“火郁发之”理论在医学领域应用广泛,眼科临床也不例外。基于历代医家的深入阐释与经验总结,该理论在眼科疾病治疗中展现出显著效果与广泛适用性。古今医学文献均记载了丰富的成功案例,印证了其科学性及在眼科领域的实践价值。本文从...“火郁发之”理论在医学领域应用广泛,眼科临床也不例外。基于历代医家的深入阐释与经验总结,该理论在眼科疾病治疗中展现出显著效果与广泛适用性。古今医学文献均记载了丰富的成功案例,印证了其科学性及在眼科领域的实践价值。本文从理论解读、与眼病的关联及眼科临床应用等方面探讨“火郁发之”理论在眼科疾病诊疗中的理论与实践意义,以期为中医眼科临床诊疗提供创新思考与新的探索方向。The theory of “Huo Yu Fa Zhi” is widely used in the medical field, and ophthalmology is no exception. Based on the in-depth interpretation and experience summary of medical practitioners in the past dynasties, the theory has shown remarkable effect and wide applicability in the treatment of eye diseases. Numerous successful cases have been recorded in ancient and modern medical literature, which confirms its scientific nature and practical value in the field of ophthalmology. This paper discusses the theoretical and practical significance of the theory of “Huo Yu Fa Zhi” in the diagnosis and treatment of eye diseases from the aspects of theoretical interpretation, correlation with eye diseases and clinical application of ophthalmology, to provide innovative thinking and new exploration direction for the clinical diagnosis and treatment of traditional Chinese ophthalmology.展开更多
肠道微生物群对于宿主的健康起着十分重要的作用,其结构复杂,功能多样,并且与不同疾病的各种病理通路有关,故而受到了广泛的研究。近期,越来越多的研究结果表明,肠道微生物群与眼部健康之间存在着重要的关联,肠–眼轴这一概念也随之兴...肠道微生物群对于宿主的健康起着十分重要的作用,其结构复杂,功能多样,并且与不同疾病的各种病理通路有关,故而受到了广泛的研究。近期,越来越多的研究结果表明,肠道微生物群与眼部健康之间存在着重要的关联,肠–眼轴这一概念也随之兴起。本综述基于PubMed、中国知网、万方数据库、维普网上以“肠–眼轴”为主题的论文,研究了已发表的关于肠道微生物群与眼部发病之间关系的研究结果,阐述并总结肠–眼轴的存在参与了一些眼部疾病的发病机制,包括青光眼、高度近视、干眼症、自身免疫性葡萄膜炎、年龄相关性黄斑变性、糖尿病视网膜病变、细菌性角膜炎。了解肠道微生物群与上述眼部疾病之间的联系,有助于开发新的治疗方法,例如益生菌、益生元或粪便微生物群移植。总之,肠–眼轴为眼科疾病的研究和防治提供了新的视角和方向。The gut microbiota plays a very important role in the health of the host. It has a complex structure and diverse functions and is related to various pathological pathways of different diseases, so it has received extensive research. Recently, more and more research results have shown that there is an important correlation between the gut microbiota and eye health, and the concept of the gut-eye axis has also emerged. This review is based on papers on “gut-eye axis” in PubMed, CNKI, Wanfang Database, and VIP database. It studies the published research results on the relationship between the gut microbiota and the onset of eye diseases, and expounds and summarizes that the existence of the gut-eye axis is involved in the pathogenesis of some eye diseases, including glaucoma, high myopia, dry eye, autoimmune uveitis, age-related macular degeneration, diabetic retinopathy, bacterial keratitis. Understanding the connection between the gut microbiota and the above eye diseases will help develop new treatment methods, such as probiotics, prebiotics, or fecal microbiota transplantation. In short, the gut-eye axis provides a new perspective and direction for the research and prevention of ophthalmic diseases.展开更多
干眼在当今社会作为一种常见的眼表疾病,严重影响了患者的视觉质量和生活质量。本文基于当前干眼的相关研究,对其分类及发病机制进行总结论述。以期为干眼的临床诊断和治疗提供全面而有价值的参考。As a common ocular surface disease,...干眼在当今社会作为一种常见的眼表疾病,严重影响了患者的视觉质量和生活质量。本文基于当前干眼的相关研究,对其分类及发病机制进行总结论述。以期为干眼的临床诊断和治疗提供全面而有价值的参考。As a common ocular surface disease, dry eye seriously affects the visual quality and quality of life of patients. Based on the current research on dry eye, this paper summarizes the classification and pathogenesis of dry eye. In order to provide a comprehensive and valuable reference for the clinical diagnosis and treatment of dry eye.展开更多
过敏性结膜炎是以眼红、眼痒、分泌物多为主要症状的一类眼科常见疾病,具有病程缠绵反复的特点。姚靖教授多年从事眼科临床疾病诊治,擅长从全身整体辨证对眼科疾病予以治疗,对于过敏性结膜炎的发病机理与治疗原则有其独到见解。姚靖教...过敏性结膜炎是以眼红、眼痒、分泌物多为主要症状的一类眼科常见疾病,具有病程缠绵反复的特点。姚靖教授多年从事眼科临床疾病诊治,擅长从全身整体辨证对眼科疾病予以治疗,对于过敏性结膜炎的发病机理与治疗原则有其独到见解。姚靖教授认为过敏性结膜炎以“风”为主要病因,其中包含外风与血虚内风,治疗上以中药自拟祛风养血方为主,在祛风止痒的基础上兼以养血扶正,使邪去病愈,亦防疾病反复,临床疗效显著。今将姚教授对该病治疗的临床经验予以总结,并附医案一则。Allergic conjunctivitis is a common ophthalmic disease with red eyes, itchy eyes and secretions as the main symptoms. Professor Yao Jing has been engaged in clinical diagnosis and treatment of ophthalmic diseases for many years, and is good at treating ophthalmic diseases from the whole body syndrome differentiation. The author has his own opinion on the pathogenesis and treatment principle of allergic conjunctivitis. Professor Yao Jing believes that allergic conjunctivitis is mainly caused by “wind”, which includes external wind and internal wind deficiency. The treatment is mainly based on traditional Chinese medicine self-designed Qufeng Yangxue prescription. On the basis of dispelling wind and relieving itching, it also adopts nourishing blood to support the right, so as to cure the evil and prevent the recurrence of disease. Today, Professor Yao’s clinical experience in the treatment of the disease is summarized, and a medical case is attached.展开更多
目的筛选2型糖尿病(T2DM)大鼠与正常大鼠血液中差异表达的microRNA(miRNA),通过生物信息学分析预测差异miRNA调控的靶基因及功能。方法取20只健康雄性SD大鼠随机分为空白对照组和T2DM模型组,每组10只。采用高脂饲料联合腹腔注射链脲佐菌...目的筛选2型糖尿病(T2DM)大鼠与正常大鼠血液中差异表达的microRNA(miRNA),通过生物信息学分析预测差异miRNA调控的靶基因及功能。方法取20只健康雄性SD大鼠随机分为空白对照组和T2DM模型组,每组10只。采用高脂饲料联合腹腔注射链脲佐菌素(STZ)制作T2DM大鼠模型,2周后提取糖尿病大鼠及正常大鼠全血,应用miRNA测序技术筛选差异miRNA。利用生物信息学方法对差异表达的miRNA靶基因进行基因本体(gene ontology,GO)和KEGG(Kyoto Encyclopedia of Genes and Genomes)通路富集分析。结果与空白对照组相比,T2DM模型组大鼠随机血糖均≥16.7 mmol/L且明显升高、持续稳定。与空白对照组相比,T2DM模型组大鼠血液中共有56个差异表达的miRNA,其中32个上调,24个下调。GO富集分析显示差异表达miRNA的靶基因主要集中在细胞质、细胞核、细胞膜等细胞组分,DNA及RNA的转录调控等生物学过程,与蛋白结合、金属离子结合、ATP结合等分子功能相关。KEGG通路富集分析显示差异表达miRNA的靶基因主要富集于糖尿病并发症、癌症等疾病通路,内吞、自噬等细胞功能通路,MAPK、mTOR、Ras、FoxO等信号通路。结论T2DM模型大鼠血液miRNA较正常大鼠差异表达变化明显,其差异表达的miRNA可能通过影响细胞的炎症免疫反应、增殖、生长分化等功能进而参与糖尿病及其并发症的发生发展。展开更多
目的:评价眼针联合鱼腥草注射液超声雾化熏眼治疗干眼症的临床效果。方法:前瞻性选取2022.06~2023.12于我院眼科就诊的干眼症患者62例,采用随机数字表法分为治疗组和对照组,治疗组采用眼针联合鱼腥草注射液超声雾化熏眼,对照组采用单纯...目的:评价眼针联合鱼腥草注射液超声雾化熏眼治疗干眼症的临床效果。方法:前瞻性选取2022.06~2023.12于我院眼科就诊的干眼症患者62例,采用随机数字表法分为治疗组和对照组,治疗组采用眼针联合鱼腥草注射液超声雾化熏眼,对照组采用单纯鱼腥草注射液超声雾化熏眼,每周治疗5天,连续治疗4周。比较两组治疗前后的眼表疾病指数(OSDI)、泪膜破裂时间(BUT)、泪液分泌试验(SIT)、泪河高度(TMH)及临床疗效。结果:两组患者治疗前OSDI、BUT、SIT、TMH基线水平无统计学差异(P > 0.05)。两组治疗后OSDI评分均下降,且治疗组OSDI评分显著低于对照组(P P P P P < 0.05)。结论:眼针联合鱼腥草注射液雾化熏眼治疗干眼症能够有效改善干眼症患者眼部症状,稳定泪膜状态,提高临床疗效。展开更多
目的:探讨基于《黄帝内经》养生理论提出的日常护眼养生模式对非增殖型糖尿病视网膜病变患者的临床应用价值,以期为该类患者的预防调护提供可参考的中医养生护眼方案。方法:选取90 (150眼)例符合纳入标准的非增殖型糖尿病视网膜患者,使...目的:探讨基于《黄帝内经》养生理论提出的日常护眼养生模式对非增殖型糖尿病视网膜病变患者的临床应用价值,以期为该类患者的预防调护提供可参考的中医养生护眼方案。方法:选取90 (150眼)例符合纳入标准的非增殖型糖尿病视网膜患者,使用随机数字表法随机分为研究组45例(74眼)和对照组45例(76眼)。两组患者均予以常规治疗,同时研究组采用《黄帝内经》护眼养生调护干预方案,对照组采用常规健康指导方案,6个月后评价及对比两组的疗效、眼底改变、最佳矫正视力、血糖指标、血脂指标、内皮素指标。结果:研究组较治疗组相比,总有效率更高(P 0.05);治疗后,研究组的ET-1水平较对照组更低(P Objective: To investigate the clinical application value of the daily eye care and health care model based on the health care theory of Huangdi Neijing for patients with nonproliferative diabetes retinopathy, and to provide a reference for the prevention and care of such patients. Methods: Ninety sick patients (150 eyes) with nonproliferative diabetes retina who conform to the inclusion criteria were chosen and randomly divided into the study group (74 eyes) and the control group (76 eyes) using the random number table method, with 45 people per group. Both groups of sick patients received routine therapies, while the study group received an intervention plan for eye protection and health preservation according to the Huangdi Neijing. The control group allowed a conventional health instructions plan, and after 6 months, the efficacy, fundus changes, best corrected visual acuity, blood glucose indicators, blood lipid indicators, endothelin indicators, and hemorheological indicators of the two teams were estimated and compared. Results: Compared with the control group, the study group had a higher overall effective rate (P 0.05);after treatment, the ET-1 level in the study group was lower than that in the control group (P < 0.05). Conclusion: The daily eye care and health care mode proposed based on the health care theory of Huangdi Neijing can stabilize vision, and reduce blood sugar and lipid in patients with non proliferative diabetes retinopathy, besides, it can also ameliorate endothelial function. It is an effective and practical TCM health care and eye care mode, which is worthy of clinical promotion and application.展开更多
目的:评价调神润目针法结合人工泪液治疗干眼症的临床效果。方法:前瞻性选取2024年1月至2024年10月于黑龙江中医药大学附属第二医院针灸二科就诊的干眼症患者70例,采用随机数字表法分为针药组和药物组,每组35例。针药组采用调神润目针...目的:评价调神润目针法结合人工泪液治疗干眼症的临床效果。方法:前瞻性选取2024年1月至2024年10月于黑龙江中医药大学附属第二医院针灸二科就诊的干眼症患者70例,采用随机数字表法分为针药组和药物组,每组35例。针药组采用调神润目针法联合人工泪液治疗,药物组单纯使用人工泪液。疗程为每日1次,连续治疗2周。比较两组治疗前后的眼表疾病指数(OSDI)、泪膜破裂时间(BUT)、泪液分泌试验(SIT)、角膜荧光素染色(FL)及泪河高度(TMH)等指标,评估临床疗效。结果:两组患者治疗前OSDI、BUT、SIT、FL、TMH基线水平无统计学差异(P > 0.05)。治疗后两组OSDI评分均下降,且针药组显著低于药物组(P Objective: To evaluate the clinical efficacy of the Tiaoshen Runmu acupuncture method combined with artificial tears in the treatment of dry eye disease. Methods: A prospective study was conducted from January 2024 to October 2024 at the Acupuncture Department of the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, involving 70 dry eye patients. The patients were randomly divided into two groups: an acupuncture plus medication group (n = 35) and a medication-only group (n = 35). The acupuncture plus medication group received the Tiaoshen Runmu acupuncture method combined with artificial tears, while the medication-only group was treated with artificial tears alone. Treatment was administered once daily for two consecutive weeks. The Ocular Surface Disease Index (OSDI), Tear Film Breakup Time (BUT), Schirmer I Test (SIT), Fluorescein Staining (FL), and Tear Meniscus Height (TMH) were compared between the two groups to assess clinical efficacy. Results: Baseline levels of OSDI, BUT, SIT, FL, and TMH showed no significant differences between the two groups before treatment (P > 0.05). After treatment, OSDI scores in both groups decreased, with the acupuncture plus medication group showing significantly lower OSDI scores than the medication-only group (P < 0.05). BUT, SIT, FL, and TMH all improved significantly in both groups, with the acupuncture plus medication group showing greater improvements compared to the medication-only group (P < 0.05). The total clinical efficacy rate in the acupuncture plus medication group was significantly higher than that of the medication-only group (P < 0.05). Conclusion: The Tiaoshen Runmu acupuncture method combined with artificial tears is effective in improving the symptoms of dry eye disease, promoting tear secretion, and stabilizing tear film. The clinical efficacy is significantly better than artificial tears alone.展开更多
文摘“火郁发之”理论在医学领域应用广泛,眼科临床也不例外。基于历代医家的深入阐释与经验总结,该理论在眼科疾病治疗中展现出显著效果与广泛适用性。古今医学文献均记载了丰富的成功案例,印证了其科学性及在眼科领域的实践价值。本文从理论解读、与眼病的关联及眼科临床应用等方面探讨“火郁发之”理论在眼科疾病诊疗中的理论与实践意义,以期为中医眼科临床诊疗提供创新思考与新的探索方向。The theory of “Huo Yu Fa Zhi” is widely used in the medical field, and ophthalmology is no exception. Based on the in-depth interpretation and experience summary of medical practitioners in the past dynasties, the theory has shown remarkable effect and wide applicability in the treatment of eye diseases. Numerous successful cases have been recorded in ancient and modern medical literature, which confirms its scientific nature and practical value in the field of ophthalmology. This paper discusses the theoretical and practical significance of the theory of “Huo Yu Fa Zhi” in the diagnosis and treatment of eye diseases from the aspects of theoretical interpretation, correlation with eye diseases and clinical application of ophthalmology, to provide innovative thinking and new exploration direction for the clinical diagnosis and treatment of traditional Chinese ophthalmology.
文摘肠道微生物群对于宿主的健康起着十分重要的作用,其结构复杂,功能多样,并且与不同疾病的各种病理通路有关,故而受到了广泛的研究。近期,越来越多的研究结果表明,肠道微生物群与眼部健康之间存在着重要的关联,肠–眼轴这一概念也随之兴起。本综述基于PubMed、中国知网、万方数据库、维普网上以“肠–眼轴”为主题的论文,研究了已发表的关于肠道微生物群与眼部发病之间关系的研究结果,阐述并总结肠–眼轴的存在参与了一些眼部疾病的发病机制,包括青光眼、高度近视、干眼症、自身免疫性葡萄膜炎、年龄相关性黄斑变性、糖尿病视网膜病变、细菌性角膜炎。了解肠道微生物群与上述眼部疾病之间的联系,有助于开发新的治疗方法,例如益生菌、益生元或粪便微生物群移植。总之,肠–眼轴为眼科疾病的研究和防治提供了新的视角和方向。The gut microbiota plays a very important role in the health of the host. It has a complex structure and diverse functions and is related to various pathological pathways of different diseases, so it has received extensive research. Recently, more and more research results have shown that there is an important correlation between the gut microbiota and eye health, and the concept of the gut-eye axis has also emerged. This review is based on papers on “gut-eye axis” in PubMed, CNKI, Wanfang Database, and VIP database. It studies the published research results on the relationship between the gut microbiota and the onset of eye diseases, and expounds and summarizes that the existence of the gut-eye axis is involved in the pathogenesis of some eye diseases, including glaucoma, high myopia, dry eye, autoimmune uveitis, age-related macular degeneration, diabetic retinopathy, bacterial keratitis. Understanding the connection between the gut microbiota and the above eye diseases will help develop new treatment methods, such as probiotics, prebiotics, or fecal microbiota transplantation. In short, the gut-eye axis provides a new perspective and direction for the research and prevention of ophthalmic diseases.
文摘干眼在当今社会作为一种常见的眼表疾病,严重影响了患者的视觉质量和生活质量。本文基于当前干眼的相关研究,对其分类及发病机制进行总结论述。以期为干眼的临床诊断和治疗提供全面而有价值的参考。As a common ocular surface disease, dry eye seriously affects the visual quality and quality of life of patients. Based on the current research on dry eye, this paper summarizes the classification and pathogenesis of dry eye. In order to provide a comprehensive and valuable reference for the clinical diagnosis and treatment of dry eye.
文摘过敏性结膜炎是以眼红、眼痒、分泌物多为主要症状的一类眼科常见疾病,具有病程缠绵反复的特点。姚靖教授多年从事眼科临床疾病诊治,擅长从全身整体辨证对眼科疾病予以治疗,对于过敏性结膜炎的发病机理与治疗原则有其独到见解。姚靖教授认为过敏性结膜炎以“风”为主要病因,其中包含外风与血虚内风,治疗上以中药自拟祛风养血方为主,在祛风止痒的基础上兼以养血扶正,使邪去病愈,亦防疾病反复,临床疗效显著。今将姚教授对该病治疗的临床经验予以总结,并附医案一则。Allergic conjunctivitis is a common ophthalmic disease with red eyes, itchy eyes and secretions as the main symptoms. Professor Yao Jing has been engaged in clinical diagnosis and treatment of ophthalmic diseases for many years, and is good at treating ophthalmic diseases from the whole body syndrome differentiation. The author has his own opinion on the pathogenesis and treatment principle of allergic conjunctivitis. Professor Yao Jing believes that allergic conjunctivitis is mainly caused by “wind”, which includes external wind and internal wind deficiency. The treatment is mainly based on traditional Chinese medicine self-designed Qufeng Yangxue prescription. On the basis of dispelling wind and relieving itching, it also adopts nourishing blood to support the right, so as to cure the evil and prevent the recurrence of disease. Today, Professor Yao’s clinical experience in the treatment of the disease is summarized, and a medical case is attached.
文摘目的筛选2型糖尿病(T2DM)大鼠与正常大鼠血液中差异表达的microRNA(miRNA),通过生物信息学分析预测差异miRNA调控的靶基因及功能。方法取20只健康雄性SD大鼠随机分为空白对照组和T2DM模型组,每组10只。采用高脂饲料联合腹腔注射链脲佐菌素(STZ)制作T2DM大鼠模型,2周后提取糖尿病大鼠及正常大鼠全血,应用miRNA测序技术筛选差异miRNA。利用生物信息学方法对差异表达的miRNA靶基因进行基因本体(gene ontology,GO)和KEGG(Kyoto Encyclopedia of Genes and Genomes)通路富集分析。结果与空白对照组相比,T2DM模型组大鼠随机血糖均≥16.7 mmol/L且明显升高、持续稳定。与空白对照组相比,T2DM模型组大鼠血液中共有56个差异表达的miRNA,其中32个上调,24个下调。GO富集分析显示差异表达miRNA的靶基因主要集中在细胞质、细胞核、细胞膜等细胞组分,DNA及RNA的转录调控等生物学过程,与蛋白结合、金属离子结合、ATP结合等分子功能相关。KEGG通路富集分析显示差异表达miRNA的靶基因主要富集于糖尿病并发症、癌症等疾病通路,内吞、自噬等细胞功能通路,MAPK、mTOR、Ras、FoxO等信号通路。结论T2DM模型大鼠血液miRNA较正常大鼠差异表达变化明显,其差异表达的miRNA可能通过影响细胞的炎症免疫反应、增殖、生长分化等功能进而参与糖尿病及其并发症的发生发展。
文摘目的:评价眼针联合鱼腥草注射液超声雾化熏眼治疗干眼症的临床效果。方法:前瞻性选取2022.06~2023.12于我院眼科就诊的干眼症患者62例,采用随机数字表法分为治疗组和对照组,治疗组采用眼针联合鱼腥草注射液超声雾化熏眼,对照组采用单纯鱼腥草注射液超声雾化熏眼,每周治疗5天,连续治疗4周。比较两组治疗前后的眼表疾病指数(OSDI)、泪膜破裂时间(BUT)、泪液分泌试验(SIT)、泪河高度(TMH)及临床疗效。结果:两组患者治疗前OSDI、BUT、SIT、TMH基线水平无统计学差异(P > 0.05)。两组治疗后OSDI评分均下降,且治疗组OSDI评分显著低于对照组(P P P P P < 0.05)。结论:眼针联合鱼腥草注射液雾化熏眼治疗干眼症能够有效改善干眼症患者眼部症状,稳定泪膜状态,提高临床疗效。
文摘目的:探讨基于《黄帝内经》养生理论提出的日常护眼养生模式对非增殖型糖尿病视网膜病变患者的临床应用价值,以期为该类患者的预防调护提供可参考的中医养生护眼方案。方法:选取90 (150眼)例符合纳入标准的非增殖型糖尿病视网膜患者,使用随机数字表法随机分为研究组45例(74眼)和对照组45例(76眼)。两组患者均予以常规治疗,同时研究组采用《黄帝内经》护眼养生调护干预方案,对照组采用常规健康指导方案,6个月后评价及对比两组的疗效、眼底改变、最佳矫正视力、血糖指标、血脂指标、内皮素指标。结果:研究组较治疗组相比,总有效率更高(P 0.05);治疗后,研究组的ET-1水平较对照组更低(P Objective: To investigate the clinical application value of the daily eye care and health care model based on the health care theory of Huangdi Neijing for patients with nonproliferative diabetes retinopathy, and to provide a reference for the prevention and care of such patients. Methods: Ninety sick patients (150 eyes) with nonproliferative diabetes retina who conform to the inclusion criteria were chosen and randomly divided into the study group (74 eyes) and the control group (76 eyes) using the random number table method, with 45 people per group. Both groups of sick patients received routine therapies, while the study group received an intervention plan for eye protection and health preservation according to the Huangdi Neijing. The control group allowed a conventional health instructions plan, and after 6 months, the efficacy, fundus changes, best corrected visual acuity, blood glucose indicators, blood lipid indicators, endothelin indicators, and hemorheological indicators of the two teams were estimated and compared. Results: Compared with the control group, the study group had a higher overall effective rate (P 0.05);after treatment, the ET-1 level in the study group was lower than that in the control group (P < 0.05). Conclusion: The daily eye care and health care mode proposed based on the health care theory of Huangdi Neijing can stabilize vision, and reduce blood sugar and lipid in patients with non proliferative diabetes retinopathy, besides, it can also ameliorate endothelial function. It is an effective and practical TCM health care and eye care mode, which is worthy of clinical promotion and application.
文摘目的:评价调神润目针法结合人工泪液治疗干眼症的临床效果。方法:前瞻性选取2024年1月至2024年10月于黑龙江中医药大学附属第二医院针灸二科就诊的干眼症患者70例,采用随机数字表法分为针药组和药物组,每组35例。针药组采用调神润目针法联合人工泪液治疗,药物组单纯使用人工泪液。疗程为每日1次,连续治疗2周。比较两组治疗前后的眼表疾病指数(OSDI)、泪膜破裂时间(BUT)、泪液分泌试验(SIT)、角膜荧光素染色(FL)及泪河高度(TMH)等指标,评估临床疗效。结果:两组患者治疗前OSDI、BUT、SIT、FL、TMH基线水平无统计学差异(P > 0.05)。治疗后两组OSDI评分均下降,且针药组显著低于药物组(P Objective: To evaluate the clinical efficacy of the Tiaoshen Runmu acupuncture method combined with artificial tears in the treatment of dry eye disease. Methods: A prospective study was conducted from January 2024 to October 2024 at the Acupuncture Department of the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, involving 70 dry eye patients. The patients were randomly divided into two groups: an acupuncture plus medication group (n = 35) and a medication-only group (n = 35). The acupuncture plus medication group received the Tiaoshen Runmu acupuncture method combined with artificial tears, while the medication-only group was treated with artificial tears alone. Treatment was administered once daily for two consecutive weeks. The Ocular Surface Disease Index (OSDI), Tear Film Breakup Time (BUT), Schirmer I Test (SIT), Fluorescein Staining (FL), and Tear Meniscus Height (TMH) were compared between the two groups to assess clinical efficacy. Results: Baseline levels of OSDI, BUT, SIT, FL, and TMH showed no significant differences between the two groups before treatment (P > 0.05). After treatment, OSDI scores in both groups decreased, with the acupuncture plus medication group showing significantly lower OSDI scores than the medication-only group (P < 0.05). BUT, SIT, FL, and TMH all improved significantly in both groups, with the acupuncture plus medication group showing greater improvements compared to the medication-only group (P < 0.05). The total clinical efficacy rate in the acupuncture plus medication group was significantly higher than that of the medication-only group (P < 0.05). Conclusion: The Tiaoshen Runmu acupuncture method combined with artificial tears is effective in improving the symptoms of dry eye disease, promoting tear secretion, and stabilizing tear film. The clinical efficacy is significantly better than artificial tears alone.
