目的 探索生理性衰老受试者中大脑体积的变化以及全脑功能网络的特征性改变。方法 纳入正常中老年组志愿者组(50~80岁)42名(HC group 1,HCg1),中青年组(20~40岁)健康志愿者33名(HC group 2,HCg2)。通过基于体素的形态学分析,对T_(1)序...目的 探索生理性衰老受试者中大脑体积的变化以及全脑功能网络的特征性改变。方法 纳入正常中老年组志愿者组(50~80岁)42名(HC group 1,HCg1),中青年组(20~40岁)健康志愿者33名(HC group 2,HCg2)。通过基于体素的形态学分析,对T_(1)序列分割出的全脑皮质及白质体积进行组间比较。之后,对两组的静息态脑功能成像进行基于网络的分析,比较全脑功能网络与脑区的连接特征并对比功能连接均值。结果 在灰质体积分析中,HCg1较HCg2在双侧颞叶、额叶、小脑出现了显著的灰质体积减小(P<0.05,FDR多重比较校正P<0.01),白质体积的缩小发生在胼胝体体部及双侧穹窿脚。全脑网络连接均值比较中,HCg1表现出了更高的平均功能连接值(P<0.05,FDR多重比较校正P<0.01)。结论 不同年龄段皮质及白质形态出现多个区域的萎缩,提示衰老过程伴随着多种局部基础生理机能的降低。但通过全脑功能网络的连接特征说明,大脑前部代偿性的功能连接增强,可能是脑功能的强健性及脑储备能力出现的原因之一。展开更多
Dual-layer spectral detector CT is a new spectrum CT imaging technology based on detector being able to obtain both images similar to true plain and spectral images in one time scanning.The reconstructed multi-paramet...Dual-layer spectral detector CT is a new spectrum CT imaging technology based on detector being able to obtain both images similar to true plain and spectral images in one time scanning.The reconstructed multi-parameter spectral images can not only improve image quality,enhance tissue contrast,increase the visualization and detection ability of occult lesions,but also provide qualitative and quantitative analysis of the lesions,so as to provide more imaging information and multi-dimensional diagnostic basis.The research progresses of dual-layer spectral detector CT for preoperative evaluation on colorectal cancer were reviewed in this article.展开更多
文摘目的 探索生理性衰老受试者中大脑体积的变化以及全脑功能网络的特征性改变。方法 纳入正常中老年组志愿者组(50~80岁)42名(HC group 1,HCg1),中青年组(20~40岁)健康志愿者33名(HC group 2,HCg2)。通过基于体素的形态学分析,对T_(1)序列分割出的全脑皮质及白质体积进行组间比较。之后,对两组的静息态脑功能成像进行基于网络的分析,比较全脑功能网络与脑区的连接特征并对比功能连接均值。结果 在灰质体积分析中,HCg1较HCg2在双侧颞叶、额叶、小脑出现了显著的灰质体积减小(P<0.05,FDR多重比较校正P<0.01),白质体积的缩小发生在胼胝体体部及双侧穹窿脚。全脑网络连接均值比较中,HCg1表现出了更高的平均功能连接值(P<0.05,FDR多重比较校正P<0.01)。结论 不同年龄段皮质及白质形态出现多个区域的萎缩,提示衰老过程伴随着多种局部基础生理机能的降低。但通过全脑功能网络的连接特征说明,大脑前部代偿性的功能连接增强,可能是脑功能的强健性及脑储备能力出现的原因之一。
文摘Dual-layer spectral detector CT is a new spectrum CT imaging technology based on detector being able to obtain both images similar to true plain and spectral images in one time scanning.The reconstructed multi-parameter spectral images can not only improve image quality,enhance tissue contrast,increase the visualization and detection ability of occult lesions,but also provide qualitative and quantitative analysis of the lesions,so as to provide more imaging information and multi-dimensional diagnostic basis.The research progresses of dual-layer spectral detector CT for preoperative evaluation on colorectal cancer were reviewed in this article.
