In this study,a 2000-year simulation forced by transient,external forcings is carried out with the Community Earth System Model.The authors investigate the spatiotemporal features of climate change in the Han Dynasty(...In this study,a 2000-year simulation forced by transient,external forcings is carried out with the Community Earth System Model.The authors investigate the spatiotemporal features of climate change in the Han Dynasty(1–200 A.D.)using the empirical orthogonal function(EOF)method.The leading EOF mode of the annua mean temperature anomalies shows a uniform variation of temperature over the whole of China,while the second EOF mode indicates opposite variations of temperature between western and eastern China.For the annual mean precipitation anomalies,the first EOF mode indicates a meridional dipole pattern over eastern China,with increased(decreased)precipitation to the south of the Yangtze River and decreased(increased)precipitation to the north.The leading mode of the 850 h Pa winds and sea level pressure in summer exhibits a southwesterly(northeasterly)anomaly over South China,which is associated with a strengthened(reduced)meridional sea level pressure gradient.Compared to reconstructions,the model can capture the majority of features of climate changes in the Han Dynasty,though it underestimates the magnitude.展开更多
Background and Objective:Diffuse large B-cell lymphoma (DLBCL), the most common type of non-Hodgkin's lymphoma (NHL), is heterogeneous on molecular and clinical levels, therefore, its prognosis is difficult to pre...Background and Objective:Diffuse large B-cell lymphoma (DLBCL), the most common type of non-Hodgkin's lymphoma (NHL), is heterogeneous on molecular and clinical levels, therefore, its prognosis is difficult to predict.This study aimed to evaluate the value of Blimp-1 protein and Hans classification in predicting the prognosis of DLBCL and their interrelation.Methods:The clinical records of 136 patients with DLBCL were reviewed.The patients were followed up for 5-80 months (median, 39 months).Immunohistochemical staining for CD10, MUM1, Bcl-6, and Blimp-1 were performed on paraffin-embedded tumor tissues from the 136 patients.The correlations of Blimp-1 protein and Hans classification in prognosis of DLBCL and their interrelation were analyzed.Results:Blimp-1 was detected in 38 (30.0%) patients, and was associated with a significantly shorter overall survival (OS) (P=0.030).Using the Hans classification based upon the expression of CD10, Bcl-6, and MUM1, 54 patients had germinal center B-cell (GCB) phenotype and 82 had non-GCB phenotype.The 5-year OS rate was 75% in the GCB group and 52% in the non-GCB group (P=0.020).The positive rate of Blimp-1 was 22.2% in the GCB group and 31.7% in the non-GCB group (P=0.329).The Cox regression multivariate analysis showed that international prognosis index (IPI) and Hans classification had independent prognostic significance, whereas Blimp-1 was not an independent prognostic factor.Conclusions:The patients with GCB subtype of DLBCL had better prognosis than the non-GCB subtype.High level of Blimp-1 expression in the patients with DLBCL implies a shorter survival, but it is not associated with Hans classification.展开更多
基金supported by the Strategic and Special Frontier Project of Science and Technology of the Chinese Academy of Sciences(Grant No.XDA05080803)the National Natural Science Foundation of China(Grant Nos.41402158,41472160,and 41305073)
文摘In this study,a 2000-year simulation forced by transient,external forcings is carried out with the Community Earth System Model.The authors investigate the spatiotemporal features of climate change in the Han Dynasty(1–200 A.D.)using the empirical orthogonal function(EOF)method.The leading EOF mode of the annua mean temperature anomalies shows a uniform variation of temperature over the whole of China,while the second EOF mode indicates opposite variations of temperature between western and eastern China.For the annual mean precipitation anomalies,the first EOF mode indicates a meridional dipole pattern over eastern China,with increased(decreased)precipitation to the south of the Yangtze River and decreased(increased)precipitation to the north.The leading mode of the 850 h Pa winds and sea level pressure in summer exhibits a southwesterly(northeasterly)anomaly over South China,which is associated with a strengthened(reduced)meridional sea level pressure gradient.Compared to reconstructions,the model can capture the majority of features of climate changes in the Han Dynasty,though it underestimates the magnitude.
文摘Background and Objective:Diffuse large B-cell lymphoma (DLBCL), the most common type of non-Hodgkin's lymphoma (NHL), is heterogeneous on molecular and clinical levels, therefore, its prognosis is difficult to predict.This study aimed to evaluate the value of Blimp-1 protein and Hans classification in predicting the prognosis of DLBCL and their interrelation.Methods:The clinical records of 136 patients with DLBCL were reviewed.The patients were followed up for 5-80 months (median, 39 months).Immunohistochemical staining for CD10, MUM1, Bcl-6, and Blimp-1 were performed on paraffin-embedded tumor tissues from the 136 patients.The correlations of Blimp-1 protein and Hans classification in prognosis of DLBCL and their interrelation were analyzed.Results:Blimp-1 was detected in 38 (30.0%) patients, and was associated with a significantly shorter overall survival (OS) (P=0.030).Using the Hans classification based upon the expression of CD10, Bcl-6, and MUM1, 54 patients had germinal center B-cell (GCB) phenotype and 82 had non-GCB phenotype.The 5-year OS rate was 75% in the GCB group and 52% in the non-GCB group (P=0.020).The positive rate of Blimp-1 was 22.2% in the GCB group and 31.7% in the non-GCB group (P=0.329).The Cox regression multivariate analysis showed that international prognosis index (IPI) and Hans classification had independent prognostic significance, whereas Blimp-1 was not an independent prognostic factor.Conclusions:The patients with GCB subtype of DLBCL had better prognosis than the non-GCB subtype.High level of Blimp-1 expression in the patients with DLBCL implies a shorter survival, but it is not associated with Hans classification.
