Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous system.Recent evidence has challenged the classical view of the functio...Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous system.Recent evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to axons.Despite the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is lacking.We delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature oligodendrocytes.Indeed,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination preferences.Furthermore,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system region.Age and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric disorders.Nevertheless,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined investigations.Future studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte heterogeneity.Such research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,hold promise for the development of therapeutic interventions targeting varied central nervous system pathology.展开更多
Layered rare-earth metal oxides,harnessing the dual properties of oxides and two-dimensional layered materials,exhibit remarkable thermal stability and quantum confinement effects.Therefore,this work adopts the first-...Layered rare-earth metal oxides,harnessing the dual properties of oxides and two-dimensional layered materials,exhibit remarkable thermal stability and quantum confinement effects.Therefore,this work adopts the first-principles calculation combined with the Boltzmann transport theory to predict the thermoelectric properties of NdZnSbO compound.The coexistence of weak interlayer van der Waals interactions,robust intralayer ionic bonding,and partial covalent bonding leads to remarkable bonding heterogeneity,which engenders pronounced phonon scattering and imposes constraints on thermal transport along the out-of-plane direction.The weakened chemical bonds induced by the antibonding states,together with the rattling-like behavior of the Zn atom,culminate in the profound anharmonicity in the layered NdZnSbO compound.The weakening bond and heavy element contribute to the softness of phonon modes,which significantly diminishes the phonon group velocity.The redistribution-dominated four-phonon scattering process spans a large optical gap,which effectively reduces the lattice thermal conductivity.The NdZnSbO compound exhibits direct semiconductor characteristic with a bandgap of 0.73 e V by adopting the Heyd-Scuseria-Ernzerhof(HSE06)functional in combination with spin–orbit coupling(SOC)effect.The multi-valley feature of NdZnSbO compound augur favorably for band degeneracy,thus amplifying the power factor.Consequently,an optimal figure-of-merit(ZT)of 3.40 at 900 K is achieved for the n-type NdZnSbO compound.The present study delves deeply insights into the origins for the low thermal conductivity of NdZnSbO compound and proposes an optimization scheme to enhance overall thermoelectric performance.展开更多
ESG(Environmental,Social,and Governance)performance has emerged as a central metric in assessing corporate sustainability.Utilizing ESG rating data for A-share listed companies on the Shanghai Stock Exchange spanning ...ESG(Environmental,Social,and Governance)performance has emerged as a central metric in assessing corporate sustainability.Utilizing ESG rating data for A-share listed companies on the Shanghai Stock Exchange spanning from 2019 to 2022,coupled with measures of corporate transformation and upgrading,this study introduces green innovation as a mediating variable to dissect the impact of ESG ratings on corporate transformation and upgrading.The key findings of this research are as follows:(1)ESG ratings positively influence corporate transformation and upgrading,a conclusion that retains robustness after a comprehensive series of tests and discussions on endogeneity.(2)Mechanism analysis reveals that ESG ratings foster corporate transformation and upgrading by enhancing corporate green innovation.(3)In comparison with other industries,the influence of ESG ratings on corporate transformation and upgrading is notably more pronounced among heavily polluting industries among listed companies in China.Additionally,ESG ratings exhibit a more significant promotional effect on non-state-owned enterprises compared to state-owned enterprises.Larger enterprises play a more substantial role in transformation and upgrading than small and medium-sized enterprises.The promotional effect of ESG ratings is more evident in enterprises with poor information disclosure quality.Furthermore,as media attention increases,so does the impact of ESG ratings on corporate transformation.This study offers valuable policy insights from the ESG rating perspective,aiming to propel corporate transformation and upgrading,thereby contributing to economic high-quality and sustainable development.展开更多
Chilled chicken is inevitably contaminated by microorganisms during slaughtering and processing,resulting in spoilage.Cutting parts of chilled chicken,especially wings,feet,and other skin-on products,are abundant in c...Chilled chicken is inevitably contaminated by microorganisms during slaughtering and processing,resulting in spoilage.Cutting parts of chilled chicken,especially wings,feet,and other skin-on products,are abundant in collagen,which may be the primary target for degradation by spoilage microorganisms.In this work,a total of 17 isolates of spoilage bacteria that could secrete both collagenase and lipase were determined by raw-chicken juice agar(RJA)method,and the results showed that 7 strains of Serratia,Aeromonas,and Pseudomonas could significantly decompose the collagen ingredients.The gelatin zymography showed that Serratia liquefaciens(F5)and(G7)had apparent degradation bands around 50 kDa,and Aeromonas veronii(G8)and Aeromonas salmonicida(H8)had a band around.65 and 95 kDa,respectively.The lipase and collagenase activities were detected isolate-by-isolate,with F5 showing the highest collagenase activity.For spoilage ability on meat in situ,F5 performed strongest in spoilage ability,indicated by the total viable counts,total volatile basic nitrogen content,sensory scores,lipase,and collagenase activity.This study provides a theoretical basis for spoilage heterogeneity of strains with high-producing collagenase in meat.展开更多
Reservoir heterogeneities play a crucial role in governing reservoir performance and management.Traditionally,detailed and inter-well heterogeneity analyses are commonly performed by mapping seismic facies change in t...Reservoir heterogeneities play a crucial role in governing reservoir performance and management.Traditionally,detailed and inter-well heterogeneity analyses are commonly performed by mapping seismic facies change in the seismic data,which is a time-intensive task.Many researchers have utilized a robust Grey-level co-occurrence matrix(GLCM)-based texture attributes to map reservoir heterogeneity.However,these attributes take seismic data as input and might not be sensitive to lateral lithology variation.To incorporate the lithology information,we have developed an innovative impedance-based texture approach using GLCM workflow by integrating 3D acoustic impedance volume(a rock propertybased attribute)obtained from a deep convolution network-based impedance inversion.Our proposed workflow is anticipated to be more sensitive toward mapping lateral changes than the conventional amplitude-based texture approach,wherein seismic data is used as input.To evaluate the improvement,we applied the proposed workflow to the full-stack 3D seismic data from the Poseidon field,NW-shelf,Australia.This study demonstrates that a better demarcation of reservoir gas sands with improved lateral continuity is achievable with the presented approach compared to the conventional approach.In addition,we assess the implication of multi-stage faulting on facies distribution for effective reservoir characterization.This study also suggests a well-bounded potential reservoir facies distribution along the parallel fault lines.Thus,the proposed approach provides an efficient strategy by integrating the impedance information with texture attributes to improve the inference on reservoir heterogeneity,which can serve as a promising tool for identifying potential reservoir zones for both production benefits and fluid storage.展开更多
In groundwater hydrology,aquitard heterogeneity is often less considered compared to aquifers,despite its significant impact on groundwater hydraulics and groundwater resources evaluation.A semi-analytical solution is...In groundwater hydrology,aquitard heterogeneity is often less considered compared to aquifers,despite its significant impact on groundwater hydraulics and groundwater resources evaluation.A semi-analytical solution is derived for pumping-induced well hydraulics and groundwater budget with consideration of vertical heterogeneity in aquitard hydraulic conductivity(K)and specific storage(S_(s)).The proposed new solution is innovative in its partitioning of the aquitard into multiple homogeneous sub-layers to enable consideration of various forms of vertically heterogeneous K or S_(s).Two scenarios of analytical investigations are explored:one is the presence of aquitard interlayers with distinct K or S_(s) values,a common field-scale occurrence;another is an exponentially depth-decaying aquitard S_(s),a regional-scale phenomenon supported by statistical analysis.Analytical investigations reveal that a low-K interlayer can significantly increase aquifer drawdown and enhance aquifer/aquitard depletion;a high-S_(s) interlayer can noticeably reduce aquifer drawdown and increase aquitard depletion.Locations of low-K or high-S_(s) interlayers also significantly impact well hydraulics and groundwater budget.In the context of an exponentially depth-decaying aquitard S_(s),a larger decay exponent can enhance aquifer drawdown.When using current models with a vertically homogeneous aquitard,half the sum of the geometric and harmonic means of exponentially depth-decaying aquitard S_(s) should be used to calculate aquitard depletion and unconfined aquifer leakage.展开更多
The post-collisional Cenozoic basic volcanic rocks in NE Turkey show temporal variations in whole-rock lithophile element and highly siderophile element(HSE)systematics that are mainly associated with the nature of su...The post-collisional Cenozoic basic volcanic rocks in NE Turkey show temporal variations in whole-rock lithophile element and highly siderophile element(HSE)systematics that are mainly associated with the nature of sub-continental lithospheric mantle(SCLM)sources and parental melt generation.So far,the traditional whole-rock lithophile geochemical data of these basic volcanic rocks have provided important constraints on the nature of SCLM sources.Integrated lithophile element and HSE geochemical data of these basic volcanic rocks also reveal the heterogeneity of the SCLM source,which is principally related to variable metasomatism resulting from previous subduction(s)and post-collisional mantle-crust interactions in an extensional setting.Lithophile element geochemical features suggest that the parental magmas have derived from metasomatized spinel-to garnet-bearing SCLM sources for Eocene and Miocene basic volcanic rocks with subduction signatures whereas originated from spinel-to garnet-bearing SCLM sources for Mio-Pliocene and Plio-Quaternary basaltic volcanic rocks without the subduction signature.Lithophile element and HSE geo-chemistry also reveal that Eocene and Miocene basic vol-canic rocks were affected by more pronounced crustal contamination than the basaltic volcanic rocks of Mio-Pliocene and Quaternary.Furthermore,the integrated lithophile element and HSE compositions of these basic volcanic rocks,together with the regional asymmetric lithospheric delamination model,reveal that the compositional variation(especially due to metasomatism)was significant temporally in the heterogeneity of the SCLM sources from which parental magmas formed during the Cenozoic era.展开更多
The Lower Cretaceous Manville Group of Upper Mc Murray Formation is one of the main bitumen reservoirs in Athabasca.In this study,the relationship between reservoirs heterogeneity and bitumen geochemical characteristi...The Lower Cretaceous Manville Group of Upper Mc Murray Formation is one of the main bitumen reservoirs in Athabasca.In this study,the relationship between reservoirs heterogeneity and bitumen geochemical characteristics were analyzed through core and microscopic observation,lab analysis,petrophysics and logging data.Based on the sedimentology framework,the formation environment of high-quality oil sand reservoirs and their significance for development were discussed.The results indicate that four types lithofacies were recognized in the Upper Mc Murray Formation based on their depositional characteristics.Each lithofacies reservoirs has unique physical properties,and is subject to varying degrees of degradation,resulting in diversity of bitumen content and geochemical composition.The tidal bar(TB)or tidal channel(TC)facies reservoir have excellent physical properties,which are evaluated as gas or water intervals due to strong degradation.The reservoir of sand bar(SB)facies was evaluated as oil intervals,due to its poor physical properties and weak degradation.The reservoir of mixed flat(MF)facies is composed of sand intercalated with laminated shale,which is evaluated as poor oil intervals due to its poor connectivity.The shale content in oil sand reservoir is very important for the reservoir physical properties and bitumen degradation degree.In the context of regional biodegradation,oil sand reservoirs with good physical properties will suffer from strong degradation,while oil sand reservoirs with relatively poor physical properties are more conducive to the bitumen preservation.展开更多
Transportation accessibility has been treated as an important means of reducing the urban-rural income disparity.However,only a few studies have examined the effects of different types of transportation accessibility ...Transportation accessibility has been treated as an important means of reducing the urban-rural income disparity.However,only a few studies have examined the effects of different types of transportation accessibility on urban-rural income disparity and their spatial heterogeneity.Based on data from 285 prefecture-level(and above)Chinese cities in 2000,2005,2010,2015,and 2020,this study uses spatial econometric models to examine how highway accessibility and railway accessibility influence the urban-rural income disparity and to identify their spatial heterogeneity.The result reveals that highway accessibility and railway accessibility have‘coreperiphery’ring-like circle structures.The urban-rural income disparity exhibits strong spatial clustering effects.Both highway accessibility and railway accessibility are negatively associated with urban-rural income disparity,and the former having a greater effect size.Moreover,there is a substitution effect between highway accessibility and railway accessibility in the whole sample.Furthermore,these associations differ in geographic regions.In the central region,highway accessibility is more important in reducing the urban-rural income disparity,but its effect is weakened with the increase of railway accessibility.In the western region,railway accessibility has a larger effect on narrowing the urban-rural income disparity,and this effect is strengthened by the increase of highway accessibility.We conclude that improving transportation accessibility is conducive to reducing the urban-rural income disparity but its effect is spatial heterogenetic.Highways and railways should be developed in a coordinated manner to promote an integrated transport network system.展开更多
To investigate the complex macro-mechanical properties of coal from a micro-mechanical perspective,we have conducted a series of micro-mechanical experiments on coal using a nano-indentation instrument.These experimen...To investigate the complex macro-mechanical properties of coal from a micro-mechanical perspective,we have conducted a series of micro-mechanical experiments on coal using a nano-indentation instrument.These experiments were conducted under both dynamic and static loading conditions,allowing us to gather the micro-mechanical parameters of coal for further analysis of its micro-mechanical heterogeneity using the box counting statistical method and the Weibull model.The research findings indicate that the load–displacement curves of the coal mass under the two different loading modes exhibit noticeable discreteness.This can be attributed to the stress concentration phenomenon caused by variations in the mechanical properties of the micro-units during the loading process of the coal mass.Consequently,there are significant fluctuations in the micro-mechanical parameters of the coal mass.Moreover,the mechanical heterogeneity of the coal at the nanoscale was confirmed based on the calculation results of the standard deviation coefficient and Weibull modulus of the coal body’s micromechanical parameters.These results reveal the influence of microstructural defects and minerals on the uniformity of the stress field distribution within the loaded coal body,as well as on the ductility characteristics of the micro-defect structure.Furthermore,there is a pronounced heterogeneity in the micromechanical parameters.Furthermore,we have established a relationship between the macro and micro elastic modulus of coal by applying the Mori-Tanaka homogenization method.This relationship holds great significance for revealing the micro-mechanical failure mechanism of coal.展开更多
Objective This study aimed to explore the spatial heterogeneity and risk factors for dental caries in 12-year-old children in Shanxi province,China.Methods The data encompassed 3,721 participants from the two most rec...Objective This study aimed to explore the spatial heterogeneity and risk factors for dental caries in 12-year-old children in Shanxi province,China.Methods The data encompassed 3,721 participants from the two most recent oral health surveys conducted across 16 districts in Shanxi Province in 2015 and 2018.Eighteen specific variables were analyzed to examine the interplay between socioeconomic factors,medical resources and environmental conditions.The Geo-detector model was employed to assess the impacts and interactions of these ecological factors.Results Socioeconomic factors(Q=0.30,P<0.05)exhibited a more substantial impact compared to environmental(Q=0.19,P<0.05)and medical resource factors(Q=0.25,P<0.05).Notably,the urban population percentage(UPP)demonstrated the most significant explanatory power for the spatial heterogeneity in caries prevalence,as denoted by its highest q-value(q=0.51,P<0.05).Additionally,the spatial distribution’s heterogeneity of caries was significantly affected by SO2 concentration(q=0.39,P<0.05)and water fluoride levels(q=0.27,P<0.05)among environmental factors.Conclusion The prevalence of caries exhibited spatial heterogeneity,escalating from North to South in Shanxi Province,China,influenced by socioeconomic factors,medical resources,and environmental conditions to varying extents.展开更多
Mountain biodiversity is of great importance to biogeography and ecology.However,it is unclear what ecological and evolutionary processes best explain the generation and maintenance of its high levels of species diver...Mountain biodiversity is of great importance to biogeography and ecology.However,it is unclear what ecological and evolutionary processes best explain the generation and maintenance of its high levels of species diversity.In this study,we determined which of six common hypotheses(e.g.,climate hypotheses,habitat heterogeneity hypothesis and island biogeography theory)best explain global patterns of species diversity in Rhododendron.We found that Rhododendron diversity patterns were most strongly explained by proxies of island biogeography theory(i.e.,mountain area)and habitat heterogeneity(i.e.,elevation range).When we examined other relationships important to island biogeography theory,we found that the planimetric area and the volume of mountains were positively correlated with the Rhododendron diversity,whereas the‘mountains-to-mainland’distance was negatively correlated with Rhododendron diversity and shared species.Our findings demonstrate that Rhododendron diversity can be explained by island biogeography theory and habitat heterogeneity,and mountains can be regarded as islands which supported island biogeography theory.展开更多
Despite having significant effects on social contagions,individual heterogeneity has frequently been overlooked in earlier studies.To better understand the complexity of social contagions,a non-Markovian model incorpo...Despite having significant effects on social contagions,individual heterogeneity has frequently been overlooked in earlier studies.To better understand the complexity of social contagions,a non-Markovian model incorporating heterogeneous social influence and adoption thresholds is introduced.For theoretical analysis,a generalized edge-based compartmental theory which considers the heterogeneities of social influence and adoption thresholds is developed.Focusing on the final adoption size,the critical propagation probability,and the phase transition type,social contagions for adoption thresholds that follow normal distributions with various standard deviations,follow various distributions,and correlate with degrees are investigated.When thresholds follow normal distributions,a larger standard deviation results in a larger final adoption size when the information propagation probability is relatively low.However,when the information propagation probability is relatively high,a larger standard deviation results in a smaller final adoption size.When thresholds follow various distributions,crossover phenomena in phase transition are observed when investigating the relationship of the final adoption size versus the average adoption threshold for some threshold distributions.When thresholds are correlated with degrees,similar crossover phenomena occur when investigating the relationship of the final adoption size versus the degree correlation index.Additionally,we find that increasing the heterogeneity of social influence suppresses the effects of adoption threshold heterogeneity on social contagions in three cases.Our theory predictions agree well with the simulation results.展开更多
This study quantified climate effects on wheat yield heterogeneity in the North China Plain from 1960 to 2020,by integrating the Agricultural Production Systems sIMulator,Optimal Parameters–based Geographical Detecto...This study quantified climate effects on wheat yield heterogeneity in the North China Plain from 1960 to 2020,by integrating the Agricultural Production Systems sIMulator,Optimal Parameters–based Geographical Detector model,and Ensemble Empirical Mode Decomposition model.The factors dominating yield heterogeneity varied by growth stage.For sowing to anthesis,anthesis to maturation,and the entire growth season,minimum temperature,radiation,and vapor pressure deficit has the greatest effect on yield heterogeneity.Interannual periodic oscillations govern the long–term evolution of climate effects on yield heterogeneity from 1960 to 2020.展开更多
Understanding the spatial heterogeneity of debris-flow-prone areas holds significant implications for regional risk management, particularly in seismically active regions with geological faults. Despite the significan...Understanding the spatial heterogeneity of debris-flow-prone areas holds significant implications for regional risk management, particularly in seismically active regions with geological faults. Despite the significance of this knowledge, a comprehensive quantification of the influence of regional topographical and geological factors on the spatial heterogeneity of debris-flow-prone areas has been lacking. This study selected the Hengduan Mountains, an earthquake-prone region characterized by diverse surface conditions and complex landforms, as a representative study area. An improved units zoning and objective factors identification methodology was employed in earthquake and fault analysis to assess the impact of seismic activity and geological factors on spatial heterogeneity of debrisflow prone areas. Results showed that the application of GIS technology with hydrodynamic intensity and geographical units analysis can effectively analyze debris-flow prone areas. Meanwhile, earthquake and fault zones obviously increase the density of debrisflow prone catchments and make them unevenly distributed. The number of debris-flow prone areas shows a nonlinear variation with the gradual increase of geomorphic factor value. Specifically, the area with 1000 m-2500 m elevation difference, 25°-30° average slope, and 0.13-0.15 land use index is the most favorable conditions for debris-flow occurrence;The average annual rainfall from 600 to 1150 mm and landslides gradient from 16° to 35° are the main causal factors to trigger debris flow. Our study sheds light on the quantification of spatial heterogeneity in debris flow-prone areas in earthquake-prone regions, which can offer crucial support for post-debris flow risk management strategies.展开更多
For media with inclusions(e.g.,precipitates,voids,reinforcements,and others),the difference in lattice parameter and the elastic modulus between the matrix and inclusions cause stress concentration at the interfaces.T...For media with inclusions(e.g.,precipitates,voids,reinforcements,and others),the difference in lattice parameter and the elastic modulus between the matrix and inclusions cause stress concentration at the interfaces.These stress fields depend on the inclusions’size,shape,and distribution and will respond instantly to the evolving microstructure.This study develops a phase-field model concerningmodulus heterogeneity.The effect of modulus heterogeneity on the growth process and equilibrium state of theαplate in Ti-6Al-4V during precipitation is evaluated.Theαprecipitate exhibits strong anisotropy in shape upon cooling due to the interplay of the elastic strain and interfacial energy.The calculated orientation of the habit plane using the homogeneous modulus ofαphase shows the smallest deviation fromthat of the habit plane observed in the experiment,compared to the case where the homogeneous modulus ofβphase is adopted.In addition,the equilibrium volume ofαphase within the systemusing homogeneousβmodulus exhibits the largest dependency on the applied stresses.The stress fields across theα/βinterface are further calculated under the assumption of modulus heterogeneity and compared to those using homogeneous modulus of eitherαorβphase.This study provides an essential theoretical basis for developing mechanics models concerning systems with heterogeneous structures.展开更多
Land surface evapotranspiration(ET)is a critical component in the hydrological cycle but has not well been understood in data-scarce areas especially in river basins,like Nujiang River(NRB)which is characterized by la...Land surface evapotranspiration(ET)is a critical component in the hydrological cycle but has not well been understood in data-scarce areas especially in river basins,like Nujiang River(NRB)which is characterized by large elevation gradient and different vegetation zones with complex processes of water and energy exchange.The quality of ET from optical remote sensing is constrained by cloud cover which is common in the NRB in the monsoon seasons.To understand factors controlling the spatial-temporal heterogeneity of ET in NRB,we employed the Variable Infiltration Capacity(VIC)hydrological model by parameter optimization with support of quality controlled remote sensing ET product and observed river runoff series in the river.The modeled ET has increased during 1984-2018,which might be one of the reasons for the runoff decrease but precipitation increase in the same period.ET increase and runoff decrease tended to be quicker within altitudinal band of 2000-4000 m than in other areas in NRB.We observed that ET variation in different climatic zones were controlled by different factors.ET is generally positively correlated with precipitation,temperature,and shortwave radiation but negatively with relative humidity.In the Tundra Climate(Et)zone in the upper reach of NRB,ET is controlled by precipitation,while it is controlled by shortwave radiation in the snow climate with dry winter(Dw)zone.ET increase is influenced by the increase of temperature,wind speed,and shortwave radiation in the middle and downstream of NRB with warm temperate climate,fully humid(Cf)and warm temperate climate with dry winter(Cw).展开更多
The COVID-19 pandemic has caused severe global disasters,highlighting the importance of understanding the details and trends of epidemic transmission in order to introduce efficient intervention measures.While the wid...The COVID-19 pandemic has caused severe global disasters,highlighting the importance of understanding the details and trends of epidemic transmission in order to introduce efficient intervention measures.While the widely used deterministic compartmental models have qualitatively presented continuous “analytical” insight and captured some transmission features,their treatment usually lacks spatiotemporal variation.Here,we propose a stochastic individual dynamical(SID)model to mimic the random and heterogeneous nature of epidemic propagation.The SID model provides a unifying framework for representing the spatiotemporal variations of epidemic development by tracking the movements of each individual.Using this model,we reproduce the infection curves for COVID-19 cases in different areas globally and find the local dynamics and heterogeneity at the individual level that affect the disease outbreak.The macroscopic trend of virus spreading is clearly illustrated from the microscopic perspective,enabling a quantitative assessment of different interventions.Seemingly,this model is also applicable to studying stochastic processes at the “meter scale”,e.g.,human society’s collective dynamics.展开更多
Recent advances in deep neural networks have shed new light on physics,engineering,and scientific computing.Reconciling the data-centered viewpoint with physical simulation is one of the research hotspots.The physicsi...Recent advances in deep neural networks have shed new light on physics,engineering,and scientific computing.Reconciling the data-centered viewpoint with physical simulation is one of the research hotspots.The physicsinformedneural network(PINN)is currently the most general framework,which is more popular due to theconvenience of constructing NNs and excellent generalization ability.The automatic differentiation(AD)-basedPINN model is suitable for the homogeneous scientific problem;however,it is unclear how AD can enforce fluxcontinuity across boundaries between cells of different properties where spatial heterogeneity is represented bygrid cells with different physical properties.In this work,we propose a criss-cross physics-informed convolutionalneural network(CC-PINN)learning architecture,aiming to learn the solution of parametric PDEs with spatialheterogeneity of physical properties.To achieve the seamless enforcement of flux continuity and integration ofphysicalmeaning into CNN,a predefined 2D convolutional layer is proposed to accurately express transmissibilitybetween adjacent cells.The efficacy of the proposedmethodwas evaluated through predictions of several petroleumreservoir problems with spatial heterogeneity and compared against state-of-the-art(PINN)through numericalanalysis as a benchmark,which demonstrated the superiority of the proposed method over the PINN.展开更多
Cancer,a disease as intricate as it is devastating,continues to challenge the medical and scientific community[1].Its complex nature is epitomized by the tumor microenvironment and tumor heterogeneity.As we delve deep...Cancer,a disease as intricate as it is devastating,continues to challenge the medical and scientific community[1].Its complex nature is epitomized by the tumor microenvironment and tumor heterogeneity.As we delve deeper into the realms of cancer research,the advent of transcriptome analysis has emerged as a powerful torchbearer,illuminating our understanding of these enigmatic facets of cancer biology[2].展开更多
基金supported by a grant from the Progressive MS Alliance(BRAVE in MS)Le Grand Portage Fund。
文摘Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous system.Recent evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to axons.Despite the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is lacking.We delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature oligodendrocytes.Indeed,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination preferences.Furthermore,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system region.Age and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric disorders.Nevertheless,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined investigations.Future studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte heterogeneity.Such research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,hold promise for the development of therapeutic interventions targeting varied central nervous system pathology.
基金Financial supports from the National Natural Science Foundation of China(21503039)Department of Science and Technology of Liaoning Province(2019MS164)+1 种基金Department of Education of Liaoning Province(LJ2020JCL034)Discipline Innovation Team of Liaoning Technical University(LNTU20TD-16)are greatly acknowledged。
文摘Layered rare-earth metal oxides,harnessing the dual properties of oxides and two-dimensional layered materials,exhibit remarkable thermal stability and quantum confinement effects.Therefore,this work adopts the first-principles calculation combined with the Boltzmann transport theory to predict the thermoelectric properties of NdZnSbO compound.The coexistence of weak interlayer van der Waals interactions,robust intralayer ionic bonding,and partial covalent bonding leads to remarkable bonding heterogeneity,which engenders pronounced phonon scattering and imposes constraints on thermal transport along the out-of-plane direction.The weakened chemical bonds induced by the antibonding states,together with the rattling-like behavior of the Zn atom,culminate in the profound anharmonicity in the layered NdZnSbO compound.The weakening bond and heavy element contribute to the softness of phonon modes,which significantly diminishes the phonon group velocity.The redistribution-dominated four-phonon scattering process spans a large optical gap,which effectively reduces the lattice thermal conductivity.The NdZnSbO compound exhibits direct semiconductor characteristic with a bandgap of 0.73 e V by adopting the Heyd-Scuseria-Ernzerhof(HSE06)functional in combination with spin–orbit coupling(SOC)effect.The multi-valley feature of NdZnSbO compound augur favorably for band degeneracy,thus amplifying the power factor.Consequently,an optimal figure-of-merit(ZT)of 3.40 at 900 K is achieved for the n-type NdZnSbO compound.The present study delves deeply insights into the origins for the low thermal conductivity of NdZnSbO compound and proposes an optimization scheme to enhance overall thermoelectric performance.
文摘ESG(Environmental,Social,and Governance)performance has emerged as a central metric in assessing corporate sustainability.Utilizing ESG rating data for A-share listed companies on the Shanghai Stock Exchange spanning from 2019 to 2022,coupled with measures of corporate transformation and upgrading,this study introduces green innovation as a mediating variable to dissect the impact of ESG ratings on corporate transformation and upgrading.The key findings of this research are as follows:(1)ESG ratings positively influence corporate transformation and upgrading,a conclusion that retains robustness after a comprehensive series of tests and discussions on endogeneity.(2)Mechanism analysis reveals that ESG ratings foster corporate transformation and upgrading by enhancing corporate green innovation.(3)In comparison with other industries,the influence of ESG ratings on corporate transformation and upgrading is notably more pronounced among heavily polluting industries among listed companies in China.Additionally,ESG ratings exhibit a more significant promotional effect on non-state-owned enterprises compared to state-owned enterprises.Larger enterprises play a more substantial role in transformation and upgrading than small and medium-sized enterprises.The promotional effect of ESG ratings is more evident in enterprises with poor information disclosure quality.Furthermore,as media attention increases,so does the impact of ESG ratings on corporate transformation.This study offers valuable policy insights from the ESG rating perspective,aiming to propel corporate transformation and upgrading,thereby contributing to economic high-quality and sustainable development.
基金financed by grants from the Natural Science Foundation of Jiangsu Province in China (BK20221515)the National Natural Science Foundation of China (32172266)。
文摘Chilled chicken is inevitably contaminated by microorganisms during slaughtering and processing,resulting in spoilage.Cutting parts of chilled chicken,especially wings,feet,and other skin-on products,are abundant in collagen,which may be the primary target for degradation by spoilage microorganisms.In this work,a total of 17 isolates of spoilage bacteria that could secrete both collagenase and lipase were determined by raw-chicken juice agar(RJA)method,and the results showed that 7 strains of Serratia,Aeromonas,and Pseudomonas could significantly decompose the collagen ingredients.The gelatin zymography showed that Serratia liquefaciens(F5)and(G7)had apparent degradation bands around 50 kDa,and Aeromonas veronii(G8)and Aeromonas salmonicida(H8)had a band around.65 and 95 kDa,respectively.The lipase and collagenase activities were detected isolate-by-isolate,with F5 showing the highest collagenase activity.For spoilage ability on meat in situ,F5 performed strongest in spoilage ability,indicated by the total viable counts,total volatile basic nitrogen content,sensory scores,lipase,and collagenase activity.This study provides a theoretical basis for spoilage heterogeneity of strains with high-producing collagenase in meat.
文摘Reservoir heterogeneities play a crucial role in governing reservoir performance and management.Traditionally,detailed and inter-well heterogeneity analyses are commonly performed by mapping seismic facies change in the seismic data,which is a time-intensive task.Many researchers have utilized a robust Grey-level co-occurrence matrix(GLCM)-based texture attributes to map reservoir heterogeneity.However,these attributes take seismic data as input and might not be sensitive to lateral lithology variation.To incorporate the lithology information,we have developed an innovative impedance-based texture approach using GLCM workflow by integrating 3D acoustic impedance volume(a rock propertybased attribute)obtained from a deep convolution network-based impedance inversion.Our proposed workflow is anticipated to be more sensitive toward mapping lateral changes than the conventional amplitude-based texture approach,wherein seismic data is used as input.To evaluate the improvement,we applied the proposed workflow to the full-stack 3D seismic data from the Poseidon field,NW-shelf,Australia.This study demonstrates that a better demarcation of reservoir gas sands with improved lateral continuity is achievable with the presented approach compared to the conventional approach.In addition,we assess the implication of multi-stage faulting on facies distribution for effective reservoir characterization.This study also suggests a well-bounded potential reservoir facies distribution along the parallel fault lines.Thus,the proposed approach provides an efficient strategy by integrating the impedance information with texture attributes to improve the inference on reservoir heterogeneity,which can serve as a promising tool for identifying potential reservoir zones for both production benefits and fluid storage.
基金financially supported by the National Key Research and Development Program of China(Grant No.2019YFC1804301)the National Science Fourdation of China(Grant No.42272279,41902244)partial support from a Discovery Grant awarded by the Natural Sciences and Engineering Research Council of Canada(NSERC)。
文摘In groundwater hydrology,aquitard heterogeneity is often less considered compared to aquifers,despite its significant impact on groundwater hydraulics and groundwater resources evaluation.A semi-analytical solution is derived for pumping-induced well hydraulics and groundwater budget with consideration of vertical heterogeneity in aquitard hydraulic conductivity(K)and specific storage(S_(s)).The proposed new solution is innovative in its partitioning of the aquitard into multiple homogeneous sub-layers to enable consideration of various forms of vertically heterogeneous K or S_(s).Two scenarios of analytical investigations are explored:one is the presence of aquitard interlayers with distinct K or S_(s) values,a common field-scale occurrence;another is an exponentially depth-decaying aquitard S_(s),a regional-scale phenomenon supported by statistical analysis.Analytical investigations reveal that a low-K interlayer can significantly increase aquifer drawdown and enhance aquifer/aquitard depletion;a high-S_(s) interlayer can noticeably reduce aquifer drawdown and increase aquitard depletion.Locations of low-K or high-S_(s) interlayers also significantly impact well hydraulics and groundwater budget.In the context of an exponentially depth-decaying aquitard S_(s),a larger decay exponent can enhance aquifer drawdown.When using current models with a vertically homogeneous aquitard,half the sum of the geometric and harmonic means of exponentially depth-decaying aquitard S_(s) should be used to calculate aquitard depletion and unconfined aquifer leakage.
文摘The post-collisional Cenozoic basic volcanic rocks in NE Turkey show temporal variations in whole-rock lithophile element and highly siderophile element(HSE)systematics that are mainly associated with the nature of sub-continental lithospheric mantle(SCLM)sources and parental melt generation.So far,the traditional whole-rock lithophile geochemical data of these basic volcanic rocks have provided important constraints on the nature of SCLM sources.Integrated lithophile element and HSE geochemical data of these basic volcanic rocks also reveal the heterogeneity of the SCLM source,which is principally related to variable metasomatism resulting from previous subduction(s)and post-collisional mantle-crust interactions in an extensional setting.Lithophile element geochemical features suggest that the parental magmas have derived from metasomatized spinel-to garnet-bearing SCLM sources for Eocene and Miocene basic volcanic rocks with subduction signatures whereas originated from spinel-to garnet-bearing SCLM sources for Mio-Pliocene and Plio-Quaternary basaltic volcanic rocks without the subduction signature.Lithophile element and HSE geo-chemistry also reveal that Eocene and Miocene basic vol-canic rocks were affected by more pronounced crustal contamination than the basaltic volcanic rocks of Mio-Pliocene and Quaternary.Furthermore,the integrated lithophile element and HSE compositions of these basic volcanic rocks,together with the regional asymmetric lithospheric delamination model,reveal that the compositional variation(especially due to metasomatism)was significant temporally in the heterogeneity of the SCLM sources from which parental magmas formed during the Cenozoic era.
基金sponsored by Major Science and Technology Special Project of CNPC(Grant No.2023ZZ07)。
文摘The Lower Cretaceous Manville Group of Upper Mc Murray Formation is one of the main bitumen reservoirs in Athabasca.In this study,the relationship between reservoirs heterogeneity and bitumen geochemical characteristics were analyzed through core and microscopic observation,lab analysis,petrophysics and logging data.Based on the sedimentology framework,the formation environment of high-quality oil sand reservoirs and their significance for development were discussed.The results indicate that four types lithofacies were recognized in the Upper Mc Murray Formation based on their depositional characteristics.Each lithofacies reservoirs has unique physical properties,and is subject to varying degrees of degradation,resulting in diversity of bitumen content and geochemical composition.The tidal bar(TB)or tidal channel(TC)facies reservoir have excellent physical properties,which are evaluated as gas or water intervals due to strong degradation.The reservoir of sand bar(SB)facies was evaluated as oil intervals,due to its poor physical properties and weak degradation.The reservoir of mixed flat(MF)facies is composed of sand intercalated with laminated shale,which is evaluated as poor oil intervals due to its poor connectivity.The shale content in oil sand reservoir is very important for the reservoir physical properties and bitumen degradation degree.In the context of regional biodegradation,oil sand reservoirs with good physical properties will suffer from strong degradation,while oil sand reservoirs with relatively poor physical properties are more conducive to the bitumen preservation.
基金Under the auspices of National Natural Science Foundation of China(No.42371214,42101184)Chenguang Program of Shanghai Education Development Foundation and Shanghai Municipal Education Commission(No.22CGA27)Funded Projects for the Academic Leaders and Academic Backbone,Shaanxi Normal University(No.18QNGG013)。
文摘Transportation accessibility has been treated as an important means of reducing the urban-rural income disparity.However,only a few studies have examined the effects of different types of transportation accessibility on urban-rural income disparity and their spatial heterogeneity.Based on data from 285 prefecture-level(and above)Chinese cities in 2000,2005,2010,2015,and 2020,this study uses spatial econometric models to examine how highway accessibility and railway accessibility influence the urban-rural income disparity and to identify their spatial heterogeneity.The result reveals that highway accessibility and railway accessibility have‘coreperiphery’ring-like circle structures.The urban-rural income disparity exhibits strong spatial clustering effects.Both highway accessibility and railway accessibility are negatively associated with urban-rural income disparity,and the former having a greater effect size.Moreover,there is a substitution effect between highway accessibility and railway accessibility in the whole sample.Furthermore,these associations differ in geographic regions.In the central region,highway accessibility is more important in reducing the urban-rural income disparity,but its effect is weakened with the increase of railway accessibility.In the western region,railway accessibility has a larger effect on narrowing the urban-rural income disparity,and this effect is strengthened by the increase of highway accessibility.We conclude that improving transportation accessibility is conducive to reducing the urban-rural income disparity but its effect is spatial heterogenetic.Highways and railways should be developed in a coordinated manner to promote an integrated transport network system.
基金Projects(U23B2093,52274245)supported by the National Natural Science Foundation of ChinaProject(KFJJ22-15M)supported by the Opening Project of State Key Laboratory of Explosion Science and Technology,China。
文摘To investigate the complex macro-mechanical properties of coal from a micro-mechanical perspective,we have conducted a series of micro-mechanical experiments on coal using a nano-indentation instrument.These experiments were conducted under both dynamic and static loading conditions,allowing us to gather the micro-mechanical parameters of coal for further analysis of its micro-mechanical heterogeneity using the box counting statistical method and the Weibull model.The research findings indicate that the load–displacement curves of the coal mass under the two different loading modes exhibit noticeable discreteness.This can be attributed to the stress concentration phenomenon caused by variations in the mechanical properties of the micro-units during the loading process of the coal mass.Consequently,there are significant fluctuations in the micro-mechanical parameters of the coal mass.Moreover,the mechanical heterogeneity of the coal at the nanoscale was confirmed based on the calculation results of the standard deviation coefficient and Weibull modulus of the coal body’s micromechanical parameters.These results reveal the influence of microstructural defects and minerals on the uniformity of the stress field distribution within the loaded coal body,as well as on the ductility characteristics of the micro-defect structure.Furthermore,there is a pronounced heterogeneity in the micromechanical parameters.Furthermore,we have established a relationship between the macro and micro elastic modulus of coal by applying the Mori-Tanaka homogenization method.This relationship holds great significance for revealing the micro-mechanical failure mechanism of coal.
基金supported by scientific research project of the Health Commission of Shanxi Province[NO.2018104]Science and Technology Innovation Project of Shanxi Province[NO.2020L0217 and 2022L172]+1 种基金Key Research and Development Projects of Shanxi Province[NO.A2021-113]Chinese Stomatological Association Dental Doctors Caries Prevention Ability Improvement Project[NO.CSA-ICP2022-05].
文摘Objective This study aimed to explore the spatial heterogeneity and risk factors for dental caries in 12-year-old children in Shanxi province,China.Methods The data encompassed 3,721 participants from the two most recent oral health surveys conducted across 16 districts in Shanxi Province in 2015 and 2018.Eighteen specific variables were analyzed to examine the interplay between socioeconomic factors,medical resources and environmental conditions.The Geo-detector model was employed to assess the impacts and interactions of these ecological factors.Results Socioeconomic factors(Q=0.30,P<0.05)exhibited a more substantial impact compared to environmental(Q=0.19,P<0.05)and medical resource factors(Q=0.25,P<0.05).Notably,the urban population percentage(UPP)demonstrated the most significant explanatory power for the spatial heterogeneity in caries prevalence,as denoted by its highest q-value(q=0.51,P<0.05).Additionally,the spatial distribution’s heterogeneity of caries was significantly affected by SO2 concentration(q=0.39,P<0.05)and water fluoride levels(q=0.27,P<0.05)among environmental factors.Conclusion The prevalence of caries exhibited spatial heterogeneity,escalating from North to South in Shanxi Province,China,influenced by socioeconomic factors,medical resources,and environmental conditions to varying extents.
基金supported by the National Natural Science Foundation of China(NO.41901060).
文摘Mountain biodiversity is of great importance to biogeography and ecology.However,it is unclear what ecological and evolutionary processes best explain the generation and maintenance of its high levels of species diversity.In this study,we determined which of six common hypotheses(e.g.,climate hypotheses,habitat heterogeneity hypothesis and island biogeography theory)best explain global patterns of species diversity in Rhododendron.We found that Rhododendron diversity patterns were most strongly explained by proxies of island biogeography theory(i.e.,mountain area)and habitat heterogeneity(i.e.,elevation range).When we examined other relationships important to island biogeography theory,we found that the planimetric area and the volume of mountains were positively correlated with the Rhododendron diversity,whereas the‘mountains-to-mainland’distance was negatively correlated with Rhododendron diversity and shared species.Our findings demonstrate that Rhododendron diversity can be explained by island biogeography theory and habitat heterogeneity,and mountains can be regarded as islands which supported island biogeography theory.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.62266030 and 61863025)。
文摘Despite having significant effects on social contagions,individual heterogeneity has frequently been overlooked in earlier studies.To better understand the complexity of social contagions,a non-Markovian model incorporating heterogeneous social influence and adoption thresholds is introduced.For theoretical analysis,a generalized edge-based compartmental theory which considers the heterogeneities of social influence and adoption thresholds is developed.Focusing on the final adoption size,the critical propagation probability,and the phase transition type,social contagions for adoption thresholds that follow normal distributions with various standard deviations,follow various distributions,and correlate with degrees are investigated.When thresholds follow normal distributions,a larger standard deviation results in a larger final adoption size when the information propagation probability is relatively low.However,when the information propagation probability is relatively high,a larger standard deviation results in a smaller final adoption size.When thresholds follow various distributions,crossover phenomena in phase transition are observed when investigating the relationship of the final adoption size versus the average adoption threshold for some threshold distributions.When thresholds are correlated with degrees,similar crossover phenomena occur when investigating the relationship of the final adoption size versus the degree correlation index.Additionally,we find that increasing the heterogeneity of social influence suppresses the effects of adoption threshold heterogeneity on social contagions in three cases.Our theory predictions agree well with the simulation results.
基金funded by the Key Research and Development and Promotion Projects of Henan Province (242102320237)the National Natural Science Foundation of China (51879268).
文摘This study quantified climate effects on wheat yield heterogeneity in the North China Plain from 1960 to 2020,by integrating the Agricultural Production Systems sIMulator,Optimal Parameters–based Geographical Detector model,and Ensemble Empirical Mode Decomposition model.The factors dominating yield heterogeneity varied by growth stage.For sowing to anthesis,anthesis to maturation,and the entire growth season,minimum temperature,radiation,and vapor pressure deficit has the greatest effect on yield heterogeneity.Interannual periodic oscillations govern the long–term evolution of climate effects on yield heterogeneity from 1960 to 2020.
基金supported by the Hubei Provincial Engineering Research Center of Slope Habitat Construction Technique Using Cement-based Materials Open Research Program (Grant No. 2022SNJ112022SNJ12)+4 种基金National Natural Science Foundation of China (Grant No. 42371014)Hubei Key Laboratory of Disaster Prevention and Mitigation (China Three Gorges University) Open Research Program (Grant No. 2022KJZ122023KJZ19)CRSRI Open Research Program (Grant No. CKWV2021888/KY)the Key Laboratory of Mountain Hazards and Earth Surface Processes, Chinese Academy of Sciences (Grant No. KLMHESP20-0)。
文摘Understanding the spatial heterogeneity of debris-flow-prone areas holds significant implications for regional risk management, particularly in seismically active regions with geological faults. Despite the significance of this knowledge, a comprehensive quantification of the influence of regional topographical and geological factors on the spatial heterogeneity of debris-flow-prone areas has been lacking. This study selected the Hengduan Mountains, an earthquake-prone region characterized by diverse surface conditions and complex landforms, as a representative study area. An improved units zoning and objective factors identification methodology was employed in earthquake and fault analysis to assess the impact of seismic activity and geological factors on spatial heterogeneity of debrisflow prone areas. Results showed that the application of GIS technology with hydrodynamic intensity and geographical units analysis can effectively analyze debris-flow prone areas. Meanwhile, earthquake and fault zones obviously increase the density of debrisflow prone catchments and make them unevenly distributed. The number of debris-flow prone areas shows a nonlinear variation with the gradual increase of geomorphic factor value. Specifically, the area with 1000 m-2500 m elevation difference, 25°-30° average slope, and 0.13-0.15 land use index is the most favorable conditions for debris-flow occurrence;The average annual rainfall from 600 to 1150 mm and landslides gradient from 16° to 35° are the main causal factors to trigger debris flow. Our study sheds light on the quantification of spatial heterogeneity in debris flow-prone areas in earthquake-prone regions, which can offer crucial support for post-debris flow risk management strategies.
基金the financial support from the National Key Research and Development Program of China under Grant No.2022YFB3707803the Key Research Project of Zhejiang Laboratory under Grant No.2021PE0AC02+2 种基金the National Natural Science Foundation of China under Grant No.U2230102RS acknowledges the open research fund of Songshan Lake Materials Laboratory(2021SLABFK06)Guangdong Basic and Applied Basic Research Foundation(2024A1515011873).
文摘For media with inclusions(e.g.,precipitates,voids,reinforcements,and others),the difference in lattice parameter and the elastic modulus between the matrix and inclusions cause stress concentration at the interfaces.These stress fields depend on the inclusions’size,shape,and distribution and will respond instantly to the evolving microstructure.This study develops a phase-field model concerningmodulus heterogeneity.The effect of modulus heterogeneity on the growth process and equilibrium state of theαplate in Ti-6Al-4V during precipitation is evaluated.Theαprecipitate exhibits strong anisotropy in shape upon cooling due to the interplay of the elastic strain and interfacial energy.The calculated orientation of the habit plane using the homogeneous modulus ofαphase shows the smallest deviation fromthat of the habit plane observed in the experiment,compared to the case where the homogeneous modulus ofβphase is adopted.In addition,the equilibrium volume ofαphase within the systemusing homogeneousβmodulus exhibits the largest dependency on the applied stresses.The stress fields across theα/βinterface are further calculated under the assumption of modulus heterogeneity and compared to those using homogeneous modulus of eitherαorβphase.This study provides an essential theoretical basis for developing mechanics models concerning systems with heterogeneous structures.
基金supported by the National Natural Science Foundation of China(42171129)the second Tibetan Plateau Scientific Expedition and Research(2019QZKK0208)Yunnan University Talent Introduction Research Project(YJRC3201702)。
文摘Land surface evapotranspiration(ET)is a critical component in the hydrological cycle but has not well been understood in data-scarce areas especially in river basins,like Nujiang River(NRB)which is characterized by large elevation gradient and different vegetation zones with complex processes of water and energy exchange.The quality of ET from optical remote sensing is constrained by cloud cover which is common in the NRB in the monsoon seasons.To understand factors controlling the spatial-temporal heterogeneity of ET in NRB,we employed the Variable Infiltration Capacity(VIC)hydrological model by parameter optimization with support of quality controlled remote sensing ET product and observed river runoff series in the river.The modeled ET has increased during 1984-2018,which might be one of the reasons for the runoff decrease but precipitation increase in the same period.ET increase and runoff decrease tended to be quicker within altitudinal band of 2000-4000 m than in other areas in NRB.We observed that ET variation in different climatic zones were controlled by different factors.ET is generally positively correlated with precipitation,temperature,and shortwave radiation but negatively with relative humidity.In the Tundra Climate(Et)zone in the upper reach of NRB,ET is controlled by precipitation,while it is controlled by shortwave radiation in the snow climate with dry winter(Dw)zone.ET increase is influenced by the increase of temperature,wind speed,and shortwave radiation in the middle and downstream of NRB with warm temperate climate,fully humid(Cf)and warm temperate climate with dry winter(Cw).
基金supported by the National Natural Science Foundation of China(Grant No.22273034)the Frontiers Science Center for Critical Earth Material Cycling of Nanjing University。
文摘The COVID-19 pandemic has caused severe global disasters,highlighting the importance of understanding the details and trends of epidemic transmission in order to introduce efficient intervention measures.While the widely used deterministic compartmental models have qualitatively presented continuous “analytical” insight and captured some transmission features,their treatment usually lacks spatiotemporal variation.Here,we propose a stochastic individual dynamical(SID)model to mimic the random and heterogeneous nature of epidemic propagation.The SID model provides a unifying framework for representing the spatiotemporal variations of epidemic development by tracking the movements of each individual.Using this model,we reproduce the infection curves for COVID-19 cases in different areas globally and find the local dynamics and heterogeneity at the individual level that affect the disease outbreak.The macroscopic trend of virus spreading is clearly illustrated from the microscopic perspective,enabling a quantitative assessment of different interventions.Seemingly,this model is also applicable to studying stochastic processes at the “meter scale”,e.g.,human society’s collective dynamics.
基金the National Natural Science Foundation of China(No.52274048)Beijing Natural Science Foundation(No.3222037)+1 种基金the CNPC 14th Five-Year Perspective Fundamental Research Project(No.2021DJ2104)the Science Foundation of China University of Petroleum,Beijing(No.2462021YXZZ010).
文摘Recent advances in deep neural networks have shed new light on physics,engineering,and scientific computing.Reconciling the data-centered viewpoint with physical simulation is one of the research hotspots.The physicsinformedneural network(PINN)is currently the most general framework,which is more popular due to theconvenience of constructing NNs and excellent generalization ability.The automatic differentiation(AD)-basedPINN model is suitable for the homogeneous scientific problem;however,it is unclear how AD can enforce fluxcontinuity across boundaries between cells of different properties where spatial heterogeneity is represented bygrid cells with different physical properties.In this work,we propose a criss-cross physics-informed convolutionalneural network(CC-PINN)learning architecture,aiming to learn the solution of parametric PDEs with spatialheterogeneity of physical properties.To achieve the seamless enforcement of flux continuity and integration ofphysicalmeaning into CNN,a predefined 2D convolutional layer is proposed to accurately express transmissibilitybetween adjacent cells.The efficacy of the proposedmethodwas evaluated through predictions of several petroleumreservoir problems with spatial heterogeneity and compared against state-of-the-art(PINN)through numericalanalysis as a benchmark,which demonstrated the superiority of the proposed method over the PINN.
基金National Nature Science Foundation for young scientist in Jiangsu Province(BK20220729).
文摘Cancer,a disease as intricate as it is devastating,continues to challenge the medical and scientific community[1].Its complex nature is epitomized by the tumor microenvironment and tumor heterogeneity.As we delve deeper into the realms of cancer research,the advent of transcriptome analysis has emerged as a powerful torchbearer,illuminating our understanding of these enigmatic facets of cancer biology[2].
