It has been well established that the recovery ability of central nervous system （CNS） is very poor in adult mammals. As a result, CNS trauma generally leads to severe and persistent functional deficits. Thus, the i...It has been well established that the recovery ability of central nervous system （CNS） is very poor in adult mammals. As a result, CNS trauma generally leads to severe and persistent functional deficits. Thus, the investigation in this field becomes a ＂hot spot＂. Up to date, accumulating evidence supports the hypothesis that the failure of CNS neurons to regenerate is not due to their intrinsic inability to grow new axons, but due to their growth state and due to lack of a permissive growth environment. Therefore, any successful approaches to facilitate the regeneration of injured CNS axons will likely include multiple steps： keeping neurons alive in a certain growth-state, preventing the formation of a glial scar, overcoming inhibitory molecules present in the myelin debris, and giving direction to the growing axons. This brief review focused on the recent progress in the neuron regeneration of CNS in adult mammals.展开更多
有限元方法(finite element method,FEM)是一种有效的应力计算分析方法,已逐渐被应用于人体结构生物力学功能研究。本文综述了颈椎有限元模型的构建、发展、材料属性赋值以及验证,并阐述了国内外研究者利用FEM在颈椎挥鞭样损伤成伤机制...有限元方法(finite element method,FEM)是一种有效的应力计算分析方法,已逐渐被应用于人体结构生物力学功能研究。本文综述了颈椎有限元模型的构建、发展、材料属性赋值以及验证,并阐述了国内外研究者利用FEM在颈椎挥鞭样损伤成伤机制和生物力学响应分析等方面取得的研究成果。展开更多
目的利用线粒体细胞色素c氧化酶亚基Ⅰ(cytochrome c oxidase subunitⅠ,COⅠ)基因序列对长三角地区常见嗜尸性蝇类物种进行分子鉴定并验证其可靠性。方法于野外放置的大型家猪尸体上采集并经实验室多代培养、遗传稳定的长三角地区常见...目的利用线粒体细胞色素c氧化酶亚基Ⅰ(cytochrome c oxidase subunitⅠ,COⅠ)基因序列对长三角地区常见嗜尸性蝇类物种进行分子鉴定并验证其可靠性。方法于野外放置的大型家猪尸体上采集并经实验室多代培养、遗传稳定的长三角地区常见嗜尸性蝇类共3科6属7个物种,提取全基因组DNA后扩增COⅠ基因片段,正反向测序后拼接,通过Mega 7.0.26等软件分析扩增片段的碱基组成和种间进化分歧率,并采用邻接(neighbor joining,NJ)法和非加权组平均法(unweighted pair-group method with arithmetic means,UPGMA)构建长三角地区常见嗜尸性蝇类COⅠ基因序列的系统发育树。结果不同蝇类物种的平均碱基组成为A(30.14%)、T(38.23%)、C(15.98%)、G(15.65%)。种间进化分歧率在2.2%~15.3%,最低在大头金蝇和肥躯金蝇之间,最高在厩腐蝇和棕尾别麻蝇之间。结论利用COⅠ基因能够较好地鉴别长三角地区的常见嗜尸性蝇类物种。展开更多
基金supported by the National Natural Science Foundation of China(No.30571909,No.30872666)the Youth Teacher Foundation of Jiangsu Pro-vince(No.BU134701)China,and the Medical Development Foundation of Soochow University(No.EE134615)
文摘It has been well established that the recovery ability of central nervous system （CNS） is very poor in adult mammals. As a result, CNS trauma generally leads to severe and persistent functional deficits. Thus, the investigation in this field becomes a ＂hot spot＂. Up to date, accumulating evidence supports the hypothesis that the failure of CNS neurons to regenerate is not due to their intrinsic inability to grow new axons, but due to their growth state and due to lack of a permissive growth environment. Therefore, any successful approaches to facilitate the regeneration of injured CNS axons will likely include multiple steps： keeping neurons alive in a certain growth-state, preventing the formation of a glial scar, overcoming inhibitory molecules present in the myelin debris, and giving direction to the growing axons. This brief review focused on the recent progress in the neuron regeneration of CNS in adult mammals.
