目的观察调神活血止痛针刺法与卡马西平治疗丘脑痛的作用特点。方法采用交叉试验设计,将11例确诊患者按最小不平衡指数法随机分为1组(先针刺治疗后西药治疗6例)和2组(先西药治疗后针刺治疗5例)。每种疗法疗程10天,两种方法间有10天洗脱...目的观察调神活血止痛针刺法与卡马西平治疗丘脑痛的作用特点。方法采用交叉试验设计,将11例确诊患者按最小不平衡指数法随机分为1组(先针刺治疗后西药治疗6例)和2组(先西药治疗后针刺治疗5例)。每种疗法疗程10天,两种方法间有10天洗脱期,总疗程30天。进行统计分析时,针刺组和西药组均为11例。分别应用视觉模拟评分法(VAS)和美国安德森肿瘤中心(Anderson Cancer Center)疼痛评估表(MD疼痛值)进行疗效评定,记录两组患者每天VAS和MD疼痛值,得到变化曲线。结果治疗后,两组患者VAS和MD疼痛值均较治疗前明显下降(P<0.05);在治疗期间,两组疼痛曲线均表现出下降的趋势,针刺组变化趋势是一个平缓而稳定的下降过程;西药组则显示先有较大幅度下降,在经过一个平台期后又出现了相对大幅度的下降,呈梯形样走势。结论累计效应可能是针刺主要的镇痛作用;西药可能更主要是通过迅速起效而发挥作用的。展开更多
Objective To explore the therapeutic efficacy and mechanism of acupuncture at Lieque （列缺 LU 7） in treatment of cervical vertigo （CV）. Methods Forty CV patients met the inclusion criteria were enrolled and treate...Objective To explore the therapeutic efficacy and mechanism of acupuncture at Lieque （列缺 LU 7） in treatment of cervical vertigo （CV）. Methods Forty CV patients met the inclusion criteria were enrolled and treated with acupuncture at bilateral LU 7 points, once daily with 10 times as a course. The changes of blood flow velocity in bilateral vertebral artery and basilar artery were observed through transcranial doppler sonography （TCD） before treatment, after deqi with acupuncture and after a course of treatment, respectively. The scores and therapeutic efficacy on clinical symptoms were assessed according to CV symptoms and the functional assessment scale as well as the Criteria-for Diagnosis and Curative Effect in TCM Syndromes before treatment and after a course of treatment. Results Before treatment, after deqi and after a course of treatment, the blood flow velocity of basilar artery （BA）, left vertebral artery （LVA） and right vertebral artery （RVA） in 22 patients with a decreased blood flow velocity were respectively 23.20±4.84 vs 26.30 ± 4.17 vs 29.20 ± 4.20 （mm/s, BA）, 21.65 ± 3.62 vs 24.20 ± 2.89 vs 26.40 ± 3.62 （mm/s, LVA） and 21.90±3.04 vs 24.25±3.01 vs 26.50_±3.95 （mm/s, RVA）, while in 18 patients with an increased blood flow velocity were respectively 39.94 ± 8.24 vs 35.17 ± 4.84 vs 32.06 ± 3.49 （mm/s, BA）, 41.83 ± 5.64 vs 37.28 ± 2.32 vs 35.61 ± 2.09 （mm/s, LVA） and 37.11 ± 9.83 vs 32.22 ± 6.13 vs 28.11 ± 4.12 （mm/s, RVA）. Except that the difference of blood flow velocity of RVA was not significant in patients with an increased blood flow velocity before treatment and after deqi （P 〉 0.05）, the Vm of all vessels in 40 patients was improved after deqi with acupuncture and a course of treatment （P〈0.01, P〈0.05）. According to CV symptoms and the functional assessment scale, before treatment and after a course of treatment, the scores were 15.68 ± 5.35 and 26.30 ± 3.76, respectively, indicating that after a course of treatment, the symptoms were significantly improved （P 〈 0.01）. According to the Criteria for Diagnosis and Curative E.f]ect in TCM Syndromes, after a course of treatment, the total effective rate was 100% （40/40） and the cured rate was 55.0% （22/40）. Conclusion Acupuncture at LU 7 not only improves the blood supply of vertebral-basilar artery in CV patients, but also has a significant curative effect on improving the clinical symptoms.展开更多
Objective To study the feasibility of the crossover trial design and the minimal imbalance index random distribution method in the clinical small-sample-size randomized controlled trial（RCT） research of thalamic pai...Objective To study the feasibility of the crossover trial design and the minimal imbalance index random distribution method in the clinical small-sample-size randomized controlled trial（RCT） research of thalamic pain treated with acupuncture under the guidance of evidence-based medicine（EBM）.Methods The crossover trial design was adopted.Eleven cases with the definite diagnosis were randomized into a program-I group（6 cases,treated with acupuncture before western medicine） and a program-II group（5 cases,treated with western medicine before acupuncture） according to the minimal imbalance index method.In the statistical analysis,the groups were named as an acupuncture group and a western medicine group separately,11 cases in each one.Acupuncture was applied to Xìmén（郄门 PC 4）,Yīnxì（阴郄 HT 6）,Xuèhǎi（血海 SP 10）,etc.In the control treatment,Carbamazepine was prescribed for oral administration.Either the duration of treatment or the wash-out period was 10 days.The visual analogue scale（VAS） was adopted for the efficacy assessment.Results The total effective was 100.0%（11/11） after treatment in either group.The remarkably effective rates were 63.6%（7/11） and 36.4%（4/11） in the acupuncture group and the western medicine group separately,without statistically significant difference in comparison.Conclusion The crossover trial design and the minimal imbalance index distribution method can accomplish RCT of the clinical acupuncture and moxibustion research with the small sample size involved.They can provide the high-quality evidences for clinical acupuncture research.Acupuncture therapy can achieve the same therapeutic effect as Carbamazepine,the common western medicine,and the efficacy of it is potentially superior to that of western medicine.展开更多
Objective： To observe the clinical efficacy of acupuncture-moxibustion therapy of ＂banking up original qi and consolidating the foundation＂ for prevention and treatment of seasonal allergic rhinitis.Methods： Sixty...Objective： To observe the clinical efficacy of acupuncture-moxibustion therapy of ＂banking up original qi and consolidating the foundation＂ for prevention and treatment of seasonal allergic rhinitis.Methods： Sixty included patients were divided into two groups according to the random number table method with 30 patients in each group. In acupuncture group, warming-needle moxibustion was carried out at Zúsānlǐ（足三里ST 36）, and cone moxibustion on Fùzǐ（附子Radix Aconiti Lateralis Praeparata） cake was conducted at Guānyuán（关元CV 4）, Qìhǎi（气海CV 6） and Dàzhuī（大椎GV 14）. The treatment was conducted in May or June（2 months before the onset of rhinitis in this area）. The treatment was carried out for once every other day and three times per week. Treatment for 24 times was considered as 1 course of treatment. No intervention treatment was conducted in control group. The score of rhinitis symptom, the visual analogue scale（VAS） score changes of total nasal symptom score（TNSS） and total non-nasal symptom score（TNNSS） of patients in 2015 and in 2016 were observed, and the clinical efficacy of the two groups was compared.Results：（1） The score of rhinitis symptom, the VAS score changes of TNSS and TNNSS in acupuncture group in 2016 declined when compared with the results in 2015, which were 4.57 ±0.82 vs 9.40 ± 1.89,13.37 ± 4.01 vs 30.80 ±4.77 and 15.93 ±6.30 vs 46.13 ± 9.79（P〈 0.001）, the results in acupuncture group after treatment were lower than that in control group at same time, which were 4.57 ±0.82 vs 7.53 ±2.06,13.37±4.01 vs 27.17±6.84,15.93±6.30 vs 35.53±11.69（all P〈0.001）. According to comparison, there was no obvious difference in the results in control group at the two time points, which were 8.60 ±2.39 vs7.53 ± 2.06, 29.63 ± 6.30 vs 27.17 ± 6.84 and 40.90 ±12.31 vs 35.53± 11.69（all P〉 0.05）.（2） The total effective rate was 96.7%（29/30） in acupuncture group and 10%（3/30） in control group, and the difference was statistically significant（P〈 0.001）.Conclusion： Acupuncture-moxibustion therapy of ＂banking up original qi and consolidating the foundation＂ was effective on prevention and treatment of seasonal allergic rhinitis.展开更多
文摘目的观察调神活血止痛针刺法与卡马西平治疗丘脑痛的作用特点。方法采用交叉试验设计,将11例确诊患者按最小不平衡指数法随机分为1组(先针刺治疗后西药治疗6例)和2组(先西药治疗后针刺治疗5例)。每种疗法疗程10天,两种方法间有10天洗脱期,总疗程30天。进行统计分析时,针刺组和西药组均为11例。分别应用视觉模拟评分法(VAS)和美国安德森肿瘤中心(Anderson Cancer Center)疼痛评估表(MD疼痛值)进行疗效评定,记录两组患者每天VAS和MD疼痛值,得到变化曲线。结果治疗后,两组患者VAS和MD疼痛值均较治疗前明显下降(P<0.05);在治疗期间,两组疼痛曲线均表现出下降的趋势,针刺组变化趋势是一个平缓而稳定的下降过程;西药组则显示先有较大幅度下降,在经过一个平台期后又出现了相对大幅度的下降,呈梯形样走势。结论累计效应可能是针刺主要的镇痛作用;西药可能更主要是通过迅速起效而发挥作用的。
文摘Objective To explore the therapeutic efficacy and mechanism of acupuncture at Lieque （列缺 LU 7） in treatment of cervical vertigo （CV）. Methods Forty CV patients met the inclusion criteria were enrolled and treated with acupuncture at bilateral LU 7 points, once daily with 10 times as a course. The changes of blood flow velocity in bilateral vertebral artery and basilar artery were observed through transcranial doppler sonography （TCD） before treatment, after deqi with acupuncture and after a course of treatment, respectively. The scores and therapeutic efficacy on clinical symptoms were assessed according to CV symptoms and the functional assessment scale as well as the Criteria-for Diagnosis and Curative Effect in TCM Syndromes before treatment and after a course of treatment. Results Before treatment, after deqi and after a course of treatment, the blood flow velocity of basilar artery （BA）, left vertebral artery （LVA） and right vertebral artery （RVA） in 22 patients with a decreased blood flow velocity were respectively 23.20±4.84 vs 26.30 ± 4.17 vs 29.20 ± 4.20 （mm/s, BA）, 21.65 ± 3.62 vs 24.20 ± 2.89 vs 26.40 ± 3.62 （mm/s, LVA） and 21.90±3.04 vs 24.25±3.01 vs 26.50_±3.95 （mm/s, RVA）, while in 18 patients with an increased blood flow velocity were respectively 39.94 ± 8.24 vs 35.17 ± 4.84 vs 32.06 ± 3.49 （mm/s, BA）, 41.83 ± 5.64 vs 37.28 ± 2.32 vs 35.61 ± 2.09 （mm/s, LVA） and 37.11 ± 9.83 vs 32.22 ± 6.13 vs 28.11 ± 4.12 （mm/s, RVA）. Except that the difference of blood flow velocity of RVA was not significant in patients with an increased blood flow velocity before treatment and after deqi （P 〉 0.05）, the Vm of all vessels in 40 patients was improved after deqi with acupuncture and a course of treatment （P〈0.01, P〈0.05）. According to CV symptoms and the functional assessment scale, before treatment and after a course of treatment, the scores were 15.68 ± 5.35 and 26.30 ± 3.76, respectively, indicating that after a course of treatment, the symptoms were significantly improved （P 〈 0.01）. According to the Criteria for Diagnosis and Curative E.f]ect in TCM Syndromes, after a course of treatment, the total effective rate was 100% （40/40） and the cured rate was 55.0% （22/40）. Conclusion Acupuncture at LU 7 not only improves the blood supply of vertebral-basilar artery in CV patients, but also has a significant curative effect on improving the clinical symptoms.
基金Supported by research project of "Innovation Engineering" of The First Affiliated Hospital of Tianjin University of TCM:Academy 0804
文摘Objective To study the feasibility of the crossover trial design and the minimal imbalance index random distribution method in the clinical small-sample-size randomized controlled trial（RCT） research of thalamic pain treated with acupuncture under the guidance of evidence-based medicine（EBM）.Methods The crossover trial design was adopted.Eleven cases with the definite diagnosis were randomized into a program-I group（6 cases,treated with acupuncture before western medicine） and a program-II group（5 cases,treated with western medicine before acupuncture） according to the minimal imbalance index method.In the statistical analysis,the groups were named as an acupuncture group and a western medicine group separately,11 cases in each one.Acupuncture was applied to Xìmén（郄门 PC 4）,Yīnxì（阴郄 HT 6）,Xuèhǎi（血海 SP 10）,etc.In the control treatment,Carbamazepine was prescribed for oral administration.Either the duration of treatment or the wash-out period was 10 days.The visual analogue scale（VAS） was adopted for the efficacy assessment.Results The total effective was 100.0%（11/11） after treatment in either group.The remarkably effective rates were 63.6%（7/11） and 36.4%（4/11） in the acupuncture group and the western medicine group separately,without statistically significant difference in comparison.Conclusion The crossover trial design and the minimal imbalance index distribution method can accomplish RCT of the clinical acupuncture and moxibustion research with the small sample size involved.They can provide the high-quality evidences for clinical acupuncture research.Acupuncture therapy can achieve the same therapeutic effect as Carbamazepine,the common western medicine,and the efficacy of it is potentially superior to that of western medicine.
基金Supported by Baotou Medical Science and Technology Project:Wsjj2015060~~
文摘Objective： To observe the clinical efficacy of acupuncture-moxibustion therapy of ＂banking up original qi and consolidating the foundation＂ for prevention and treatment of seasonal allergic rhinitis.Methods： Sixty included patients were divided into two groups according to the random number table method with 30 patients in each group. In acupuncture group, warming-needle moxibustion was carried out at Zúsānlǐ（足三里ST 36）, and cone moxibustion on Fùzǐ（附子Radix Aconiti Lateralis Praeparata） cake was conducted at Guānyuán（关元CV 4）, Qìhǎi（气海CV 6） and Dàzhuī（大椎GV 14）. The treatment was conducted in May or June（2 months before the onset of rhinitis in this area）. The treatment was carried out for once every other day and three times per week. Treatment for 24 times was considered as 1 course of treatment. No intervention treatment was conducted in control group. The score of rhinitis symptom, the visual analogue scale（VAS） score changes of total nasal symptom score（TNSS） and total non-nasal symptom score（TNNSS） of patients in 2015 and in 2016 were observed, and the clinical efficacy of the two groups was compared.Results：（1） The score of rhinitis symptom, the VAS score changes of TNSS and TNNSS in acupuncture group in 2016 declined when compared with the results in 2015, which were 4.57 ±0.82 vs 9.40 ± 1.89,13.37 ± 4.01 vs 30.80 ±4.77 and 15.93 ±6.30 vs 46.13 ± 9.79（P〈 0.001）, the results in acupuncture group after treatment were lower than that in control group at same time, which were 4.57 ±0.82 vs 7.53 ±2.06,13.37±4.01 vs 27.17±6.84,15.93±6.30 vs 35.53±11.69（all P〈0.001）. According to comparison, there was no obvious difference in the results in control group at the two time points, which were 8.60 ±2.39 vs7.53 ± 2.06, 29.63 ± 6.30 vs 27.17 ± 6.84 and 40.90 ±12.31 vs 35.53± 11.69（all P〉 0.05）.（2） The total effective rate was 96.7%（29/30） in acupuncture group and 10%（3/30） in control group, and the difference was statistically significant（P〈 0.001）.Conclusion： Acupuncture-moxibustion therapy of ＂banking up original qi and consolidating the foundation＂ was effective on prevention and treatment of seasonal allergic rhinitis.
