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Experimental Investigation of the Hydrodynamic Characteristics of A Modular Floating Structure System Integrated with WEC-Type Floating Artificial Reefs 被引量:1
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作者 LI Yan-wei REN Nian-xin +2 位作者 CAI Wen-yu LIU Ya-qiong OU Jin-ping 《China Ocean Engineering》 CSCD 2024年第6期1082-1090,共9页
Integrating wave energy converters(WECs)with offshore platforms offers numerous advantages,such as reducing wave loads,supplying energy to the platform,and cost-sharing in construction.This paper reports an experiment... Integrating wave energy converters(WECs)with offshore platforms offers numerous advantages,such as reducing wave loads,supplying energy to the platform,and cost-sharing in construction.This paper reports an experimental investigation focusing on the hydrodynamic characteristics of a proposed modular floating structure system integrated with WEC-type floating artificial reefs.The proposed system comprises several serially arranged hexagonal floating structures,anchored by tension legs,and integrated with outermost WEC-type floating artificial reefs.A simplified wave energy converter utilizing the relative pitch motion between adjacent modules for energy conversion was constructed in the scale model test.The effects of chain-type modular expansion on the multi-body motion response,mooring tension response,and WEC performance of the system have been thoroughly investigated.The experimental results indicate that increasing the number of hexagonal modules can notably reduce the system’s surge response,particularly under survival sea conditions.The connection of the outermost reef modules slightly increases the tension leg load of the adjacent module,whereas the tension leg load remains relatively consistent across the inner hexagonal modules.Furthermore,through a comparison of the dynamic responses of the hexagonal module connected and unconnected outermost reefs,the good performance in terms of energy conversion and wave attenuation of the WECtype floating artificial reef modules was effectively validated.The main results from this work can provide useful references for engineering applications involving modular floating structures integrated with WECs. 展开更多
关键词 modular floating structure model test hydrodynamic characteristics WEC floating artificial reef
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Parametric Design of Modular Fixture Structure 被引量:2
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作者 陈冰冰 《Journal of Donghua University(English Edition)》 EI CAS 2001年第2期108-111,共4页
Based on an example of its typical structure, the concept of modular fixture structure module is presented, and the structure module system of modular fixture is summarized. Then the parametric design of structure is ... Based on an example of its typical structure, the concept of modular fixture structure module is presented, and the structure module system of modular fixture is summarized. Then the parametric design of structure is discussed, and its advantages are also emphasized.Furthermore, some specific methods are provided, such as the selection of fixture components, the determination and input of parameters, drawing representative model,and the creation of drawing. Finally an applied example of strcture parametric design is presented. 展开更多
关键词 modular FIXTURE CAD structure module parametric design
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Detecting and describing the modular structures of weighted networks
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作者 李克平 高自友 《Chinese Physics B》 SCIE EI CAS CSCD 2007年第8期2304-2309,共6页
In the functional properties of complex networks, modules play a central role. In this paper, we propose a new method to detect and describe the modular structures of weighted networks. In order to test the proposed m... In the functional properties of complex networks, modules play a central role. In this paper, we propose a new method to detect and describe the modular structures of weighted networks. In order to test the proposed method, as an example, we use our method to analyse the structural properties of the Chinese railway network. Here, the stations are regarded as the nodes and the track sections are regarded as the links. Rigorous analysis of the existing data shows that using the proposed algorithm, the nodes of network can be classified naturally. Moreover, there are several core nodes in each module. Remarkably, we introduce the correlation function Grs, and use it to distinguish the different modules in weighted networks. 展开更多
关键词 weighted networks modular structure railway network
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Investigation on Effects of Mooring Line Fractures and Connector Failures for A Hybrid Modular Floating Structure System
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作者 LIU Ya-qiong REN Nian-xin OU Jin-ping 《China Ocean Engineering》 SCIE EI CSCD 2022年第6期880-893,共14页
The present work reports a Hybrid Modular Floating Structure(HMFS)system with typical malfunction conditions.The effects of both fractured mooring lines and failed connectors on main hydrodynamic responses(mooring lin... The present work reports a Hybrid Modular Floating Structure(HMFS)system with typical malfunction conditions.The effects of both fractured mooring lines and failed connectors on main hydrodynamic responses(mooring line tensions,module motions,connector loads and wave power production)of the HMFS system under typical sea con-ditions are comparatively investigated.The results indicate that the mooring tension distribution,certain module motions(surge,sway and yaw)and connector loads(Mz)are significantly influenced by mooring line fractures.The adjacent mooring line of the fractured line on the upstream side suffers the largest tension among the remaining mooring lines,and the case with two fractured mooring lines in the same group on the upstream side is the most dangerous among all cases of two-line failures in view of mooring line tensions,module motions and connector loads.There-fore,one emergency strategy with appropriate relaxation of a proper mooring line has been proposed and proved effective to reduce the risk of more progressive mooring line fractures.In addition,connector failures substantially affect certain module motions(heave and pitch),certain connector loads(Fz and My)and wave power production.The present work can be helpful and instructive for studies on malfunction conditions of modular floating structure(MFS)systems. 展开更多
关键词 Hybrid modular Floating structure(HMFS)system mooring line fractures connector failures hydrodynamic responses emergency strategy
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The Geometry of Felix Escrig. Simplified ModellingTechniques for Modular Deployable Structures ofExpandable Frames
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作者 Mauricio Soto-Rubio 《Journal of Civil Engineering and Architecture》 2020年第3期121-132,共12页
This paper catalogues the morphology of modular deployable structures of expandable frames developed by the late Felix Escrig at the University of Seville, Spain. The research describes the geometric logic behind thes... This paper catalogues the morphology of modular deployable structures of expandable frames developed by the late Felix Escrig at the University of Seville, Spain. The research describes the geometric logic behind these structures, proposes simplified graphic methods for their design, and outlines their characteristics according to their level of geometric precision, structural stability and deployability. Finally, the paper establishes tools and guidelines for their future development. 展开更多
关键词 DEPLOYABLE EXPANDABLE modular collapsible pantographic scissor structures.
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Structural Carpentry in Qing Dynasty-A Framework for the Hierarchically Modularized Chinese Timber Structural Design 被引量:1
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作者 龚清宇 《Transactions of Tianjin University》 EI CAS 2002年第1期16-21,共6页
This article, by using mathematical expressions, offers a scientific framework for understanding how the grading system of Qing′s structural carpentry determines the design and construction in the grand style timber... This article, by using mathematical expressions, offers a scientific framework for understanding how the grading system of Qing′s structural carpentry determines the design and construction in the grand style timber architecture.The Qing′s grand style timber structure, which is ready for prefabrication and assembly, is extremely hierarchical oriented and significantly standardized. The general procedure in designing a grand style timber structure is to start with the grade that defines the basic module (dou kou); next comes with the number of bracket set (cuan), the number of longitudinal bays and the number of purlins which affect its plan and cross section; thirdly choose a roof type that determines its longitudinal section and the facade as well. A series of formulae are conducted to help depict the layout, cross sectional roof curvature and special longitudinal treatments in 4 sloped and 9 spined roofs respectively. 展开更多
关键词 structural carpentry mathematical expression grand style Qing Dynasty modular system Chinese timber structural design
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Tekla Structures软件在油气田地面工程加工设计中的应用 被引量:4
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作者 苗升 《石油工程建设》 2015年第2期47-51,共5页
为提高油气田地面工程建设质量和效率,工程详细设计完成后进行加工设计十分必要。文章结合中石化胜利油建工程有限公司在伊朗和加纳的油气田地面工程项目,详细介绍了应用Tekla Structures软件进行钢结构加工设计的优越性和具体做法。该... 为提高油气田地面工程建设质量和效率,工程详细设计完成后进行加工设计十分必要。文章结合中石化胜利油建工程有限公司在伊朗和加纳的油气田地面工程项目,详细介绍了应用Tekla Structures软件进行钢结构加工设计的优越性和具体做法。该软件能快捷、准确地创建结构3D模型,且自动生成所需的图纸和各种精确报表,便于发现加工设计中的问题从而进一步优化设计,对节约工程成本和缩短工期具有重要意义。 展开更多
关键词 质量和效率 Tekla structures软件 3D建模 钢结构 油气田地面工程 模块化施工
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Research on Community Structure in Bus Transport Networks 被引量:1
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作者 YANG Xu-Hua WANG Bo SUN You-Xian 《Communications in Theoretical Physics》 SCIE CAS CSCD 2009年第12期1025-1030,共6页
We abstract the bus transport networks(BTNs)to two kinds of complex networks with space L and spaceP methods respectively.Using improved community detecting algorithm(PKM agglomerative algorithm),we analyzethe communi... We abstract the bus transport networks(BTNs)to two kinds of complex networks with space L and spaceP methods respectively.Using improved community detecting algorithm(PKM agglomerative algorithm),we analyzethe community property of two kinds of BTNs graphs.The results show that the BTNs graph described with space Lmethod have obvious community property,but the other kind of BTNs graph described with space P method have not.The reason is that the BTNs graph described with space P method have the intense overlapping community propertyand general community division algorithms can not identify this kind of community structure.To overcome this problem,we propose a novel community structure called N-depth community and present a corresponding community detectingalgorithm,which can detect overlapping community.Applying the novel community structure and detecting algorithmto a BTN evolution model described with space P,whose network property agrees well with real BTNs',we get obviouscommunity property. 展开更多
关键词 bus transport network overlapping community structure CLIQUE modularITY N-depth community
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Typical Structure Design of Stainless Steel Metro Car Body and Analysis Thereof
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作者 ZHANG Quan LUO Chao WANG Feng 《外文科技期刊数据库(文摘版)工程技术》 2021年第6期143-146,共6页
The car body steel structure based on stainless steel material has the advantages of high strength, corrosion resistance, no coating, good fire performance, maintenance free, environmental protection and so on. Howeve... The car body steel structure based on stainless steel material has the advantages of high strength, corrosion resistance, no coating, good fire performance, maintenance free, environmental protection and so on. However, the steel structure of rail transit passenger car body generally adopts the overall bearing structure of plate beam combination, and the structural form is relatively complex, which is composed of beam structure and thin plate combination welding. Through the optimization design of the typical structural design of a project of the company, the manufacturing process is further shortened through the optimization and improvement of the structure, which improves the adaptability of components and production equipment, greatly simplifies the demand for roof structure, reduces the welding of most accessories, improves the standardization level of roof structure, and lays the foundation for the realization of modular car body assembly. 展开更多
关键词 stainless steel plate beam structure modularIZATION structural optimization
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Modularized and Parametric Modeling Technology for Finite Element Simulations of Underground Engineering under Complicated Geological Conditions
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作者 Jiaqi Wu Li Zhuo +4 位作者 Jianliang Pei Yao Li Hongqiang Xie Jiaming Wu Huaizhong Liu 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第7期621-645,共25页
The surrounding geological conditions and supporting structures of underground engineering are often updated during construction,and these updates require repeated numerical modeling.To improve the numerical modeling ... The surrounding geological conditions and supporting structures of underground engineering are often updated during construction,and these updates require repeated numerical modeling.To improve the numerical modeling efficiency of underground engineering,a modularized and parametric modeling cloud server is developed by using Python codes.The basic framework of the cloud server is as follows:input the modeling parameters into the web platform,implement Rhino software and FLAC3D software to model and run simulations in the cloud server,and return the simulation results to the web platform.The modeling program can automatically generate instructions that can run the modeling process in Rhino based on the input modeling parameters.The main modules of the modeling program include modeling the 3D geological structures,the underground engineering structures,and the supporting structures as well as meshing the geometric models.In particular,various cross-sections of underground caverns are crafted as parametricmodules in themodeling program.Themodularized and parametric modeling program is used for a finite element simulation of the underground powerhouse of the Shuangjiangkou Hydropower Station.This complicatedmodel is rapidly generated for the simulation,and the simulation results are reasonable.Thus,this modularized and parametric modeling program is applicable for three-dimensional finite element simulations and analyses. 展开更多
关键词 Underground engineering modularized and parametric modeling finite element method complex geological structure cloud modeling
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Application Strategies of Modular Design in Assembled Teaching Buildings
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作者 Huina Li 《Journal of Contemporary Educational Research》 2024年第6期50-56,共7页
As an efficient,environmentally friendly,energy-saving construction method,assembled buildings are now widely used in campus building construction.Modular design thinking is system-based design thinking,and its applic... As an efficient,environmentally friendly,energy-saving construction method,assembled buildings are now widely used in campus building construction.Modular design thinking is system-based design thinking,and its application to the design of an assembled teaching building project will comprehensively improve the rationality of the teaching building and component design.The paper focuses on the application of modular design thinking in assembled teaching building design,aiming to provide references for China’s architectural design units,giving full play to the advantages of modular design thinking in future teaching building design projects,and enhancing the level of design,for the construction of the teaching building and the basis of the technical guarantee. 展开更多
关键词 modular design Assembled teaching building Basic module division structured parameter design Online publication:July 3 2024
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服务型制造网络组织结构优化分析
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作者 祝爱民 刘硕 +1 位作者 侯芳 郝军红 《沈阳工业大学学报(社会科学版)》 2025年第1期77-86,共10页
数字技术的广泛应用加剧了社会经济系统的复杂性,这种复杂性不仅存在于整体层面,而且渗透进企业组织内部,对经典组织结构造成颠覆性影响。为了适应这一挑战,服务型制造网络应运而生,它作为一种协作式组织结构,集成了制造和服务功能,构... 数字技术的广泛应用加剧了社会经济系统的复杂性,这种复杂性不仅存在于整体层面,而且渗透进企业组织内部,对经典组织结构造成颠覆性影响。为了适应这一挑战,服务型制造网络应运而生,它作为一种协作式组织结构,集成了制造和服务功能,构成了复杂的网络组织体系。该结构的本质在于通过存量优化和增量调整实现企业组织的变革,形成基于生产要素关系和空间布局的关联网络。优化服务型制造网络组织结构被认为是推动我国经济高质量发展和提升产业链现代化水平的重要引擎。使用自主式服务型制造网络连接评价方法对服务型制造网络组织结构进行优化,基于经典自主式综合评价方法给出服务型制造网络连接权重;在服务型制造网络模块度测算中考虑价值系数即被评价对象优先突出自身主体及合作生态网络中高密度连接节点优势;借助模块度概念,应用GN算法求解,以优化服务型制造网络组织结构;最后,通过算例应用对方法进行说明和讨论,拓展蕴含价值系数的模块度在网络组织优化中的应用。该方法能够有效应对复杂的网络环境和多主体间的协同需求,适用于多主体多重交互的应用场景和基于网络空间的虚拟化集聚生产模式,不仅为服务型制造网络的研究提供了新的思路,也为推动我国经济高质量发展,提升产业链现代化水平提供了参考。 展开更多
关键词 综合评价方法 服务型制造 网络组织结构 模块度
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无粘结模块化装配式结构抗震性能试验研究
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作者 王宏伟 齐鑫 +1 位作者 曾宪涛 陈绘锦 《力学与实践》 2025年第1期148-164,共17页
为促进模块化装配式结构建筑的抗震力学性能研究及推广应用,构建了无粘结模块化装配式框架结构关键节点力学模型,分析了不同振动工况下结构的位移振幅变化特征;设计了装配式框架结构和普通框架结构试验模型,开展了单向定频正弦振动载荷... 为促进模块化装配式结构建筑的抗震力学性能研究及推广应用,构建了无粘结模块化装配式框架结构关键节点力学模型,分析了不同振动工况下结构的位移振幅变化特征;设计了装配式框架结构和普通框架结构试验模型,开展了单向定频正弦振动载荷试验,构造了表征两种结构对于定频正弦振动位移响应的楼层位移对比因子和工况位移影响因子,从结构位移、结构各楼层的水平方向加速度响应及装配式结构模块间剪应力振动响应等多角度对比分析了装配式框架结构相对于普通框架结构的抗震稳定性。研究结果表明,装配式结构位移理论值与试验结果吻合度较高,模块化装配式结构设计合理;相比于普通框架结构,无粘结模块装配框架结构在较高振动频率工况下的结构位移更小,水平方向加速度动力特性更趋于稳定;装配式结构模块间剪应力监测结果显示,结构中柱节点较边柱节点的剪应力变化显著,抵抗模块剪切作用更为明显,是影响装配式结构稳定性的关键节点。 展开更多
关键词 装配式结构 模块化 力学模型 振动试验 抗震性能
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Design of a novel modular self-reconfigurable robot capable of self-turning
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作者 乔贵方 宋光明 +2 位作者 张颖 孙慧玉 韦中 《Journal of Southeast University(English Edition)》 EI CAS 2016年第3期293-300,共8页
To solve the problem of inaccurate angle adjustment in the self-assembly process, a new homogenous hybrid modular self-reconfigurable robot-Xmobot is designed. Each module has four rotary joints and a self-turning mec... To solve the problem of inaccurate angle adjustment in the self-assembly process, a new homogenous hybrid modular self-reconfigurable robot-Xmobot is designed. Each module has four rotary joints and a self-turning mechanism. With the proposed self-turning mechanism, the angle adjusting accuracy of the module is increased to 2°, and the relative position adjusting efficiency of the module in the self-assembly process is also improved. The measured maximum moving distance of the proposed module in a gait cycle is 11.0 cm. Aiming at the multiple degree of freedom (MDOF) feature of the proposed module, a motion controller based on the central pattern generator (CPG) is proposed. The control of five joints of the module only requires two CPG oscillators. The CPG-based motion controller has three basic output modes, i. e. the oscillation, the rotation, and the fixed modes. The serpentine and the wheeled movements of the H-shaped robot are simulated, respectively. The results show that the average velocities of the two movements are 15. 2 and 20. 1 m/min, respectively. The proposed CPG-based motion controller is evaluated to be effective. 展开更多
关键词 central pattern generator modular self-reconfigurable robot structural design motion simulation
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模块化气动软体爬行机器人的设计与分析
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作者 尹宏飞 吕跃东 宋晓娟 《机械传动》 北大核心 2025年第1期64-73,共10页
【目的】模块化软体机器人具备高柔韧性与理论上的无限自由度,可以适应各种复杂的环境和任务需求。为此,设计了一种仿蜂巢软体驱动单元,将多个该单元连接组成可以实现不同功能的模块化驱动软体机器人。【方法】对设计的仿蜂巢软体驱动... 【目的】模块化软体机器人具备高柔韧性与理论上的无限自由度,可以适应各种复杂的环境和任务需求。为此,设计了一种仿蜂巢软体驱动单元,将多个该单元连接组成可以实现不同功能的模块化驱动软体机器人。【方法】对设计的仿蜂巢软体驱动单元进行了材料选择与力学分析,建立了软体驱动单元内部驱动气压与变形量之间的非线性关系模型,并采用有限元仿真验证了该模型的有效性;基于仿蜂巢软体驱动单元模块,设计了伸缩型软体机器人和双向弯曲型软体机器人,并对两种构型的软体机器人进行有限元仿真;最后,进行了软体机器人的制作以及模块化驱动软体机器人的试验研究。【结果】仿真结果表明,双向弯曲型软体机器人比相同长度的伸缩型软体机器人在伸缩变形范围上更大,其承载能力较伸缩型软体机器人也更好。试验结果表明,双向弯曲型软体机器人可以实现仿蠕虫的直线爬行与转向运动。并且两种构型的软体机器人试验结果与仿真结果基本保持一致。 展开更多
关键词 模块化 气动软体机器人 非线性模型 结构仿真分析
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Motion simulation and experiment of a novel modular self-reconfigurable robot
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作者 吴秋轩 曹广益 费燕琼 《Journal of Southeast University(English Edition)》 EI CAS 2006年第2期185-190,共6页
Based on the character of the modular self-reconfigurable (MSR) robot, a novel homogeneous and lattice MSR robot, M-Cubes, was designed. Each module unit of the robot has 12 freedoms and is composed of six rotary jo... Based on the character of the modular self-reconfigurable (MSR) robot, a novel homogeneous and lattice MSR robot, M-Cubes, was designed. Each module unit of the robot has 12 freedoms and is composed of six rotary joints and one cubic link. An attached/detached mechanism was designed on the rotary joints. A novel space transmitting system was placed on the inner portion of the cubic link. A motor separately transmitted torque to the six joints which were distributed equally on six surfaces of the cubic link. The example of a basic motion for the module was demonstrated. The result shows that the robot is concise and compact in structure, highly efficient in transmission, credible in connecting, and simple in controlling. At the same time, a simulator is developed to graphically design the system configuration, the reconfiguration process and the motion of cluster modules. The character of local action for the cellular automata (CA) is utilized. Each module is simplified as a cell. The transition rules of the CA are developed to combine with the genetic algorithm (GA) and applied to each module to accomplish distributed control. Simulation proves that the method is effective and feasible. 展开更多
关键词 modular self-reconfigurable robot structure design motion simulation distributed control
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模块化机翼初步结构设计方法
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作者 樊福磊 李毅 +1 位作者 陈春颖 贾兆虎 《航空工程进展》 2025年第1期158-168,共11页
飞机模块化设计可以增加飞机的任务类型,降低成本。在机翼模块化结构设计初期,由于翼尖变形量不明确导致无法衡量不同展长机翼的结构刚度特征对系统目标函数(结构质量最小)的贡献差异。针对上述问题,在灵敏度协调优化方法的基础上,系统... 飞机模块化设计可以增加飞机的任务类型,降低成本。在机翼模块化结构设计初期,由于翼尖变形量不明确导致无法衡量不同展长机翼的结构刚度特征对系统目标函数(结构质量最小)的贡献差异。针对上述问题,在灵敏度协调优化方法的基础上,系统级中引入各子系统级的权重系数模拟实际设计工作中不同子系统对系统目标函数的贡献存在差别的现象,并给出不同展长机翼结构(不同子系统级)的权重系数的计算方法,形成含子系统级权重的灵敏度协调优化方法;通过模块化桁架和模块化机翼结构优化算例的求解,对模块化机翼初步结构设计方法进行验证。结果表明:含子系统级权重的灵敏度协调优化方法能够获得既满足强度要求又具有一定刚度的模块化机翼初步结构。 展开更多
关键词 模块化飞机 模块化结构 结构优化 灵敏度协调优化 子系统权重
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建筑空间适应性设计原型初探
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作者 曾凡博 韩林飞 《华中建筑》 2025年第3期10-15,共6页
建筑空间适应性一直是当代建筑设计的重要议题,然而相关讨论往往停留在技术层面,鲜少有对其空间本体的研究。该文以类型学视角对建筑空间适应性设计原型进行概念剖析及类型梳理。研究空间原型不仅可以挖掘现代主义建筑对适应性设计的思... 建筑空间适应性一直是当代建筑设计的重要议题,然而相关讨论往往停留在技术层面,鲜少有对其空间本体的研究。该文以类型学视角对建筑空间适应性设计原型进行概念剖析及类型梳理。研究空间原型不仅可以挖掘现代主义建筑对适应性设计的思考,也可以梳理出现代建筑面向未来发展的新路径。研究明晰了适应性在建筑学中的概念及特质,揭秘了建筑空间适应性的三大原型:通用空间、开放平面、动态结构。通过案例分析解构了建筑空间适应性模式并阐述了三大原型的局限性,分析并提出模块化设计的解决对策,以“行为单元”结合“组合优化”的方式绘制未来建筑空间适应性设计新范式,对于今天更好地认知当代建筑空间适应性设计的发展前景具有重要意义。 展开更多
关键词 适应性 空间原型 通用空间 开放平面 动态结构 模块化设计
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GEMIN5 and neurodevelopmental diseases: From functional insights to disease perception
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作者 Encarnacion Martinez-Salas Rosario Francisco-Velilla 《Neural Regeneration Research》 2026年第1期187-194,共8页
GEMIN5 is a predominantly cytoplasmic multifunctional protein, known to be involved in recognizing snRNAs through its WD40 repeats domain placed at the N-terminus. A dimerization domain in the middle region acts as a ... GEMIN5 is a predominantly cytoplasmic multifunctional protein, known to be involved in recognizing snRNAs through its WD40 repeats domain placed at the N-terminus. A dimerization domain in the middle region acts as a hub for protein–protein interaction, while a non-canonical RNA-binding site is placed towards the C-terminus. The singular organization of structural domains present in GEMIN5 enables this protein to perform multiple functions through its ability to interact with distinct partners, both RNAs and proteins. This protein exerts a different role in translation regulation depending on its physiological state, such that while GEMIN5 down-regulates global RNA translation, the C-terminal half of the protein promotes translation of its mRNA. Additionally, GEMIN5 is responsible for the preferential partitioning of mRNAs into polysomes. Besides selective translation, GEMIN5 forms part of distinct ribonucleoprotein complexes, reflecting the dynamic organization of macromolecular complexes in response to internal and external signals. In accordance with its contribution to fundamental cellular processes, recent reports described clinical loss of function mutants suggesting that GEMIN5 deficiency is detrimental to cell growth and survival. Remarkably, patients carrying GEMIN5 biallelic variants suffer from neurodevelopmental delay, hypotonia, and cerebellar ataxia. Molecular analyses of individual variants, which are defective in protein dimerization, display decreased levels of ribosome association, reinforcing the involvement of the protein in translation regulation. Importantly, the number of clinical variants and the phenotypic spectrum associated with GEMIN5 disorders is increasing as the knowledge of the protein functions and the pathways linked to its activity augments. Here we discuss relevant advances concerning the functional and structural features of GEMIN5 and its separate domains in RNA-binding, protein interactome, and translation regulation, and how these data can help to understand the involvement of protein malfunction in clinical variants found in patients developing neurodevelopmental disorders. 展开更多
关键词 Gemin5 variants modular organization neurodevelopmental diseases RNA-binding proteins selective translation structural domains
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Topology optimization of modular structures with multiple assemblies and applications to airborne shelves
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作者 Jie WANG Tong GAO +3 位作者 Ming LI Jihong ZHU Longlong SONG Weihong ZHANG 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2024年第4期321-332,共12页
This work is devoted to the aeronautical application of topology optimization for modular structures with multiple assemblies that consist of repeated standard modules and optional reinforcements.These kinds of struct... This work is devoted to the aeronautical application of topology optimization for modular structures with multiple assemblies that consist of repeated standard modules and optional reinforcements.These kinds of structures are widely used owing to their transportability,reconfigurability,low manufacturing and service costs.In this work,the design of airborne shelves with modular structures characterized by the standard module configuration is formulated for the first time as a topology optimization problem of multiple assemblies and multiple load cases subjected to the volume constraint.It is shown that the weighted compliance design of multiple assemblies is a compromising solution compared to the optimization result of each individual assembly of standard modules.Meanwhile,the performance of optimized airborne shelves with the modular structures can effectively be ameliorated with the help of reinforcements. 展开更多
关键词 Topology optimization modular structures Multiple assemblies Standard modules Airborne shelves
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