痛风性关节炎(GA)是人体内嘌呤代谢紊乱和(或)尿酸排泄异常引起的一组代谢性疾病。其发病原因多与饮食结构、蛋白质、糖、脂肪过多摄入有关。临床表现为关节红肿热痛,严重影响患者日常生活,因此对抗GA的药物等的研究较为迫切。西药治疗G...痛风性关节炎(GA)是人体内嘌呤代谢紊乱和(或)尿酸排泄异常引起的一组代谢性疾病。其发病原因多与饮食结构、蛋白质、糖、脂肪过多摄入有关。临床表现为关节红肿热痛,严重影响患者日常生活,因此对抗GA的药物等的研究较为迫切。西药治疗GA的药物如秋水仙碱等,虽能在短期内缓解疼痛,但是长期使用不良反应明显;与西药相比,中医药治疗GA疗效确切,安全性强,更易被患者接受。近年来,业界开展了大量研究探索中医药通过调控NOD样受体热蛋白结构域相关蛋白3 (NLRP3)信号通路治疗GA的作用机制。但目前尚缺乏关于中医药调控NLRP3通路进而治疗GA的全面系统的总结。本文简单阐述了NLRP3炎症信号通路与GA发生发展的关系和中医对痛风性关节炎的认识及诊疗经验,并总结了中药有效成分、中药复方及其制剂、中医外治干预NLRP3炎症小体治疗GA的最新研究报道,以期为GA发病机制及药物治疗的深入研究提供新思路,为临床上运用中医药防治GA提供依据。Gouty arthritis (GA) is a metabolic disorder of purine metabolism and/or abnormal uric acid excretion in the body. The etiology is related to excessive intake of diet, protein, sugar and fat. Clinical manifestations of joint redness, swelling, heat and pain, seriously affect the daily life of patients, so anti-GA drug research is more urgent. Western medicine for the treatment of GA, such as colchicine, can relieve pain in a short time, but the adverse reactions of long-term use are obvious. Compared with Western medicine, traditional Chinese medicine in treating GA is more effective, safer and more acceptable to patients. In recent years, many researches have been carried out to explore the mechanism of TCM treating GA by regulating the signal pathway of NOD receptor thermoprotein domain related protein 3 (NLRP3). However, there is still a lack of a comprehensive and systematic summary of TCM regulation of NLRP3 pathway to treat GA. In this paper, the relationship between NLRP3 inflammatory signaling pathway and the development of GA, the understanding of TCM and the experience of diagnosis and treatment of gouty arthritis were briefly discussed. And it summarized the latest research reports on the effective components of Chinese herbal medicine, Chinese herbal compound and its preparation, TCM external treatment intervention NLRP3 inflammatory body treatment of GA. It is expected to provide a new idea for the further study of pathogenesis and drug treatment of GA, and provide a basis for the prevention and treatment of GA with TCM.展开更多
类风湿性关节炎是临床常见的累及关节及周围软组织的一种慢性自身免疫性疾病,其发病与自身免疫反应密切相关,主要依附于辅助性T细胞(Th17)及调节性T细胞(Treg)失衡,机体免疫稳态失调所致,因此,调节Th17/Treg平衡逐渐成为临床防治RA的新...类风湿性关节炎是临床常见的累及关节及周围软组织的一种慢性自身免疫性疾病,其发病与自身免疫反应密切相关,主要依附于辅助性T细胞(Th17)及调节性T细胞(Treg)失衡,机体免疫稳态失调所致,因此,调节Th17/Treg平衡逐渐成为临床防治RA的新靶点。文章旨在探讨近五年来单味中药有效成分、中药复方及中医外治在恢复Th17/Treg细胞平衡的作用机制,总结其通过调节炎症因子生成、干预信号通路等发挥的治疗作用,以期为临床采用中医药作为RA替代疗法提供坚实的理论依据。Rheumatoid arthritis (RA) is a common chronic autoimmune disease affecting joints and surrounding soft tissues. Its pathogenesis is closely related to autoimmune response, mainly dependent on the imbalance of helper T cells (Th17) and regulatory T cells (Treg), and the imbalance of immune homeostasis. Therefore, regulating the Th17/Treg balance has gradually become a new target for the clinical prevention and treatment of RA. This article aims to explore the mechanism of single TCM active ingredients, TCM compound, and external treatment in restoring the balance of Th17/Treg cells in the past five years and summarize its therapeutic effects by regulating the production of inflammatory factors and interfering with signaling pathways, so as to provide a solid theoretical basis for clinical application of TCM as an alternative therapy for RA.展开更多
目的:为了研究和提高周围神经病理性疼痛(peripherally-induced Neuropathic Pain, pNP)的诊断和治疗,通过检索知网(CNKI)、万方(WF)、维普(VIP)、中国生物医学文献数据库(CBM)等数据库从2014年至2024年08月的针刺治疗周围神经病理性疼...目的:为了研究和提高周围神经病理性疼痛(peripherally-induced Neuropathic Pain, pNP)的诊断和治疗,通过检索知网(CNKI)、万方(WF)、维普(VIP)、中国生物医学文献数据库(CBM)等数据库从2014年至2024年08月的针刺治疗周围神经病理性疼痛的文献,建立各家运用针刺在周围神经病理性疼痛临床治疗中的高频选穴的数据库,运用数据挖掘技术探析选穴及配伍规律。结论:给出核心常用腧穴处方,并据病情辩证加减腧穴,为临床治疗周围神经病理性疼痛提供新思路。Objective: To study and improve the diagnosis and treatment of peripherally-induced neuropathic pain, by searching the literature on acupuncture treatment of peripheral neuropathic pain in China Knowledge Network (CNKI), WanFang, VIP, and China Biomedical Literature Database (CBM) databases from 2014 to August 2024, and establishing a database of high-frequency acupoints selected by each family using acupuncture in the clinical treatment of peripheral neuropathic pain, data mining techniques were used to analyse the rules of selecting and combining acupoints. Conclusion: The prescription of core commonly used acupoints and the addition and subtraction of acupoints according to the dialectic of the condition are given to provide new ideas for the clinical treatment of peripheral neuropathic pain.展开更多
产后缺乳是产后常见病之一,产妇分娩后泌乳量少、甚或无,无法满足婴幼儿的需求。目前西医治疗手段主要有使用胃动力药 + 维生素E、镇痛剂及催产素等,皆有一定疗效,但其副作用过多,中药治疗为大多数产妇所接受,然而其药物成分不确定性可...产后缺乳是产后常见病之一,产妇分娩后泌乳量少、甚或无,无法满足婴幼儿的需求。目前西医治疗手段主要有使用胃动力药 + 维生素E、镇痛剂及催产素等,皆有一定疗效,但其副作用过多,中药治疗为大多数产妇所接受,然而其药物成分不确定性可能会对乳汁的成分产生一定影响,因此,综合当前各种治疗方法,不断寻求最优治疗方案则显得尤为重要。本文通过分析近6年来针灸治疗产后缺乳的临床研究文献,总结针灸治疗该病的相关方法(子午流注针法、杵针、电针、穴位按摩、董氏奇穴、腹针、刮痧、麦粒灸等)和疗效,旨在为临床治疗提供参考。Postpartum hypogalactia is one of the common postpartum diseases, the amount of milk after childbirth is small, or even no, cannot meet the needs of infants and young children. At present, Western medicine mainly uses gastric motivity drugs + vitamin E, analgesics and oxytocin, all of which have certain efficacy, but there are too many side effects. Chinese medicine treatment is accepted by most parturients, but the uncertainty of its drug composition may have a certain impact on the composition of milk. Therefore, it is particularly important to integrate various current treatment methods and constantly seek the optimal treatment plan. Based on the analysis of clinical research literature on the treatment of postpartum lack of milk by acupuncture in the past 6 years, this paper summarizes the relevant methods of acupuncture and moxibustion for the treatment of this disease (meridian injection acupuncture, clubbing needle, electric acupuncture, acupressure, Dongshi Qi point, abdominal acupuncture, guasha, wheat moxibustion, etc.) and their effects, aiming to provide reference for clinical treatment.展开更多
椎动脉型颈椎病是颈椎病当中的一种常见类型,由于现代生活方式的改变,椎动脉型颈椎病的发病率较前升高,且容易反复发作。近年来,越来越多的研究证实针刺疗法在椎动脉型颈椎病中疗效确切。本文综述了近十年针刺疗法治疗椎动脉型颈椎病的...椎动脉型颈椎病是颈椎病当中的一种常见类型,由于现代生活方式的改变,椎动脉型颈椎病的发病率较前升高,且容易反复发作。近年来,越来越多的研究证实针刺疗法在椎动脉型颈椎病中疗效确切。本文综述了近十年针刺疗法治疗椎动脉型颈椎病的临床机制研究文献,发现针刺主要是通过改善颈部血流状态和血管内皮功能、降低血液粘滞性和降低炎性因子水平、恢复颈椎生理曲度等方面发挥治疗作用,进一步分析了目前该领域存在的不足,旨在为未来的针刺治疗椎动脉型颈椎病提供更多的研究方向和策略。Vertebrobasilar type of cervical spondylosis is a common type of cervical spondylosis, and its incidence has increased due to the change of modern lifestyle. Vertebrobasilar type of cervical spondylosis is prone to recurrence. In recent years, more and more studies have confirmed that acupuncture therapy has definite therapeutic effects in vertebrobasilar type of cervical spondylosis. This review summarizes the clinical mechanism research literature on acupuncture therapy for vertebrobasilar type of cervical spondylosis in the past ten years, and found that acupuncture mainly plays a therapeutic role by improving the blood flow state and endothelial function of the neck vessels, reducing blood viscosity, and lowering the level of inflammatory factors, and restoring the physiological curvature of the cervical spine. Furthermore, the current field's shortcomings are analyzed, aiming to provide more research directions and strategies for future acupuncture treatment of vertebrobasilar type of cervical spondylosis.展开更多
重度周围性面瘫(Severe Peripheral Facial Paralysis, SPFP)是临床上的治疗难题,分析面神经损伤平面和程度对该病病理特征的影响,并以此为依据探讨治疗策略,推荐采用House-Brackmann (H-B)分级面神经功能分级系统与同心圆针电极肌电图(...重度周围性面瘫(Severe Peripheral Facial Paralysis, SPFP)是临床上的治疗难题,分析面神经损伤平面和程度对该病病理特征的影响,并以此为依据探讨治疗策略,推荐采用House-Brackmann (H-B)分级面神经功能分级系统与同心圆针电极肌电图(electromyography, EMG)联合诊断,以提高诊断精确度。强调动态监测对适应病理变化的重要性,并及时调整治疗方案。急性期电针治疗,尤其是疏密波电针,对神经保护和功能恢复效果显著,对SPFP有着积极启示和探索意义。结合H-B分级和EMG监测,可优化电针治疗策略。针刺深度和角度是关键治疗变量,需进一步研究以制定个性化方案。研究应探索综合治疗和新技术,提升治疗精准度。本文旨在为SPFP的临床治疗提供科学依据和新思路。Severe Peripheral Facial Paralysis (SPFP) is a therapeutic challenge in clinical practice. Analyzing the impact of the plane and degree of facial nerve injury on the pathological characteristics of the disease and the basis for treatment strategies, it is recommended to use the House-Brackmann (H-B grading) facial nerve function grading system in conjunction with concentric needle electrode electromyography (EMG) for diagnosis to improve diagnostic accuracy. The importance of dynamic monitoring to adapt to pathological changes and the timely adjustment of treatment plans is emphasized. Electroacupuncture treatment during the acute phase, especially with sparse-dense wave electroacupuncture, has a significant effect on nerve protection and functional recovery, offering positive insights and exploratory significance for Severe Peripheral Facial Paralysis (SPFP). By combining H-B grading and EMG monitoring, the electroacupuncture treatment strategy can be optimized. The depth and angle of acupuncture need further research to develop personalized plans. Research should explore comprehensive treatments and new technologies to enhance the precision of treatment. This article aims to provide a scientific basis and new ideas for the clinical treatment of SPFP.展开更多
文摘痛风性关节炎(GA)是人体内嘌呤代谢紊乱和(或)尿酸排泄异常引起的一组代谢性疾病。其发病原因多与饮食结构、蛋白质、糖、脂肪过多摄入有关。临床表现为关节红肿热痛,严重影响患者日常生活,因此对抗GA的药物等的研究较为迫切。西药治疗GA的药物如秋水仙碱等,虽能在短期内缓解疼痛,但是长期使用不良反应明显;与西药相比,中医药治疗GA疗效确切,安全性强,更易被患者接受。近年来,业界开展了大量研究探索中医药通过调控NOD样受体热蛋白结构域相关蛋白3 (NLRP3)信号通路治疗GA的作用机制。但目前尚缺乏关于中医药调控NLRP3通路进而治疗GA的全面系统的总结。本文简单阐述了NLRP3炎症信号通路与GA发生发展的关系和中医对痛风性关节炎的认识及诊疗经验,并总结了中药有效成分、中药复方及其制剂、中医外治干预NLRP3炎症小体治疗GA的最新研究报道,以期为GA发病机制及药物治疗的深入研究提供新思路,为临床上运用中医药防治GA提供依据。Gouty arthritis (GA) is a metabolic disorder of purine metabolism and/or abnormal uric acid excretion in the body. The etiology is related to excessive intake of diet, protein, sugar and fat. Clinical manifestations of joint redness, swelling, heat and pain, seriously affect the daily life of patients, so anti-GA drug research is more urgent. Western medicine for the treatment of GA, such as colchicine, can relieve pain in a short time, but the adverse reactions of long-term use are obvious. Compared with Western medicine, traditional Chinese medicine in treating GA is more effective, safer and more acceptable to patients. In recent years, many researches have been carried out to explore the mechanism of TCM treating GA by regulating the signal pathway of NOD receptor thermoprotein domain related protein 3 (NLRP3). However, there is still a lack of a comprehensive and systematic summary of TCM regulation of NLRP3 pathway to treat GA. In this paper, the relationship between NLRP3 inflammatory signaling pathway and the development of GA, the understanding of TCM and the experience of diagnosis and treatment of gouty arthritis were briefly discussed. And it summarized the latest research reports on the effective components of Chinese herbal medicine, Chinese herbal compound and its preparation, TCM external treatment intervention NLRP3 inflammatory body treatment of GA. It is expected to provide a new idea for the further study of pathogenesis and drug treatment of GA, and provide a basis for the prevention and treatment of GA with TCM.
文摘类风湿性关节炎是临床常见的累及关节及周围软组织的一种慢性自身免疫性疾病,其发病与自身免疫反应密切相关,主要依附于辅助性T细胞(Th17)及调节性T细胞(Treg)失衡,机体免疫稳态失调所致,因此,调节Th17/Treg平衡逐渐成为临床防治RA的新靶点。文章旨在探讨近五年来单味中药有效成分、中药复方及中医外治在恢复Th17/Treg细胞平衡的作用机制,总结其通过调节炎症因子生成、干预信号通路等发挥的治疗作用,以期为临床采用中医药作为RA替代疗法提供坚实的理论依据。Rheumatoid arthritis (RA) is a common chronic autoimmune disease affecting joints and surrounding soft tissues. Its pathogenesis is closely related to autoimmune response, mainly dependent on the imbalance of helper T cells (Th17) and regulatory T cells (Treg), and the imbalance of immune homeostasis. Therefore, regulating the Th17/Treg balance has gradually become a new target for the clinical prevention and treatment of RA. This article aims to explore the mechanism of single TCM active ingredients, TCM compound, and external treatment in restoring the balance of Th17/Treg cells in the past five years and summarize its therapeutic effects by regulating the production of inflammatory factors and interfering with signaling pathways, so as to provide a solid theoretical basis for clinical application of TCM as an alternative therapy for RA.
文摘目的:为了研究和提高周围神经病理性疼痛(peripherally-induced Neuropathic Pain, pNP)的诊断和治疗,通过检索知网(CNKI)、万方(WF)、维普(VIP)、中国生物医学文献数据库(CBM)等数据库从2014年至2024年08月的针刺治疗周围神经病理性疼痛的文献,建立各家运用针刺在周围神经病理性疼痛临床治疗中的高频选穴的数据库,运用数据挖掘技术探析选穴及配伍规律。结论:给出核心常用腧穴处方,并据病情辩证加减腧穴,为临床治疗周围神经病理性疼痛提供新思路。Objective: To study and improve the diagnosis and treatment of peripherally-induced neuropathic pain, by searching the literature on acupuncture treatment of peripheral neuropathic pain in China Knowledge Network (CNKI), WanFang, VIP, and China Biomedical Literature Database (CBM) databases from 2014 to August 2024, and establishing a database of high-frequency acupoints selected by each family using acupuncture in the clinical treatment of peripheral neuropathic pain, data mining techniques were used to analyse the rules of selecting and combining acupoints. Conclusion: The prescription of core commonly used acupoints and the addition and subtraction of acupoints according to the dialectic of the condition are given to provide new ideas for the clinical treatment of peripheral neuropathic pain.
文摘产后缺乳是产后常见病之一,产妇分娩后泌乳量少、甚或无,无法满足婴幼儿的需求。目前西医治疗手段主要有使用胃动力药 + 维生素E、镇痛剂及催产素等,皆有一定疗效,但其副作用过多,中药治疗为大多数产妇所接受,然而其药物成分不确定性可能会对乳汁的成分产生一定影响,因此,综合当前各种治疗方法,不断寻求最优治疗方案则显得尤为重要。本文通过分析近6年来针灸治疗产后缺乳的临床研究文献,总结针灸治疗该病的相关方法(子午流注针法、杵针、电针、穴位按摩、董氏奇穴、腹针、刮痧、麦粒灸等)和疗效,旨在为临床治疗提供参考。Postpartum hypogalactia is one of the common postpartum diseases, the amount of milk after childbirth is small, or even no, cannot meet the needs of infants and young children. At present, Western medicine mainly uses gastric motivity drugs + vitamin E, analgesics and oxytocin, all of which have certain efficacy, but there are too many side effects. Chinese medicine treatment is accepted by most parturients, but the uncertainty of its drug composition may have a certain impact on the composition of milk. Therefore, it is particularly important to integrate various current treatment methods and constantly seek the optimal treatment plan. Based on the analysis of clinical research literature on the treatment of postpartum lack of milk by acupuncture in the past 6 years, this paper summarizes the relevant methods of acupuncture and moxibustion for the treatment of this disease (meridian injection acupuncture, clubbing needle, electric acupuncture, acupressure, Dongshi Qi point, abdominal acupuncture, guasha, wheat moxibustion, etc.) and their effects, aiming to provide reference for clinical treatment.
文摘椎动脉型颈椎病是颈椎病当中的一种常见类型,由于现代生活方式的改变,椎动脉型颈椎病的发病率较前升高,且容易反复发作。近年来,越来越多的研究证实针刺疗法在椎动脉型颈椎病中疗效确切。本文综述了近十年针刺疗法治疗椎动脉型颈椎病的临床机制研究文献,发现针刺主要是通过改善颈部血流状态和血管内皮功能、降低血液粘滞性和降低炎性因子水平、恢复颈椎生理曲度等方面发挥治疗作用,进一步分析了目前该领域存在的不足,旨在为未来的针刺治疗椎动脉型颈椎病提供更多的研究方向和策略。Vertebrobasilar type of cervical spondylosis is a common type of cervical spondylosis, and its incidence has increased due to the change of modern lifestyle. Vertebrobasilar type of cervical spondylosis is prone to recurrence. In recent years, more and more studies have confirmed that acupuncture therapy has definite therapeutic effects in vertebrobasilar type of cervical spondylosis. This review summarizes the clinical mechanism research literature on acupuncture therapy for vertebrobasilar type of cervical spondylosis in the past ten years, and found that acupuncture mainly plays a therapeutic role by improving the blood flow state and endothelial function of the neck vessels, reducing blood viscosity, and lowering the level of inflammatory factors, and restoring the physiological curvature of the cervical spine. Furthermore, the current field's shortcomings are analyzed, aiming to provide more research directions and strategies for future acupuncture treatment of vertebrobasilar type of cervical spondylosis.
文摘重度周围性面瘫(Severe Peripheral Facial Paralysis, SPFP)是临床上的治疗难题,分析面神经损伤平面和程度对该病病理特征的影响,并以此为依据探讨治疗策略,推荐采用House-Brackmann (H-B)分级面神经功能分级系统与同心圆针电极肌电图(electromyography, EMG)联合诊断,以提高诊断精确度。强调动态监测对适应病理变化的重要性,并及时调整治疗方案。急性期电针治疗,尤其是疏密波电针,对神经保护和功能恢复效果显著,对SPFP有着积极启示和探索意义。结合H-B分级和EMG监测,可优化电针治疗策略。针刺深度和角度是关键治疗变量,需进一步研究以制定个性化方案。研究应探索综合治疗和新技术,提升治疗精准度。本文旨在为SPFP的临床治疗提供科学依据和新思路。Severe Peripheral Facial Paralysis (SPFP) is a therapeutic challenge in clinical practice. Analyzing the impact of the plane and degree of facial nerve injury on the pathological characteristics of the disease and the basis for treatment strategies, it is recommended to use the House-Brackmann (H-B grading) facial nerve function grading system in conjunction with concentric needle electrode electromyography (EMG) for diagnosis to improve diagnostic accuracy. The importance of dynamic monitoring to adapt to pathological changes and the timely adjustment of treatment plans is emphasized. Electroacupuncture treatment during the acute phase, especially with sparse-dense wave electroacupuncture, has a significant effect on nerve protection and functional recovery, offering positive insights and exploratory significance for Severe Peripheral Facial Paralysis (SPFP). By combining H-B grading and EMG monitoring, the electroacupuncture treatment strategy can be optimized. The depth and angle of acupuncture need further research to develop personalized plans. Research should explore comprehensive treatments and new technologies to enhance the precision of treatment. This article aims to provide a scientific basis and new ideas for the clinical treatment of SPFP.
