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Pollution source identification methods and remediation technologies of groundwater: A review 被引量:1
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作者 Ya-ci Liu Yu-hong Fei +2 位作者 Ya-song Li Xi-lin Bao Peng-wei Zhang 《China Geology》 CAS CSCD 2024年第1期125-137,共13页
Groundwater is an important source of drinking water.Groundwater pollution severely endangers drinking water safety and sustainable social development.In the case of groundwater pollution,the top priority is to identi... Groundwater is an important source of drinking water.Groundwater pollution severely endangers drinking water safety and sustainable social development.In the case of groundwater pollution,the top priority is to identify pollution sources,and accurate information on pollution sources is the premise of efficient remediation.Then,an appropriate pollution remediation scheme should be developed according to information on pollution sources,site conditions,and economic costs.The methods for identifying pollution sources mainly include geophysical exploration,geochemistry,isotopic tracing,and numerical modeling.Among these identification methods,only the numerical modeling can recognize various information on pollution sources,while other methods can only identify a certain aspect of pollution sources.The remediation technologies of groundwater can be divided into in-situ and ex-situ remediation technologies according to the remediation location.The in-situ remediation technologies enjoy low costs and a wide remediation range,but their remediation performance is prone to be affected by environmental conditions and cause secondary pollution.The ex-situ remediation technologies boast high remediation efficiency,high processing capacity,and high treatment concentration but suffer high costs.Different methods for pollution source identification and remediation technologies are applicable to different conditions.To achieve the expected identification and remediation results,it is feasible to combine several methods and technologies according to the actual hydrogeological conditions of contaminated sites and the nature of pollutants.Additionally,detailed knowledge about the hydrogeological conditions and stratigraphic structure of the contaminated site is the basis of all work regardless of the adopted identification methods or remediation technologies. 展开更多
关键词 Groundwater pollution Identification of pollution sources Geophysical exploration identification Geochemistry identification Isotopic tracing Numerical modeling Remediation technology Hydrogeological conditions Hydrogeological survey engineering
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A Fusion Neutron Source Driven Sub-Critical Nuclear Energy System: A Way for Early Application of Fusion Technology 被引量:11
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作者 吴宜灿 《Plasma Science and Technology》 SCIE EI CAS CSCD 2001年第6期1085-1092,共8页
This paper proposes a sub-critical nuclear energy system driven by fusion neutron source, FDS, which can be used to transmute long-lived radioactive wastes and to produce fissile nuclear fuel as a way for early applic... This paper proposes a sub-critical nuclear energy system driven by fusion neutron source, FDS, which can be used to transmute long-lived radioactive wastes and to produce fissile nuclear fuel as a way for early application of fusion technology. The necessity and feasibility to develop that system in China are illustrated on the basis of prediction of the demand of energy source in the first half of the 21th century, the status of current fission energy supply and the progress in fusion technology in the world. The characteristics of fusion neutron driver and the potential for transmutation of long-lived nuclear wastes and breeding of fissile nuclear fuel in a blanket are analyzed. A scenario of development steps is proposed. 展开更多
关键词 A Way for Early Application of Fusion technology A Fusion Neutron source Driven Sub-Critical Nuclear Energy System
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Water source identification in mines combining LIF technology and ResNet 被引量:1
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作者 YAN Peng-cheng ZHAO Yu-ting +2 位作者 LI Guo-dong WANG Jing-bao WANG Wen-chang 《Journal of Mountain Science》 SCIE CSCD 2023年第11期3392-3401,共10页
The problem of mine water source has always been an important hidden danger in mine safety production.The water source under the mine working face may lead to geological disasters,such as mine collapse and water disas... The problem of mine water source has always been an important hidden danger in mine safety production.The water source under the mine working face may lead to geological disasters,such as mine collapse and water disaster.The research background of mine water source identification involves many fields such as mining production,environmental protection,resource utilization and technological progress.It is a comprehensive and interdisciplinary subject,which helps to improve the safety and sustainability of mine production.Therefore,timely and accurate identification and control of mine water source is very important to ensure mine production safety.Laser-Induced Fluorescence(LIF)technology,characterized by high sensitivity,specificity,and spatial resolution,overcomes the time-consuming nature of traditional chemical methods.In this experiment,sandstone water and old air water were collected from the Huainan mining area as original samples.Five types of mixed water samples were prepared by varying their proportions,in addition to the two original water samples,resulting in a total of seven different water samples for testing.Four preprocessing methods,namely,MinMaxScaler,StandardScaler,Standard Normal Variate(SNV)transformation,and Centering Transformation(CT),were applied to preprocess the original spectral data to reduce noise and interference.CT was determined as the optimal preprocessing method based on class discrimination,data distribution,and data range.To maintain the original data features while reducing the data dimension,including the original spectral data,five sets of data were subjected to Principal Component Analysis(PCA)and Linear Discriminant Analysis(LDA)dimensionality reduction.Through comparing the clustering effect and Fisher's ratio of the first three dimensions,PCA was identified as the optimal dimensionality reduction method.Finally,two neural network models,CT+PCA+CNN and CT+PCA+ResNet,were constructed by combining Convolutional Neural Networks(CNN)and Residual Neural Networks(ResNet),respectively.When selecting the neural network models,the training time,number of iterative parameters,accuracy,and cross-entropy loss function in the classification problem were compared to determine the model best suited for water source data.The results indicated that CT+PCA+ResNet was the optimal approach for water source identification in this study. 展开更多
关键词 Water source identification Mine safety LIF technology CT PCA ResNet
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RESEARCH ON TECHNOLOGY OF CONTROLLED SOURCE RADIO MAGNETOTELLURIC SYSTEM'S TRANSMITTER
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作者 Xu Yongfeng Liu Lihua +2 位作者 Wu Kai Geng Zhi Fang Guangyou 《Journal of Electronics(China)》 2014年第6期609-618,共10页
The basic theory and principle of the artificial Controlled Source Radio Magneto Telluric(CSRMT) method is studied and a novel CSRMT transmitter in kH z frequency band is designed. The specific circuit and measured re... The basic theory and principle of the artificial Controlled Source Radio Magneto Telluric(CSRMT) method is studied and a novel CSRMT transmitter in kH z frequency band is designed. The specific circuit and measured results of some key modules in transmitter are presented, and some outdoor experimental tests have been carried out, which shows that the completed prototype of transmitter can generate a continuous sine current with frequency up to 35.33 k Hz, peak-to-peak amplitude up to 40 A, and realize a reliable transmitting mode with multi-frequency and high-current. The transmitter has a wide operating band, large magnetic moment and high waveform fidelity, and can meet the requirements of shallow geological exploration with high-resolution. 展开更多
关键词 Controlled source Radio Magneto Telluric(CSRMT) Transmitter technology Sine wave source Large current BROADBAND
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Web Development of Spatial Content Management System through the Use of Free and Open-Source Technologies. Case Study in Rural Areas 被引量:2
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作者 Ioannis Pispidikis Efi Dimopoulou 《Journal of Geographic Information System》 2015年第5期527-540,共14页
The rapid development of the technology of the web systems and GIS, in conjunction with the world economic crisis, formed the content for the promotion and development of free systems and open-source technologies. At ... The rapid development of the technology of the web systems and GIS, in conjunction with the world economic crisis, formed the content for the promotion and development of free systems and open-source technologies. At the same time, the tendency toward the standardization of data, metadata and services, with the aim of creating common “Language” for the reading and the dissemination of information available, is a basic research area in the global scientific community in this field. The development of WebGIS systems, taking advantage of the free technology, also contributes to finding more economical solutions, where the use of such systems is more directly accessible. The aim of this research work is, through the analysis of technologies for the Internet, and also the architecture of the WebGIS systems, to investigate the possibilities and to develop the appropriate free technologies, so as to design and implement a spatial content management system for the web. Search with the use of the latter, is the best response to the needs and visualization application maps, with scope in rural areas. In addition, reference is made to the existing content management systems, which provide both processing spatial data, and easily create a WebGIS application. 展开更多
关键词 WEBGIS OPEN source technologIES Free Systems
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Source,migration,distribution,toxicological effects and remediation technologies of arsenic in groundwater in China 被引量:1
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作者 Zhen Wang Hua-ming Guo +1 位作者 Hai-yan Liu Wei-min Zhang 《China Geology》 CAS CSCD 2023年第3期476-493,共18页
Groundwater with high arsenic(As) content seriously threatens human life and health. Drinking high-As groundwater for a long time will lead to various pathological changes such as skin cancer, liver cancer,and kidney ... Groundwater with high arsenic(As) content seriously threatens human life and health. Drinking high-As groundwater for a long time will lead to various pathological changes such as skin cancer, liver cancer,and kidney cancer. High-As groundwater has become one of the most serious environmental geological problems in China and even internationally. This paper aims to systematically summarize the sources,migration, distribution, toxicological effects, and treatment techniques of As in natural groundwater in China based on a large number of literature surveys. High-As groundwater in China is mainly distributed in the inland basins in arid and semi-arid environments and the alluvial and lacustrine aquifers in river deltas in humid environments, which are in neutral to weakly alkaline and strongly reducing environments.The content of As in groundwater varies widely, and As(Ⅲ) is the main form. The main mechanism of the formation of high-As groundwater in China is the reduced dissolution of Fe and Mn oxides under the action of organic matter and primary microorganisms, alkaline environment, intense evaporation and concentration, long-term water-rock interaction, and slow groundwater velocity, which promote the continuous migration and enrichment of As in groundwater. There are obvious differences in the toxicity of different forms of As. The toxic of As(Ⅲ) is far more than As(V), which is considered to be more toxic than methyl arsenate(MMA) and dimethyl arsenate(DMA). Inorganic As entering the body is metabolized through a combination of methylation(detoxification) and reduction(activation) and catalyzed by a series of methyltransferases and reductases. At present, remediation methods for high-As groundwater mainly include ion exchange technology, membrane filtration technology, biological treatment technology, nanocomposite adsorption technology, electrochemical technology, and so on. All the above remediation methods still have certain limitations, and it is urgent to develop treatment materials and technical means with stronger As removal performance and sustainability. With the joint efforts of scientists and governments of various countries in the future, this worldwide problem of drinking-water As poisoning will be solved as soon as possible. This paper systematically summarizes and discusses the hot research results of natural high-As groundwater, which could provide a reference for the related research of high-As groundwater in China and even the world. 展开更多
关键词 High arsenic groundwater source and distribution Enrichment mechanism Skin cancer Liver cancer Kidney cancer Toxicological effect Remediation technology Ecological geological survey engineering Hydrogeological survey engineering
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Analysis of displacement damage effects on the charge-coupled device induced by neutrons at Back-n in the China Spallation Neutron Source 被引量:2
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作者 薛院院 王祖军 +9 位作者 陈伟 郭晓强 姚志斌 何宝平 聂栩 赖善坤 黄港 盛江坤 马武英 缑石龙 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第7期435-442,共8页
Displacement damage effects on the charge-coupled device(CCD)induced by neutrons at the back-streaming white neutron source(Back-n)in the China Spallation Neutron Source(CSNS)are analyzed according to an online irradi... Displacement damage effects on the charge-coupled device(CCD)induced by neutrons at the back-streaming white neutron source(Back-n)in the China Spallation Neutron Source(CSNS)are analyzed according to an online irradiation experiment.The hot pixels,random telegraph signal(RTS),mean dark signal,dark current and dark signal non-uniformity(DSNU)induced by Back-n are presented.The dark current is calculated according to the mean dark signal at various integration times.The single-particle displacement damage and transient response are also observed based on the online measurement data.The trends of hot pixels,mean dark signal,DSNU and RTS degradation are related to the integration time and irradiation fluence.The mean dark signal,dark current and DSNU2 are nearly linear with neutron irradiation fluence when nearly all the pixels do not reach saturation.In addition,the mechanisms of the displacement damage effects on the CCD are demonstrated by combining the experimental results and technology computer-aided design(TCAD)simulation.Radiation-induced traps in the space charge region of the CCD will act as generation/recombination centers of electron-hole pairs,leading to an increase in the dark signal. 展开更多
关键词 displacement damage effects charge-coupled device(CCD) China Spallation Neutron source(CSNS) MECHANISMS technology computer-aided design(TCAD)
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Strategic information perception methods and practices in the open source intelligence 被引量:1
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作者 曾文 Li Hui 《High Technology Letters》 EI CAS 2018年第3期330-336,共7页
Open source intelligence is one of the most important public data sources for strategic information analysis. One of the primary and core issues of strategic information research is information perception,so this pape... Open source intelligence is one of the most important public data sources for strategic information analysis. One of the primary and core issues of strategic information research is information perception,so this paper mainly expounds the perception method for strategic information perception in the open source intelligence environment as well as the framework and basic process of information perception. This paper argues that in order to match the information perception result with the information depiction result,it conducts practical exploration for the results of information acquisition,perception,depiction and analysis. This paper introduces and develops a monitoring platform for information perception. The results show that the method proposed in this paper is feasible. 展开更多
关键词 open source intelligence (OSINT) open source information (OSIF) information perception methods and practices INFORMATION science and technology
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Application of Dual-Energy CT Non-Linear Fusion Technology in Improving CTA Image Quality of Renal Cancer 被引量:1
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作者 Shuiqing Zhuo Xiaoling Chen +2 位作者 Jingping Yu Sihui Zeng Lizhi Liu 《Open Journal of Medical Imaging》 2018年第3期73-80,共8页
Objective: To explore the significance of dual-energy CT non-linear fusion technique in improving the quality of CTA image of renal cancer. Methods: The CTA images of 100 patients who had been confirmed by pathology a... Objective: To explore the significance of dual-energy CT non-linear fusion technique in improving the quality of CTA image of renal cancer. Methods: The CTA images of 100 patients who had been confirmed by pathology as renal cancer were collected and were randomly divided into experimental group and control group with 50 cases respectively. The two groups of patients were treated with iodine concentration of 300 mg/ml and 350 mg/ml non-ionic contrast agent, with a dosage of 1.5 ml/kg and an injection rate of 4 ml/s. The contrast agent intelligently tracking method was adopted bolus. The control group used the conventional CTA scanning, with a reference tube voltage/tube current of 100 kv/ref150 mas. The experimental group adopted the double energy scanning, with ball tube A and ball tube B. The reference tube voltage/tube current was 100 kv/ref250 mas and sn150 kv/ref125 mas respectively. The images of the experimental group were non-linear fused to obtain the Mono+ 55 kev single-energy images. The CT value, SNR contrast ratio of the abdominal aorta, renal artery and tumor tissue of the experimental group images and the 100 KV images and the Mono+ 55 kev images of the control group were compared. The objective evaluation and subjective evaluation of the image quality of the three groups of images was performed. Results: The results showed that the 100 kV images of the experimental group were statistically different from those of the control group (P05) in CT value, SNR and CNR (P 0.05). And there was no statistically significant difference between the non-linear fusion single-energy Mono+ 55 kev images and the control group images in CT value, SNR and CNR (P > 0.05). The subjective evaluation of image quality showed that there was no significant difference between Mono+ 55 kev images and control group images, and the quality of Mono+ 55 kev images was higher than that of experimental group 100 kV images. Conclusion: The dual-energy CT non-linear fusion technique can improve the quality of CTA image in patients with renal cancer, and it is possible to obtain high quality CTA images with low iodine concentration contrast agent. 展开更多
关键词 Dual-source CT NON-LINEAR FUSION technology RENAL Cancer COMPUTED Tomographic ANGIOGRAPHY Image Quality
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Research on Optimal Control Method and Key Technology of New Energy Power System
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作者 WANG Zheng WANG Chuanyu LIU Xinglong 《外文科技期刊数据库(文摘版)工程技术》 2021年第8期180-182,共5页
With the rapid development of the times, whether it is people's daily life or social production, the demand for energy is increasing rapidly. The consumption of non-renewable energy is very serious, which leads to... With the rapid development of the times, whether it is people's daily life or social production, the demand for energy is increasing rapidly. The consumption of non-renewable energy is very serious, which leads to various environmental pollution problems and threatens the development of human society. Under this background, the application of new energy power system has become a new direction to solve the above problems. However, at this stage, the application of new energy power is facing the dual threat of uncertainty and instability. Therefore, it is very necessary to actively explore the optimization control methods and key technologies of new energy power system, which is also the focus of this paper. 展开更多
关键词 power system new energy sources optimization control key technology method research
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Mapping Spatial Data on the Web Using Free and Open-Source Tools: A Prototype Implementation
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作者 Sunil Pratap Singh Preetvanti Singh 《Journal of Geographic Information System》 2014年第1期30-39,共10页
There is a growing need for web-based geographic information systems for easy and fast dissemination, sharing, displaying and processing of spatial information. The tremendous growth in the use of web and open-source ... There is a growing need for web-based geographic information systems for easy and fast dissemination, sharing, displaying and processing of spatial information. The tremendous growth in the use of web and open-source geospatial resources has sparked development of web-based spatial applications to address multidisciplinary issues with spatial dimensions. This paper presents the integration of open-source geospatial tools and web technology to visualize and interact with spatial data using web browser. The goal of this paper is to implement a prototype system for web-based mapping by providing step-by-step instructions in order to encourage the eager developers and interested readers to publish their maps on the web with no prior technical experience in map servers. The implementation of mapping prototype shows the utilization of open-source geospatial tools which results in a rapid implementation with minimal or no software input cost. 展开更多
关键词 OPEN-source technology WEB-BASED MAPPING WEB technology GEOGRAPHIC Information System Spatial Application
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技术生命周期视角下颠覆性技术早期识别方法研究
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作者 侯艳辉 陈荣 王家坤 《情报学报》 北大核心 2025年第2期157-170,共14页
针对目前颠覆性技术识别过程中忽略技术演化特征的问题,本文提出一种考虑技术生命周期阶段性和特征异质性的颠覆性技术早期识别方法。首先,采用Sentence-BERT (sentence bidirectional encoder representation from transformers)对专... 针对目前颠覆性技术识别过程中忽略技术演化特征的问题,本文提出一种考虑技术生命周期阶段性和特征异质性的颠覆性技术早期识别方法。首先,采用Sentence-BERT (sentence bidirectional encoder representation from transformers)对专利摘要进行向量化。其次,构建过滤识别系统。第一层使用LOCI (local outlier factor with constraint integration)异常检测算法识别离群专利并分类;第二层,采用S曲线生命周期识别,对处于成熟期的专利类别进行过滤;第三层,对萌芽阶段的专利进行创新性测度;第四层,对成长阶段的专利文本、技术报道数据进行颠覆性测度,完成过滤。最后,以量子信息技术领域为例,阐述该识别方法的应用过程。研究结果表明,量子信息领域共发现三个萌芽期颠覆性主题和三个成长期颠覆性主题,与官方发布的报告进行对比,结果一致,验证了本文方法的可行性与有效性。 展开更多
关键词 技术生命周期 早期识别 过滤识别 多源数据 量子信息
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基于开源科技项目数据的多模态知识图谱构建研究
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作者 窦永香 解哲辉 汤晓芳 《情报理论与实践》 北大核心 2025年第3期32-40,共9页
[目的/意义]在全球科技竞争日益激烈的背景下,开源情报作为研究和预测世界科技发展趋势的重要工具,对于科技情报工作的重要性愈发凸显。科技项目数据作为科技情报的重要数据来源和分析对象,呈现出多源、多模态的特性,对其进行深度分析... [目的/意义]在全球科技竞争日益激烈的背景下,开源情报作为研究和预测世界科技发展趋势的重要工具,对于科技情报工作的重要性愈发凸显。科技项目数据作为科技情报的重要数据来源和分析对象,呈现出多源、多模态的特性,对其进行深度分析和挖掘,并服务于管理与决策活动,是新时期科技资源高效利用的重要途径。[方法/过程]文章将情报工作流程与多模态知识图谱构建流程相融合,提出了基于开源科技项目数据的多模态知识图谱构建框架,包含需求分析、开源情报采集、多模态科技项目知识图谱构建以及知识图谱服务4个关键环节,并详细讨论了每个环节中的核心内容。[结果/结论]以美国情报高级研究计划局(IARPA)公开项目的多模态数据为例,遵循上述框架构建了包含项目、机构、人员、技术、文档、图像、视频7类实体及多种关系的多模态知识图谱。未来,可将多模态知识图谱与问答系统、推荐系统相结合,为科技管理决策提供更加智能化的情报服务。 展开更多
关键词 开源情报 科技项目 多模态知识图谱 科技情报 数据挖掘 科技管理
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“测氡-磁”法探测小窑自然发火技术的应用研究
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作者 胡相明 洪海博 +4 位作者 董浩 吴佰谦 孙自超 王伟 张茜 《煤炭科学技术》 北大核心 2025年第2期200-210,共11页
山西小窑煤矿自然发火区域存在火源多且分布范围较广、火源位置隐蔽难以准确探测、漏风通道多、难以防治的实际问题。为了准确探测火源位置及范围,首先,从自然发火区域探测手段的探测机理开展研究,基于测氡法与磁法探测火区基础理论,提... 山西小窑煤矿自然发火区域存在火源多且分布范围较广、火源位置隐蔽难以准确探测、漏风通道多、难以防治的实际问题。为了准确探测火源位置及范围,首先,从自然发火区域探测手段的探测机理开展研究,基于测氡法与磁法探测火区基础理论,提出了地面“测氡-磁”联合技术探测原理对小窑火源的位置与范围进行精确探测;其次,使用FD213α能谱氡测量仪和GSM-19T磁力仪现场采集小窑隐蔽火源数据,采用地面“测氡-磁”联合技术对采集数据处理分析,综合圈定小窑隐蔽火源的位置与范围,并利用井下测温与测气钻孔,结合初步探测结果和井下巷道分布情况,对火源位置进行了核实;最后采用钻孔注浆技术进行火区治理,并采取束管气体监测和复测氡法联合技术对火区治理效果进行检测。试验结果发现:井下测温与测气钻孔结果成功验证“测氡-磁”联合技术圈定的隐蔽火源的位置与范围,本次试验共圈定隐蔽火区面积约213 m^(2);钻孔注浆火区治理工作累积充填材料约1 862 m~3;治理效果检测表明圈定火区内部指标气体CO体积分数降为0,氡浓度趋于正常水平,治理工作取得良好的效果。 展开更多
关键词 小煤窑隐蔽火区 火源测探 磁法与测氡联用法 钻孔注浆技术 束管监测
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基于OPCUA和ETL的伺服阀综合应用系统设计
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作者 何军红 黎长鑫 董方辰 《工业仪表与自动化装置》 2025年第1期29-35,87,共8页
针对伺服阀生产过程中存在的设备种类繁多、不同供应商设备之间无法交换数据、数据集成工作复杂困难的问题,提出基于OPC UA (Object Linking and Embedding for Process Control Unified Architecture)和ETL (Extract-Transform-Load)... 针对伺服阀生产过程中存在的设备种类繁多、不同供应商设备之间无法交换数据、数据集成工作复杂困难的问题,提出基于OPC UA (Object Linking and Embedding for Process Control Unified Architecture)和ETL (Extract-Transform-Load)的综合解决方案。该方案使用OPC UA作为通信协议完成设备之间的高效通信,利用ETL技术设计并实现了伺服阀综合应用系统。样机试验验证了方案的有效性。该方案实现了产线信息化过程中的设备互操作能力,是确保伺服阀质量可靠性和性能一致性的关键基础技术。 展开更多
关键词 OPC UA ETL技术 伺服阀 多源数据融合
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地球物理勘探技术在地下水资源探测中的应用研究
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作者 朱紫祥 胡俊杰 《中国资源综合利用》 2025年第3期66-70,共5页
为掌握水资源分布及评估质量,研究地球物理勘探技术在地下水资源探测中的应用。结合待测区域地理地质情况设计勘测剖面,选择联合剖面法、高密度电法、天然源面波法获取其视电阻率、等值线图及剖面图,分析地下资源分布,保证地下水资源探... 为掌握水资源分布及评估质量,研究地球物理勘探技术在地下水资源探测中的应用。结合待测区域地理地质情况设计勘测剖面,选择联合剖面法、高密度电法、天然源面波法获取其视电阻率、等值线图及剖面图,分析地下资源分布,保证地下水资源探测结果的可靠性。测试显示,3种探测技术均具备较好的探测精度,误差均低于5%;它们均可准确揭示地质构造和水资源分布,为区域地下资源管理提供可靠依据。 展开更多
关键词 地球物理勘探技术 地下水资源 联合剖面法 高密度电法 天然源面波法
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非侵入性光生物调节治疗技术在阿尔茨海默病中的应用
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作者 郭延光 魏双红 +6 位作者 王韵乐 陈思 HOSSEIN Chamkouri 陈鹏 司健敏 牛朝诗 陈雷 《生物化学与生物物理进展》 北大核心 2025年第3期654-668,共15页
随着中国人口结构老龄化,公共卫生领域迫切需要应对阿尔茨海默病(Alzheimer’s disease,AD)带来的重大社会发展问题。AD临床治疗能够使用的药物十分有限且使用一段时间后治疗效果不佳。尽管全球投入大量物力和财力进行药物研发,但药物... 随着中国人口结构老龄化,公共卫生领域迫切需要应对阿尔茨海默病(Alzheimer’s disease,AD)带来的重大社会发展问题。AD临床治疗能够使用的药物十分有限且使用一段时间后治疗效果不佳。尽管全球投入大量物力和财力进行药物研发,但药物治疗临床试验进展十分缓慢。近30年来,仅有7款AD药物获得美国食品药品监督管理局(Food and Drug Administration,FDA)批准。传统药物治疗价格昂贵且只能起到延缓AD病情作用,而无法阻止神经元进行性退化过程。因此,探究发展AD新兴治疗手段刻不容缓。光生物调节(photobiomodulation,PBM)是一种非侵入性的治疗方法,利用红光或近红外光刺激细胞代谢和细胞学反应。PBM可以改善脑部代谢和血液循环,修复脑部受损神经元,激发树突和神经元生长,有望发展成为与药物治疗互补的无创伤神经治疗手段。本文阐述了AD病理学特征、致病机理与现有治疗策略面临的难题,综述了PBM治疗AD的细胞与动物模型和临床研究,总结了光疗历史与先进PBM光疗设备研发现状,最后对发展用于AD PBM治疗的先进光子技术与光疗器械装备进行了展望。 展开更多
关键词 阿尔茨海默病 光生物调节 发光二极管光源 医疗器械 光子技术
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海洋发光菌的分离培养研究进展
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作者 刘青 李琦琦 +1 位作者 李洁 杨键 《环境监测管理与技术》 北大核心 2025年第1期15-20,共6页
综述了海洋发光菌的分离培养技术,以及甘油、无机盐、温度、盐度、酸碱度和渗透压等对海洋发光菌生长和发光的影响。目前分离的海洋发光菌主要为弧菌属、另类弧菌属、发光杆菌属、希瓦氏菌属和小浴氏菌属,分析了其物种多样性和生境来源... 综述了海洋发光菌的分离培养技术,以及甘油、无机盐、温度、盐度、酸碱度和渗透压等对海洋发光菌生长和发光的影响。目前分离的海洋发光菌主要为弧菌属、另类弧菌属、发光杆菌属、希瓦氏菌属和小浴氏菌属,分析了其物种多样性和生境来源。归纳总结了海洋发光菌在环境监测、生物医学、通信遥感、生活照明等4个方面的应用,提出了在海洋发光菌培养基中加入特定的营养物质或调控底物、利用自动化和机器学习进行高通量微生物培养、对培养物采用先检测后筛选的分离培养策略等后续研究方向。 展开更多
关键词 海洋发光菌 分离方法 培养技术 物种多样性 生境来源
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长江江苏段地表水中典型抗生素赋存特征及来源分析
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作者 张璐 刘伟 +3 位作者 刘树洋 周亮 岳强 黄纯凯 《安全与环境工程》 北大核心 2025年第1期263-272,共10页
采用超高效液相色谱三重四级杆质谱法,对南京、泰州、苏州3个城市长江流域干流及入江支流断面和水源地水环境中7大类30种抗生素的赋存特征和来源进行了研究,并对流域内的医院、制药企业和城镇污水处理厂的废水展开调研。结果表明:各抗... 采用超高效液相色谱三重四级杆质谱法,对南京、泰州、苏州3个城市长江流域干流及入江支流断面和水源地水环境中7大类30种抗生素的赋存特征和来源进行了研究,并对流域内的医院、制药企业和城镇污水处理厂的废水展开调研。结果表明:各抗生素的检测浓度在ND(未检出)~7.79 ng/L之间,检出浓度最高的3类抗生素分别是氯霉素类、林可霉素类和磺胺类,其浓度依次为59.48、55.14和30.87 ng/L,分别占抗生素浓度总和的37.5%、34.8%和19.5%;四环素类抗生素未被检出;在水处理设施的出水中检出大量喹诺酮类和大环内酯类抗生素,表明现有传统污水处理工艺对该类抗生素的去除能力有限。因此,未来应进一步关注高级氧化、生物强化及新型组合工艺技术的研发和应用。 展开更多
关键词 抗生素 长江江苏段 赋存特征 污染源 处理技术
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工业源大气污染物排放、检测和监管现状及展望
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作者 范可欣 高健 +5 位作者 陕亮 陈嘉翊 马彤 高锐 陈建华 刘翰青 《环境工程技术学报》 北大核心 2025年第1期193-202,共10页
为有效应对生态环境挑战并实现“双碳”目标,我国实施了一系列的生态环境保护策略,为重点行业制定了更为严格的治理标准,对工业源的监管提出了新要求。回顾了我国工业源大气污染排放现状及其对环境空气质量的影响,综合评价了当前采用的... 为有效应对生态环境挑战并实现“双碳”目标,我国实施了一系列的生态环境保护策略,为重点行业制定了更为严格的治理标准,对工业源的监管提出了新要求。回顾了我国工业源大气污染排放现状及其对环境空气质量的影响,综合评价了当前采用的固定源污染排放检测手段以及相应的排放监管方法。结果表明,在加强工业源管控的背景下,污染状况已得到明显改善。未来通过多源数据融合,有望进一步提升工业源污染监测的准确性和时效性,从而实现对工业源排放更为精准和实时的监管。随着信息技术的发展,物联网、大数据在工业源监管领域的应用越来越广泛,在一定程度上弥补了目前工业源监管精准性和时空分辨率上的不足。企业用电数据覆盖面广、实时性强、数据质量高,可设计开发用电监管指标,作为工业污染源排放的辅助监管手段推广应用。 展开更多
关键词 工业源 大气污染 排放检测 监管技术 用电数据
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