骨膜是包裹在骨皮质表面的一层薄而坚韧的结缔组织膜,由外层纤维层和内层生发层共两层组成。覆盖整个骨面达80%以上,为骨组织提供血液供应和初始干细胞,主要起固定、营养和保护的作用,大量研究证明骨膜具有显著的成骨潜能。因此,构建仿...骨膜是包裹在骨皮质表面的一层薄而坚韧的结缔组织膜,由外层纤维层和内层生发层共两层组成。覆盖整个骨面达80%以上,为骨组织提供血液供应和初始干细胞,主要起固定、营养和保护的作用,大量研究证明骨膜具有显著的成骨潜能。因此,构建仿生骨膜替代物修复骨缺损越来越受到研究者的重视。近年来人工骨膜材料也取得了重大进步,各种新型的人工骨膜材料也被证实在修复骨缺损方面确有其效。本文系统总结了人工骨膜现阶段的研究进展,为相关领域的研究人员提供了参考,有助于推动人工骨膜的临床转化。The periosteum is a thin and tough connective tissue membrane wrapped around the surface of the bone cortex, consisting of two layers: the outer fibrous layer and the inner germinal layer. It covers more than 80% of the entire bone surface, provides blood supply and initial stem cells for bone tissue, and mainly plays the role of fixation, nutrition and protection. A large number of studies have shown that the periosteum has significant osteogenic potential. Therefore, the construction of bionic periosteum substitutes to repair bone defects has attracted more and more attention from researchers. In recent years, artificial periosteum materials have also made significant progress, and various new artificial periosteum materials have also been proven to be effective in repairing bone defects. This article systematically summarizes the current research progress of artificial periosteum, provides a reference for researchers in related fields, and helps promote the clinical transformation of artificial periosteum.展开更多
文摘骨膜是包裹在骨皮质表面的一层薄而坚韧的结缔组织膜,由外层纤维层和内层生发层共两层组成。覆盖整个骨面达80%以上,为骨组织提供血液供应和初始干细胞,主要起固定、营养和保护的作用,大量研究证明骨膜具有显著的成骨潜能。因此,构建仿生骨膜替代物修复骨缺损越来越受到研究者的重视。近年来人工骨膜材料也取得了重大进步,各种新型的人工骨膜材料也被证实在修复骨缺损方面确有其效。本文系统总结了人工骨膜现阶段的研究进展,为相关领域的研究人员提供了参考,有助于推动人工骨膜的临床转化。The periosteum is a thin and tough connective tissue membrane wrapped around the surface of the bone cortex, consisting of two layers: the outer fibrous layer and the inner germinal layer. It covers more than 80% of the entire bone surface, provides blood supply and initial stem cells for bone tissue, and mainly plays the role of fixation, nutrition and protection. A large number of studies have shown that the periosteum has significant osteogenic potential. Therefore, the construction of bionic periosteum substitutes to repair bone defects has attracted more and more attention from researchers. In recent years, artificial periosteum materials have also made significant progress, and various new artificial periosteum materials have also been proven to be effective in repairing bone defects. This article systematically summarizes the current research progress of artificial periosteum, provides a reference for researchers in related fields, and helps promote the clinical transformation of artificial periosteum.
