Ecological monitoring vehicles are equipped with a range of sensors and monitoring devices designed to gather data on ecological and environmental factors.These vehicles are crucial in various fields,including environ...Ecological monitoring vehicles are equipped with a range of sensors and monitoring devices designed to gather data on ecological and environmental factors.These vehicles are crucial in various fields,including environmental science research,ecological and environmental monitoring projects,disaster response,and emergency management.A key method employed in these vehicles for achieving high-precision positioning is LiDAR(lightlaser detection and ranging)-Visual Simultaneous Localization and Mapping(SLAM).However,maintaining highprecision localization in complex scenarios,such as degraded environments or when dynamic objects are present,remains a significant challenge.To address this issue,we integrate both semantic and texture information from LiDAR and cameras to enhance the robustness and efficiency of data registration.Specifically,semantic information simplifies the modeling of scene elements,reducing the reliance on dense point clouds,which can be less efficient.Meanwhile,visual texture information complements LiDAR-Visual localization by providing additional contextual details.By incorporating semantic and texture details frompaired images and point clouds,we significantly improve the quality of data association,thereby increasing the success rate of localization.This approach not only enhances the operational capabilities of ecological monitoring vehicles in complex environments but also contributes to improving the overall efficiency and effectiveness of ecological monitoring and environmental protection efforts.展开更多
In reward-based crowdfunding, projects are to disclose the operational risks and mitigation strategies for delivering the physical rewards during the funding phase. However, limited knowledge exists regarding projects...In reward-based crowdfunding, projects are to disclose the operational risks and mitigation strategies for delivering the physical rewards during the funding phase. However, limited knowledge exists regarding projects’ operational risks and mitigation strategies during the funding phase. In contributing to the literature, the study uses data on Kickstarter.com and conducts a content analysis to explore themes and their relationships. The results reveal various operational risks and associated mitigation strategies. Among the identified themes, product-related, contract manufacturers, and supply markets are the most expected risks, while outsourced production and proactive sourcing are the popular mitigation strategies. Also, the finding reveals that proactive sourcing and outsourced production, in-house production and post-campaign sourcing, contract manufacturer risk, and project internal risk are themes forming clusters. The results extend crowdfunding risk disclosure literature and set the tone for future research in crowdfunding operational risk management. Finally, other business implications are drawn for crowdfunding practitioners.展开更多
Objective: This study evaluates the impact of handshake and information support on patients’ outcomes during laparoscopic cholecystectomy. It examines the effects on their physiological and psychological responses an...Objective: This study evaluates the impact of handshake and information support on patients’ outcomes during laparoscopic cholecystectomy. It examines the effects on their physiological and psychological responses and overall satisfaction with nursing care. Methods: A total of 84 patients scheduled for laparoscopic cholecystectomy were selected through convenient sampling and randomly assigned to either the control group or the intervention group using a random number table. Each group consisted of 42 patients. The control group received standard surgical nursing care. In addition to standard care, the intervention group received handshake and information support from the circulating nurse before anesthesia induction. Vital signs were recorded before surgery and before anesthesia induction. Anxiety levels were measured using the State-Trait Anxiety Inventory (STAI) and the State-Anxiety Inventory (S-AI), while nursing satisfaction was assessed using a numerical rating scale. Results: No significant differences were found between the two groups in systolic and diastolic blood pressures before surgery and anesthesia induction (P > 0.05). However, there was a significant difference in heart rate before anesthesia induction (P Conclusion: Providing handshake and information support before anesthesia induction effectively reduces stress, alleviates anxiety, and enhances comfort and satisfaction among patients undergoing laparoscopic cholecystectomy.展开更多
Background: For nursing students, gathering social information is essential for understanding healthcare and social issues and developing critical thinking and decision-making skills. However, the choice of informatio...Background: For nursing students, gathering social information is essential for understanding healthcare and social issues and developing critical thinking and decision-making skills. However, the choice of information sources varies by age and individual habits. With the widespread use of the internet, there are notable differences between younger and older generations in their reliance on the internet versus traditional media sources like newspapers and television. Given the wide age range and diverse backgrounds of nursing students, understanding generational differences in information-gathering methods is important for implementing effective education. Purpose: The purpose of this study is to identify how nursing students in different age groups obtain social information and to examine media usage trends by age group. Additionally, we aim to use the findings to provide insights into effective information dissemination methods in nursing education. Results: The results showed that nursing students in their teens to forties, regardless of gender, primarily relied on the internet as their main information source, with television playing a secondary role. In contrast, students in their fifties tended to obtain information more often from newspapers and television than from the internet. This highlights an age-related difference in preferred information sources, with older students showing a greater reliance on traditional media. Conclusions: This study demonstrates that nursing students use different information-gathering methods based on their age, suggesting a need to custo-mize information dissemination strategies in nursing education. Digital media may be more effective for younger students, while traditional media or printed materials might better serve older students. Educational institutions should consider these generational differences in media usage and adopt strategies that meet the diverse needs of their student populations.展开更多
Background: The availability of essential medicines and medical supplies is crucial for effectively delivering healthcare services. In Zambia, the Logistics Management Information System (LMIS) is a key tool for manag...Background: The availability of essential medicines and medical supplies is crucial for effectively delivering healthcare services. In Zambia, the Logistics Management Information System (LMIS) is a key tool for managing the supply chain of these commodities. This study aimed to evaluate the effectiveness of LMIS in ensuring the availability of essential medicines and medical supplies in public hospitals in the Copperbelt Province of Zambia. Materials and Methods: From February to April 2022, a cross-sectional study was conducted in 12 public hospitals across the Copperbelt Province. Data were collected using structured questionnaires, checklists, and stock control cards. The study assessed LMIS availability, training, and knowledge among pharmacy personnel, as well as data accuracy, product availability, and order fill rates. Descriptive statistics were used to analyse the data. Results: All surveyed hospitals had LMIS implemented and were using eLMIS as the primary LMIS. Only 47% and 48% of pharmacy personnel received training in eLMIS and Essential Medicines Logistics Improvement Program (EMLIP), respectively. Most personnel demonstrated good knowledge of LMIS, with 77.7% able to log in to eLMIS Facility Edition, 76.6% able to locate stock control cards in the system, and 78.7% able to perform transactions. However, data accuracy from physical and electronic records varied from 0% to 60%, and product availability ranged from 50% to 80%. Order fill rates from Zambia Medicines and Medical Supplies Agency (ZAMMSA) were consistently below 30%. Discrepancies were observed between physical stock counts and eLMIS records. Conclusion: This study found that most hospitals in the Copperbelt Province of Zambia have implemented LMIS use. While LMIS implementation is high in the Copperbelt Province of Zambia, challenges such as low training levels, data inaccuracies, low product availability, and order fill rates persist. Addressing these issues requires a comprehensive approach, including capacity building, data quality improvement, supply chain coordination, and investment in infrastructure and human resources. Strengthening LMIS effectiveness is crucial for improving healthcare delivery and patient outcomes in Zambia.展开更多
General Rules Journal of Polyphenols publishes research articles,reviews and short communications in English,on the fields of the science and technology of plant polyphenols.
With the continuous advancement of information technology,traditional teaching management models can no longer meet the demands of modern laboratory management.Information management,characterized by efficiency,conven...With the continuous advancement of information technology,traditional teaching management models can no longer meet the demands of modern laboratory management.Information management,characterized by efficiency,convenience,and intelligence,provides new ideas and directions for reforming laboratory teaching management models in higher education.Based on this,this paper explores reform strategies and practical approaches for laboratory teaching management models from the perspective of information management,aiming to offer references for enhancing the modernization and intelligentization of laboratory teaching management.展开更多
Climate downscaling is used to transform large-scale meteorological data into small-scale data with enhanced detail,which finds wide applications in climate modeling,numerical weather forecasting,and renewable energy....Climate downscaling is used to transform large-scale meteorological data into small-scale data with enhanced detail,which finds wide applications in climate modeling,numerical weather forecasting,and renewable energy.Although deeplearning-based downscaling methods effectively capture the complex nonlinear mapping between meteorological data of varying scales,the supervised deep-learning-based downscaling methods suffer from insufficient high-resolution data in practice,and unsupervised methods struggle with accurately inferring small-scale specifics from limited large-scale inputs due to small-scale uncertainty.This article presents DualDS,a dual-learning framework utilizing a Generative Adversarial Network–based neural network and subgrid-scale auxiliary information for climate downscaling.Such a learning method is unified in a two-stream framework through up-and downsamplers,where the downsampler is used to simulate the information loss process during the upscaling,and the upsampler is used to reconstruct lost details and correct errors incurred during the upscaling.This dual learning strategy can eliminate the dependence on high-resolution ground truth data in the training process and refine the downscaling results by constraining the mapping process.Experimental findings demonstrate that DualDS is comparable to several state-of-the-art deep learning downscaling approaches,both qualitatively and quantitatively.Specifically,for a single surface-temperature data downscaling task,our method is comparable with other unsupervised algorithms with the same dataset,and we can achieve a 0.469 dB higher peak signal-to-noise ratio,0.017 higher structural similarity,0.08 lower RMSE,and the best correlation coefficient.In summary,this paper presents a novel approach to addressing small-scale uncertainty issues in unsupervised downscaling processes.展开更多
Online education has become a critical mode of instruction in Chinese universities,particularly during and after the COVID-19 pandemic.This study examines information management in online education through a triadic f...Online education has become a critical mode of instruction in Chinese universities,particularly during and after the COVID-19 pandemic.This study examines information management in online education through a triadic framework encompassing classroom information management,teaching effectiveness management,and teaching information management.Drawing on in-depth interviews with administrators,teachers,and students,the findings reveal three primary challenges in online education:the absence of embodied information,the uncontrollable nature of online platforms,and nonverbal overload caused by Zoom fatigue.Teachers face difficulties maintaining presence and interaction due to limited feedback from students and risks associated with class recordings.Students experience increased psychological and physical fatigue due to the overlap of learning and living spaces.Recommendations to address these issues include enhancing teacher-student interaction to foster a sense of presence,improving the transparency of course information to align expectations,and adopting user-friendly teaching platforms with privacy safeguards.These insights aim to improve the security,effectiveness,and experience of online education in higher education institutions.展开更多
With the advent of the information age,people’s production and life are more closely connected with the Internet.Internet technology not only improves the production efficiency,but also provides great convenience for...With the advent of the information age,people’s production and life are more closely connected with the Internet.Internet technology not only improves the production efficiency,but also provides great convenience for people’s life.At present,people’s requirements for computer information technology are gradually increasing.When we look directly at the information transmission and storage capacity,computer information technology cannot meet the market demand.Due to rapid development,the integration of artificial intelligence(AI)can enable the development of computer information technology.In this paper,computer information technology and artificial intelligence integration act as a starting point,and the integration of the development of the two is analyzed for reference.展开更多
The security of information transmission and processing due to unknown vulnerabilities and backdoors in cyberspace is becoming increasingly problematic.However,there is a lack of effective theory to mathematically dem...The security of information transmission and processing due to unknown vulnerabilities and backdoors in cyberspace is becoming increasingly problematic.However,there is a lack of effective theory to mathematically demonstrate the security of information transmission and processing under nonrandom noise(or vulnerability backdoor attack)conditions in cyberspace.This paper first proposes a security model for cyberspace information transmission and processing channels based on error correction coding theory.First,we analyze the fault tolerance and non-randomness problem of Dynamic Heterogeneous Redundancy(DHR)structured information transmission and processing channel under the condition of non-random noise or attacks.Secondly,we use a mathematical statistical method to demonstrate that for non-random noise(or attacks)on discrete memory channels,there exists a DHR-structured channel and coding scheme that enables the average system error probability to be arbitrarily small.Finally,to construct suitable coding and heterogeneous channels,we take Turbo code as an example and simulate the effects of different heterogeneity,redundancy,output vector length,verdict algorithm and dynamism on the system,which is an important guidance for theory and engineering practice.展开更多
Information spreading has been investigated for many years,but the mechanism of why the information explosively catches on overnight is still under debate.This explosive spreading phenomenon was usually considered dri...Information spreading has been investigated for many years,but the mechanism of why the information explosively catches on overnight is still under debate.This explosive spreading phenomenon was usually considered driven separately by social reinforcement or higher-order interactions.However,due to the limitations of empirical data and theoretical analysis,how the higher-order network structure affects the explosive information spreading under the role of social reinforcement has not been fully explored.In this work,we propose an information-spreading model by considering the social reinforcement in real and synthetic higher-order networks,describable as hypergraphs.Depending on the average group size(hyperedge cardinality)and node membership(hyperdegree),we observe two different spreading behaviors:(i)The spreading progress is not sensitive to social reinforcement,resulting in the information localized in a small part of nodes;(ii)a strong social reinforcement will promote the large-scale spread of information and induce an explosive transition.Moreover,a large average group size and membership would be beneficial to the appearance of the explosive transition.Further,we display that the heterogeneity of the node membership and group size distributions benefit the information spreading.Finally,we extend the group-based approximate master equations to verify the simulation results.Our findings may help us to comprehend the rapidly information-spreading phenomenon in modern society.展开更多
The Advanced French course is a core subject for the major of French,and ideological and political education is an important component of its teaching.By restructuring the teaching content according to the educational...The Advanced French course is a core subject for the major of French,and ideological and political education is an important component of its teaching.By restructuring the teaching content according to the educational modules of ideological and political education,we can provide a more comprehensive and systematic educational experience.Empowered by information technology,this approach broadens the dimensions of ideological and political education in the Advanced French course.Meanwhile,the learning outcomes from the“first classroom”can be transformed into the results of the“second classroom”through social platforms such as WeChat public accounts,micro-video competitions,and innovation projects,achieving the effect of spreading Chinese culture and telling Chinese stories.By using diverse evaluation criteria,we continuously improve teaching and learning activities and innovate the teaching model of ideological and political education.展开更多
Single-photon sensors are novel devices with extremely high single-photon sensitivity and temporal resolution.However,these advantages also make them highly susceptible to noise.Moreover,single-photon cameras face sev...Single-photon sensors are novel devices with extremely high single-photon sensitivity and temporal resolution.However,these advantages also make them highly susceptible to noise.Moreover,single-photon cameras face severe quantization as low as 1 bit/frame.These factors make it a daunting task to recover high-quality scene information from noisy single-photon data.Most current image reconstruction methods for single-photon data are mathematical approaches,which limits information utilization and algorithm performance.In this work,we propose a hybrid information enhancement model which can significantly enhance the efficiency of information utilization by leveraging attention mechanisms from both spatial and channel branches.Furthermore,we introduce a structural feature enhance module for the FFN of the transformer,which explicitly improves the model's ability to extract and enhance high-frequency structural information through two symmetric convolution branches.Additionally,we propose a single-photon data simulation pipeline based on RAW images to address the challenge of the lack of single-photon datasets.Experimental results show that the proposed method outperforms state-of-the-art methods in various noise levels and exhibits a more efficient capability for recovering high-frequency structures and extracting information.展开更多
Advanced geological prediction is a crucial means to ensure safety and efficiency in tunnel construction.However,diff erent advanced geological forecasting methods have their own limitations,resulting in poor detectio...Advanced geological prediction is a crucial means to ensure safety and efficiency in tunnel construction.However,diff erent advanced geological forecasting methods have their own limitations,resulting in poor detection accuracy.Using multiple methods to carry out a comprehensive evaluation can eff ectively improve the accuracy of advanced geological prediction results.In this study,geological information is combined with the detection results of geophysical methods,including transient electromagnetic,induced polarization,and tunnel seismic prediction,to establish a comprehensive analysis method of adverse geology.First,the possible main adverse geological problems are determined according to the geological information.Subsequently,various physical parameters of the rock mass in front of the tunnel face can then be derived on the basis of multisource geophysical data.Finally,based on the analysis results of geological information,the multisource data fusion algorithm is used to determine the type,location,and scale of adverse geology.The advanced geological prediction results that can provide eff ective guidance for tunnel construction can then be obtained.展开更多
BACKGROUND As one of the fatal diseases with high incidence,lung cancer has seriously endangered public health and safety.Elderly patients usually have poor self-care and are more likely to show a series of psychologi...BACKGROUND As one of the fatal diseases with high incidence,lung cancer has seriously endangered public health and safety.Elderly patients usually have poor self-care and are more likely to show a series of psychological problems.AIM To investigate the effectiveness of the initial check,information exchange,final accuracy check,reaction(IIFAR)information care model on the mental health status of elderly patients with lung cancer.METHODS This study is a single-centre study.We randomly recruited 60 elderly patients with lung cancer who attended our hospital from January 2021 to January 2022.These elderly patients with lung cancer were randomly divided into two groups,with the control group taking the conventional propaganda and education and the observation group taking the IIFAR information care model based on the conventional care protocol.The differences in psychological distress,anxiety and depression,life quality,fatigue,and the locus of control in psychology were compared between these two groups,and the causes of psychological distress were analyzed.RESULTS After the intervention,Distress Thermometer,Hospital Anxiety and Depression Scale(HADS)for anxiety and the HADS for depression,Revised Piper’s Fatigue Scale,and Chance Health Locus of Control scores were lower in the observation group compared to the pre-intervention period in the same group and were significantly lower in the observation group compared to those of the control group(P<0.05).After the intervention,Quality of Life Questionnaire Core 30(QLQ-C30),Internal Health Locus of Control,and Powerful Others Health Locus of Control scores were significantly higher in the observation and the control groups compared to the pre-intervention period in their same group,and QLQ-C30 scores were significantly higher in the observation group compared to those of the control group(P<0.05).CONCLUSION The IIFAR information care model can help elderly patients with lung cancer by reducing their anxiety and depression,psychological distress,and fatigue,improving their tendencies on the locus of control in psychology,and enhancing their life qualities.展开更多
The presence of numerous uncertainties in hybrid decision information systems(HDISs)renders attribute reduction a formidable task.Currently available attribute reduction algorithms,including those based on Pawlak attr...The presence of numerous uncertainties in hybrid decision information systems(HDISs)renders attribute reduction a formidable task.Currently available attribute reduction algorithms,including those based on Pawlak attribute importance,Skowron discernibility matrix,and information entropy,struggle to effectively manages multiple uncertainties simultaneously in HDISs like the precise measurement of disparities between nominal attribute values,and attributes with fuzzy boundaries and abnormal values.In order to address the aforementioned issues,this paper delves into the study of attribute reduction withinHDISs.First of all,a novel metric based on the decision attribute is introduced to solve the problem of accurately measuring the differences between nominal attribute values.The newly introduced distance metric has been christened the supervised distance that can effectively quantify the differences between the nominal attribute values.Then,based on the newly developed metric,a novel fuzzy relationship is defined from the perspective of“feedback on parity of attribute values to attribute sets”.This new fuzzy relationship serves as a valuable tool in addressing the challenges posed by abnormal attribute values.Furthermore,leveraging the newly introduced fuzzy relationship,the fuzzy conditional information entropy is defined as a solution to the challenges posed by fuzzy attributes.It effectively quantifies the uncertainty associated with fuzzy attribute values,thereby providing a robust framework for handling fuzzy information in hybrid information systems.Finally,an algorithm for attribute reduction utilizing the fuzzy conditional information entropy is presented.The experimental results on 12 datasets show that the average reduction rate of our algorithm reaches 84.04%,and the classification accuracy is improved by 3.91%compared to the original dataset,and by an average of 11.25%compared to the other 9 state-of-the-art reduction algorithms.The comprehensive analysis of these research results clearly indicates that our algorithm is highly effective in managing the intricate uncertainties inherent in hybrid data.展开更多
This paper proposes an artificial intelligence-based robust information hiding algorithm to address the issue of confidential information being susceptible to noise attacks during transmission.The algorithm we designe...This paper proposes an artificial intelligence-based robust information hiding algorithm to address the issue of confidential information being susceptible to noise attacks during transmission.The algorithm we designed aims to mitigate the impact of various noise attacks on the integrity of secret information during transmission.The method we propose involves encoding secret images into stylized encrypted images and applies adversarial transfer to both the style and content features of the original and embedded data.This process effectively enhances the concealment and imperceptibility of confidential information,thereby improving the security of such information during transmission and reducing security risks.Furthermore,we have designed a specialized attack layer to simulate real-world attacks and common noise scenarios encountered in practical environments.Through adversarial training,the algorithm is strengthened to enhance its resilience against attacks and overall robustness,ensuring better protection against potential threats.Experimental results demonstrate that our proposed algorithm successfully enhances the concealment and unknowability of secret information while maintaining embedding capacity.Additionally,it ensures the quality and fidelity of the stego image.The method we propose not only improves the security and robustness of information hiding technology but also holds practical application value in protecting sensitive data and ensuring the invisibility of confidential information.展开更多
Hyperspectral images typically have high spectral resolution but low spatial resolution,which impacts the reliability and accuracy of subsequent applications,for example,remote sensingclassification and mineral identi...Hyperspectral images typically have high spectral resolution but low spatial resolution,which impacts the reliability and accuracy of subsequent applications,for example,remote sensingclassification and mineral identification.But in traditional methods via deep convolution neural net-works,indiscriminately extracting and fusing spectral and spatial features makes it challenging toutilize the differentiated information across adjacent spectral channels.Thus,we proposed a multi-branch interleaved iterative upsampling hyperspectral image super-resolution reconstruction net-work(MIIUSR)to address the above problems.We reinforce spatial feature extraction by integrat-ing detailed features from different receptive fields across adjacent channels.Furthermore,we pro-pose an interleaved iterative upsampling process during the reconstruction stage,which progres-sively fuses incremental information among adjacent frequency bands.Additionally,we add twoparallel three dimensional(3D)feature extraction branches to the backbone network to extractspectral and spatial features of varying granularity.We further enhance the backbone network’sconstruction results by leveraging the difference between two dimensional(2D)channel-groupingspatial features and 3D multi-granularity features.The results obtained by applying the proposednetwork model to the CAVE test set show that,at a scaling factor of×4,the peak signal to noiseratio,spectral angle mapping,and structural similarity are 37.310 dB,3.525 and 0.9438,respec-tively.Besides,extensive experiments conducted on the Harvard and Foster datasets demonstratethe superior potential of the proposed model in hyperspectral super-resolution reconstruction.展开更多
BACKGROUND Acute liver failure(ALF)has a high mortality with widespread hepatocyte death involving ferroptosis and pyroptosis.The silent information regulator sirtuin 1(SIRT1)-mediated deacetylation affects multiple b...BACKGROUND Acute liver failure(ALF)has a high mortality with widespread hepatocyte death involving ferroptosis and pyroptosis.The silent information regulator sirtuin 1(SIRT1)-mediated deacetylation affects multiple biological processes,including cellular senescence,apoptosis,sugar and lipid metabolism,oxidative stress,and inflammation.AIM To investigate the association between ferroptosis and pyroptosis and the upstream regulatory mechanisms.METHODS This study included 30 patients with ALF and 30 healthy individuals who underwent serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST)testing.C57BL/6 mice were also intraperitoneally pretreated with SIRT1,p53,or glutathione peroxidase 4(GPX4)inducers and inhibitors and injected with lipopolysaccharide(LPS)/D-galactosamine(D-GalN)to induce ALF.Gasdermin D(GSDMD)^(-/-)mice were used as an experimental group.Histological changes in liver tissue were monitored by hematoxylin and eosin staining.ALT,AST,glutathione,reactive oxygen species,and iron levels were measured using commercial kits.Ferroptosis-and pyroptosis-related protein and mRNA expression was detected by western blot and quantitative real-time polymerase chain reaction.SIRT1,p53,and GSDMD were assessed by immunofluorescence analysis.RESULTS Serum AST and ALT levels were elevated in patients with ALF.SIRT1,solute carrier family 7a member 11(SLC7A11),and GPX4 protein expression was decreased and acetylated p5,p53,GSDMD,and acyl-CoA synthetase long-chain family member 4(ACSL4)protein levels were elevated in human ALF liver tissue.In the p53 and ferroptosis inhibitor-treated and GSDMD^(-/-)groups,serum interleukin(IL)-1β,tumour necrosis factor alpha,IL-6,IL-2 and C-C motif ligand 2 levels were decreased and hepatic impairment was mitigated.In mice with GSDMD knockout,p53 was reduced,GPX4 was increased,and ferroptotic events(depletion of SLC7A11,elevation of ACSL4,and iron accumulation)were detected.In vitro,knockdown of p53 and overexpression of GPX4 reduced AST and ALT levels,the cytostatic rate,and GSDMD expression,restoring SLC7A11 depletion.Moreover,SIRT1 agonist and overexpression of SIRT1 alleviated acute liver injury and decreased iron deposition compared with results in the model group,accompanied by reduced p53,GSDMD,and ACSL4,and increased SLC7A11 and GPX4.Inactivation of SIRT1 exacerbated ferroptotic and pyroptotic cell death and aggravated liver injury in LPS/D-GalNinduced in vitro and in vivo models.CONCLUSION SIRT1 activation attenuates LPS/D-GalN-induced ferroptosis and pyroptosis by inhibiting the p53/GPX4/GSDMD signaling pathway in ALF.展开更多
基金supported by the project“GEF9874:Strengthening Coordinated Approaches to Reduce Invasive Alien Species(lAS)Threats to Globally Significant Agrobiodiversity and Agroecosystems in China”funding from the Excellent Talent Training Funding Project in Dongcheng District,Beijing,with project number 2024-dchrcpyzz-9.
文摘Ecological monitoring vehicles are equipped with a range of sensors and monitoring devices designed to gather data on ecological and environmental factors.These vehicles are crucial in various fields,including environmental science research,ecological and environmental monitoring projects,disaster response,and emergency management.A key method employed in these vehicles for achieving high-precision positioning is LiDAR(lightlaser detection and ranging)-Visual Simultaneous Localization and Mapping(SLAM).However,maintaining highprecision localization in complex scenarios,such as degraded environments or when dynamic objects are present,remains a significant challenge.To address this issue,we integrate both semantic and texture information from LiDAR and cameras to enhance the robustness and efficiency of data registration.Specifically,semantic information simplifies the modeling of scene elements,reducing the reliance on dense point clouds,which can be less efficient.Meanwhile,visual texture information complements LiDAR-Visual localization by providing additional contextual details.By incorporating semantic and texture details frompaired images and point clouds,we significantly improve the quality of data association,thereby increasing the success rate of localization.This approach not only enhances the operational capabilities of ecological monitoring vehicles in complex environments but also contributes to improving the overall efficiency and effectiveness of ecological monitoring and environmental protection efforts.
文摘In reward-based crowdfunding, projects are to disclose the operational risks and mitigation strategies for delivering the physical rewards during the funding phase. However, limited knowledge exists regarding projects’ operational risks and mitigation strategies during the funding phase. In contributing to the literature, the study uses data on Kickstarter.com and conducts a content analysis to explore themes and their relationships. The results reveal various operational risks and associated mitigation strategies. Among the identified themes, product-related, contract manufacturers, and supply markets are the most expected risks, while outsourced production and proactive sourcing are the popular mitigation strategies. Also, the finding reveals that proactive sourcing and outsourced production, in-house production and post-campaign sourcing, contract manufacturer risk, and project internal risk are themes forming clusters. The results extend crowdfunding risk disclosure literature and set the tone for future research in crowdfunding operational risk management. Finally, other business implications are drawn for crowdfunding practitioners.
文摘Objective: This study evaluates the impact of handshake and information support on patients’ outcomes during laparoscopic cholecystectomy. It examines the effects on their physiological and psychological responses and overall satisfaction with nursing care. Methods: A total of 84 patients scheduled for laparoscopic cholecystectomy were selected through convenient sampling and randomly assigned to either the control group or the intervention group using a random number table. Each group consisted of 42 patients. The control group received standard surgical nursing care. In addition to standard care, the intervention group received handshake and information support from the circulating nurse before anesthesia induction. Vital signs were recorded before surgery and before anesthesia induction. Anxiety levels were measured using the State-Trait Anxiety Inventory (STAI) and the State-Anxiety Inventory (S-AI), while nursing satisfaction was assessed using a numerical rating scale. Results: No significant differences were found between the two groups in systolic and diastolic blood pressures before surgery and anesthesia induction (P > 0.05). However, there was a significant difference in heart rate before anesthesia induction (P Conclusion: Providing handshake and information support before anesthesia induction effectively reduces stress, alleviates anxiety, and enhances comfort and satisfaction among patients undergoing laparoscopic cholecystectomy.
文摘Background: For nursing students, gathering social information is essential for understanding healthcare and social issues and developing critical thinking and decision-making skills. However, the choice of information sources varies by age and individual habits. With the widespread use of the internet, there are notable differences between younger and older generations in their reliance on the internet versus traditional media sources like newspapers and television. Given the wide age range and diverse backgrounds of nursing students, understanding generational differences in information-gathering methods is important for implementing effective education. Purpose: The purpose of this study is to identify how nursing students in different age groups obtain social information and to examine media usage trends by age group. Additionally, we aim to use the findings to provide insights into effective information dissemination methods in nursing education. Results: The results showed that nursing students in their teens to forties, regardless of gender, primarily relied on the internet as their main information source, with television playing a secondary role. In contrast, students in their fifties tended to obtain information more often from newspapers and television than from the internet. This highlights an age-related difference in preferred information sources, with older students showing a greater reliance on traditional media. Conclusions: This study demonstrates that nursing students use different information-gathering methods based on their age, suggesting a need to custo-mize information dissemination strategies in nursing education. Digital media may be more effective for younger students, while traditional media or printed materials might better serve older students. Educational institutions should consider these generational differences in media usage and adopt strategies that meet the diverse needs of their student populations.
文摘Background: The availability of essential medicines and medical supplies is crucial for effectively delivering healthcare services. In Zambia, the Logistics Management Information System (LMIS) is a key tool for managing the supply chain of these commodities. This study aimed to evaluate the effectiveness of LMIS in ensuring the availability of essential medicines and medical supplies in public hospitals in the Copperbelt Province of Zambia. Materials and Methods: From February to April 2022, a cross-sectional study was conducted in 12 public hospitals across the Copperbelt Province. Data were collected using structured questionnaires, checklists, and stock control cards. The study assessed LMIS availability, training, and knowledge among pharmacy personnel, as well as data accuracy, product availability, and order fill rates. Descriptive statistics were used to analyse the data. Results: All surveyed hospitals had LMIS implemented and were using eLMIS as the primary LMIS. Only 47% and 48% of pharmacy personnel received training in eLMIS and Essential Medicines Logistics Improvement Program (EMLIP), respectively. Most personnel demonstrated good knowledge of LMIS, with 77.7% able to log in to eLMIS Facility Edition, 76.6% able to locate stock control cards in the system, and 78.7% able to perform transactions. However, data accuracy from physical and electronic records varied from 0% to 60%, and product availability ranged from 50% to 80%. Order fill rates from Zambia Medicines and Medical Supplies Agency (ZAMMSA) were consistently below 30%. Discrepancies were observed between physical stock counts and eLMIS records. Conclusion: This study found that most hospitals in the Copperbelt Province of Zambia have implemented LMIS use. While LMIS implementation is high in the Copperbelt Province of Zambia, challenges such as low training levels, data inaccuracies, low product availability, and order fill rates persist. Addressing these issues requires a comprehensive approach, including capacity building, data quality improvement, supply chain coordination, and investment in infrastructure and human resources. Strengthening LMIS effectiveness is crucial for improving healthcare delivery and patient outcomes in Zambia.
文摘General Rules Journal of Polyphenols publishes research articles,reviews and short communications in English,on the fields of the science and technology of plant polyphenols.
文摘With the continuous advancement of information technology,traditional teaching management models can no longer meet the demands of modern laboratory management.Information management,characterized by efficiency,convenience,and intelligence,provides new ideas and directions for reforming laboratory teaching management models in higher education.Based on this,this paper explores reform strategies and practical approaches for laboratory teaching management models from the perspective of information management,aiming to offer references for enhancing the modernization and intelligentization of laboratory teaching management.
基金supported by the following funding bodies:the National Key Research and Development Program of China(Grant No.2020YFA0608000)National Science Foundation of China(Grant Nos.42075142,42375148,42125503+2 种基金42130608)FY-APP-2022.0609,Sichuan Province Key Tech nology Research and Development project(Grant Nos.2024ZHCG0168,2024ZHCG0176,2023YFG0305,2023YFG-0124,and 23ZDYF0091)the CUIT Science and Technology Innovation Capacity Enhancement Program project(Grant No.KYQN202305)。
文摘Climate downscaling is used to transform large-scale meteorological data into small-scale data with enhanced detail,which finds wide applications in climate modeling,numerical weather forecasting,and renewable energy.Although deeplearning-based downscaling methods effectively capture the complex nonlinear mapping between meteorological data of varying scales,the supervised deep-learning-based downscaling methods suffer from insufficient high-resolution data in practice,and unsupervised methods struggle with accurately inferring small-scale specifics from limited large-scale inputs due to small-scale uncertainty.This article presents DualDS,a dual-learning framework utilizing a Generative Adversarial Network–based neural network and subgrid-scale auxiliary information for climate downscaling.Such a learning method is unified in a two-stream framework through up-and downsamplers,where the downsampler is used to simulate the information loss process during the upscaling,and the upsampler is used to reconstruct lost details and correct errors incurred during the upscaling.This dual learning strategy can eliminate the dependence on high-resolution ground truth data in the training process and refine the downscaling results by constraining the mapping process.Experimental findings demonstrate that DualDS is comparable to several state-of-the-art deep learning downscaling approaches,both qualitatively and quantitatively.Specifically,for a single surface-temperature data downscaling task,our method is comparable with other unsupervised algorithms with the same dataset,and we can achieve a 0.469 dB higher peak signal-to-noise ratio,0.017 higher structural similarity,0.08 lower RMSE,and the best correlation coefficient.In summary,this paper presents a novel approach to addressing small-scale uncertainty issues in unsupervised downscaling processes.
文摘Online education has become a critical mode of instruction in Chinese universities,particularly during and after the COVID-19 pandemic.This study examines information management in online education through a triadic framework encompassing classroom information management,teaching effectiveness management,and teaching information management.Drawing on in-depth interviews with administrators,teachers,and students,the findings reveal three primary challenges in online education:the absence of embodied information,the uncontrollable nature of online platforms,and nonverbal overload caused by Zoom fatigue.Teachers face difficulties maintaining presence and interaction due to limited feedback from students and risks associated with class recordings.Students experience increased psychological and physical fatigue due to the overlap of learning and living spaces.Recommendations to address these issues include enhancing teacher-student interaction to foster a sense of presence,improving the transparency of course information to align expectations,and adopting user-friendly teaching platforms with privacy safeguards.These insights aim to improve the security,effectiveness,and experience of online education in higher education institutions.
文摘With the advent of the information age,people’s production and life are more closely connected with the Internet.Internet technology not only improves the production efficiency,but also provides great convenience for people’s life.At present,people’s requirements for computer information technology are gradually increasing.When we look directly at the information transmission and storage capacity,computer information technology cannot meet the market demand.Due to rapid development,the integration of artificial intelligence(AI)can enable the development of computer information technology.In this paper,computer information technology and artificial intelligence integration act as a starting point,and the integration of the development of the two is analyzed for reference.
基金supported by National Key R&D Program of China for Young Scientists:Cyberspace Endogenous Security Mechanisms and Evaluation Methods(No.2022YFB3102800).
文摘The security of information transmission and processing due to unknown vulnerabilities and backdoors in cyberspace is becoming increasingly problematic.However,there is a lack of effective theory to mathematically demonstrate the security of information transmission and processing under nonrandom noise(or vulnerability backdoor attack)conditions in cyberspace.This paper first proposes a security model for cyberspace information transmission and processing channels based on error correction coding theory.First,we analyze the fault tolerance and non-randomness problem of Dynamic Heterogeneous Redundancy(DHR)structured information transmission and processing channel under the condition of non-random noise or attacks.Secondly,we use a mathematical statistical method to demonstrate that for non-random noise(or attacks)on discrete memory channels,there exists a DHR-structured channel and coding scheme that enables the average system error probability to be arbitrarily small.Finally,to construct suitable coding and heterogeneous channels,we take Turbo code as an example and simulate the effects of different heterogeneity,redundancy,output vector length,verdict algorithm and dynamism on the system,which is an important guidance for theory and engineering practice.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.12305043 and 12165016)the Natural Science Foundation of Jiangsu Province(Grant No.BK20220511)+1 种基金the Project of Undergraduate Scientific Research(Grant No.22A684)the support from the Jiangsu Specially-Appointed Professor Program。
文摘Information spreading has been investigated for many years,but the mechanism of why the information explosively catches on overnight is still under debate.This explosive spreading phenomenon was usually considered driven separately by social reinforcement or higher-order interactions.However,due to the limitations of empirical data and theoretical analysis,how the higher-order network structure affects the explosive information spreading under the role of social reinforcement has not been fully explored.In this work,we propose an information-spreading model by considering the social reinforcement in real and synthetic higher-order networks,describable as hypergraphs.Depending on the average group size(hyperedge cardinality)and node membership(hyperdegree),we observe two different spreading behaviors:(i)The spreading progress is not sensitive to social reinforcement,resulting in the information localized in a small part of nodes;(ii)a strong social reinforcement will promote the large-scale spread of information and induce an explosive transition.Moreover,a large average group size and membership would be beneficial to the appearance of the explosive transition.Further,we display that the heterogeneity of the node membership and group size distributions benefit the information spreading.Finally,we extend the group-based approximate master equations to verify the simulation results.Our findings may help us to comprehend the rapidly information-spreading phenomenon in modern society.
基金2023 Xi’an Fanyi University-Level Education and Teaching Reform Research Project“Research on Information Technology-Based Innovative Model of Civics and Politics in the Advanced French Course”(J23B17)。
文摘The Advanced French course is a core subject for the major of French,and ideological and political education is an important component of its teaching.By restructuring the teaching content according to the educational modules of ideological and political education,we can provide a more comprehensive and systematic educational experience.Empowered by information technology,this approach broadens the dimensions of ideological and political education in the Advanced French course.Meanwhile,the learning outcomes from the“first classroom”can be transformed into the results of the“second classroom”through social platforms such as WeChat public accounts,micro-video competitions,and innovation projects,achieving the effect of spreading Chinese culture and telling Chinese stories.By using diverse evaluation criteria,we continuously improve teaching and learning activities and innovate the teaching model of ideological and political education.
文摘Single-photon sensors are novel devices with extremely high single-photon sensitivity and temporal resolution.However,these advantages also make them highly susceptible to noise.Moreover,single-photon cameras face severe quantization as low as 1 bit/frame.These factors make it a daunting task to recover high-quality scene information from noisy single-photon data.Most current image reconstruction methods for single-photon data are mathematical approaches,which limits information utilization and algorithm performance.In this work,we propose a hybrid information enhancement model which can significantly enhance the efficiency of information utilization by leveraging attention mechanisms from both spatial and channel branches.Furthermore,we introduce a structural feature enhance module for the FFN of the transformer,which explicitly improves the model's ability to extract and enhance high-frequency structural information through two symmetric convolution branches.Additionally,we propose a single-photon data simulation pipeline based on RAW images to address the challenge of the lack of single-photon datasets.Experimental results show that the proposed method outperforms state-of-the-art methods in various noise levels and exhibits a more efficient capability for recovering high-frequency structures and extracting information.
基金National Natural Science Foundation of China(grant numbers 42293351,41877239,51422904 and 51379112).
文摘Advanced geological prediction is a crucial means to ensure safety and efficiency in tunnel construction.However,diff erent advanced geological forecasting methods have their own limitations,resulting in poor detection accuracy.Using multiple methods to carry out a comprehensive evaluation can eff ectively improve the accuracy of advanced geological prediction results.In this study,geological information is combined with the detection results of geophysical methods,including transient electromagnetic,induced polarization,and tunnel seismic prediction,to establish a comprehensive analysis method of adverse geology.First,the possible main adverse geological problems are determined according to the geological information.Subsequently,various physical parameters of the rock mass in front of the tunnel face can then be derived on the basis of multisource geophysical data.Finally,based on the analysis results of geological information,the multisource data fusion algorithm is used to determine the type,location,and scale of adverse geology.The advanced geological prediction results that can provide eff ective guidance for tunnel construction can then be obtained.
文摘BACKGROUND As one of the fatal diseases with high incidence,lung cancer has seriously endangered public health and safety.Elderly patients usually have poor self-care and are more likely to show a series of psychological problems.AIM To investigate the effectiveness of the initial check,information exchange,final accuracy check,reaction(IIFAR)information care model on the mental health status of elderly patients with lung cancer.METHODS This study is a single-centre study.We randomly recruited 60 elderly patients with lung cancer who attended our hospital from January 2021 to January 2022.These elderly patients with lung cancer were randomly divided into two groups,with the control group taking the conventional propaganda and education and the observation group taking the IIFAR information care model based on the conventional care protocol.The differences in psychological distress,anxiety and depression,life quality,fatigue,and the locus of control in psychology were compared between these two groups,and the causes of psychological distress were analyzed.RESULTS After the intervention,Distress Thermometer,Hospital Anxiety and Depression Scale(HADS)for anxiety and the HADS for depression,Revised Piper’s Fatigue Scale,and Chance Health Locus of Control scores were lower in the observation group compared to the pre-intervention period in the same group and were significantly lower in the observation group compared to those of the control group(P<0.05).After the intervention,Quality of Life Questionnaire Core 30(QLQ-C30),Internal Health Locus of Control,and Powerful Others Health Locus of Control scores were significantly higher in the observation and the control groups compared to the pre-intervention period in their same group,and QLQ-C30 scores were significantly higher in the observation group compared to those of the control group(P<0.05).CONCLUSION The IIFAR information care model can help elderly patients with lung cancer by reducing their anxiety and depression,psychological distress,and fatigue,improving their tendencies on the locus of control in psychology,and enhancing their life qualities.
基金Anhui Province Natural Science Research Project of Colleges and Universities(2023AH040321)Excellent Scientific Research and Innovation Team of Anhui Colleges(2022AH010098).
文摘The presence of numerous uncertainties in hybrid decision information systems(HDISs)renders attribute reduction a formidable task.Currently available attribute reduction algorithms,including those based on Pawlak attribute importance,Skowron discernibility matrix,and information entropy,struggle to effectively manages multiple uncertainties simultaneously in HDISs like the precise measurement of disparities between nominal attribute values,and attributes with fuzzy boundaries and abnormal values.In order to address the aforementioned issues,this paper delves into the study of attribute reduction withinHDISs.First of all,a novel metric based on the decision attribute is introduced to solve the problem of accurately measuring the differences between nominal attribute values.The newly introduced distance metric has been christened the supervised distance that can effectively quantify the differences between the nominal attribute values.Then,based on the newly developed metric,a novel fuzzy relationship is defined from the perspective of“feedback on parity of attribute values to attribute sets”.This new fuzzy relationship serves as a valuable tool in addressing the challenges posed by abnormal attribute values.Furthermore,leveraging the newly introduced fuzzy relationship,the fuzzy conditional information entropy is defined as a solution to the challenges posed by fuzzy attributes.It effectively quantifies the uncertainty associated with fuzzy attribute values,thereby providing a robust framework for handling fuzzy information in hybrid information systems.Finally,an algorithm for attribute reduction utilizing the fuzzy conditional information entropy is presented.The experimental results on 12 datasets show that the average reduction rate of our algorithm reaches 84.04%,and the classification accuracy is improved by 3.91%compared to the original dataset,and by an average of 11.25%compared to the other 9 state-of-the-art reduction algorithms.The comprehensive analysis of these research results clearly indicates that our algorithm is highly effective in managing the intricate uncertainties inherent in hybrid data.
基金the National Natural Science Foundation of China(Nos.62272478,61872384)Natural Science Foundation of Shanxi Province(No.2023-JC-YB-584)+1 种基金National Natural Science Foundation of China(No.62172436)Engineering University of PAP’s Funding for Scientific Research Innovation Team,Engineering University of PAP’s Funding for Key Researcher(No.KYGG202011).
文摘This paper proposes an artificial intelligence-based robust information hiding algorithm to address the issue of confidential information being susceptible to noise attacks during transmission.The algorithm we designed aims to mitigate the impact of various noise attacks on the integrity of secret information during transmission.The method we propose involves encoding secret images into stylized encrypted images and applies adversarial transfer to both the style and content features of the original and embedded data.This process effectively enhances the concealment and imperceptibility of confidential information,thereby improving the security of such information during transmission and reducing security risks.Furthermore,we have designed a specialized attack layer to simulate real-world attacks and common noise scenarios encountered in practical environments.Through adversarial training,the algorithm is strengthened to enhance its resilience against attacks and overall robustness,ensuring better protection against potential threats.Experimental results demonstrate that our proposed algorithm successfully enhances the concealment and unknowability of secret information while maintaining embedding capacity.Additionally,it ensures the quality and fidelity of the stego image.The method we propose not only improves the security and robustness of information hiding technology but also holds practical application value in protecting sensitive data and ensuring the invisibility of confidential information.
基金the National Natural Science Foun-dation of China(Nos.61471263,61872267 and U21B2024)the Natural Science Foundation of Tianjin,China(No.16JCZDJC31100)Tianjin University Innovation Foundation(No.2021XZC0024).
文摘Hyperspectral images typically have high spectral resolution but low spatial resolution,which impacts the reliability and accuracy of subsequent applications,for example,remote sensingclassification and mineral identification.But in traditional methods via deep convolution neural net-works,indiscriminately extracting and fusing spectral and spatial features makes it challenging toutilize the differentiated information across adjacent spectral channels.Thus,we proposed a multi-branch interleaved iterative upsampling hyperspectral image super-resolution reconstruction net-work(MIIUSR)to address the above problems.We reinforce spatial feature extraction by integrat-ing detailed features from different receptive fields across adjacent channels.Furthermore,we pro-pose an interleaved iterative upsampling process during the reconstruction stage,which progres-sively fuses incremental information among adjacent frequency bands.Additionally,we add twoparallel three dimensional(3D)feature extraction branches to the backbone network to extractspectral and spatial features of varying granularity.We further enhance the backbone network’sconstruction results by leveraging the difference between two dimensional(2D)channel-groupingspatial features and 3D multi-granularity features.The results obtained by applying the proposednetwork model to the CAVE test set show that,at a scaling factor of×4,the peak signal to noiseratio,spectral angle mapping,and structural similarity are 37.310 dB,3.525 and 0.9438,respec-tively.Besides,extensive experiments conducted on the Harvard and Foster datasets demonstratethe superior potential of the proposed model in hyperspectral super-resolution reconstruction.
基金Supported by National Natural Science Foundation of China,No.82060123Doctoral Start-up Fund of Affiliated Hospital of Guizhou Medical University,No.gysybsky-2021-28+1 种基金Fund Project of Guizhou Provincial Science and Technology Department,No.[2020]1Y299Guizhou Provincial Health Commission,No.gzwjk2019-1-082。
文摘BACKGROUND Acute liver failure(ALF)has a high mortality with widespread hepatocyte death involving ferroptosis and pyroptosis.The silent information regulator sirtuin 1(SIRT1)-mediated deacetylation affects multiple biological processes,including cellular senescence,apoptosis,sugar and lipid metabolism,oxidative stress,and inflammation.AIM To investigate the association between ferroptosis and pyroptosis and the upstream regulatory mechanisms.METHODS This study included 30 patients with ALF and 30 healthy individuals who underwent serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST)testing.C57BL/6 mice were also intraperitoneally pretreated with SIRT1,p53,or glutathione peroxidase 4(GPX4)inducers and inhibitors and injected with lipopolysaccharide(LPS)/D-galactosamine(D-GalN)to induce ALF.Gasdermin D(GSDMD)^(-/-)mice were used as an experimental group.Histological changes in liver tissue were monitored by hematoxylin and eosin staining.ALT,AST,glutathione,reactive oxygen species,and iron levels were measured using commercial kits.Ferroptosis-and pyroptosis-related protein and mRNA expression was detected by western blot and quantitative real-time polymerase chain reaction.SIRT1,p53,and GSDMD were assessed by immunofluorescence analysis.RESULTS Serum AST and ALT levels were elevated in patients with ALF.SIRT1,solute carrier family 7a member 11(SLC7A11),and GPX4 protein expression was decreased and acetylated p5,p53,GSDMD,and acyl-CoA synthetase long-chain family member 4(ACSL4)protein levels were elevated in human ALF liver tissue.In the p53 and ferroptosis inhibitor-treated and GSDMD^(-/-)groups,serum interleukin(IL)-1β,tumour necrosis factor alpha,IL-6,IL-2 and C-C motif ligand 2 levels were decreased and hepatic impairment was mitigated.In mice with GSDMD knockout,p53 was reduced,GPX4 was increased,and ferroptotic events(depletion of SLC7A11,elevation of ACSL4,and iron accumulation)were detected.In vitro,knockdown of p53 and overexpression of GPX4 reduced AST and ALT levels,the cytostatic rate,and GSDMD expression,restoring SLC7A11 depletion.Moreover,SIRT1 agonist and overexpression of SIRT1 alleviated acute liver injury and decreased iron deposition compared with results in the model group,accompanied by reduced p53,GSDMD,and ACSL4,and increased SLC7A11 and GPX4.Inactivation of SIRT1 exacerbated ferroptotic and pyroptotic cell death and aggravated liver injury in LPS/D-GalNinduced in vitro and in vivo models.CONCLUSION SIRT1 activation attenuates LPS/D-GalN-induced ferroptosis and pyroptosis by inhibiting the p53/GPX4/GSDMD signaling pathway in ALF.
