本文综述了核因子-κB (NF-κB)信号通路在慢性阻塞性肺疾病(COPD)中的作用以及中医药调节NF-κB的相关基础及临床研究进展。中医药通过下调NF-κB信号通路水平来调节细胞因子的释放,减轻COPD气道、肺实质及肺血管的慢性炎症反应,缓解...本文综述了核因子-κB (NF-κB)信号通路在慢性阻塞性肺疾病(COPD)中的作用以及中医药调节NF-κB的相关基础及临床研究进展。中医药通过下调NF-κB信号通路水平来调节细胞因子的释放,减轻COPD气道、肺实质及肺血管的慢性炎症反应,缓解气道及血管平滑肌细胞的过度增殖,从而调控气道黏液的高分泌、延缓气道重塑,改善COPD患者的临床症状及肺功能。This article reviews the role of nuclear factor-κB (NF-κB) signaling pathway in chronic obstructive pulmonary disease(COPD) and the basic and clinical research progress of traditional Chinese medicine in regulating NF-κB. Traditional Chinese medicine regulates the release of cytokines by down-regulating the level of NF-κB signaling pathway, reduces the chronic inflammatory response of COPD airway, lung parenchyma and pulmonary vessels, and relieves the excessive proliferation of airway and vascular smooth muscle cells, thereby regulating airway mucus hypersecretion, delaying airway remodeling, and improving the clinical symptoms and lung function of COPD patients.展开更多
文摘本文综述了核因子-κB (NF-κB)信号通路在慢性阻塞性肺疾病(COPD)中的作用以及中医药调节NF-κB的相关基础及临床研究进展。中医药通过下调NF-κB信号通路水平来调节细胞因子的释放,减轻COPD气道、肺实质及肺血管的慢性炎症反应,缓解气道及血管平滑肌细胞的过度增殖,从而调控气道黏液的高分泌、延缓气道重塑,改善COPD患者的临床症状及肺功能。This article reviews the role of nuclear factor-κB (NF-κB) signaling pathway in chronic obstructive pulmonary disease(COPD) and the basic and clinical research progress of traditional Chinese medicine in regulating NF-κB. Traditional Chinese medicine regulates the release of cytokines by down-regulating the level of NF-κB signaling pathway, reduces the chronic inflammatory response of COPD airway, lung parenchyma and pulmonary vessels, and relieves the excessive proliferation of airway and vascular smooth muscle cells, thereby regulating airway mucus hypersecretion, delaying airway remodeling, and improving the clinical symptoms and lung function of COPD patients.
