多囊卵巢综合征(PCOS)因其病因复杂,症状繁多,严重影响女性的身心健康,然而其发病机制尚未阐明。近年来越来越多的研究证实,细胞自噬和凋亡在PCOS的发生发展中起关键作用,且自噬与PCOS相关的代谢异常,如胰岛素抵抗(IR)密切相关。PI3K/Ak...多囊卵巢综合征(PCOS)因其病因复杂,症状繁多,严重影响女性的身心健康,然而其发病机制尚未阐明。近年来越来越多的研究证实,细胞自噬和凋亡在PCOS的发生发展中起关键作用,且自噬与PCOS相关的代谢异常,如胰岛素抵抗(IR)密切相关。PI3K/Akt/mTOR信号通路是经典的自噬信号通路。基于目前中医药治疗PCOS的研究现状,本文就PI3K/Akt/mTOR信号通路在PCOS中的作用机制及中医药通过调控该通路治疗PCOS的研究进展进行综述,为PCOS的防治提供新思路。Polycystic ovary syndrome (PCOS), due to its complex etiology and numerous symptoms, seriously affects the physical and mental health of women. However, its pathogenesis has not yet been elucidated. In recent years, more and more studies have confirmed that autophagy and apoptosis play a crucial role in the occurrence and development of PCOS, and autophagy is closely related to metabolic abnormalities related to PCOS, such as insulin resistance (IR). The PI3K/Akt/mTOR signaling pathway is a classic autophagy signaling pathway. Based on the current research status of traditional Chinese medicine in the treatment of PCOS, this article reviews the mechanism of PI3K/Akt/mTOR signaling pathway in PCOS and the research progress of traditional Chinese medicine in regulating this pathway to treat PCOS, providing new ideas for the prevention and treatment of PCOS.展开更多
目的:应用CiteSpace文献计量学方法对中医药治疗多囊卵巢综合征(Polycystic Ovarian Syndrome, PCOS)伴胰岛素抵抗(Insulin Resistant, IR)的研究进程与方向进行可视化分析。方法:检索中国知网数据库和Web of Science核心合集数据库2002...目的:应用CiteSpace文献计量学方法对中医药治疗多囊卵巢综合征(Polycystic Ovarian Syndrome, PCOS)伴胰岛素抵抗(Insulin Resistant, IR)的研究进程与方向进行可视化分析。方法:检索中国知网数据库和Web of Science核心合集数据库2002~2022年中医药治疗PCOS-IR的相关文献,通过CiteSpace6.1R3软件绘制相应的知识图谱,对作者、机构、关键词共现、突现和聚类进行分析。结果:共纳入中文文献1065篇,英文文献436篇,侯丽辉、Stener victorin、Elisabet分别是中、英文发文量最多的作者,国内对该领域研究成果比国外多且起步早。主要研究内容有中医药治疗PCOS-IR的作用机制、中医特色疗法、中药药理分析、临床疗效观察等方面。结论:研究者们未来会聚焦于中医疗法对PCOS-IR作用机制的研究,注重内治法联合外治法或中西医结合治疗,并尽可能地开展动物试验探讨其起效的作用机理,以期对该疾病临床诊疗提供一定指导。Objective: To visually analyze the research process and direction of traditional Chinese medicine in the treatment of polycystic ovary syndrome with insulin resistance by CiteSpace bibliometrics. Methods: Search China knowledge net database and Web of Science core collection database related literature of traditional Chinese medicine treatment of PCOS-IR from 2002 to 2022, draw the corresponding knowledge graph through CiteSpace6.1R3 software, and analyze the co-occurrence, emergence and clustering of authors, institutions and keywords. Results: After screening, 1065 literatures were included in CNKI database and 436 literatures were included in Web of Science core database. The author co-occurrence analysis shows that the largest number of publications at home and abroad are Hou Lihui and Stener victorin, Elisabet. Domestic research results in this field are more than foreign countries and started earlier. The main research contents include the mechanism of action of Chinese medicine in the treatment of PCOS-IR, characteristic therapies of Chinese medicine, pharmacological analysis of Chinese medicine, and observation of clinical efficacy. Conclusion: In the future, researchers will focus on the role of TCM in the prevention, regression and healing of PCOS-IR, emphasizing the combination of internal and external therapies or the combination of Chinese and Western medicines, as well as conducting animal experiments as much as possible to explore the mechanism of its effect, with a view to providing some guidance for the clinical diagnosis and treatment of this disease.展开更多
在我国,胃溃疡是最常见的消化系统疾病之一,其发病率较高,多发于45~55岁之间,约占患病总人数的1/5。近年来,由于生活节奏的加快和精神压力的增加,该疾病的发病率也在不断上升,并逐渐成为各类消化道疾病的首位。胃溃疡主要以上腹部疼痛为...在我国,胃溃疡是最常见的消化系统疾病之一,其发病率较高,多发于45~55岁之间,约占患病总人数的1/5。近年来,由于生活节奏的加快和精神压力的增加,该疾病的发病率也在不断上升,并逐渐成为各类消化道疾病的首位。胃溃疡主要以上腹部疼痛为主,开始时有一定规律,一般是在饭后一小时之内就会出现,如胃酸过多或食物刺激较强时,就会出现剧烈的腹痛,可伴有绞痛,少数患者表现为上腹部烧灼感或针刺感等不适。作为一种临床的常见病、多发病,其发病主要与幽门螺杆菌感染导致的胃酸、胃蛋白酶原活性、胃壁细胞的破坏有关。从中医的角度讲,胃溃疡属于中医“胃脘痛”、“脘痞”、“痞满”等范畴,其病因病机认为,此病多与饮食不节、情志失调有关。目前治疗胃溃疡的药物主要有抑酸药、质子泵抑制剂、胶体铋剂等。但长期服用药物会对胃粘膜造成损害,降低疗效。近些年来,中医在胃溃疡的防治中发挥了重要的作用。本文就中医治疗胃溃疡的进展进行综述,为此病的防治提供参考。In China, gastric ulcer is one of the most common digestive system diseases, with a high incidence rate, which mostly occurs between 45 and 55 years old, accounting for about 1/5 of the total number of patients. In recent years, due to the acceleration of the pace of life and the increase of mental stress, the incidence rate of the disease is also rising, and gradually becomes the first of all kinds of digestive tract diseases. Gastric ulcer is mainly characterized by upper abdominal pain, which has a certain pattern at the beginning and usually appears within one hour after meals. When there is excessive stomach acid or strong food stimulation, severe abdominal pain may occur, accompanied by colic. A few patients may experience discomfort such as burning sensation or needle pricking sensation in the upper abdomen. As a common and frequently occurring clinical disease, its onset is mainly related to the destruction of gastric acid, pepsinogen activity, and gastric wall cells caused by Helicobacter pylori infection. From the perspective of traditional Chinese medicine, gastric ulcer belongs to the categories of “epigastric pain”, “epigastric pain”, “epigastric fullness”, etc. Its etiology and pathogenesis are believed to be related to irregular diet and emotional disorders. At present, the main drugs used to treat gastric ulcers include acid suppressants, proton pump inhibitors, colloidal bismuth agents, etc. However, long-term use of medication can cause damage to the gastric mucosa and reduce its therapeutic effect. In recent years, traditional Chinese medicine has played an important role in the prevention and treatment of gastric ulcers. This article reviews the progress of traditional Chinese medicine in treating gastric ulcers, providing reference for the prevention and treatment of this disease.展开更多
糖尿病肾病(diabetic kidney disease, DKD)是指糖尿病患者由于血糖长期控制不佳,导致尿白蛋白排泄率增加和肾小球滤过率进行性下降,进而引起的肾脏病变。西医在治疗DKD蛋白尿方面,已经有了一些有效的药物,如肾素–血管紧张素系统抑制剂...糖尿病肾病(diabetic kidney disease, DKD)是指糖尿病患者由于血糖长期控制不佳,导致尿白蛋白排泄率增加和肾小球滤过率进行性下降,进而引起的肾脏病变。西医在治疗DKD蛋白尿方面,已经有了一些有效的药物,如肾素–血管紧张素系统抑制剂(RASi)、钠–葡萄糖共转运蛋白2抑制剂(SGLT2i)、胰高血糖素样肽-1受体激动剂(GLP-1RA)以及盐皮质激素受体拮抗剂(MRA)等。然而,尽管这些药物能够在一定程度上控制DKD的进展,但尚未找到能够完全逆转或阻止其病程发展的最佳方法。在这种背景下,中医药治疗DKD的研究和应用显得尤为重要。中医药凭借其独特的理论和治疗方法,在糖尿病肾病的治疗中显示出一定的优势和潜力。基于以上,本文将对中医药治疗糖尿病肾病研究进展进行分析,论述中医药治疗DKD的病因病机、辨证分型、方药治疗等内容。Diabetic kidney disease (DKD) refers to the kidney diseases caused by the increase of urinary albumin excretion rate and the progressive decrease of glomerular filtration rate in diabetic patients due to the long-term poor control of blood sugar. Western medicine has some effective drugs for the treatment of DKD proteinuria, such as renin-angiotensin system inhibitor (RASi), sodium-glucose cotransporter 2 inhibitor (SGLT2i), glucagon-like peptide-1 receptor agonist (GLP-1RA) and salocorticoid receptor antagonist (MRA). However, although these drugs are able to control the progression of DKD to some extent, the best way to completely reverse or stop its progression has not yet been found. In this context, the research and application of traditional Chinese medicine treatment of DKD is particularly important. With its unique theory and treatment methods, traditional Chinese medicine has shown certain advantages and potential in the treatment of diabetic nephropathy. Based on the above, this paper will analyze the research progress of TCM treatment of diabetic nephropathy, and discuss the etiology and pathogenesis, syndrome differentiation and prescription treatment of TCM treatment of DKD.展开更多
文摘多囊卵巢综合征(PCOS)因其病因复杂,症状繁多,严重影响女性的身心健康,然而其发病机制尚未阐明。近年来越来越多的研究证实,细胞自噬和凋亡在PCOS的发生发展中起关键作用,且自噬与PCOS相关的代谢异常,如胰岛素抵抗(IR)密切相关。PI3K/Akt/mTOR信号通路是经典的自噬信号通路。基于目前中医药治疗PCOS的研究现状,本文就PI3K/Akt/mTOR信号通路在PCOS中的作用机制及中医药通过调控该通路治疗PCOS的研究进展进行综述,为PCOS的防治提供新思路。Polycystic ovary syndrome (PCOS), due to its complex etiology and numerous symptoms, seriously affects the physical and mental health of women. However, its pathogenesis has not yet been elucidated. In recent years, more and more studies have confirmed that autophagy and apoptosis play a crucial role in the occurrence and development of PCOS, and autophagy is closely related to metabolic abnormalities related to PCOS, such as insulin resistance (IR). The PI3K/Akt/mTOR signaling pathway is a classic autophagy signaling pathway. Based on the current research status of traditional Chinese medicine in the treatment of PCOS, this article reviews the mechanism of PI3K/Akt/mTOR signaling pathway in PCOS and the research progress of traditional Chinese medicine in regulating this pathway to treat PCOS, providing new ideas for the prevention and treatment of PCOS.
文摘目的:应用CiteSpace文献计量学方法对中医药治疗多囊卵巢综合征(Polycystic Ovarian Syndrome, PCOS)伴胰岛素抵抗(Insulin Resistant, IR)的研究进程与方向进行可视化分析。方法:检索中国知网数据库和Web of Science核心合集数据库2002~2022年中医药治疗PCOS-IR的相关文献,通过CiteSpace6.1R3软件绘制相应的知识图谱,对作者、机构、关键词共现、突现和聚类进行分析。结果:共纳入中文文献1065篇,英文文献436篇,侯丽辉、Stener victorin、Elisabet分别是中、英文发文量最多的作者,国内对该领域研究成果比国外多且起步早。主要研究内容有中医药治疗PCOS-IR的作用机制、中医特色疗法、中药药理分析、临床疗效观察等方面。结论:研究者们未来会聚焦于中医疗法对PCOS-IR作用机制的研究,注重内治法联合外治法或中西医结合治疗,并尽可能地开展动物试验探讨其起效的作用机理,以期对该疾病临床诊疗提供一定指导。Objective: To visually analyze the research process and direction of traditional Chinese medicine in the treatment of polycystic ovary syndrome with insulin resistance by CiteSpace bibliometrics. Methods: Search China knowledge net database and Web of Science core collection database related literature of traditional Chinese medicine treatment of PCOS-IR from 2002 to 2022, draw the corresponding knowledge graph through CiteSpace6.1R3 software, and analyze the co-occurrence, emergence and clustering of authors, institutions and keywords. Results: After screening, 1065 literatures were included in CNKI database and 436 literatures were included in Web of Science core database. The author co-occurrence analysis shows that the largest number of publications at home and abroad are Hou Lihui and Stener victorin, Elisabet. Domestic research results in this field are more than foreign countries and started earlier. The main research contents include the mechanism of action of Chinese medicine in the treatment of PCOS-IR, characteristic therapies of Chinese medicine, pharmacological analysis of Chinese medicine, and observation of clinical efficacy. Conclusion: In the future, researchers will focus on the role of TCM in the prevention, regression and healing of PCOS-IR, emphasizing the combination of internal and external therapies or the combination of Chinese and Western medicines, as well as conducting animal experiments as much as possible to explore the mechanism of its effect, with a view to providing some guidance for the clinical diagnosis and treatment of this disease.
文摘在我国,胃溃疡是最常见的消化系统疾病之一,其发病率较高,多发于45~55岁之间,约占患病总人数的1/5。近年来,由于生活节奏的加快和精神压力的增加,该疾病的发病率也在不断上升,并逐渐成为各类消化道疾病的首位。胃溃疡主要以上腹部疼痛为主,开始时有一定规律,一般是在饭后一小时之内就会出现,如胃酸过多或食物刺激较强时,就会出现剧烈的腹痛,可伴有绞痛,少数患者表现为上腹部烧灼感或针刺感等不适。作为一种临床的常见病、多发病,其发病主要与幽门螺杆菌感染导致的胃酸、胃蛋白酶原活性、胃壁细胞的破坏有关。从中医的角度讲,胃溃疡属于中医“胃脘痛”、“脘痞”、“痞满”等范畴,其病因病机认为,此病多与饮食不节、情志失调有关。目前治疗胃溃疡的药物主要有抑酸药、质子泵抑制剂、胶体铋剂等。但长期服用药物会对胃粘膜造成损害,降低疗效。近些年来,中医在胃溃疡的防治中发挥了重要的作用。本文就中医治疗胃溃疡的进展进行综述,为此病的防治提供参考。In China, gastric ulcer is one of the most common digestive system diseases, with a high incidence rate, which mostly occurs between 45 and 55 years old, accounting for about 1/5 of the total number of patients. In recent years, due to the acceleration of the pace of life and the increase of mental stress, the incidence rate of the disease is also rising, and gradually becomes the first of all kinds of digestive tract diseases. Gastric ulcer is mainly characterized by upper abdominal pain, which has a certain pattern at the beginning and usually appears within one hour after meals. When there is excessive stomach acid or strong food stimulation, severe abdominal pain may occur, accompanied by colic. A few patients may experience discomfort such as burning sensation or needle pricking sensation in the upper abdomen. As a common and frequently occurring clinical disease, its onset is mainly related to the destruction of gastric acid, pepsinogen activity, and gastric wall cells caused by Helicobacter pylori infection. From the perspective of traditional Chinese medicine, gastric ulcer belongs to the categories of “epigastric pain”, “epigastric pain”, “epigastric fullness”, etc. Its etiology and pathogenesis are believed to be related to irregular diet and emotional disorders. At present, the main drugs used to treat gastric ulcers include acid suppressants, proton pump inhibitors, colloidal bismuth agents, etc. However, long-term use of medication can cause damage to the gastric mucosa and reduce its therapeutic effect. In recent years, traditional Chinese medicine has played an important role in the prevention and treatment of gastric ulcers. This article reviews the progress of traditional Chinese medicine in treating gastric ulcers, providing reference for the prevention and treatment of this disease.
文摘糖尿病肾病(diabetic kidney disease, DKD)是指糖尿病患者由于血糖长期控制不佳,导致尿白蛋白排泄率增加和肾小球滤过率进行性下降,进而引起的肾脏病变。西医在治疗DKD蛋白尿方面,已经有了一些有效的药物,如肾素–血管紧张素系统抑制剂(RASi)、钠–葡萄糖共转运蛋白2抑制剂(SGLT2i)、胰高血糖素样肽-1受体激动剂(GLP-1RA)以及盐皮质激素受体拮抗剂(MRA)等。然而,尽管这些药物能够在一定程度上控制DKD的进展,但尚未找到能够完全逆转或阻止其病程发展的最佳方法。在这种背景下,中医药治疗DKD的研究和应用显得尤为重要。中医药凭借其独特的理论和治疗方法,在糖尿病肾病的治疗中显示出一定的优势和潜力。基于以上,本文将对中医药治疗糖尿病肾病研究进展进行分析,论述中医药治疗DKD的病因病机、辨证分型、方药治疗等内容。Diabetic kidney disease (DKD) refers to the kidney diseases caused by the increase of urinary albumin excretion rate and the progressive decrease of glomerular filtration rate in diabetic patients due to the long-term poor control of blood sugar. Western medicine has some effective drugs for the treatment of DKD proteinuria, such as renin-angiotensin system inhibitor (RASi), sodium-glucose cotransporter 2 inhibitor (SGLT2i), glucagon-like peptide-1 receptor agonist (GLP-1RA) and salocorticoid receptor antagonist (MRA). However, although these drugs are able to control the progression of DKD to some extent, the best way to completely reverse or stop its progression has not yet been found. In this context, the research and application of traditional Chinese medicine treatment of DKD is particularly important. With its unique theory and treatment methods, traditional Chinese medicine has shown certain advantages and potential in the treatment of diabetic nephropathy. Based on the above, this paper will analyze the research progress of TCM treatment of diabetic nephropathy, and discuss the etiology and pathogenesis, syndrome differentiation and prescription treatment of TCM treatment of DKD.
