目的:观察和比较舒洛地特(SDX)联合缬沙坦(VAL)治疗Ⅲ期、Ⅳ期糖尿病肾病(DN)的临床效果及对患者肝肾功能、凝血功能的影响。方法:选取我院2014年6月~2016年6月收治的146例DN患者,按照随机数字表法均分为两组。对照组予VAL治疗,观察组...目的:观察和比较舒洛地特(SDX)联合缬沙坦(VAL)治疗Ⅲ期、Ⅳ期糖尿病肾病(DN)的临床效果及对患者肝肾功能、凝血功能的影响。方法:选取我院2014年6月~2016年6月收治的146例DN患者,按照随机数字表法均分为两组。对照组予VAL治疗,观察组在此基础上联合SDX治疗,记录比较两组临床疗效,治疗前后肝肾功能指标和凝血功能指标以及治疗期间不良反应的发生情况。结果:经3个月治疗后,观察组总有效率为95.9%,明显高于对照组的84.9%(P<0.05)。两组治疗前后血清γ-GT、ALT、BUN、Scr水平及APTT、PT值组内及组间比较差异均无统计学意义(P>0.05)。与治疗前相比,两组治疗后24h UAlb、尿α1-MG和血浆FIB水平均显著下降(P<0.01),且观察组治疗后24 h UAlb、尿α1-MG和血浆FIB水平降低程度均显著高于对照组同期(P<0.01)。观察组不良反应率为9.6%,较对照组(8.2%)相比差异无统计学意义(P>0.05)。结论:应用SDX联合VAL治疗Ⅲ、Ⅳ期糖尿病肾病患者更能显著提高其临床疗效,提高肾功能,且对患者肝功能及凝血功能均无显著影响。展开更多
Different acupuncture-moxibustion therapies can produce different clinical effects, that is, the effect has specificity, which is significantly important in obtaining acupuncture-moxibustion efficacy. In this study, t...Different acupuncture-moxibustion therapies can produce different clinical effects, that is, the effect has specificity, which is significantly important in obtaining acupuncture-moxibustion efficacy. In this study, the clinical application laws of fire needle, acupoint injection, catgut embedment, acupoint application, moxibustion therapy and filiform needle acupuncture were summarized in the aspects of category of disease, efficacy and related prescriptions （such as medication and acupoint selection） based on the result of data mining, and the general applicable categories of disease of acupuncture-moxibustion treatment methods were further screened, so as to guide the clinical application and give play to the best efficacy.展开更多
文摘目的:观察和比较舒洛地特(SDX)联合缬沙坦(VAL)治疗Ⅲ期、Ⅳ期糖尿病肾病(DN)的临床效果及对患者肝肾功能、凝血功能的影响。方法:选取我院2014年6月~2016年6月收治的146例DN患者,按照随机数字表法均分为两组。对照组予VAL治疗,观察组在此基础上联合SDX治疗,记录比较两组临床疗效,治疗前后肝肾功能指标和凝血功能指标以及治疗期间不良反应的发生情况。结果:经3个月治疗后,观察组总有效率为95.9%,明显高于对照组的84.9%(P<0.05)。两组治疗前后血清γ-GT、ALT、BUN、Scr水平及APTT、PT值组内及组间比较差异均无统计学意义(P>0.05)。与治疗前相比,两组治疗后24h UAlb、尿α1-MG和血浆FIB水平均显著下降(P<0.01),且观察组治疗后24 h UAlb、尿α1-MG和血浆FIB水平降低程度均显著高于对照组同期(P<0.01)。观察组不良反应率为9.6%,较对照组(8.2%)相比差异无统计学意义(P>0.05)。结论:应用SDX联合VAL治疗Ⅲ、Ⅳ期糖尿病肾病患者更能显著提高其临床疗效,提高肾功能,且对患者肝功能及凝血功能均无显著影响。
基金National Natural Science Foundation of China:81072883,81173342,81473773Scientific Research Project of Hebei Education Department:Z 2014145Planned Project of Young Talents in Colleges and Universities in Hebei Province:BJ 2014047
文摘Different acupuncture-moxibustion therapies can produce different clinical effects, that is, the effect has specificity, which is significantly important in obtaining acupuncture-moxibustion efficacy. In this study, the clinical application laws of fire needle, acupoint injection, catgut embedment, acupoint application, moxibustion therapy and filiform needle acupuncture were summarized in the aspects of category of disease, efficacy and related prescriptions （such as medication and acupoint selection） based on the result of data mining, and the general applicable categories of disease of acupuncture-moxibustion treatment methods were further screened, so as to guide the clinical application and give play to the best efficacy.
