A facile synthesis of 2,2-disubstituted idanes was achieved by the reductive cyclization of 1-(o-bromomethylphenyl)-2,2-disubstituted-ethylenes(electron-withdrawing substituents) with an NAD(P)H model, 1-benzyl-1,4-di...A facile synthesis of 2,2-disubstituted idanes was achieved by the reductive cyclization of 1-(o-bromomethylphenyl)-2,2-disubstituted-ethylenes(electron-withdrawing substituents) with an NAD(P)H model, 1-benzyl-1,4-dihydronicotinamide, in yields from moderate to good. The study revealed that \{1-benzyl\}-1,4-dihydronicotinamide can be used in synthetic organic chemistry as an effective reductant.展开更多
文摘A facile synthesis of 2,2-disubstituted idanes was achieved by the reductive cyclization of 1-(o-bromomethylphenyl)-2,2-disubstituted-ethylenes(electron-withdrawing substituents) with an NAD(P)H model, 1-benzyl-1,4-dihydronicotinamide, in yields from moderate to good. The study revealed that \{1-benzyl\}-1,4-dihydronicotinamide can be used in synthetic organic chemistry as an effective reductant.
