Objective To investigate the relationship between the consumption of antibacterial agents and resistance rate of Klebsiela pneumoniae(KP)in the hospital respiratory unit for 3 consecutive years in 2005-2007.Methods Th...Objective To investigate the relationship between the consumption of antibacterial agents and resistance rate of Klebsiela pneumoniae(KP)in the hospital respiratory unit for 3 consecutive years in 2005-2007.Methods The total antibacterial consumption expressed as defined DDDs/100BD,as well as resistance rate of total KP and producing ESBLs KP were collected,and their correlation was analyzed.Results The rate of resistance of KP to cefoperazone/sulbactam,Cefepime,Imipenem,Moxifloxacin was significantly positively associated with the consumption of Cefotaxime,Ceftazidime,Moxifloxacin,Amikacin respectively;A significant positive association was observed between the rate of resistance of KP to Piperacillin/Tazobactam,Ceftriaxone and the consumption of Imipenem;The rate of resistance of KP to Piperacillin,Cefotaxime,Ciprofloxacin was significantly positively associated with the consumption of Levofloxacin.ESBLs producing bacilli of KP were detected in 44 of 75 isolates(58.7%),The rate of resistance of producing ESBLs KP to Piperacillin/Tazobactam,Ceftriaxone was significantly positively associated with the consumption of Imipenem,Ceftazidime;A significant positive association was observed between the rate of resistance of producing ESBLs KP to Piperacillin,Imipenem and the consumption of Moxifloxacin.There was no significant correlation in other drugs.Conclusions A relationship existed between antimicrobial consumption and rates of resistance of KP in the hospital respiratory unit.We must use antibiotics carefully and with reason to control and lessen the drug resistance of bacterial.展开更多
Density functional theory （DFT） was used to calculate molecular descriptors （properties） for 12 fluoro-quinolone with anti-S.pneumoniae activity. Principal component analysis （PCA） and hierarchical cluster analy...Density functional theory （DFT） was used to calculate molecular descriptors （properties） for 12 fluoro-quinolone with anti-S.pneumoniae activity. Principal component analysis （PCA） and hierarchical cluster analysis （HCA） were employed to reduce dimensionality and investigate in which variables should be more effective for classifying fluoroquinolones according to their degree of an-S.pneumoniae activity. The PCA results showed that the variables ELUMO, Q3, Q5, QA, logP, MR, VOL and △EHL of these compounds were responsible for the anti-S.pneumoniae activity. The HCA results were similar to those obtained with PCA.The methodologies of PCA and HCA provide a reliable rule for classifying new fluoroquinolones with antiS.pneumoniae activity. By using the chemometric results, 6 synthetic compounds were analyzed through the PCA and HCA and two of them are proposed as active molecules with anti-S.pneumoniae, which is consistent with the results of clinic experiments.展开更多
Background: The Air Force Health Study collected reproductive outcomes for live-born children of male Air Force veterans of the Vietnam War. Methods: Dioxin values for participants were obtained from blood samples. An...Background: The Air Force Health Study collected reproductive outcomes for live-born children of male Air Force veterans of the Vietnam War. Methods: Dioxin values for participants were obtained from blood samples. Analyses were conducted of occurrence of 16 specific categories of birth defects and developmental disabilities. Children were categorized as conceived before and after the start of participants’ Vietnam War service. Children conceived before the start of Vietnam War service were treated as being conceived when their fathers had unquantifiable dioxin values. Children conceived after the start of Vietnam War service for participants with missing dioxin values were excluded from primary analyses, but were used to assess the impact of their exclusion on conclusions. Correlation between values for specific categories for multiple children fathered by the same participant was accounted for. The dose-response relationship was treated as a step function increasing for dioxin values larger than adaptively identified individual thresholds changing with the specific category. Results: For 15 of 16 specific categories, the probability of occurrence increased substantially for a sufficiently high dioxin level above identified thresholds. Exclusion of children due to missing dioxin likely did not affect these results. Conclusions: Results supported the conclusion of substantial adverse effects on a wide variety of specific categories of birth defects and developmental disabilities due to sufficiently high exposures to dioxin, a toxic contaminant of Agent Orange used for herbicide spraying in the Vietnam War. Results may hold more generally, but might also have been affected by a variety of limitations.展开更多
Ecological capital operation is a major means for innovation of ecological environment protection,and provides ecological security for sustainable economic and social development.In this paper,key factors for construc...Ecological capital operation is a major means for innovation of ecological environment protection,and provides ecological security for sustainable economic and social development.In this paper,key factors for construction of incentive mechanism of ecological capital operation are explored from government cognition,enterprise attitude and public awareness.Via model building and parameter setting,incentive mechanism system of single objective is established effectively,to promote effective realization of regional ecological capital operation.展开更多
In order to solve principal-agent problems caused by interest inconformity and information asymmetry during information security outsourcing, it is necessary to design a reasonable incentive mechanism to promote clien...In order to solve principal-agent problems caused by interest inconformity and information asymmetry during information security outsourcing, it is necessary to design a reasonable incentive mechanism to promote client enterprises to complete outsourcing service actively. The incentive mechanism model of information security outsourcing is designed based on the principal-agent theory. Through analyzing the factors such as enterprise information assets value, invasion probability, information security environment, the agent cost coefficient and agency risk preference degree how to impact on the incentive mechanism, conclusions show that an enterprise information assets value and invasion probability have a positive influence on the fixed fee and the compensation coefficient; while information security environment, the agent cost coefficient and agency risk preference degree have a negative influence on the compensation coefficient. Therefore, the principal enterprises should reasonably design the fixed fee and the compensation coefficient to encourage information security outsourcing agency enterprises to the full extent.展开更多
α-Galactosylceramides, which can be recognized by natural killer T （NKT） cells, are now attracting more and more attention due to their therapeutic potential in cancer, infection and autoimmune diseases. Advances h...α-Galactosylceramides, which can be recognized by natural killer T （NKT） cells, are now attracting more and more attention due to their therapeutic potential in cancer, infection and autoimmune diseases. Advances have been achieved in discovering compounds with better activities and efforts have been made to understand the structure-activity relationships （SARs） of these NKT cell ligands. In this review, we discuss the structure modifications based on KRN7000, the principal glycolipid used in the study of NKT cell stimulation, and the SARs based on these modified structures.展开更多
A new set of descriptors, HSEHPCSV （component score vector of hydrophobic, steric, and electronic properties together with hydrogen bonding contributions）, were derived from principal component analyses of 95 physic...A new set of descriptors, HSEHPCSV （component score vector of hydrophobic, steric, and electronic properties together with hydrogen bonding contributions）, were derived from principal component analyses of 95 physicochemical variables of 20 natural amino acids separately according to different kinds of properties described, namely, hydrophobic, steric, and electronic properties as well as hydrogen bonding contributions. HSEHPCSV scales were then employed to express structures of angiotensin-converting enzyme inhibitors, bitter tasting thresholds and bactericidal 18 peptide, and to construct QSAR models based on partial least square （PLS）. The results obtained are as follows： the multiple correlation coefficient （R2cum） of 0.846, 0.917 and 0.993, leave-one-out cross validated Q2cm of 0.835, 0.865 and 0.899, and root-mean-square error for estimated error （RMSEE） of 0.396, 0.187and 0.22, respectively. Satisfactory results showed that, as new amino acid scales, data of HSEHPCSV may be a useful structural expression methodology＇for the studies on peptide QSAR （quantitative structure-activity relationship） due to many advantages such as plentiful structural information, definite physical and chemical meaning and easy interpretation.展开更多
10 quantum chemical descriptors of 21 aromatic compounds have been calculated by the semi-empirical quantum chemical method AM1. The Quantitative Structure-Biodegradability Relationships （QSBR） studies were performe...10 quantum chemical descriptors of 21 aromatic compounds have been calculated by the semi-empirical quantum chemical method AM1. The Quantitative Structure-Biodegradability Relationships （QSBR） studies were performed by the multiple linear regression （MLR）, principal component regression （PCR） and back propagation artificial neural network （BP-ANN）, respectively. The root mean square error （RMSE） of the training and validation sets of the BP-ANN model are 0.1363 and 0.0244, the mean absolute percentage errors （MAPE） are 0.1638 and 0.0326, the squared correlation coefficients （R^2） are 0.9853 and 0.9996, respectively. The results show that the BP-ANN model achieved a better prediction result than those of MLR and PCR. In addition, some insights into the structural factors affecting the aerobic biodegradation mechanism were discussed in detail.展开更多
The new Chinese rules on agency do not impose broad“fiduciary”duties on agents—instead,there are a number of specific provisions designed to protect the principal against particular abuses to which it is peculiarly...The new Chinese rules on agency do not impose broad“fiduciary”duties on agents—instead,there are a number of specific provisions designed to protect the principal against particular abuses to which it is peculiarly vulnerable in the principal/agent relationship.Chinese law,thus,deliberately refuses to follow the lead of English law,which imposes very strict and wide-ranging fiduciary duties on agents.This paper argues that this is probably wise.English law has to be seen against a matrix of a system of commercial law which was forged on the anvil of international trade and commodity supply contracts,leading to a set of rules that prefer certainty of outcomes(and the avoidance of litigation)overachieving particular justice in individual cases(such as might have been achieved by subjecting English law to an overarching“good faith”principle).English commercial law is adversarial,not cooperative.This explains why,in a relationship that is characterized by cooperation,such as the principal/agent relationship,the general rules of English commercial law are replaced by wide,justice-oriented rules.A system that is already based on cooperation,for which Chinese law is almost paradigmatic,is likely much more adept at applying the general rules to the agency relationship than English law would be.展开更多
INTRODUCTIONCrypt epithelial cells in normal small intestineproliferate at a high speed. But they are verydifficult to culture in vitro and passage stably. A lotof studies have been done[1-16]. Some domestic labsisola...INTRODUCTIONCrypt epithelial cells in normal small intestineproliferate at a high speed. But they are verydifficult to culture in vitro and passage stably. A lotof studies have been done[1-16]. Some domestic labsisolated and cultured crypt cells from embryonalintestines and aseptic animal intestine, but failed.We introduced normal rat epithelial cell line-IEC-6from the USA and its living condition for stablepassage was successfully established after trials. Thecell line was testified to be the small intestinalepithelial cell by electron microscopy,immunihistochemistry and enzymatic histoch-emistry. It has been applied to some relatedresearch work[17-21]. It was found that manyfactors were involved in the culture system. Ourpresent study focuses on the culture method and theinfluencing factors on IEC-6.展开更多
Optimizing the structure of agricultural insurance subsidies is of great significance to increasing the supply of agricultural insurance and strengthening the effects of agricultural insurance policies.This paper opti...Optimizing the structure of agricultural insurance subsidies is of great significance to increasing the supply of agricultural insurance and strengthening the effects of agricultural insurance policies.This paper optimized the structure of agricultural insurance subsidies.It decomposed insurance activities into three parts:underwriting,claim settlement,and agricultural services.Next,it incorporated adverse selection risks,moral hazards,agricultural production and operation risks,insurance company's behavioral decisions and its risk attitudes into the multi-task principal agent analysis framework.Finally,it discussed how the government designs a subsidy mechanism and adjusts the subsidy structure to increase the insurance supply.展开更多
This paper takes Principal-agent Theory as the basic analysis flame to analyze the modern corporate principal and agent in a state of the two sides in asymmetric information on the basis of self-interest maximization,...This paper takes Principal-agent Theory as the basic analysis flame to analyze the modern corporate principal and agent in a state of the two sides in asymmetric information on the basis of self-interest maximization, and the game strategy which revolves the information disclosure and hideaway to launch, and therefore can get the game way which causes the auditing institution. The equilibrium in game of the information disclosure causes the auditing institution, the expense and cost which the audit profession consumes is the company governs reduces the information not asymmetrical diligently center essential agency costs.展开更多
This paper deals with personal data use by firms in the e-business environment from the viewpoint of business administration and information ethics. Whereas the tremendous development of information and communication ...This paper deals with personal data use by firms in the e-business environment from the viewpoint of business administration and information ethics. Whereas the tremendous development of information and communication technology (ICT) has made it easier for firms to acquire, store, share, and utilise personal data on their customers, firms that use personal data are exposed to risks related to privacy issues. Since individuals fear the invasion of their privacy, the failure of a firm to appear or remain trustworthy would make it difficult for it to maintain accurate, up-to-date databases and to construct desirable business processes, which would affect the bottom line. Therefore, modern firms should do what they can to ensure that their customers trust them. For them, one promising way to remain trustworthy is to behave as a moral agent. Although it is difficult for any firm to meet the conditions necessary to be a moral agent, competence in behaving as a moral agent is a hard-to-imitate capability af firms for which personal data use is vital for enjoying the benefits of business relationships in the e-business environment.展开更多
The optimization investment policy decision of SCM-Supply Chain Management-implementation has been analysed under symmetric and asymmetric information conditions. For both conditions, SCM implementation options’ deci...The optimization investment policy decision of SCM-Supply Chain Management-implementation has been analysed under symmetric and asymmetric information conditions. For both conditions, SCM implementation options’ decision optimizing models have been developed. In these models, both clients and vendors try to pursue their own benefits. Based upon the principal-agent theory, the models show to what extent a principal (a client) needs to pay more to an agent (a vendor) in a context of asymmetric information. For the client, it is important to understand the extra costs to be able to adopt effective strategies to stimulate a vendor to perform an optimal implementation of a SCM system. The results of a simulation experiment regarding SCM implementation options illustrate and verify the theoretical findings and confirm the general notion that the less informed party is obliged to pay information rent to the better-informed party.展开更多
With respect to different risk preference of an agent in a supply chain, linear-contract models are designed according to the principal-agent theory. The study shows that the risk preference of an agent directly corre...With respect to different risk preference of an agent in a supply chain, linear-contract models are designed according to the principal-agent theory. The study shows that the risk preference of an agent directly correlates with the incentive compensation coefficient of principal, order quantity of principal and production capability level of the agent. The principal should offer an appropriate incentive contract according to the risk preference of the agent, or choose an agent holding a different risk preference to establish the supply chain.展开更多
This paper points out that the principal and agent may have different prior probability to the uncertain state of the world, and the influence of the state to the agent′s effort cost should be considered in the analy...This paper points out that the principal and agent may have different prior probability to the uncertain state of the world, and the influence of the state to the agent′s effort cost should be considered in the analysis of a principal\|agent relationship. Taking this opinion into a simple principal\|agent model, we get some conclusion with new meaning.展开更多
文摘Objective To investigate the relationship between the consumption of antibacterial agents and resistance rate of Klebsiela pneumoniae(KP)in the hospital respiratory unit for 3 consecutive years in 2005-2007.Methods The total antibacterial consumption expressed as defined DDDs/100BD,as well as resistance rate of total KP and producing ESBLs KP were collected,and their correlation was analyzed.Results The rate of resistance of KP to cefoperazone/sulbactam,Cefepime,Imipenem,Moxifloxacin was significantly positively associated with the consumption of Cefotaxime,Ceftazidime,Moxifloxacin,Amikacin respectively;A significant positive association was observed between the rate of resistance of KP to Piperacillin/Tazobactam,Ceftriaxone and the consumption of Imipenem;The rate of resistance of KP to Piperacillin,Cefotaxime,Ciprofloxacin was significantly positively associated with the consumption of Levofloxacin.ESBLs producing bacilli of KP were detected in 44 of 75 isolates(58.7%),The rate of resistance of producing ESBLs KP to Piperacillin/Tazobactam,Ceftriaxone was significantly positively associated with the consumption of Imipenem,Ceftazidime;A significant positive association was observed between the rate of resistance of producing ESBLs KP to Piperacillin,Imipenem and the consumption of Moxifloxacin.There was no significant correlation in other drugs.Conclusions A relationship existed between antimicrobial consumption and rates of resistance of KP in the hospital respiratory unit.We must use antibiotics carefully and with reason to control and lessen the drug resistance of bacterial.
基金This work was supported by National Nature Science Foundation of China and China Academy of Engineering Physics （No. 10376021） Provincial National Science Foundation of He＇nan （No. 2004601107）.
文摘Density functional theory （DFT） was used to calculate molecular descriptors （properties） for 12 fluoro-quinolone with anti-S.pneumoniae activity. Principal component analysis （PCA） and hierarchical cluster analysis （HCA） were employed to reduce dimensionality and investigate in which variables should be more effective for classifying fluoroquinolones according to their degree of an-S.pneumoniae activity. The PCA results showed that the variables ELUMO, Q3, Q5, QA, logP, MR, VOL and △EHL of these compounds were responsible for the anti-S.pneumoniae activity. The HCA results were similar to those obtained with PCA.The methodologies of PCA and HCA provide a reliable rule for classifying new fluoroquinolones with antiS.pneumoniae activity. By using the chemometric results, 6 synthetic compounds were analyzed through the PCA and HCA and two of them are proposed as active molecules with anti-S.pneumoniae, which is consistent with the results of clinic experiments.
文摘Background: The Air Force Health Study collected reproductive outcomes for live-born children of male Air Force veterans of the Vietnam War. Methods: Dioxin values for participants were obtained from blood samples. Analyses were conducted of occurrence of 16 specific categories of birth defects and developmental disabilities. Children were categorized as conceived before and after the start of participants’ Vietnam War service. Children conceived before the start of Vietnam War service were treated as being conceived when their fathers had unquantifiable dioxin values. Children conceived after the start of Vietnam War service for participants with missing dioxin values were excluded from primary analyses, but were used to assess the impact of their exclusion on conclusions. Correlation between values for specific categories for multiple children fathered by the same participant was accounted for. The dose-response relationship was treated as a step function increasing for dioxin values larger than adaptively identified individual thresholds changing with the specific category. Results: For 15 of 16 specific categories, the probability of occurrence increased substantially for a sufficiently high dioxin level above identified thresholds. Exclusion of children due to missing dioxin likely did not affect these results. Conclusions: Results supported the conclusion of substantial adverse effects on a wide variety of specific categories of birth defects and developmental disabilities due to sufficiently high exposures to dioxin, a toxic contaminant of Agent Orange used for herbicide spraying in the Vietnam War. Results may hold more generally, but might also have been affected by a variety of limitations.
基金Supported by Humanities and Social Sciences Research Project of Ministry of Education(19YJA790053)Hunan Social Science Foundation Project(18YBA244)
文摘Ecological capital operation is a major means for innovation of ecological environment protection,and provides ecological security for sustainable economic and social development.In this paper,key factors for construction of incentive mechanism of ecological capital operation are explored from government cognition,enterprise attitude and public awareness.Via model building and parameter setting,incentive mechanism system of single objective is established effectively,to promote effective realization of regional ecological capital operation.
基金The National Natural Science Foundation of China(No.71071033)the Youth Foundation of Humanity and Social Scienceof Ministry of Education of China(No.11YJC630234)
文摘In order to solve principal-agent problems caused by interest inconformity and information asymmetry during information security outsourcing, it is necessary to design a reasonable incentive mechanism to promote client enterprises to complete outsourcing service actively. The incentive mechanism model of information security outsourcing is designed based on the principal-agent theory. Through analyzing the factors such as enterprise information assets value, invasion probability, information security environment, the agent cost coefficient and agency risk preference degree how to impact on the incentive mechanism, conclusions show that an enterprise information assets value and invasion probability have a positive influence on the fixed fee and the compensation coefficient; while information security environment, the agent cost coefficient and agency risk preference degree have a negative influence on the compensation coefficient. Therefore, the principal enterprises should reasonably design the fixed fee and the compensation coefficient to encourage information security outsourcing agency enterprises to the full extent.
基金National Natural Science Foundation of China (Grant No.90713010)"863"Program from the Ministry of Science and Technology of China (Grant No.2006AA09Z405).
文摘α-Galactosylceramides, which can be recognized by natural killer T （NKT） cells, are now attracting more and more attention due to their therapeutic potential in cancer, infection and autoimmune diseases. Advances have been achieved in discovering compounds with better activities and efforts have been made to understand the structure-activity relationships （SARs） of these NKT cell ligands. In this review, we discuss the structure modifications based on KRN7000, the principal glycolipid used in the study of NKT cell stimulation, and the SARs based on these modified structures.
基金Supported by the National High Technology Research and Development Program of China (863 Program, No. 2006AA02Z312)
文摘A new set of descriptors, HSEHPCSV （component score vector of hydrophobic, steric, and electronic properties together with hydrogen bonding contributions）, were derived from principal component analyses of 95 physicochemical variables of 20 natural amino acids separately according to different kinds of properties described, namely, hydrophobic, steric, and electronic properties as well as hydrogen bonding contributions. HSEHPCSV scales were then employed to express structures of angiotensin-converting enzyme inhibitors, bitter tasting thresholds and bactericidal 18 peptide, and to construct QSAR models based on partial least square （PLS）. The results obtained are as follows： the multiple correlation coefficient （R2cum） of 0.846, 0.917 and 0.993, leave-one-out cross validated Q2cm of 0.835, 0.865 and 0.899, and root-mean-square error for estimated error （RMSEE） of 0.396, 0.187and 0.22, respectively. Satisfactory results showed that, as new amino acid scales, data of HSEHPCSV may be a useful structural expression methodology＇for the studies on peptide QSAR （quantitative structure-activity relationship） due to many advantages such as plentiful structural information, definite physical and chemical meaning and easy interpretation.
基金supported by the Natural Science Foundation of Fujian Province (D0710019)the Natural Science Foundation of Overseas Chinese Affairs Office of the State Council (09QZR07)
文摘10 quantum chemical descriptors of 21 aromatic compounds have been calculated by the semi-empirical quantum chemical method AM1. The Quantitative Structure-Biodegradability Relationships （QSBR） studies were performed by the multiple linear regression （MLR）, principal component regression （PCR） and back propagation artificial neural network （BP-ANN）, respectively. The root mean square error （RMSE） of the training and validation sets of the BP-ANN model are 0.1363 and 0.0244, the mean absolute percentage errors （MAPE） are 0.1638 and 0.0326, the squared correlation coefficients （R^2） are 0.9853 and 0.9996, respectively. The results show that the BP-ANN model achieved a better prediction result than those of MLR and PCR. In addition, some insights into the structural factors affecting the aerobic biodegradation mechanism were discussed in detail.
文摘The new Chinese rules on agency do not impose broad“fiduciary”duties on agents—instead,there are a number of specific provisions designed to protect the principal against particular abuses to which it is peculiarly vulnerable in the principal/agent relationship.Chinese law,thus,deliberately refuses to follow the lead of English law,which imposes very strict and wide-ranging fiduciary duties on agents.This paper argues that this is probably wise.English law has to be seen against a matrix of a system of commercial law which was forged on the anvil of international trade and commodity supply contracts,leading to a set of rules that prefer certainty of outcomes(and the avoidance of litigation)overachieving particular justice in individual cases(such as might have been achieved by subjecting English law to an overarching“good faith”principle).English commercial law is adversarial,not cooperative.This explains why,in a relationship that is characterized by cooperation,such as the principal/agent relationship,the general rules of English commercial law are replaced by wide,justice-oriented rules.A system that is already based on cooperation,for which Chinese law is almost paradigmatic,is likely much more adept at applying the general rules to the agency relationship than English law would be.
基金Supported by the National Natural Science Foundation of China, No.39100119
文摘INTRODUCTIONCrypt epithelial cells in normal small intestineproliferate at a high speed. But they are verydifficult to culture in vitro and passage stably. A lotof studies have been done[1-16]. Some domestic labsisolated and cultured crypt cells from embryonalintestines and aseptic animal intestine, but failed.We introduced normal rat epithelial cell line-IEC-6from the USA and its living condition for stablepassage was successfully established after trials. Thecell line was testified to be the small intestinalepithelial cell by electron microscopy,immunihistochemistry and enzymatic histoch-emistry. It has been applied to some relatedresearch work[17-21]. It was found that manyfactors were involved in the culture system. Ourpresent study focuses on the culture method and theinfluencing factors on IEC-6.
基金Supported by Western Project of National Social Science Foundation of China:Research on Governance Mechanism Optimization and Risk Prevention and Control of Credit Cooperation of Farmers Cooperatives in China(16XJY021).
文摘Optimizing the structure of agricultural insurance subsidies is of great significance to increasing the supply of agricultural insurance and strengthening the effects of agricultural insurance policies.This paper optimized the structure of agricultural insurance subsidies.It decomposed insurance activities into three parts:underwriting,claim settlement,and agricultural services.Next,it incorporated adverse selection risks,moral hazards,agricultural production and operation risks,insurance company's behavioral decisions and its risk attitudes into the multi-task principal agent analysis framework.Finally,it discussed how the government designs a subsidy mechanism and adjusts the subsidy structure to increase the insurance supply.
文摘This paper takes Principal-agent Theory as the basic analysis flame to analyze the modern corporate principal and agent in a state of the two sides in asymmetric information on the basis of self-interest maximization, and the game strategy which revolves the information disclosure and hideaway to launch, and therefore can get the game way which causes the auditing institution. The equilibrium in game of the information disclosure causes the auditing institution, the expense and cost which the audit profession consumes is the company governs reduces the information not asymmetrical diligently center essential agency costs.
基金Supported by the MEXT Research Project "Global Business and IT Management: Global eSCM" at the Research Institute of Commerce, Meiji University.
文摘This paper deals with personal data use by firms in the e-business environment from the viewpoint of business administration and information ethics. Whereas the tremendous development of information and communication technology (ICT) has made it easier for firms to acquire, store, share, and utilise personal data on their customers, firms that use personal data are exposed to risks related to privacy issues. Since individuals fear the invasion of their privacy, the failure of a firm to appear or remain trustworthy would make it difficult for it to maintain accurate, up-to-date databases and to construct desirable business processes, which would affect the bottom line. Therefore, modern firms should do what they can to ensure that their customers trust them. For them, one promising way to remain trustworthy is to behave as a moral agent. Although it is difficult for any firm to meet the conditions necessary to be a moral agent, competence in behaving as a moral agent is a hard-to-imitate capability af firms for which personal data use is vital for enjoying the benefits of business relationships in the e-business environment.
文摘The optimization investment policy decision of SCM-Supply Chain Management-implementation has been analysed under symmetric and asymmetric information conditions. For both conditions, SCM implementation options’ decision optimizing models have been developed. In these models, both clients and vendors try to pursue their own benefits. Based upon the principal-agent theory, the models show to what extent a principal (a client) needs to pay more to an agent (a vendor) in a context of asymmetric information. For the client, it is important to understand the extra costs to be able to adopt effective strategies to stimulate a vendor to perform an optimal implementation of a SCM system. The results of a simulation experiment regarding SCM implementation options illustrate and verify the theoretical findings and confirm the general notion that the less informed party is obliged to pay information rent to the better-informed party.
基金The paper is supported by National Natural Science Foundation of China under Grant No60372085,60404011the Youth Foundation of Northwestern Polytechnical University
文摘With respect to different risk preference of an agent in a supply chain, linear-contract models are designed according to the principal-agent theory. The study shows that the risk preference of an agent directly correlates with the incentive compensation coefficient of principal, order quantity of principal and production capability level of the agent. The principal should offer an appropriate incentive contract according to the risk preference of the agent, or choose an agent holding a different risk preference to establish the supply chain.
文摘This paper points out that the principal and agent may have different prior probability to the uncertain state of the world, and the influence of the state to the agent′s effort cost should be considered in the analysis of a principal\|agent relationship. Taking this opinion into a simple principal\|agent model, we get some conclusion with new meaning.
