肺纤维化(Pulmonary fibrosis, PF)是一种致死性高、几乎不可逆转的肺部疾病,目前发病机制不是十分明确,且治疗手段极其匮乏,因此寻找新的治疗策略成为当务之急。核因子E2相关因子2 (Nuclear factor erythroid 2-related factor 2, NRF2...肺纤维化(Pulmonary fibrosis, PF)是一种致死性高、几乎不可逆转的肺部疾病,目前发病机制不是十分明确,且治疗手段极其匮乏,因此寻找新的治疗策略成为当务之急。核因子E2相关因子2 (Nuclear factor erythroid 2-related factor 2, NRF2)是细胞内调节抗氧化应激、炎症反应及众多生理过程的关键转录因子,近年来的研究表明,众多药物可以通过作用于NRF2相关机制发挥抗PF的功效。本文就NRF2的结构与功能、参与PF的作用途径及相关治疗作一简要综述,以期深入发掘NRF2作为治疗PF靶点的潜力。Pulmonary fibrosis (PF), a pulmonary disorder characterized by high lethality and near-irreversibility, has an incompletely elucidated pathogenesis at present, and the available treatment modalities are severely limited. Consequently, the pursuit of novel therapeutic strategies has emerged as an urgent necessity. Nuclear factor erythroid 2-related factor 2 (NRF2), a pivotal transcription factor within cells, is responsible for modulating antioxidant stress, inflammatory responses, and a multitude of physiological processes. Recent investigations have demonstrated that numerous drugs can exert anti-PF effects by acting on NRF2-related mechanisms. This article presents a concise review of the structure and function of NRF2, its pathways involved in PF, and related treatments, with the aim of deeply exploring the potential of NRF2 as a therapeutic target for PF.展开更多
磷脂酰肌醇-3-激酶(PI3K)/蛋白激酶B (AKT)通路作为信号通路中的明星通路之一,在各个领域均发挥重要作用,如心血管疾病、肿瘤、内分泌系统疾病及其他全身系统疾病等。研究发现PI3K/AKT信号通路参与细胞的生长、代谢、凋亡及糖脂代谢等途...磷脂酰肌醇-3-激酶(PI3K)/蛋白激酶B (AKT)通路作为信号通路中的明星通路之一,在各个领域均发挥重要作用,如心血管疾病、肿瘤、内分泌系统疾病及其他全身系统疾病等。研究发现PI3K/AKT信号通路参与细胞的生长、代谢、凋亡及糖脂代谢等途径,有进一步研究表明PI3K/AKT信号通路是影响代谢性心血管疾病发病和进展的重要通路之一。深入探究PI3K/AKT信号通路在心肌病中的作用机制,对心肌病的预防、治疗及预后评估具有一定的临床价值。Phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) pathway, as one of the star signaling pathways, plays an important role in various fields, such as cardiovascular diseases, tumors, endocrine system diseases and other systemic diseases. Studies have found that PI3K/AKT signaling pathway is involved in cell growth, metabolism, apoptosis, glucose and lipid metabolism, and other pathways. Further studies have shown that PI3K/AKT signaling pathway is one of the important pathways affecting the pathogenesis and progression of metabolic cardiovascular diseases. Further exploration of the mechanism of PI3K/AKT signaling pathway in cardiomyopathy has certain clinical value for the prevention, treatment and prognosis evaluation of cardiomyopathy.展开更多
目的探讨右心室间隔部(RVS)起搏和右心室心尖部(RVA)起搏对患者急性期及慢性期血流动力学的影响。方法将80例3度或高度房室传导阻滞患者随机分为两组(各40例),RVS组行RVS起搏,RVA组行RVA起搏。观察两组患者术中情况,监测术中血流动力学...目的探讨右心室间隔部(RVS)起搏和右心室心尖部(RVA)起搏对患者急性期及慢性期血流动力学的影响。方法将80例3度或高度房室传导阻滞患者随机分为两组(各40例),RVS组行RVS起搏,RVA组行RVA起搏。观察两组患者术中情况,监测术中血流动力学变化,比较两组术后随访起搏器心室起搏率、心电图QRS波宽度、心脏功能有无差异。结果两组患者手术时间、X线曝光时间以及术中电压阈值、阻抗、感知水平比较,差异均无统计学意义(P>0.05)。两组患者术中急性期心搏出量、心指数、每搏量及平均肺动脉楔入压比较,差异均有统计学意义(P<0.05)。随访12个月时两组患者的左室射血分数、左室内径缩短分数、左房室瓣口E峰血流速度与左房室瓣口A峰血流速度的比值、QRS波宽度及6 m in步行距离比较,差异均有统计学意义(P<0.05)。结论 RVS起搏是安全、有效的,具有更好的急性期血流动力学效应,长期起搏时对心脏功能的影响也较少,是一种更理想的起搏方式。展开更多
文摘肺纤维化(Pulmonary fibrosis, PF)是一种致死性高、几乎不可逆转的肺部疾病,目前发病机制不是十分明确,且治疗手段极其匮乏,因此寻找新的治疗策略成为当务之急。核因子E2相关因子2 (Nuclear factor erythroid 2-related factor 2, NRF2)是细胞内调节抗氧化应激、炎症反应及众多生理过程的关键转录因子,近年来的研究表明,众多药物可以通过作用于NRF2相关机制发挥抗PF的功效。本文就NRF2的结构与功能、参与PF的作用途径及相关治疗作一简要综述,以期深入发掘NRF2作为治疗PF靶点的潜力。Pulmonary fibrosis (PF), a pulmonary disorder characterized by high lethality and near-irreversibility, has an incompletely elucidated pathogenesis at present, and the available treatment modalities are severely limited. Consequently, the pursuit of novel therapeutic strategies has emerged as an urgent necessity. Nuclear factor erythroid 2-related factor 2 (NRF2), a pivotal transcription factor within cells, is responsible for modulating antioxidant stress, inflammatory responses, and a multitude of physiological processes. Recent investigations have demonstrated that numerous drugs can exert anti-PF effects by acting on NRF2-related mechanisms. This article presents a concise review of the structure and function of NRF2, its pathways involved in PF, and related treatments, with the aim of deeply exploring the potential of NRF2 as a therapeutic target for PF.
文摘磷脂酰肌醇-3-激酶(PI3K)/蛋白激酶B (AKT)通路作为信号通路中的明星通路之一,在各个领域均发挥重要作用,如心血管疾病、肿瘤、内分泌系统疾病及其他全身系统疾病等。研究发现PI3K/AKT信号通路参与细胞的生长、代谢、凋亡及糖脂代谢等途径,有进一步研究表明PI3K/AKT信号通路是影响代谢性心血管疾病发病和进展的重要通路之一。深入探究PI3K/AKT信号通路在心肌病中的作用机制,对心肌病的预防、治疗及预后评估具有一定的临床价值。Phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) pathway, as one of the star signaling pathways, plays an important role in various fields, such as cardiovascular diseases, tumors, endocrine system diseases and other systemic diseases. Studies have found that PI3K/AKT signaling pathway is involved in cell growth, metabolism, apoptosis, glucose and lipid metabolism, and other pathways. Further studies have shown that PI3K/AKT signaling pathway is one of the important pathways affecting the pathogenesis and progression of metabolic cardiovascular diseases. Further exploration of the mechanism of PI3K/AKT signaling pathway in cardiomyopathy has certain clinical value for the prevention, treatment and prognosis evaluation of cardiomyopathy.
文摘目的探讨右心室间隔部(RVS)起搏和右心室心尖部(RVA)起搏对患者急性期及慢性期血流动力学的影响。方法将80例3度或高度房室传导阻滞患者随机分为两组(各40例),RVS组行RVS起搏,RVA组行RVA起搏。观察两组患者术中情况,监测术中血流动力学变化,比较两组术后随访起搏器心室起搏率、心电图QRS波宽度、心脏功能有无差异。结果两组患者手术时间、X线曝光时间以及术中电压阈值、阻抗、感知水平比较,差异均无统计学意义(P>0.05)。两组患者术中急性期心搏出量、心指数、每搏量及平均肺动脉楔入压比较,差异均有统计学意义(P<0.05)。随访12个月时两组患者的左室射血分数、左室内径缩短分数、左房室瓣口E峰血流速度与左房室瓣口A峰血流速度的比值、QRS波宽度及6 m in步行距离比较,差异均有统计学意义(P<0.05)。结论 RVS起搏是安全、有效的,具有更好的急性期血流动力学效应,长期起搏时对心脏功能的影响也较少,是一种更理想的起搏方式。
