系统性红斑狼疮(systemic lupus erythematosus, SLE)是一种慢性炎症性自身免疫性疾病,可影响多个器官,包括皮肤、关节、中枢神经系统和肾脏等,其发病因素包括环境、免疫和激素因素以及遗传易感性等。TLR/MyD88信号通路是调控先天免疫...系统性红斑狼疮(systemic lupus erythematosus, SLE)是一种慢性炎症性自身免疫性疾病,可影响多个器官,包括皮肤、关节、中枢神经系统和肾脏等,其发病因素包括环境、免疫和激素因素以及遗传易感性等。TLR/MyD88信号通路是调控先天免疫反应和相关的炎症反应的重要通路之一,参与SLE疾病的发生发展。本文总结了TLR/MyD88通路的构成、激活途径,重点介绍了该信号通路在SLE中在免疫细胞中的相关机制,并总结了近年来针对TLR和MyD88的拮抗剂及其潜在的临床应用。Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease that can affect multiple organs, including the skin, joints, central nervous system, and kidneys. The pathogenic factors include environmental, immune, and hormonal factors, as well as genetic susceptibility. The TLR/MyD88 signaling pathway is one of the important pathways that regulate innate immune responses and related inflammatory responses, and is involved in the occurrence and development of systemic lupus erythematosus (SLE). This article summarizes the composition and activation pathways of the TLR/MyD88 pathway, focusing on the relevant mechanisms of this signaling pathway in immune cells in SLE, and summarizes the antagonists against TLR and MyD88 in recent years and their potential clinical applications.展开更多
系统性红斑狼疮(SLE)是一种慢性、多系统、炎症性自身免疫性疾病,具有复杂的发病机制和遗传易感性。随着对这种疾病的不断了解,发现SLE与干扰素基因特征有关,尤其I型干扰素对先天免疫系统和适应性免疫系统都有影响,本文就I型干扰素在系...系统性红斑狼疮(SLE)是一种慢性、多系统、炎症性自身免疫性疾病,具有复杂的发病机制和遗传易感性。随着对这种疾病的不断了解,发现SLE与干扰素基因特征有关,尤其I型干扰素对先天免疫系统和适应性免疫系统都有影响,本文就I型干扰素在系统性红斑狼疮中的研究进展进行综述。Systemic lupus erythematosus (SLE) is a chronic, multisystem, inflammatory autoimmune disease with complex pathogenesis and genetic susceptibility. With the increasing understanding of this disease, it has been found that SLE is associated with interferon gene characterization, especially type I interferon, which has an effect on both the innate and adaptive immune systems, and this article provides a review of the progress of type I interferon research in SLE.展开更多
文摘系统性红斑狼疮(systemic lupus erythematosus, SLE)是一种慢性炎症性自身免疫性疾病,可影响多个器官,包括皮肤、关节、中枢神经系统和肾脏等,其发病因素包括环境、免疫和激素因素以及遗传易感性等。TLR/MyD88信号通路是调控先天免疫反应和相关的炎症反应的重要通路之一,参与SLE疾病的发生发展。本文总结了TLR/MyD88通路的构成、激活途径,重点介绍了该信号通路在SLE中在免疫细胞中的相关机制,并总结了近年来针对TLR和MyD88的拮抗剂及其潜在的临床应用。Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease that can affect multiple organs, including the skin, joints, central nervous system, and kidneys. The pathogenic factors include environmental, immune, and hormonal factors, as well as genetic susceptibility. The TLR/MyD88 signaling pathway is one of the important pathways that regulate innate immune responses and related inflammatory responses, and is involved in the occurrence and development of systemic lupus erythematosus (SLE). This article summarizes the composition and activation pathways of the TLR/MyD88 pathway, focusing on the relevant mechanisms of this signaling pathway in immune cells in SLE, and summarizes the antagonists against TLR and MyD88 in recent years and their potential clinical applications.
文摘系统性红斑狼疮(SLE)是一种慢性、多系统、炎症性自身免疫性疾病,具有复杂的发病机制和遗传易感性。随着对这种疾病的不断了解,发现SLE与干扰素基因特征有关,尤其I型干扰素对先天免疫系统和适应性免疫系统都有影响,本文就I型干扰素在系统性红斑狼疮中的研究进展进行综述。Systemic lupus erythematosus (SLE) is a chronic, multisystem, inflammatory autoimmune disease with complex pathogenesis and genetic susceptibility. With the increasing understanding of this disease, it has been found that SLE is associated with interferon gene characterization, especially type I interferon, which has an effect on both the innate and adaptive immune systems, and this article provides a review of the progress of type I interferon research in SLE.
