经自然腔道取标本手术(Natural Orifice Specimen Extraction Surgery, NOSES)避免了腹壁的辅助切口,有极佳的微创效果。与传统腹腔镜手术相比,NOSES在确保彻底切除肿瘤的同时也最大限度地保留了腹壁原有的功能,规避了与腹壁切口相关的...经自然腔道取标本手术(Natural Orifice Specimen Extraction Surgery, NOSES)避免了腹壁的辅助切口,有极佳的微创效果。与传统腹腔镜手术相比,NOSES在确保彻底切除肿瘤的同时也最大限度地保留了腹壁原有的功能,规避了与腹壁切口相关的并发症,具有术后恢复快、疼痛轻、美容效果好以及术后并发症少等优点。文章综合分析了近年来有关文献的研究成果与报道,深入探讨了经自然腔道取标本手术(NOSES)在结直肠癌领域的发展历程、主要分类、适应症与禁忌症、优点与争议等方面,旨在为临床应用提供参考。Natural Orifice Specimen Extraction Surgery (NOSES) eliminates the need for auxiliary abdominal wall incisions, offering exceptional minimally invasive outcomes. Compared to traditional laparoscopic surgery, NOSES ensures complete tumor removal while preserving the abdominal wall’s natural function to the greatest extent, thus sidestepping complications linked to abdominal wall incisions. It boasts advantages such as swift postoperative recovery, minimal pain, excellent cosmetic results, and fewer postoperative complications. This article thoroughly analyzes recent research findings and relevant literature reports, delving into the evolution, primary classifications, indications, contraindications, strengths, and controversies of NOSES in colorectal cancer. The aim is to offer a reference for clinical application.展开更多
胃癌是全球最常见的恶性肿瘤之一,也是导致癌症相关死亡的主要原因之一。血管生成是肿瘤生长和转移的关键过程,异常的血管生成在胃癌的发生和发展中起着重要作用。近年来,长链非编码RNA作为一类不编码蛋白质但具有重要功能的分子,在肿...胃癌是全球最常见的恶性肿瘤之一,也是导致癌症相关死亡的主要原因之一。血管生成是肿瘤生长和转移的关键过程,异常的血管生成在胃癌的发生和发展中起着重要作用。近年来,长链非编码RNA作为一类不编码蛋白质但具有重要功能的分子,在肿瘤血管生成中发挥了关键作用。长链非编码RNA通过调控血管内皮生长因子信号通路、血管生成拟态及内皮细胞的活性等途径,促进胃癌血管生成,推动肿瘤进展。本文主要综述了长链非编码RNA在胃癌血管生成中的研究进展,并探讨了其通过不同机制影响胃癌血管生成的分子机制。Gastric cancer is one of the most prevalent malignant tumors globally and a leading cause of cancer-related mortality. Angiogenesis plays a pivotal role in tumor growth and metastasis, with aberrant vascular formation being a key factor in the onset and progression of gastric cancer. In recent years, long non-coding RNAs (lncRNAs), which do not encode proteins but perform critical regulatory functions, have emerged as significant contributors to tumor angiogenesis. LncRNAs modulate angiogenesis in gastric cancer by regulating the Vascular Endothelial Growth Factor (VEGF) signaling pathway, vascular mimicry, and endothelial cell activity, thereby promoting tumor vascularization and progression. This review summarizes the research advances in lncRNAs in gastric cancer angiogenesis and explores the molecular mechanisms through which they influence gastric cancer through different mechanisms.展开更多
文摘经自然腔道取标本手术(Natural Orifice Specimen Extraction Surgery, NOSES)避免了腹壁的辅助切口,有极佳的微创效果。与传统腹腔镜手术相比,NOSES在确保彻底切除肿瘤的同时也最大限度地保留了腹壁原有的功能,规避了与腹壁切口相关的并发症,具有术后恢复快、疼痛轻、美容效果好以及术后并发症少等优点。文章综合分析了近年来有关文献的研究成果与报道,深入探讨了经自然腔道取标本手术(NOSES)在结直肠癌领域的发展历程、主要分类、适应症与禁忌症、优点与争议等方面,旨在为临床应用提供参考。Natural Orifice Specimen Extraction Surgery (NOSES) eliminates the need for auxiliary abdominal wall incisions, offering exceptional minimally invasive outcomes. Compared to traditional laparoscopic surgery, NOSES ensures complete tumor removal while preserving the abdominal wall’s natural function to the greatest extent, thus sidestepping complications linked to abdominal wall incisions. It boasts advantages such as swift postoperative recovery, minimal pain, excellent cosmetic results, and fewer postoperative complications. This article thoroughly analyzes recent research findings and relevant literature reports, delving into the evolution, primary classifications, indications, contraindications, strengths, and controversies of NOSES in colorectal cancer. The aim is to offer a reference for clinical application.
文摘胃癌是全球最常见的恶性肿瘤之一,也是导致癌症相关死亡的主要原因之一。血管生成是肿瘤生长和转移的关键过程,异常的血管生成在胃癌的发生和发展中起着重要作用。近年来,长链非编码RNA作为一类不编码蛋白质但具有重要功能的分子,在肿瘤血管生成中发挥了关键作用。长链非编码RNA通过调控血管内皮生长因子信号通路、血管生成拟态及内皮细胞的活性等途径,促进胃癌血管生成,推动肿瘤进展。本文主要综述了长链非编码RNA在胃癌血管生成中的研究进展,并探讨了其通过不同机制影响胃癌血管生成的分子机制。Gastric cancer is one of the most prevalent malignant tumors globally and a leading cause of cancer-related mortality. Angiogenesis plays a pivotal role in tumor growth and metastasis, with aberrant vascular formation being a key factor in the onset and progression of gastric cancer. In recent years, long non-coding RNAs (lncRNAs), which do not encode proteins but perform critical regulatory functions, have emerged as significant contributors to tumor angiogenesis. LncRNAs modulate angiogenesis in gastric cancer by regulating the Vascular Endothelial Growth Factor (VEGF) signaling pathway, vascular mimicry, and endothelial cell activity, thereby promoting tumor vascularization and progression. This review summarizes the research advances in lncRNAs in gastric cancer angiogenesis and explores the molecular mechanisms through which they influence gastric cancer through different mechanisms.
