14页
The Cold-Inducible RNA-Binding Protein (CIRBP) family plays a pivotal role in cellular stress responses and tumorigenesis. Recent studies have increasingly highlighted the expression alterations of CIRBP family member... The Cold-Inducible RNA-Binding Protein (CIRBP) family plays a pivotal role in cellular stress responses and tumorigenesis. Recent studies have increasingly highlighted the expression alterations of CIRBP family members across various cancer types and their potential molecular mechanisms. This review provides a comprehensive overview of the structural characteristics and functions of the CIRBP family, alongside their expression profiles in tumors and the regulatory molecular mechanisms involved. By synthesizing current knowledge, this review aims to offer new insights and directions for future cancer therapies, emphasizing the importance of CIRBP proteins in oncological research. 展开更多
关键词 CIRBP Family TUMORS Molecular mechanisms RNA-Binding Proteins Cellular Stress
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Concurrent occurrence of adenocarcinoma and urothelial carcinoma of the prostate:Coexistence mechanisms from multiple perspectives
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作者 Xu-Chang Liu Yu-Xiang Liu Chun Liu 《World Journal of Clinical Cases》 2025年第12期5-9,共5页
This article discusses the coexistence of prostate adenocarcinoma and prostate urothelial carcinoma.Combining existing literature and research results,the potential mechanisms of the co-occurrence of these two cancers... This article discusses the coexistence of prostate adenocarcinoma and prostate urothelial carcinoma.Combining existing literature and research results,the potential mechanisms of the co-occurrence of these two cancers are explored,including the role of androgen receptor,gene mutations,and their complex interactions in cell signaling pathways,etc.Also,the hypothesis of prostate cancer transformation into urothelial carcinoma is explained from some perspectives,including tumor multipotent stem cell differentiation,epithelial-mesenchymal transition,mesenchymal-epithelial transition,and other mechanisms.Ultimately,the goal is to provide more accurate diagnoses and more personalized treatments in clinical practice,as well as to lay the foundation for improving patient prognoses in the future. 展开更多
关键词 Prostate adenocarcinoma Prostate urothelial carcinoma Coexistence mechanism Transformation mechanism TUMOR
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National collaboration mechanism for standardization research institutes established
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作者 靳吉丽 《China Standardization》 2025年第2期16-35,共20页
Hosted by China National Institute of Standardization(CNIS),the Inaugural Ceremony of the National Collaboration Mechanism for Standardization Research Institutes and the 4th Roundtable on Standardization Reform and D... Hosted by China National Institute of Standardization(CNIS),the Inaugural Ceremony of the National Collaboration Mechanism for Standardization Research Institutes and the 4th Roundtable on Standardization Reform and Development were held in Beijing on November 29,2024,to implement the National Standardization Development Outline and establish a standardization science and technology system with the comprehensive standardization research institute at the national level as the leader,and standardization research institutes at the industrial,regional and local levels as the mainstay. 展开更多
关键词 ROUND STANDARDIZATION mechanism
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A Dynamic Knowledge Base Updating Mechanism-Based Retrieval-Augmented Generation Framework for Intelligent Question-and-Answer Systems
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作者 Yu Li 《Journal of Computer and Communications》 2025年第1期41-58,共18页
In the context of power generation companies, vast amounts of specialized data and expert knowledge have been accumulated. However, challenges such as data silos and fragmented knowledge hinder the effective utilizati... In the context of power generation companies, vast amounts of specialized data and expert knowledge have been accumulated. However, challenges such as data silos and fragmented knowledge hinder the effective utilization of this information. This study proposes a novel framework for intelligent Question-and-Answer (Q&A) systems based on Retrieval-Augmented Generation (RAG) to address these issues. The system efficiently acquires domain-specific knowledge by leveraging external databases, including Relational Databases (RDBs) and graph databases, without additional fine-tuning for Large Language Models (LLMs). Crucially, the framework integrates a Dynamic Knowledge Base Updating Mechanism (DKBUM) and a Weighted Context-Aware Similarity (WCAS) method to enhance retrieval accuracy and mitigate inherent limitations of LLMs, such as hallucinations and lack of specialization. Additionally, the proposed DKBUM dynamically adjusts knowledge weights within the database, ensuring that the most recent and relevant information is utilized, while WCAS refines the alignment between queries and knowledge items by enhanced context understanding. Experimental validation demonstrates that the system can generate timely, accurate, and context-sensitive responses, making it a robust solution for managing complex business logic in specialized industries. 展开更多
关键词 Retrieval-Augmented Generation Question-and-Answer Large Language Models Dynamic Knowledge Base Updating mechanism Weighted Context-Aware Similarity
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