目的:基于数据挖掘探讨刘松山教授治疗儿童再生障碍性贫血的用药规律。方法:收集2023年10月~2024年10月于成都中医药大学附属医院血液科门诊治疗的再生障碍性贫血患儿。使用古今医案云平台软件对药物的频次、药物属性、关联药物、聚类...目的:基于数据挖掘探讨刘松山教授治疗儿童再生障碍性贫血的用药规律。方法:收集2023年10月~2024年10月于成都中医药大学附属医院血液科门诊治疗的再生障碍性贫血患儿。使用古今医案云平台软件对药物的频次、药物属性、关联药物、聚类分析等进行分析。结果:150首处方共涉及129味中药,排名前10位的药物分别是黄芪、熟地黄、菟丝子、巴戟天、续断、白术、生地黄、赤芍、补骨脂、牡丹皮,药性以温、寒、平性最多,药味以甘、苦为主,归经以肝、肾、脾为主,重要药对为黄芪–熟地黄。聚类分析获得核心药物组合2组。结论:刘松山教授治疗儿童再生障碍性贫血以健脾补肾、益精填髓为主,先后天同治,兼清热、凉血、理气,着重恢复骨髓化生气血的生理功能。Objective: To explore the medication rules of Professor Liu Songshan in the treatment of aplastic anemia in children based on data mining. Methods: Children with aplastic anemia who were treated in the Department of Hematology, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine from October 2023 to October 2024 were collected. The ancient and modern medical case cloud platform software was used to analyze the frequency, drug properties, related drugs, and cluster analysis of drugs. Results: A total of 129 traditional Chinese medicines were involved in 150 prescriptions. The top 10 drugs were Astragalus, Rehmanniae Radix Praeparata, Cuscuta chinensis, Morinda officinalis, Dipsacus, Atractylodes macrocephala, Rehmanniae Radix Praeparata, Paeoniae Radix Rubra, Psoralea corylifolia and Cortex Moutan. The medicinal properties were mostly warm, cold and flat. The flavors were mainly sweet and bitter. The meridians were mainly liver, kidney and spleen. The important drug pair was Astragalus-Rehmanniae Radix Praeparata. Cluster analysis obtained two groups of core drug combinations. Conclusion: Professor Liu Songshan’s treatment of aplastic anemia in children is mainly based on invigorating spleen and kidney, benefiting essence and filling marrow. He has been treated with the same treatment, and has the functions of clearing heat, cooling blood and regulating qi, focusing on restoring the physiological function of bone marrow transforming into qi and blood.展开更多
白血病(acute leukemia, AL)是起源于骨髓造血干细胞的恶性克隆性疾病,急性髓系白血病(acute myelogenous leukemia, AML)是其中的一种,是目前最主要的急性白血病亚型。现阶段研究表明,在AML中,Wnt通路对维持LSCs功能尤为重要,山豆根中...白血病(acute leukemia, AL)是起源于骨髓造血干细胞的恶性克隆性疾病,急性髓系白血病(acute myelogenous leukemia, AML)是其中的一种,是目前最主要的急性白血病亚型。现阶段研究表明,在AML中,Wnt通路对维持LSCs功能尤为重要,山豆根中的生物碱类、黄酮类、苯并呋喃类、三萜类、多糖类等化合物具有良好的抗肿瘤活性,可通过多成分、多靶点、多途径抑制肿瘤细胞增殖、分化、迁移和诱导凋亡,对多种类型的恶性肿瘤均有较好的抗癌效果。本文阐述了山豆根治疗白血病及肿瘤通路研究进展及现状,为山豆根治疗血液肿瘤提供参考。Acute leukemia (AL) is a malignant clonal disease originating from bone marrow hematopoietic stem cells, and acute myeloid leukemia (AML) is one of them, currently the most common subtype of acute leukemia. At present, research has shown that the Wnt pathway is particularly important in maintaining the function of LSCs in AML. Alkaloids, flavonoids, benzofurans, triterpenoids, polysaccharides, and other compounds in Sophora alopecuroides root have good anti-tumor activity and can inhibit tumor cell proliferation, differentiation, migration, and induce apoptosis through multiple components, targets, and pathways. They have good anti-cancer effects on various types of malignant tumors. This article elaborates on the research progress and current status of Shandougen in the treatment of leukemia and tumor pathways, providing reference for Shandougen in the treatment of hematological tumors.展开更多
文摘目的:基于数据挖掘探讨刘松山教授治疗儿童再生障碍性贫血的用药规律。方法:收集2023年10月~2024年10月于成都中医药大学附属医院血液科门诊治疗的再生障碍性贫血患儿。使用古今医案云平台软件对药物的频次、药物属性、关联药物、聚类分析等进行分析。结果:150首处方共涉及129味中药,排名前10位的药物分别是黄芪、熟地黄、菟丝子、巴戟天、续断、白术、生地黄、赤芍、补骨脂、牡丹皮,药性以温、寒、平性最多,药味以甘、苦为主,归经以肝、肾、脾为主,重要药对为黄芪–熟地黄。聚类分析获得核心药物组合2组。结论:刘松山教授治疗儿童再生障碍性贫血以健脾补肾、益精填髓为主,先后天同治,兼清热、凉血、理气,着重恢复骨髓化生气血的生理功能。Objective: To explore the medication rules of Professor Liu Songshan in the treatment of aplastic anemia in children based on data mining. Methods: Children with aplastic anemia who were treated in the Department of Hematology, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine from October 2023 to October 2024 were collected. The ancient and modern medical case cloud platform software was used to analyze the frequency, drug properties, related drugs, and cluster analysis of drugs. Results: A total of 129 traditional Chinese medicines were involved in 150 prescriptions. The top 10 drugs were Astragalus, Rehmanniae Radix Praeparata, Cuscuta chinensis, Morinda officinalis, Dipsacus, Atractylodes macrocephala, Rehmanniae Radix Praeparata, Paeoniae Radix Rubra, Psoralea corylifolia and Cortex Moutan. The medicinal properties were mostly warm, cold and flat. The flavors were mainly sweet and bitter. The meridians were mainly liver, kidney and spleen. The important drug pair was Astragalus-Rehmanniae Radix Praeparata. Cluster analysis obtained two groups of core drug combinations. Conclusion: Professor Liu Songshan’s treatment of aplastic anemia in children is mainly based on invigorating spleen and kidney, benefiting essence and filling marrow. He has been treated with the same treatment, and has the functions of clearing heat, cooling blood and regulating qi, focusing on restoring the physiological function of bone marrow transforming into qi and blood.
文摘白血病(acute leukemia, AL)是起源于骨髓造血干细胞的恶性克隆性疾病,急性髓系白血病(acute myelogenous leukemia, AML)是其中的一种,是目前最主要的急性白血病亚型。现阶段研究表明,在AML中,Wnt通路对维持LSCs功能尤为重要,山豆根中的生物碱类、黄酮类、苯并呋喃类、三萜类、多糖类等化合物具有良好的抗肿瘤活性,可通过多成分、多靶点、多途径抑制肿瘤细胞增殖、分化、迁移和诱导凋亡,对多种类型的恶性肿瘤均有较好的抗癌效果。本文阐述了山豆根治疗白血病及肿瘤通路研究进展及现状,为山豆根治疗血液肿瘤提供参考。Acute leukemia (AL) is a malignant clonal disease originating from bone marrow hematopoietic stem cells, and acute myeloid leukemia (AML) is one of them, currently the most common subtype of acute leukemia. At present, research has shown that the Wnt pathway is particularly important in maintaining the function of LSCs in AML. Alkaloids, flavonoids, benzofurans, triterpenoids, polysaccharides, and other compounds in Sophora alopecuroides root have good anti-tumor activity and can inhibit tumor cell proliferation, differentiation, migration, and induce apoptosis through multiple components, targets, and pathways. They have good anti-cancer effects on various types of malignant tumors. This article elaborates on the research progress and current status of Shandougen in the treatment of leukemia and tumor pathways, providing reference for Shandougen in the treatment of hematological tumors.
