AIM:To explore the relationship between retinal exudative changes in neonates and perinatal toxoplasmosis,others,rubella,cytomegalovirus,and herpes simplex virus(TORCH)infections,as well as the characteristics of TORC...AIM:To explore the relationship between retinal exudative changes in neonates and perinatal toxoplasmosis,others,rubella,cytomegalovirus,and herpes simplex virus(TORCH)infections,as well as the characteristics of TORCH infection in neonates with retinal exudative changes.METHODS:Retrospective study.A total of 612 neonates with retinal exudative changes detected during ophthalmic screening in our hospital from May 2019 to March 2023 were selected.TORCH tests were performed on these neonates,and the results were subjected to statistical analysis to determine the infection characteristics.The neonates with retinal exudative changes were grouped by sex and age,the characteristics of TORCH infection were analyzed,and the positive rates were compared.RESULTS:Among the 612 neonates with retinal exudative changes,the highest positive rate was observed for cytomegalovirus(CMV-IgG)(96.7%),followed by rubella virus(RV-IgG)(73.9%).Mixed infections with two or three viruses were also observed,with the highest positive rate for mixed infection of RV-IgG and CMV-IgG reaching 71.2%.There was no statistically significant difference in TORCH infection among neonates of different sex(P>0.05).However,there were statistically significant differences in RV-IgG and CMV-IgM infections with retinal exudative changes among neonates of different age groups(P<0.05).CONCLUSION:Perinatal TORCH infection may be an important factor causing retinal exudative changes in neonates.The differences in various infections are not related to sex but are related to different age groups.展开更多
相比双绒毛膜双胎,单绒毛膜双胎发生不良结局的风险更大,同时具有较高的胎儿畸形率、早产率、胎儿及新生儿死亡率。加拿大妇产科医师学会(the Society of Obstetrician and Gynaecologists of Canada,SOGC)回顾了正常和复杂性单绒毛膜...相比双绒毛膜双胎,单绒毛膜双胎发生不良结局的风险更大,同时具有较高的胎儿畸形率、早产率、胎儿及新生儿死亡率。加拿大妇产科医师学会(the Society of Obstetrician and Gynaecologists of Canada,SOGC)回顾了正常和复杂性单绒毛膜双胎妊娠的系统评价结果、随机对照临床试验和观察性研究结果,发布了第440号临床实践指南。该指南旨在为产科医师提供适当的指导,及时并恰当地识别和处理单绒毛膜双胎的各种并发症,从而降低围产儿病率和死亡率。展开更多
Premature ovarian failure(POF)is a prevalent gynecological disorder with significant implications for the physical and mental well-being of affected individuals.Liu Wei Di Huang Wan(LWDHW),a Chinese herbal compound,ha...Premature ovarian failure(POF)is a prevalent gynecological disorder with significant implications for the physical and mental well-being of affected individuals.Liu Wei Di Huang Wan(LWDHW),a Chinese herbal compound,has demonstrated efficacy in alleviating the effects of POF.However,the underlying mechanism of action of LWDHW remains unclear.This study aimed to elucidate the potential molecular mechanism of LWDHW in treating POF using network pharmacology and molecular docking techniques.The active ingredients of LWDHW were initially screened through the TCMSP platform.At the same time,the relevant target genes associated with POF were identified using databases such as Disgenet,TTD,Drugbank,Gene Cards,OMIM,and Pharm GKB.Data analysis was conducted using the R language,Cytoscape,and STRING to construct and analyze the traditional Chinese medicine(TCM)regulatory network and protein-protein interaction(PPI)network maps.Subsequently,GO and KEGG enrichment analyses were performed using the R language.Finally,molecular docking was carried out between the protein receptors of the core genes and the corresponding small-molecule ligands.The study revealed 49 components and 189 predicted targets(after de-duplication)of LWDHW,along with 4524 targets(after de-duplication)associated with POF.Through comparative analysis,163 potential genes were identified as common targets of LWDHW and POF,participating in biological processes such as response to chemical substances,molecular function regulation,and signaling receptor binding.Key biological pathways implicated included the MAPK signaling pathway,IL-17 signaling pathway,and HIF-1 signaling pathway,among others.Molecular docking results demonstrated a robust binding ability between the core genes of LWDHW and their corresponding ingredients.In conclusion,this comprehensive analysis provided insights into the potential molecular mechanisms of LWDHW in treating POF.The identified common targets and associated pathways contributed to our understanding of how LWDHW exerted its therapeutic effects,paving the way for further research and clinical applications.It is worth noting that future studies with experimental validation and clinical trials are essential to confirm these findings and establish the safety and efficacy of LWDHW in the treatment of POF.展开更多
产后出血(postpartum hemorrhage,PPH)一直是导致全球孕产妇死亡的重要原因。传统的产后出血定义为:胎儿娩出后24h内,阴道分娩失血量≥500mL或剖宫产后失血量≥1000mL。加拿大妇产科医师学会(the Society of Obste-tricians and Gynaeco...产后出血(postpartum hemorrhage,PPH)一直是导致全球孕产妇死亡的重要原因。传统的产后出血定义为:胎儿娩出后24h内,阴道分娩失血量≥500mL或剖宫产后失血量≥1000mL。加拿大妇产科医师学会(the Society of Obste-tricians and Gynaecologists of Canada,SOGC)综合了部分发达国家的数据。展开更多
目的观察非典型乳腺纤维腺瘤患者自动乳腺容积扫描(automated breast volume scanner,ABVS)联合常规超声声像图特征,探讨其与组织病理分型的关系。方法169例乳腺纤维腺瘤患者均行ABVS联合常规超声检查及组织穿刺活检病理检查,观察超声...目的观察非典型乳腺纤维腺瘤患者自动乳腺容积扫描(automated breast volume scanner,ABVS)联合常规超声声像图特征,探讨其与组织病理分型的关系。方法169例乳腺纤维腺瘤患者均行ABVS联合常规超声检查及组织穿刺活检病理检查,观察超声声像图特征。根据组织病理结果分为复杂型组15例和单纯型组154例,比较2组非典型乳腺纤维腺瘤比率及非典型乳腺纤维腺瘤的超声声像图特征。结果169例患者中典型乳腺纤维腺瘤93例,表现为椭圆形,边界清晰,包膜完整,内部回声均匀;非典型乳腺纤维腺瘤76例,表现为形态不规则60例(78.9%),边缘不光整30例(39.5%),微钙化16例(21.1%),方位不平行7例(9.2%),回声不均匀6例(7.9%),后方回声衰减6例(7.9%),血流较丰富5例(6.6%),阻力指数>0.72例(2.6%),汇聚征1例(1.3%)。复杂型组非典型乳腺纤维腺瘤14例,其中乳头状大汗腺化生5例,囊肿3例,上皮钙化4例,硬化性腺病1例,乳头状大汗腺化生+硬化性腺病1例;单纯型组非典型乳腺纤维腺瘤62例;复杂型组非典型乳腺纤维腺瘤比率(93.3%)高于单纯型组(40.3%)(χ^(2)=15.558,P<0.001)。复杂型组非典型乳腺纤维腺瘤内部回声不均质、微小钙化比率(35.7%、42.9%)均高于单纯型组(1.6%、16.1%)(χ^(2)=18.265,P=0.001;χ^(2)=4.909,P=0.027),形态不规则、边缘模糊、边缘小叶、方位不平行、血流较丰富比率(78.6%、28.6%、14.3%、14.3%、14.3%)与单纯型组(56.5%、16.1%、12.9%、8.1%、4.8%)比较差异均无统计学意义(P>0.05)。结论ABVS联合常规超声检查为非典型乳腺纤维腺瘤的声像图特征多表现为形态不规则、边缘不光整及微钙化,汇聚征少见;复杂型非典型乳腺纤维腺瘤超声声像图较单纯型更易表现为内部回声不均质、微小钙化等。展开更多
文摘AIM:To explore the relationship between retinal exudative changes in neonates and perinatal toxoplasmosis,others,rubella,cytomegalovirus,and herpes simplex virus(TORCH)infections,as well as the characteristics of TORCH infection in neonates with retinal exudative changes.METHODS:Retrospective study.A total of 612 neonates with retinal exudative changes detected during ophthalmic screening in our hospital from May 2019 to March 2023 were selected.TORCH tests were performed on these neonates,and the results were subjected to statistical analysis to determine the infection characteristics.The neonates with retinal exudative changes were grouped by sex and age,the characteristics of TORCH infection were analyzed,and the positive rates were compared.RESULTS:Among the 612 neonates with retinal exudative changes,the highest positive rate was observed for cytomegalovirus(CMV-IgG)(96.7%),followed by rubella virus(RV-IgG)(73.9%).Mixed infections with two or three viruses were also observed,with the highest positive rate for mixed infection of RV-IgG and CMV-IgG reaching 71.2%.There was no statistically significant difference in TORCH infection among neonates of different sex(P>0.05).However,there were statistically significant differences in RV-IgG and CMV-IgM infections with retinal exudative changes among neonates of different age groups(P<0.05).CONCLUSION:Perinatal TORCH infection may be an important factor causing retinal exudative changes in neonates.The differences in various infections are not related to sex but are related to different age groups.
文摘相比双绒毛膜双胎,单绒毛膜双胎发生不良结局的风险更大,同时具有较高的胎儿畸形率、早产率、胎儿及新生儿死亡率。加拿大妇产科医师学会(the Society of Obstetrician and Gynaecologists of Canada,SOGC)回顾了正常和复杂性单绒毛膜双胎妊娠的系统评价结果、随机对照临床试验和观察性研究结果,发布了第440号临床实践指南。该指南旨在为产科医师提供适当的指导,及时并恰当地识别和处理单绒毛膜双胎的各种并发症,从而降低围产儿病率和死亡率。
基金Science and Technology Commission Joint Traditional Chinese Medicine Project of Chongqing,China(Grant No.2023MSXM166)。
文摘Premature ovarian failure(POF)is a prevalent gynecological disorder with significant implications for the physical and mental well-being of affected individuals.Liu Wei Di Huang Wan(LWDHW),a Chinese herbal compound,has demonstrated efficacy in alleviating the effects of POF.However,the underlying mechanism of action of LWDHW remains unclear.This study aimed to elucidate the potential molecular mechanism of LWDHW in treating POF using network pharmacology and molecular docking techniques.The active ingredients of LWDHW were initially screened through the TCMSP platform.At the same time,the relevant target genes associated with POF were identified using databases such as Disgenet,TTD,Drugbank,Gene Cards,OMIM,and Pharm GKB.Data analysis was conducted using the R language,Cytoscape,and STRING to construct and analyze the traditional Chinese medicine(TCM)regulatory network and protein-protein interaction(PPI)network maps.Subsequently,GO and KEGG enrichment analyses were performed using the R language.Finally,molecular docking was carried out between the protein receptors of the core genes and the corresponding small-molecule ligands.The study revealed 49 components and 189 predicted targets(after de-duplication)of LWDHW,along with 4524 targets(after de-duplication)associated with POF.Through comparative analysis,163 potential genes were identified as common targets of LWDHW and POF,participating in biological processes such as response to chemical substances,molecular function regulation,and signaling receptor binding.Key biological pathways implicated included the MAPK signaling pathway,IL-17 signaling pathway,and HIF-1 signaling pathway,among others.Molecular docking results demonstrated a robust binding ability between the core genes of LWDHW and their corresponding ingredients.In conclusion,this comprehensive analysis provided insights into the potential molecular mechanisms of LWDHW in treating POF.The identified common targets and associated pathways contributed to our understanding of how LWDHW exerted its therapeutic effects,paving the way for further research and clinical applications.It is worth noting that future studies with experimental validation and clinical trials are essential to confirm these findings and establish the safety and efficacy of LWDHW in the treatment of POF.
文摘产后出血(postpartum hemorrhage,PPH)一直是导致全球孕产妇死亡的重要原因。传统的产后出血定义为:胎儿娩出后24h内,阴道分娩失血量≥500mL或剖宫产后失血量≥1000mL。加拿大妇产科医师学会(the Society of Obste-tricians and Gynaecologists of Canada,SOGC)综合了部分发达国家的数据。
文摘目的观察非典型乳腺纤维腺瘤患者自动乳腺容积扫描(automated breast volume scanner,ABVS)联合常规超声声像图特征,探讨其与组织病理分型的关系。方法169例乳腺纤维腺瘤患者均行ABVS联合常规超声检查及组织穿刺活检病理检查,观察超声声像图特征。根据组织病理结果分为复杂型组15例和单纯型组154例,比较2组非典型乳腺纤维腺瘤比率及非典型乳腺纤维腺瘤的超声声像图特征。结果169例患者中典型乳腺纤维腺瘤93例,表现为椭圆形,边界清晰,包膜完整,内部回声均匀;非典型乳腺纤维腺瘤76例,表现为形态不规则60例(78.9%),边缘不光整30例(39.5%),微钙化16例(21.1%),方位不平行7例(9.2%),回声不均匀6例(7.9%),后方回声衰减6例(7.9%),血流较丰富5例(6.6%),阻力指数>0.72例(2.6%),汇聚征1例(1.3%)。复杂型组非典型乳腺纤维腺瘤14例,其中乳头状大汗腺化生5例,囊肿3例,上皮钙化4例,硬化性腺病1例,乳头状大汗腺化生+硬化性腺病1例;单纯型组非典型乳腺纤维腺瘤62例;复杂型组非典型乳腺纤维腺瘤比率(93.3%)高于单纯型组(40.3%)(χ^(2)=15.558,P<0.001)。复杂型组非典型乳腺纤维腺瘤内部回声不均质、微小钙化比率(35.7%、42.9%)均高于单纯型组(1.6%、16.1%)(χ^(2)=18.265,P=0.001;χ^(2)=4.909,P=0.027),形态不规则、边缘模糊、边缘小叶、方位不平行、血流较丰富比率(78.6%、28.6%、14.3%、14.3%、14.3%)与单纯型组(56.5%、16.1%、12.9%、8.1%、4.8%)比较差异均无统计学意义(P>0.05)。结论ABVS联合常规超声检查为非典型乳腺纤维腺瘤的声像图特征多表现为形态不规则、边缘不光整及微钙化,汇聚征少见;复杂型非典型乳腺纤维腺瘤超声声像图较单纯型更易表现为内部回声不均质、微小钙化等。
