脓毒症(Sepsis)是宿主对感染反应失调所致危及生命的器官功能障碍,具有高发病率和高死亡率,其进展为严重脓毒症或脓毒性休克时,患者预后通常较差。在脓毒症中,细胞因子通过参与全身炎症反应综合征(SIRS)和代偿性抗炎反应综合征(CARS)发...脓毒症(Sepsis)是宿主对感染反应失调所致危及生命的器官功能障碍,具有高发病率和高死亡率,其进展为严重脓毒症或脓毒性休克时,患者预后通常较差。在脓毒症中,细胞因子通过参与全身炎症反应综合征(SIRS)和代偿性抗炎反应综合征(CARS)发挥重要作用,同时在病情严重程度评估和预后预测中可能成为新型生物标志物。本文综述了细胞因子与脓毒症严重程度评估及预后预测的相关性研究,旨在为未来相关研究及临床转化提供科学依据。Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection, with a high incidence and mortality rate. When patients progress to severe sepsis or septic shock, the prognosis is usually poor. In sepsis, cytokines play an important role by participating in systemic inflammatory response syndrome (SIRS) and compensatory anti-inflammatory response syndrome (CARS), and may become novel biomarkers in severity assessment and prognosis prediction. This article reviewed the correlation between cytokines and sepsis severity assessment and prognosis prediction, aiming to provide scientific basis for future related research and clinical transformation.展开更多
文摘脓毒症(Sepsis)是宿主对感染反应失调所致危及生命的器官功能障碍,具有高发病率和高死亡率,其进展为严重脓毒症或脓毒性休克时,患者预后通常较差。在脓毒症中,细胞因子通过参与全身炎症反应综合征(SIRS)和代偿性抗炎反应综合征(CARS)发挥重要作用,同时在病情严重程度评估和预后预测中可能成为新型生物标志物。本文综述了细胞因子与脓毒症严重程度评估及预后预测的相关性研究,旨在为未来相关研究及临床转化提供科学依据。Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection, with a high incidence and mortality rate. When patients progress to severe sepsis or septic shock, the prognosis is usually poor. In sepsis, cytokines play an important role by participating in systemic inflammatory response syndrome (SIRS) and compensatory anti-inflammatory response syndrome (CARS), and may become novel biomarkers in severity assessment and prognosis prediction. This article reviewed the correlation between cytokines and sepsis severity assessment and prognosis prediction, aiming to provide scientific basis for future related research and clinical transformation.
