Periprosthetic fracture of femur is a common and complex complication after joint replacement. With the increase of operation volume, its incidence is increasing year by year. The treatment of this fracture is affecte...Periprosthetic fracture of femur is a common and complex complication after joint replacement. With the increase of operation volume, its incidence is increasing year by year. The treatment of this fracture is affected by many factors, including fracture type, prosthesis stability, patient age and comorbidities, and individualized treatment strategy is needed. In recent years, the internal fixation technology and prosthetic revision technology have made significant progress in surgical treatment, such as locking steel plate, titanium cable and bridge combined internal fixation system and other new technologies have effectively improved the treatment effect. In addition, the application of new materials and 3D printing technology, as well as the optimization of multidisciplinary cooperation mode, also provide new ideas for the treatment of complex fractures. However, there are still some problems such as inaccurate diagnosis, difficult choice of treatment options and high incidence of postoperative complications. In the future, technological innovation, the introduction of artificial intelligence and big data, and the further development of personalized treatment will bring more possibilities to improve the prognosis and quality of life of patients. This study summarizes the relevant research results and prospects the future development direction, providing references for clinical practice and subsequent research.展开更多
Drug resistance presents a significant challenge to achieving positive clinical outcomes in anti-tumor therapy.Prior research has illuminated reasons behind drug resistance,including increased drug efflux,alterations ...Drug resistance presents a significant challenge to achieving positive clinical outcomes in anti-tumor therapy.Prior research has illuminated reasons behind drug resistance,including increased drug efflux,alterations in drug targets,and abnormal activation of oncogenic pathways.However,there's a need for deeper investigation into the impact of drug-resistant cells on parental tumor cells and intricate crosstalk between tumor cells and the malignant tumor microenvironment(TME).Recent studies on extracellular vesicles(EVs)have provided valuable insights.EVs are membrane-bound particles secreted by all cells,mediating cell-to-cell communication.They contain functional cargoes like DNA,RNA,lipids,proteins,and metabolites from mother cells,delivered to other cells.Notably,EVs are increasingly recognized as regulators in the resistance to anti-cancer drugs.This review aims to summarize the mechanisms of EV-mediated anti-tumor drug resistance,covering therapeutic approaches like chemo-therapy,targeted therapy,immunotherapy and even radiotherapy.Detecting Ev-based biomarkers to predict drug resistance assists in bypassing anti-tumor drug resistance.Additionally,targeted inhibition of EV biogenesis and secretion emerges as a promising approach to counter drug resistance.We highlight the importance of conducting in-depth mechanistic research on EVs,their cargoes,and functional ap-proaches specifically focusing on EV subpopulations.These efforts will significantly advance the devel-opment of strategies to overcome drug resistance in anti-tumor therapy.展开更多
Gastric cancer(GC)is a prevalent malignant tumor within the digestive system,with over 40%of new cases and deaths related to GC globally occurring in China.Despite advancements in treatment modalities,such as surgery ...Gastric cancer(GC)is a prevalent malignant tumor within the digestive system,with over 40%of new cases and deaths related to GC globally occurring in China.Despite advancements in treatment modalities,such as surgery supplemented by adjuvant radiotherapy or chemotherapeutic agents,the prognosis for GC remains poor.New targeted therapies and immunotherapies are currently under invest-igation,but no significant breakthroughs have been achieved.Studies have indicated that GC is a heterogeneous disease,encompassing multiple subtypes with distinct biological characteristics and roles.Consequently,personalized treatment based on clinical features,pathologic typing,and molecular typing is crucial for the diagnosis and management of precancerous lesions of gastric cancer(PLGC).Current research has categorized GC into four subtypes:Epstein-Barr virus-positive,microsatellite instability,genome stability,and chromosome instability(CIN).Technologies such as multi-omics analysis and gene sequencing are being employed to identify more suitable novel testing methods in these areas.Among these,ultrasensitive chromosomal aneuploidy detection(UCAD)can detect CIN at a genome-wide level in subjects using low-depth whole genome sequencing technology,in conjunction with bioinformatics analysis,to achieve qualitative and quantitative detection of chromosomal stability.This editorial reviews recent research advancements in UCAD technology for the diagnosis and management of PLGC.展开更多
Traditional building energy-saving research focuses on technical energy-saving and energy system energy-saving,while neglecting the study of personnel's energy-consumption behavior during the building operation ph...Traditional building energy-saving research focuses on technical energy-saving and energy system energy-saving,while neglecting the study of personnel's energy-consumption behavior during the building operation phase.In order to explore people's cognitive process of building energy-saving information,this paper focuses on the representativeness of the research on building energy-saving reminder information.The results are summarized,sorted out and analyzed.Based on relevant research at home and abroad,this paper reviews the conceptual connotation of building energy-saving reminder information,research methods and influencing factors on the recognition of building energy-saving reminder information.Finally,it summarizes the research landscape of the cognitive process of building energy-saving reminder information and analyzes the existing research.In light of the shortcomings,three major research directions are proposed in the future:integrating research scenarios and focusing on the interaction of multiple scenarios in the Chinese cultural environment;broadening research methods to explore the diversity and feasibility of emerging research methods;increasing the time span and improving experimental design dynamic and continuous.展开更多
Deep learning,a pivotal technology within artificial intelligence,has made significant strides across various domains,including geoengineering.This paper explores the practical applications and challenges of integrati...Deep learning,a pivotal technology within artificial intelligence,has made significant strides across various domains,including geoengineering.This paper explores the practical applications and challenges of integrating deep learning techniques,such as Fully Connected Neural Networks(FCNNs)and Convolutional Neural Networks(CNNs),into geoengineering tasks,particularly in disaster prediction,resource exploration,and infrastructure health monitoring.The complexities of applying deep learning in geoengineering are multifaceted,involving mathematical,computational,and data processing challenges.However,the emergence of deep learning libraries,notably TensorFlow,has substantially lowered the technical barriers,enabling researchers and engineers to deploy these technologies more efficiently.Through case studies and practical examples,this paper demonstrates how TensorFlow can streamline the model development process,making deep learning more accessible to a broader audience in the field of geoengineering.The paper concludes with a discussion on the future prospects and potential advancements in the integration of deep learning within geoengineering,highlighting both the opportunities and the ongoing challenges.展开更多
With the continuous growth of the global population and the acceleration of urbanization,traditional agriculture faces severe challenges,such as labor shortages,low efficiency in agricultural resource utilization,and ...With the continuous growth of the global population and the acceleration of urbanization,traditional agriculture faces severe challenges,such as labor shortages,low efficiency in agricultural resource utilization,and uncertainties caused by climate change.Unmanned agricultural machinery,as an integral part of smart agriculture,utilizes automation and intelligent technologies to achieve precise control over the entire agricultural production process,improving production efficiency,reducing labor costs,minimizing environmental impacts,and enhancing sustainability.In recent years,with advancements in information technology,artificial intelligence,and the Internet of Things,unmanned agricultural machinery has made significant technological progress and has gradually entered the commercialization stage.This study aims to analyze the technological advancements and development trends of unmanned agricultural machinery and explore its application prospects in practical production.By investigating this emerging technology,the research not only provides a theoretical foundation for agricultural technological innovation but also offers practical references for policymakers,agricultural enterprises,and practitioners.Particularly in the critical period of global agricultural transformation,research on unmanned agricultural machinery holds significant economic,environmental,and social value.展开更多
The Silk Road Economic Belt,as a major initiative for global economic cooperation in the 21st century,has evolved into a critical economic cooperation region linking the Eurasian continent and its neighboring countrie...The Silk Road Economic Belt,as a major initiative for global economic cooperation in the 21st century,has evolved into a critical economic cooperation region linking the Eurasian continent and its neighboring countries since it was proposed by the Chinese President in 2013.This paper explores the economic cooperation modes among countries along the Silk Road Economic Belt,analyzing its cooperation mechanisms,current development status,and future prospects.By examining the diversity and complexity of economic cooperation in this region,the paper highlights both its potential and challenges,providing theoretical support for advancing regional collaboration and achieving shared prosperity.展开更多
Urine-derived stem cells(USCs)are derived from urine and harbor the potential of proliferation and multidirectional differentiation.Moreover,USCs could be reprogrammed into pluripotent stem cells[namely urine-derived ...Urine-derived stem cells(USCs)are derived from urine and harbor the potential of proliferation and multidirectional differentiation.Moreover,USCs could be reprogrammed into pluripotent stem cells[namely urine-derived induced pluripotent stem cells(UiPSCs)]through transcription factors,such as octamer binding transcription factor 4,sex determining region Y-box 2,kruppel-like factor 4,myelocytomatosis oncogene,and Nanog homeobox and protein lin-28,in which the first four are known as Yamanaka factors.Mounting evidence supports that USCs and UiPSCs possess high potential of neurogenic,myogenic,and osteogenic differentiation,indicating that they may play a crucial role in the treatment of neurological and musculoskeletal diseases.Therefore,we summarized the origin and physiological characteristics of USCs and UiPSCs and their therapeutic application in neurological and musculoskeletal disorders in this review,which not only contributes to deepen our understanding of hallmarks of USCs and UiPSCs but also provides the theoretical basis for the treatment of neurological and musculoskeletal disorders with USCs and UiPSCs.展开更多
Remarkable achievements have been made in China＇s agricultural development since the late 1970s. Nevertheless, deep-rooted problems are arising from inefficient farming practices. From mid- and long-term perspectives...Remarkable achievements have been made in China＇s agricultural development since the late 1970s. Nevertheless, deep-rooted problems are arising from inefficient farming practices. From mid- and long-term perspectives, migration of China＇s agricultural labor will slow and large-scale operation of farmland will accelerate. Although grain supply and demand have maintained a tight balance, new potentials still exist in improving grain production. Under the pressures of resource and environmental constraints, advancing the green and efficient transition of agriculture will become a new trend in China＇s agricultural development. In this context, the treatment of agricultural pollution, supply-side structural reform and innovation of agricultural subsidy policy are of strategic significance to the transition and upgrade of China＇s agriculture.展开更多
Since its proposal in 1985,the Discontinuous Deformation Analysis(DDA)has developed into a powerful tool for simulating the mechanical behaviour of rock masses and other discontinuous systems and has been widely appli...Since its proposal in 1985,the Discontinuous Deformation Analysis(DDA)has developed into a powerful tool for simulating the mechanical behaviour of rock masses and other discontinuous systems and has been widely applied in the field of geotechnical engineering.This paper systematically reviews the theoretical development of DDA,including the basic framework for solving two-dimensional and three-dimensional problems,improvements in contact detection algorithms,coupling with other numerical methods,and high-performance computing.In addition,the application of DDA in engineering problems such as wave propagation,rock blasting,slope instability,underground structures,and hydraulic structures is discussed in detail,demonstrating its wide applicability in solving complex geological and engineering problems.In the future,DDA deeply integrated with artificial intelligence(AI)may enhance its performance in simulation accuracy,computational efficiency,and engineering applications.Automated modelling,non-parametric simulation,and physical-numerical fusion in AI-based DDA may become new research directions.展开更多
The study aims to identify Albian-age oil prospects in Block A of the San Pedro margin, Côte d’Ivoire, by conducting a detailed geological interpretation. The objective is to confirm the presence of oil reservoi...The study aims to identify Albian-age oil prospects in Block A of the San Pedro margin, Côte d’Ivoire, by conducting a detailed geological interpretation. The objective is to confirm the presence of oil reservoirs trapped by favorable geological structures, identifiable through geophysical and seismic methods. The methodological approach is based on a combined analysis of studies and seismic data. Drilling data from well PA, including well logs and end-of-well reports, were used to characterize the lithological formations encountered, particularly those of the Albian. 3D seismic profiles were interpreted to identify structures conducive to hydrocarbon accumulation. Isochrone, isovelocity, and isobath maps were developed to refine the interpretation. Sedimentological analyses revealed five sandy/gritty levels between 2610 m and 3100 m, interspersed with clay, limestone, and siltstone beds. The seismic profiles highlighted two main prospects. These prospects exhibit favorable geological structures, including normal faults and structural traps that provide oil traps.展开更多
Great changes have taken place in China＇s real estate market during the 12th Five-year Plan period. The real estate market has shifted from being undersupplied to having an equilibrium of supply and demand with regio...Great changes have taken place in China＇s real estate market during the 12th Five-year Plan period. The real estate market has shifted from being undersupplied to having an equilibrium of supply and demand with regional oversupply. Real estate risks in some cities have begun to emerge, but overall real estate risks remain controllable. Given the major changes taking place in the supply and demand of China＇s real estate market and the current stage of its development, it is projected that China＇s real estate investment growth will continue to slow down during the 13th Five-year Plan period and pressures on the renovation of inventory housing will intensify. According to the changes in the development of China＇s current real estate market, the objectives of real estate development will be adjusted to put a higher premium on the development level, the quality of real estate development, and the improvement of housing conditions. Reform and policy adjustments should be carried out to effectively prevent real estate market risks and to achieve stable operations inside the real estate market itself.展开更多
China was formed by amalgamation of several small continental blocks （cratons）, micro, blocks and orogenic belts in different paleoclimatic settings. It may be correlated with other continental blocks but has its ow...China was formed by amalgamation of several small continental blocks （cratons）, micro, blocks and orogenic belts in different paleoclimatic settings. It may be correlated with other continental blocks but has its own specific characteristics; therefore the tectonic environments of China＇s marine and continental saline basins and salt, and potash, forming environment have some specific characteristics： multiple phases of salt formation, difference in salt, forming ages, migration and concentration of salt, forming processes and diversity of component materials, as well as small sizes of marine saline basins and great changes of saline basins in the late stage and occurrence of abundant liquid mineral resources. The nature of the tectonic basement exerted a key controlling effect on the formation of potash basins. The stable tectonic region was favorable for potash concentration in a quasi, stable region, and quasi, and the quasi-stable region was favorable for salt concentration and potash formation in a local stable tectonic region. Most China＇s major ancient saline basins occur in ＂quasi, cratons （continental block）＂; especially all the marine saline basins occur in continental blocks with the Precambrian basement. These regions are the key ones for potash search. Most relatively large, scale soluble salt deposits are developed in relatively stable continental nuclei. According to the characteristics of the tectonic domains where China＇s salt, forming basins are located, the North China, Yangtze and Tarim, Qaidam salt minerogenetic domains and the northern Qiangtang, western Yunnan salt minerogenetic belt may be distinguished. Their salt and potash prospects will be discussed separately.展开更多
Background: Galliformes are widely distributed throughout the world and economically important to humans as domesticated animals or gamebirds. They are at a unique position for advancing knowledge and techniques of wi...Background: Galliformes are widely distributed throughout the world and economically important to humans as domesticated animals or gamebirds. They are at a unique position for advancing knowledge and techniques of wildlife conservation as the barometer of the status of applied ecology. Populations of many galliform species have declined mainly due to habitat loss and over-hunting. An assessment of knowledge of Galliformes could help to provide guidelines for future research and conservation strategies.Methods: Using the Web of Science search engine, we conducted a literature review of galliform-related articles published from 1990 to 2016. We used the "research area" option to filter articles focused on the zoology, environmental sciences ecology, biodiversity conservation, forestry, behavioral sciences, reproductive biology, biochemistry and molecular biology, cell biology, genetics and heredity, evolutionary biology, physiology and developmental biology. We then checked duplication based on the title, abstract and full text. In addition, we examined the reference lists of selected studies to include the publications that were missed by above searching.Results: We retained 1874 articles related to the Galliformes from the initial 243,128 publications that were found. About 91.4% focused on one or two species, and 85.0% were conducted within a short duration, typically 1–2 years. The majority of the articles concentrated on macroscopic ecology(55.5%), mainly focusing on habitat selection or habitat use. With recent advances of molecular biology, the studies of taxonomy and phylogenetics rose quickly in last two decades. The study of physiology and biochemistry was no longer limited to simple description but expanded to the mechanisms of phenotype and micro-evolutionary potential. An additional area receiving increasing attention is the conservation of Galliformes, with the assessment of the conservation status and conservation management effectiveness of Galliformes(e.g. species diversity and genetic diversity) becoming the focus.Conclusions: The studies on Galliformes have made great achievements since 1990, but there are still gaps, particularly in macroscopic ecology, molecular genetics, and conservation. There is an urgent need to enhance long-term monitoring and analysis of population dynamics, and applying different disciplines to galliform conservation. Moreover, life history information of many galliform species is still lacking, which has hindered conservation efforts and effectiveness. In addition, multidiscipline studies and new technologies are not common for galliform studies, and should be encouraged.展开更多
Coal Washing Exploration in India dates back to 1900s; though, first coking coal washeries in India were installed after independence. At present, most of the coking coal washeries are owned by Public Sector Companies...Coal Washing Exploration in India dates back to 1900s; though, first coking coal washeries in India were installed after independence. At present, most of the coking coal washeries are owned by Public Sector Companies; whereas, most of the non-coking coal washeries are owned by Private Sector. Even after six decades of coal washing practices, there has not been significant development in the coal washing intelligentsia. Indian Coal Washing industry is still dependent on imported equipment, which has been designed to treat coal that is significantly different from Indian coal of drift origin. In this paper, authors have ventured into evolution of Indian Coal Washing Industry （with a focus on coking coal washing sector）, its present condition and future prospect for growth. The paper emphasizes need for developing indigenous solutions to industrial challenges and highlights importance of increased coordination among academia-research institutions and coal industry.展开更多
Monascus sp. has been widely applied for a long time in China. In recent years, the effective physiological active substances produced by Monascus sp. have been extensively investigated. The classification, cultivatio...Monascus sp. has been widely applied for a long time in China. In recent years, the effective physiological active substances produced by Monascus sp. have been extensively investigated. The classification, cultivation characteristics, physiological and biochemical properties, primary metabolites, secondary metabolites and application prospects of Monascus sp. were summarized and discussed in this paper.展开更多
Multiple sets of organic-rich shales developed in the Upper Paleozoic of the northwestern Guizhong Depression in South China. However, the exploration of these shales is presently at a relatively immature stage. The U...Multiple sets of organic-rich shales developed in the Upper Paleozoic of the northwestern Guizhong Depression in South China. However, the exploration of these shales is presently at a relatively immature stage. The Upper Paleozoic shales in the northwestern Guizhong Depression, including the Middle Devonian Luofu shale, the Nabiao shale, and the Lower Carboniferous Yanguan shale, were investigated in this study. Mineral composition analysis, organic matter analysis(including total organic carbon(TOC) content, maceral of kerogen and the vitrinite reflection(Ro)), pore characteristic analysis(including porosity and permeability, pore type identification by SEM, and pore size distribution by nitrogen sorption), methane isothermal sorption test were conducted, and the distribution and thickness of the shales were determined, Then the characteristics of the two target shales were illustrated and compared. The results show that the Upper Paleozoic shales have favorable organic matter conditions(mainly moderate to high TOC content, type Ⅰ and Ⅱ_1 kerogen and high to over maturity), good fracability potential(brittleness index(BI) > 40%), multiple pore types, stable distribution and effective thickness, and good methane sorption capacity. Therefore, the Upper Paleozoic shales in the northern Guizhong Depression have good shale gas potential and exploration prospects. Moreover, the average TOC content, average BI, thickness of the organic-rich shale(TOC > 2.0 wt%) and the shale gas resources of the Middle Devonian shales are better than those of the Lower Carboniferous shale. The Middle Devonian shales have better shale gas potential and exploration prospects than the Lower Carboniferous shales.展开更多
Since industrial revolution, the atmospheric CO2 concentration has kept a continuous increase by more than 2.2 ppm yr^-1, and approaches to almost 400 ppm at present （Jouzel 2012）. China has become the largest count...Since industrial revolution, the atmospheric CO2 concentration has kept a continuous increase by more than 2.2 ppm yr^-1, and approaches to almost 400 ppm at present （Jouzel 2012）. China has become the largest country of greenhouse gas emission （GHG）, and confronts with great challenge to mitigate GHG.展开更多
Longli 1 （ Chenopod/um qu/noa Willd） was the first new quinoa variety in China, which was bred by Pasture and Green Agriculture Institute of Gansu Academy of Agricultural Sciences through the methods of line breedin...Longli 1 （ Chenopod/um qu/noa Willd） was the first new quinoa variety in China, which was bred by Pasture and Green Agriculture Institute of Gansu Academy of Agricultural Sciences through the methods of line breeding, cultivation and domestication. In muhipeint regional test, the average yield of Longli 1 was 2 100. （30 kg/hm2, which was increased by 9.6% compared to Jingle qulnoa. Langli 1 was a mid-late mature quinoa variety. The plant was brcom-shape, with the plant height of 181.2 - 223.6 cm, the growth period of 128 - 140 d, and the branch number of 23 - 27. The seeds were round pill shaped, with 1 000-grain weight of 2.40 -3.46 g. The contents of crude protein, fat, proline and total phosphorus in seeds were 171.5 -187.8, 56.5 -59.3, 5.5 -6.9 and 4.5 -6.8 g/kg, re- spectively. I_ongli 1 presented resistance against downy mildew and leaf spot, with strong disease-resistant ability. In multipeint regional test and production test, Longli 1 displayed lodging resistance with strong regeneration ability. It also presented resistance to cold, drought, saline and alkaline, and barren, with wide adaptability. Longh 1 was suitable for planting in mountains, plain field and irrigation area with frost-free period greater than 120 d, rainfall more than 250 mm, and altitude 1 500 -3 000 m. The application prospects of quinoa were also put forward in the paper.展开更多
Objective Complex geological factors have been constraining the oil and gas exploration in the Paleozoic strata of the Qaidam Basin,although there are high-quality hydrocarbon source rocks.One of the most important re...Objective Complex geological factors have been constraining the oil and gas exploration in the Paleozoic strata of the Qaidam Basin,although there are high-quality hydrocarbon source rocks.One of the most important reasons may be reservoir densification due to the multiple stages of destructive cementation,which has hindered our understanding of the Paleozoic petroleum enrichment rules in the Qaidam basin.In recent years.展开更多
文摘Periprosthetic fracture of femur is a common and complex complication after joint replacement. With the increase of operation volume, its incidence is increasing year by year. The treatment of this fracture is affected by many factors, including fracture type, prosthesis stability, patient age and comorbidities, and individualized treatment strategy is needed. In recent years, the internal fixation technology and prosthetic revision technology have made significant progress in surgical treatment, such as locking steel plate, titanium cable and bridge combined internal fixation system and other new technologies have effectively improved the treatment effect. In addition, the application of new materials and 3D printing technology, as well as the optimization of multidisciplinary cooperation mode, also provide new ideas for the treatment of complex fractures. However, there are still some problems such as inaccurate diagnosis, difficult choice of treatment options and high incidence of postoperative complications. In the future, technological innovation, the introduction of artificial intelligence and big data, and the further development of personalized treatment will bring more possibilities to improve the prognosis and quality of life of patients. This study summarizes the relevant research results and prospects the future development direction, providing references for clinical practice and subsequent research.
基金supported by the National Natural Science Foundation of China(Grant No.:82341023)the Interdisciplinary Research Project of School of Stomatology,Wuhan University,China(Grant No.:XNJC202305)+1 种基金the Innovative Research Team of Highlevel Local Universities in Shanghai,China(Grant No.:SHSMUZLCX20212300)Planning Project of Innovation and Entrepreneurship Training of National Undergraduate of Wuhan University,China(Grant No.:202310486122).
文摘Drug resistance presents a significant challenge to achieving positive clinical outcomes in anti-tumor therapy.Prior research has illuminated reasons behind drug resistance,including increased drug efflux,alterations in drug targets,and abnormal activation of oncogenic pathways.However,there's a need for deeper investigation into the impact of drug-resistant cells on parental tumor cells and intricate crosstalk between tumor cells and the malignant tumor microenvironment(TME).Recent studies on extracellular vesicles(EVs)have provided valuable insights.EVs are membrane-bound particles secreted by all cells,mediating cell-to-cell communication.They contain functional cargoes like DNA,RNA,lipids,proteins,and metabolites from mother cells,delivered to other cells.Notably,EVs are increasingly recognized as regulators in the resistance to anti-cancer drugs.This review aims to summarize the mechanisms of EV-mediated anti-tumor drug resistance,covering therapeutic approaches like chemo-therapy,targeted therapy,immunotherapy and even radiotherapy.Detecting Ev-based biomarkers to predict drug resistance assists in bypassing anti-tumor drug resistance.Additionally,targeted inhibition of EV biogenesis and secretion emerges as a promising approach to counter drug resistance.We highlight the importance of conducting in-depth mechanistic research on EVs,their cargoes,and functional ap-proaches specifically focusing on EV subpopulations.These efforts will significantly advance the devel-opment of strategies to overcome drug resistance in anti-tumor therapy.
文摘Gastric cancer(GC)is a prevalent malignant tumor within the digestive system,with over 40%of new cases and deaths related to GC globally occurring in China.Despite advancements in treatment modalities,such as surgery supplemented by adjuvant radiotherapy or chemotherapeutic agents,the prognosis for GC remains poor.New targeted therapies and immunotherapies are currently under invest-igation,but no significant breakthroughs have been achieved.Studies have indicated that GC is a heterogeneous disease,encompassing multiple subtypes with distinct biological characteristics and roles.Consequently,personalized treatment based on clinical features,pathologic typing,and molecular typing is crucial for the diagnosis and management of precancerous lesions of gastric cancer(PLGC).Current research has categorized GC into four subtypes:Epstein-Barr virus-positive,microsatellite instability,genome stability,and chromosome instability(CIN).Technologies such as multi-omics analysis and gene sequencing are being employed to identify more suitable novel testing methods in these areas.Among these,ultrasensitive chromosomal aneuploidy detection(UCAD)can detect CIN at a genome-wide level in subjects using low-depth whole genome sequencing technology,in conjunction with bioinformatics analysis,to achieve qualitative and quantitative detection of chromosomal stability.This editorial reviews recent research advancements in UCAD technology for the diagnosis and management of PLGC.
基金supported by National Natural Science Foundation of China(Grant No.71872122).
文摘Traditional building energy-saving research focuses on technical energy-saving and energy system energy-saving,while neglecting the study of personnel's energy-consumption behavior during the building operation phase.In order to explore people's cognitive process of building energy-saving information,this paper focuses on the representativeness of the research on building energy-saving reminder information.The results are summarized,sorted out and analyzed.Based on relevant research at home and abroad,this paper reviews the conceptual connotation of building energy-saving reminder information,research methods and influencing factors on the recognition of building energy-saving reminder information.Finally,it summarizes the research landscape of the cognitive process of building energy-saving reminder information and analyzes the existing research.In light of the shortcomings,three major research directions are proposed in the future:integrating research scenarios and focusing on the interaction of multiple scenarios in the Chinese cultural environment;broadening research methods to explore the diversity and feasibility of emerging research methods;increasing the time span and improving experimental design dynamic and continuous.
基金supported by National High-level Innovative Talents Scientific Research Project in Hebei Province,China(Grant No.405492).
文摘Deep learning,a pivotal technology within artificial intelligence,has made significant strides across various domains,including geoengineering.This paper explores the practical applications and challenges of integrating deep learning techniques,such as Fully Connected Neural Networks(FCNNs)and Convolutional Neural Networks(CNNs),into geoengineering tasks,particularly in disaster prediction,resource exploration,and infrastructure health monitoring.The complexities of applying deep learning in geoengineering are multifaceted,involving mathematical,computational,and data processing challenges.However,the emergence of deep learning libraries,notably TensorFlow,has substantially lowered the technical barriers,enabling researchers and engineers to deploy these technologies more efficiently.Through case studies and practical examples,this paper demonstrates how TensorFlow can streamline the model development process,making deep learning more accessible to a broader audience in the field of geoengineering.The paper concludes with a discussion on the future prospects and potential advancements in the integration of deep learning within geoengineering,highlighting both the opportunities and the ongoing challenges.
文摘With the continuous growth of the global population and the acceleration of urbanization,traditional agriculture faces severe challenges,such as labor shortages,low efficiency in agricultural resource utilization,and uncertainties caused by climate change.Unmanned agricultural machinery,as an integral part of smart agriculture,utilizes automation and intelligent technologies to achieve precise control over the entire agricultural production process,improving production efficiency,reducing labor costs,minimizing environmental impacts,and enhancing sustainability.In recent years,with advancements in information technology,artificial intelligence,and the Internet of Things,unmanned agricultural machinery has made significant technological progress and has gradually entered the commercialization stage.This study aims to analyze the technological advancements and development trends of unmanned agricultural machinery and explore its application prospects in practical production.By investigating this emerging technology,the research not only provides a theoretical foundation for agricultural technological innovation but also offers practical references for policymakers,agricultural enterprises,and practitioners.Particularly in the critical period of global agricultural transformation,research on unmanned agricultural machinery holds significant economic,environmental,and social value.
文摘The Silk Road Economic Belt,as a major initiative for global economic cooperation in the 21st century,has evolved into a critical economic cooperation region linking the Eurasian continent and its neighboring countries since it was proposed by the Chinese President in 2013.This paper explores the economic cooperation modes among countries along the Silk Road Economic Belt,analyzing its cooperation mechanisms,current development status,and future prospects.By examining the diversity and complexity of economic cooperation in this region,the paper highlights both its potential and challenges,providing theoretical support for advancing regional collaboration and achieving shared prosperity.
基金Supported by the Key Research and Development Program of Sichuan Science and Technology Agency,No.2020YFS0043Natural Science Foundation of Sichuan Province of China,No.2023NSFSC1567+1 种基金Sichuan University Innovation Research Project,No.2023SCUH0033Innovation Team at the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University,No.2022-CXTD-05.
文摘Urine-derived stem cells(USCs)are derived from urine and harbor the potential of proliferation and multidirectional differentiation.Moreover,USCs could be reprogrammed into pluripotent stem cells[namely urine-derived induced pluripotent stem cells(UiPSCs)]through transcription factors,such as octamer binding transcription factor 4,sex determining region Y-box 2,kruppel-like factor 4,myelocytomatosis oncogene,and Nanog homeobox and protein lin-28,in which the first four are known as Yamanaka factors.Mounting evidence supports that USCs and UiPSCs possess high potential of neurogenic,myogenic,and osteogenic differentiation,indicating that they may play a crucial role in the treatment of neurological and musculoskeletal diseases.Therefore,we summarized the origin and physiological characteristics of USCs and UiPSCs and their therapeutic application in neurological and musculoskeletal disorders in this review,which not only contributes to deepen our understanding of hallmarks of USCs and UiPSCs but also provides the theoretical basis for the treatment of neurological and musculoskeletal disorders with USCs and UiPSCs.
文摘Remarkable achievements have been made in China＇s agricultural development since the late 1970s. Nevertheless, deep-rooted problems are arising from inefficient farming practices. From mid- and long-term perspectives, migration of China＇s agricultural labor will slow and large-scale operation of farmland will accelerate. Although grain supply and demand have maintained a tight balance, new potentials still exist in improving grain production. Under the pressures of resource and environmental constraints, advancing the green and efficient transition of agriculture will become a new trend in China＇s agricultural development. In this context, the treatment of agricultural pollution, supply-side structural reform and innovation of agricultural subsidy policy are of strategic significance to the transition and upgrade of China＇s agriculture.
文摘Since its proposal in 1985,the Discontinuous Deformation Analysis(DDA)has developed into a powerful tool for simulating the mechanical behaviour of rock masses and other discontinuous systems and has been widely applied in the field of geotechnical engineering.This paper systematically reviews the theoretical development of DDA,including the basic framework for solving two-dimensional and three-dimensional problems,improvements in contact detection algorithms,coupling with other numerical methods,and high-performance computing.In addition,the application of DDA in engineering problems such as wave propagation,rock blasting,slope instability,underground structures,and hydraulic structures is discussed in detail,demonstrating its wide applicability in solving complex geological and engineering problems.In the future,DDA deeply integrated with artificial intelligence(AI)may enhance its performance in simulation accuracy,computational efficiency,and engineering applications.Automated modelling,non-parametric simulation,and physical-numerical fusion in AI-based DDA may become new research directions.
文摘The study aims to identify Albian-age oil prospects in Block A of the San Pedro margin, Côte d’Ivoire, by conducting a detailed geological interpretation. The objective is to confirm the presence of oil reservoirs trapped by favorable geological structures, identifiable through geophysical and seismic methods. The methodological approach is based on a combined analysis of studies and seismic data. Drilling data from well PA, including well logs and end-of-well reports, were used to characterize the lithological formations encountered, particularly those of the Albian. 3D seismic profiles were interpreted to identify structures conducive to hydrocarbon accumulation. Isochrone, isovelocity, and isobath maps were developed to refine the interpretation. Sedimentological analyses revealed five sandy/gritty levels between 2610 m and 3100 m, interspersed with clay, limestone, and siltstone beds. The seismic profiles highlighted two main prospects. These prospects exhibit favorable geological structures, including normal faults and structural traps that provide oil traps.
文摘Great changes have taken place in China＇s real estate market during the 12th Five-year Plan period. The real estate market has shifted from being undersupplied to having an equilibrium of supply and demand with regional oversupply. Real estate risks in some cities have begun to emerge, but overall real estate risks remain controllable. Given the major changes taking place in the supply and demand of China＇s real estate market and the current stage of its development, it is projected that China＇s real estate investment growth will continue to slow down during the 13th Five-year Plan period and pressures on the renovation of inventory housing will intensify. According to the changes in the development of China＇s current real estate market, the objectives of real estate development will be adjusted to put a higher premium on the development level, the quality of real estate development, and the improvement of housing conditions. Reform and policy adjustments should be carried out to effectively prevent real estate market risks and to achieve stable operations inside the real estate market itself.
基金supported by projects of China Geological Survey(grants 1212010918025 and 1212010011810)National Natural Science Foundation of China and joint foundation(grants 40531002 and U0833601)
文摘China was formed by amalgamation of several small continental blocks （cratons）, micro, blocks and orogenic belts in different paleoclimatic settings. It may be correlated with other continental blocks but has its own specific characteristics; therefore the tectonic environments of China＇s marine and continental saline basins and salt, and potash, forming environment have some specific characteristics： multiple phases of salt formation, difference in salt, forming ages, migration and concentration of salt, forming processes and diversity of component materials, as well as small sizes of marine saline basins and great changes of saline basins in the late stage and occurrence of abundant liquid mineral resources. The nature of the tectonic basement exerted a key controlling effect on the formation of potash basins. The stable tectonic region was favorable for potash concentration in a quasi, stable region, and quasi, and the quasi-stable region was favorable for salt concentration and potash formation in a local stable tectonic region. Most China＇s major ancient saline basins occur in ＂quasi, cratons （continental block）＂; especially all the marine saline basins occur in continental blocks with the Precambrian basement. These regions are the key ones for potash search. Most relatively large, scale soluble salt deposits are developed in relatively stable continental nuclei. According to the characteristics of the tectonic domains where China＇s salt, forming basins are located, the North China, Yangtze and Tarim, Qaidam salt minerogenetic domains and the northern Qiangtang, western Yunnan salt minerogenetic belt may be distinguished. Their salt and potash prospects will be discussed separately.
基金supported by the funded by the National Key Programme of Research and 422 Development,Ministry of Science and Technology(2016YFC0503200)
文摘Background: Galliformes are widely distributed throughout the world and economically important to humans as domesticated animals or gamebirds. They are at a unique position for advancing knowledge and techniques of wildlife conservation as the barometer of the status of applied ecology. Populations of many galliform species have declined mainly due to habitat loss and over-hunting. An assessment of knowledge of Galliformes could help to provide guidelines for future research and conservation strategies.Methods: Using the Web of Science search engine, we conducted a literature review of galliform-related articles published from 1990 to 2016. We used the "research area" option to filter articles focused on the zoology, environmental sciences ecology, biodiversity conservation, forestry, behavioral sciences, reproductive biology, biochemistry and molecular biology, cell biology, genetics and heredity, evolutionary biology, physiology and developmental biology. We then checked duplication based on the title, abstract and full text. In addition, we examined the reference lists of selected studies to include the publications that were missed by above searching.Results: We retained 1874 articles related to the Galliformes from the initial 243,128 publications that were found. About 91.4% focused on one or two species, and 85.0% were conducted within a short duration, typically 1–2 years. The majority of the articles concentrated on macroscopic ecology(55.5%), mainly focusing on habitat selection or habitat use. With recent advances of molecular biology, the studies of taxonomy and phylogenetics rose quickly in last two decades. The study of physiology and biochemistry was no longer limited to simple description but expanded to the mechanisms of phenotype and micro-evolutionary potential. An additional area receiving increasing attention is the conservation of Galliformes, with the assessment of the conservation status and conservation management effectiveness of Galliformes(e.g. species diversity and genetic diversity) becoming the focus.Conclusions: The studies on Galliformes have made great achievements since 1990, but there are still gaps, particularly in macroscopic ecology, molecular genetics, and conservation. There is an urgent need to enhance long-term monitoring and analysis of population dynamics, and applying different disciplines to galliform conservation. Moreover, life history information of many galliform species is still lacking, which has hindered conservation efforts and effectiveness. In addition, multidiscipline studies and new technologies are not common for galliform studies, and should be encouraged.
文摘Coal Washing Exploration in India dates back to 1900s; though, first coking coal washeries in India were installed after independence. At present, most of the coking coal washeries are owned by Public Sector Companies; whereas, most of the non-coking coal washeries are owned by Private Sector. Even after six decades of coal washing practices, there has not been significant development in the coal washing intelligentsia. Indian Coal Washing industry is still dependent on imported equipment, which has been designed to treat coal that is significantly different from Indian coal of drift origin. In this paper, authors have ventured into evolution of Indian Coal Washing Industry （with a focus on coking coal washing sector）, its present condition and future prospect for growth. The paper emphasizes need for developing indigenous solutions to industrial challenges and highlights importance of increased coordination among academia-research institutions and coal industry.
文摘Monascus sp. has been widely applied for a long time in China. In recent years, the effective physiological active substances produced by Monascus sp. have been extensively investigated. The classification, cultivation characteristics, physiological and biochemical properties, primary metabolites, secondary metabolites and application prospects of Monascus sp. were summarized and discussed in this paper.
基金the financial support of the National Science and Technology Major Project of 2011ZX05005-003-008HZthe Science and Technology Project of Zhejiang Geological Survey Bureau(No.201713)the National Natural Science Foundation of China(No.41572110)
文摘Multiple sets of organic-rich shales developed in the Upper Paleozoic of the northwestern Guizhong Depression in South China. However, the exploration of these shales is presently at a relatively immature stage. The Upper Paleozoic shales in the northwestern Guizhong Depression, including the Middle Devonian Luofu shale, the Nabiao shale, and the Lower Carboniferous Yanguan shale, were investigated in this study. Mineral composition analysis, organic matter analysis(including total organic carbon(TOC) content, maceral of kerogen and the vitrinite reflection(Ro)), pore characteristic analysis(including porosity and permeability, pore type identification by SEM, and pore size distribution by nitrogen sorption), methane isothermal sorption test were conducted, and the distribution and thickness of the shales were determined, Then the characteristics of the two target shales were illustrated and compared. The results show that the Upper Paleozoic shales have favorable organic matter conditions(mainly moderate to high TOC content, type Ⅰ and Ⅱ_1 kerogen and high to over maturity), good fracability potential(brittleness index(BI) > 40%), multiple pore types, stable distribution and effective thickness, and good methane sorption capacity. Therefore, the Upper Paleozoic shales in the northern Guizhong Depression have good shale gas potential and exploration prospects. Moreover, the average TOC content, average BI, thickness of the organic-rich shale(TOC > 2.0 wt%) and the shale gas resources of the Middle Devonian shales are better than those of the Lower Carboniferous shale. The Middle Devonian shales have better shale gas potential and exploration prospects than the Lower Carboniferous shales.
文摘Since industrial revolution, the atmospheric CO2 concentration has kept a continuous increase by more than 2.2 ppm yr^-1, and approaches to almost 400 ppm at present （Jouzel 2012）. China has become the largest country of greenhouse gas emission （GHG）, and confronts with great challenge to mitigate GHG.
基金Agricultural Science and Technology Innovation Project of Gansu Province"Key Technology for Introduction,Innovation and Cultivation of Quinoa"(GNCX-2013-48)Youth Fund Project of Gansu Academy of Agricultural Sciences"Effect of Agronomic Measures on Growth Characteristics and Production Performance of Quinoa"(2014GAAS34)
文摘Longli 1 （ Chenopod/um qu/noa Willd） was the first new quinoa variety in China, which was bred by Pasture and Green Agriculture Institute of Gansu Academy of Agricultural Sciences through the methods of line breeding, cultivation and domestication. In muhipeint regional test, the average yield of Longli 1 was 2 100. （30 kg/hm2, which was increased by 9.6% compared to Jingle qulnoa. Langli 1 was a mid-late mature quinoa variety. The plant was brcom-shape, with the plant height of 181.2 - 223.6 cm, the growth period of 128 - 140 d, and the branch number of 23 - 27. The seeds were round pill shaped, with 1 000-grain weight of 2.40 -3.46 g. The contents of crude protein, fat, proline and total phosphorus in seeds were 171.5 -187.8, 56.5 -59.3, 5.5 -6.9 and 4.5 -6.8 g/kg, re- spectively. I_ongli 1 presented resistance against downy mildew and leaf spot, with strong disease-resistant ability. In multipeint regional test and production test, Longli 1 displayed lodging resistance with strong regeneration ability. It also presented resistance to cold, drought, saline and alkaline, and barren, with wide adaptability. Longh 1 was suitable for planting in mountains, plain field and irrigation area with frost-free period greater than 120 d, rainfall more than 250 mm, and altitude 1 500 -3 000 m. The application prospects of quinoa were also put forward in the paper.
基金supported by the National Natural Science Fund(grants No.41272159 and 41572099)Geological Survey Project of China Geological Survey (grant No.1212011120964)
文摘Objective Complex geological factors have been constraining the oil and gas exploration in the Paleozoic strata of the Qaidam Basin,although there are high-quality hydrocarbon source rocks.One of the most important reasons may be reservoir densification due to the multiple stages of destructive cementation,which has hindered our understanding of the Paleozoic petroleum enrichment rules in the Qaidam basin.In recent years.
