Cross-talk between tumor cells and mechanical stress in the tumor microenvironment has been shown to be involved in carcinogenesis.High mechanical stress in tumors can alter the metabolism and behaviors of cancer cell...Cross-talk between tumor cells and mechanical stress in the tumor microenvironment has been shown to be involved in carcinogenesis.High mechanical stress in tumors can alter the metabolism and behaviors of cancer cells and cause cancer cells to attain cancer stem-like cell properties,thus driving tumor progression and promoting metastasis.The mechanical signal is converted into a biochemical signal that activates tumorigenic signaling pathways through mechanotransduction.Herein,we describe the physical changes occurring during reprogramming of cancer cell metabolism,which regulate cancer stem cell functions and promote tumor progression and aggression.Furthermore,we highlight emerging therapeutic strategies targeting mechanotransduction signaling pathways.展开更多
Lower limb injures are frequently observed in passenger car traffic accidents.Previous studies of the injuries focus on long bone fractures by using either cadaver component tests or simulations of the long bone kinem...Lower limb injures are frequently observed in passenger car traffic accidents.Previous studies of the injuries focus on long bone fractures by using either cadaver component tests or simulations of the long bone kinematics,which lack in-depth study on the fractures in stress analysis.This paper aims to investigate lower limb impact biomechanics in real-world car to pedestrian accidents and to predict fractures of long bones in term of stress parameter for femur,tibia,and fibula.For the above purposes,a 3D finite element(FE) model of human body lower limb(HBM-LL) is developed based on human anatomy.The model consists of the pelvis,femur,tibia,fibula,patella,foot bones,primary tendons,knee joint capsule,meniscus,and ligaments.The FE model is validated by comparing the results from a lateral impact between simulations and tests with cadaver lower limb specimens.Two real-world accidents are selected from an in-depth accident database with detailed information about the accident scene,car impact speed,damage to the car,and pedestrian injuries.Multi-body system(MBS) models are used to reconstruct the kinematics of the pedestrians in the two accidents and the impact conditions are calculated for initial impact velocity and orientations of the car and pedestrian during the collision.The FE model is used to perform injury reconstructions and predict the fractures by using physical parameters,such as von Mises stress of long bones.The calculated failure level of the long bones is correlated with the injury outcomes observed from the two accident cases.The reconstruction result shows that the HBM-LL FE model has acceptable biofidelity and can be applied to predict the risk of long bone fractures.This study provides an efficient methodology to investigate the long bone fracture suffered from vehicle traffic collisions.展开更多
In this paper, the elastic wave propagation in a two-dimensional piezoelectric phononic crystal is studied by considering the mechanic-electric coupling. The generalized eigenvalue equation is obtained by the relation...In this paper, the elastic wave propagation in a two-dimensional piezoelectric phononic crystal is studied by considering the mechanic-electric coupling. The generalized eigenvalue equation is obtained by the relation of the mechanic and electric fields as well as the Bloch-Floquet theorem. The band structures of both the in-plane and anti-plane modes are calculated for a rectangular lattice by the planewave expansion method. The effects of the lattice constant ratio and the piezoelectricity with different filling fractions are analyzed. The results show that the largest gap width is not always obtained for a square lattice. In some situations, a rectangular lattice may generate larger gaps. The band gap characteristics are influenced obviously by the piezoelectricity with the larger lattice constant ratios and the filling fractions.展开更多
Evolution of eukaryotes from simple cells to complex multicellular organisms remains a mystery. Our postulate is that cytoskeletal stiffening is a necessary condition for evolution of complex multicellular organisms f...Evolution of eukaryotes from simple cells to complex multicellular organisms remains a mystery. Our postulate is that cytoskeletal stiffening is a necessary condition for evolution of complex multicellular organisms from early simple eukaryotes. Recent findings show that embryonic stem cells are as soft as primitive eukaryotes-amoebae and that differentiated tissue cells can be two orders of magnitude stiffer than embryonic stem cells. Soft embryonic stem cells become stiff as they differentiate into tissue cells of the complex multicellular organisms to match their microenvironment stiffness. We perhaps see in differentiation of embryonic stem cells (derived from inner cell mass cells) the echo of those early evolutionary events. Early soft unicellular organisms might have evolved to stiffen their cytoskeleton to protect their structural integrity from external mechanical stresses while being able to maintain form, to change shape, and to move.展开更多
Effects of butanol isomers on characteristics of combustion and emission were studied on PFI SI engine. Experiments were operated under the condition of 3 and 5 bar brake mean effective pressure (BMEP) engine loads an...Effects of butanol isomers on characteristics of combustion and emission were studied on PFI SI engine. Experiments were operated under the condition of 3 and 5 bar brake mean effective pressure (BMEP) engine loads and different equivalence ratios (φ=0.83-1.25) with engine speed of 1200 r/min using blends made of 70 vol.% gasoline and 30 vol.% butanol isomers (N30, S30, I30 and T30). The results indicated that compared with gasoline, all butanol isomer blends have higher cylinder pressure. N30 has the highest and most advanced peak pressure, and T30 shows a higher brake specific fuel consumption (BSFC) and lower brake thermal efficiency (BTE). N30 presents a lower UHC emissions and I30 has slightly higher CO emissions than other blends. For unregulated emissions, compared with gasoline, butanol isomer blends have higher acetaldehyde, and N30 produces a higher emission of 1,3-butadiene than other blends. A reduction in benzene, toluene, ethylbenzene and xylene (BTEX) has been found with butanol isomer blends.展开更多
Recently novel mechanisms with compact size and without many mechanical elements such as bearing are strongly required for medical devices such as surgical operation devices. This paper describes analysis and synthesi...Recently novel mechanisms with compact size and without many mechanical elements such as bearing are strongly required for medical devices such as surgical operation devices. This paper describes analysis and synthesis of elastic link mechanisms of a single spring beam which can be manufactured by NC coiling machines. These mechanisms are expected as disposable micro forceps. Smooth Curvature Model（SCM） with 3rd order Legendre polynomial curvature functions is applied to calculate large deformation of a curved cantilever beam by taking account of the balance between external and internal elastic forces and moments. SCM is then extended to analyze large deformation of a closed-loop curved elastic beam which is composed of multiple free curved beams. A closed-loop elastic link is divided into two free curved cantilever beams each of which is assumed as serially connected free curved cantilever beams described with SCM. The sets of coefficients of Legendre polynomials of SCM in all free curved cantilever beams are determined by taking account of the force and moment balance at connecting point where external input force is applied. The sets of coefficients of Legendre polynomials of a nonleaded closed-loop elastic link are optimized to design a link mechanism which can generate specified output motion due to input force applied at the assumed dividing point. For example, two planar micro grippers with a single pulling input force are analyzed and designed. The elastic deformation analyzed with proposed method agrees very well with that calculated with FEM. The designed micro gripper can generate the desired pinching motion. The proposed method can contribute to design compact and simple elastic mechanisms without high calculation costs.展开更多
Wind-tunnel experiments were performed to study the effect of favorable and adverse constant pressure gradients(PG)from local changes in the topography right downwind of a model wind turbine.Particle image velocimetry...Wind-tunnel experiments were performed to study the effect of favorable and adverse constant pressure gradients(PG)from local changes in the topography right downwind of a model wind turbine.Particle image velocimetry was used to characterize the near and intermediate wake regions.We explored five scenarios,two favorable,two adverse PG,and a case with negligible PG.Results show that the PGs induce a wake deflection and modulate the wake.They imposed a relatively small impact on the turbulence kinetic energy and kinematic shear stress but a comparatively dominant effect on the bulk flow on the flow recovery.Based on this,a simple formulation is used to describe the impact of PG on the wake.We modeled the base flow through a linearized perturbation method;the wake is obtained by solving a simplified,integrated streamwise momentum equation.This approach reasonably estimated the flow profile and PG-induced power output variations.展开更多
It is well-known that optimizing the wheel system of lunar rovers is essential.However,this is a difficult task due to the complex terrain of the moon and limited resources onboard lunar rovers.In this study,an experi...It is well-known that optimizing the wheel system of lunar rovers is essential.However,this is a difficult task due to the complex terrain of the moon and limited resources onboard lunar rovers.In this study,an experimental prototype was set up to analyze the existing mechanical design of a lunar rover and improve its performance.First,a new vane-telescopic walking wheel was proposed for the lunar rover with a positive and negative quadrangle suspension,considering the complex terrain of the moon.Next,the performance was optimized under the limitations of preserving the slope passage and minimizing power consumption.This was achieved via analysis of the wheel force during movement.Finally,the effectiveness of the proposed method was demonstrated by several simulation experiments.The newly designed wheel can protrude on demand and reduce energy consumption;it can be used as a reference for lunar rover development engineering in China.展开更多
The nonlinear atomistic interactions usually involve softening behavior. Instability resulting directly from this softening are called the material instability, while those unrelated to this softening are called the s...The nonlinear atomistic interactions usually involve softening behavior. Instability resulting directly from this softening are called the material instability, while those unrelated to this softening are called the structural instability. We use the finite-deformation shell theory based on the interatomic potential to show that the tension instability of single-wall carbon nanotubes is the material instability, while the compression and torsion instabilities are structural instability.展开更多
Despite significant progress in cancer research during the past decades,yet there are no major breakthroughs that can be translated into major benefits for the general public in terms of treatment or therapy for the c...Despite significant progress in cancer research during the past decades,yet there are no major breakthroughs that can be translated into major benefits for the general public in terms of treatment or therapy for the complex neoplastic diseases,especially for the malignant solid tumors.This depressing but indisputable fact leads to a call for new ideas to target tumor metastasis by editors of Nature Medicine<sup>[1]</sup>.The real problems are that the fundamental issues of transformation and malignancy in vivo are poorly understood.In a recent review on cancer,展开更多
A novel extended methodology for chatter suppression in milling process by applying external forced vibrations to the workpiece in two orthogonal directions which are the feed and cross-feed directions.Both the regene...A novel extended methodology for chatter suppression in milling process by applying external forced vibrations to the workpiece in two orthogonal directions which are the feed and cross-feed directions.Both the regenerative and forced chatter suppression during the milling process of flexible workpieces are investigated.Here,the workpiece is subject to a sinusoidal periodic force in the feed direction to disrupt the regenerative effect.Additionally,to minimize the forced chatter,the workpiece is subject to the periodic excitation force in cross-feed direction.This force is proportional to the magnitude of the estimated cutting force in cross-feed direction and has a phase opposite to the cutting force to minimize the vibration amplitudes.The effectiveness of the proposed method is evaluated numerically and experimentally,for the spindle speed located in both the local minima and local maxima of the stability lobe diagram.The numerical simulations indicate significant suppression effect in terms of vibration amplitudes,resulting in suppression of both the regenerative chatter and the forced chatter.Experiments were conducted by using a workpiece-mounted active stage composed of flexure hinges and driven by piezoelectric actuators.The experimental results agree qualitatively with the numerical simulations.The proposed method indicates a remarkable vibration reduction effect for both regenerative and forced chatters.展开更多
We studied consecutive impact loading on woven high-modulus polyethylene rope, which is used in robotics fields. An impact tester was developed to conduct the experiments. Five consecutive impact loads (five drops) we...We studied consecutive impact loading on woven high-modulus polyethylene rope, which is used in robotics fields. An impact tester was developed to conduct the experiments. Five consecutive impact loads (five drops) were applied to the rope and the stiffness of the loading part that corresponds to each drop was evaluated. The stiffness of the woven ropes was affected strongly by consecutive impact loading. The change in stiffness is undesirable in some applications such as in robotic fields. Therefore, we have proposed a method that can optimize changes in stiffness by applying a preload before impact testing (preload treatment). The experimental results show that preload is an efficient way to reduce changing rope stiffness. We have also proposed an empirical equation that can estimate the rope stiffness after arbitrary preload treatment, and this equation is a function of the number of drops and the static preload level. The equation can be used to determine the preload treatment conditions to stabilize the stiffness of the woven ropes before they are used in engineering fields.展开更多
A new simultaneous measurement method for the measurement of the three thermoelectric properties with a film-type thermocouple probe was proposed. Seebeck coefficient was measured using the steady-state condi-tion of ...A new simultaneous measurement method for the measurement of the three thermoelectric properties with a film-type thermocouple probe was proposed. Seebeck coefficient was measured using the steady-state condi-tion of the differential method. The electrical resistivity was measured us-ing the four-probe method and the thermal diffusivity is measured using the periodic heating method. The effectiveness of the proposed method was verified using constantan as a reference material. After describing the effectiveness of the method, the measurement of three thermoelectric properties of Bi0.3Sb1.7Te3, which is a thermoelectric material, was per-formed.展开更多
The elastic wave localization in disordered periodic piezoelectric rods with initial stress is studied using the transfer matrix and Lyapunov exponent method. The electric field is approximated as quasi-static. The ef...The elastic wave localization in disordered periodic piezoelectric rods with initial stress is studied using the transfer matrix and Lyapunov exponent method. The electric field is approximated as quasi-static. The effects of the initial stress on the band gap characteristics are investigated. The numerical calculations of localization factors and localization lengths are performed. It can be observed from the results that the band structures can be tuned by exerting the suitable initial stress. For different values of the piezoelectric rod length and the elastic constant, the band structures and the localization phenomena are very different. Larger disorder degree can lead to more obvious localization phenomenon.展开更多
In order to eliminate noise interference of metal magnetic memory signal in early diagnosis of stress concentration zones and metal defects, the empirical mode decomposition method combined with the magnetic field gra...In order to eliminate noise interference of metal magnetic memory signal in early diagnosis of stress concentration zones and metal defects, the empirical mode decomposition method combined with the magnetic field gradient characteristic was proposed. A compressive force periodically acting upon a casing pipe led to appreciable deformation, and magnetic signals were measured by a magnetic indicator TSC-1M-4. The raw magnetic memory signal was first decomposed into different intrinsic mode functions and a residue, and the magnetic field gradient distribution of the subsequent reconstructed signal was obtained. The experimental results show that the gradient around 350 mm represents the maximum value ignoring the marginal effect, and there is a good correlation between the real maximum field gradient and the stress concentration zone. The wavelet transform associated with envelop analysis also exhibits this gradient characteristic, indicating that the proposed method is effective for early identifying critical zones.展开更多
Harmonic thermoelastic waves in helical strands with Maxwell–Cattaneo heat conduction areinvestigated analytically and numerically. The corresponding dispersion relation is a sixth-orderalgebraic equation, governed b...Harmonic thermoelastic waves in helical strands with Maxwell–Cattaneo heat conduction areinvestigated analytically and numerically. The corresponding dispersion relation is a sixth-orderalgebraic equation, governed by six non-dimensional parameters: two thermoelastic couplingconstants, one chirality parameter, the ratio between extensional and torsional moduli, the Fouriernumber, and the dimensionless thermal relaxation. The behavior of the solutions is discussedfrom two perspectives with an asymptotic-numerical approach: (1) the effect of thermal relaxationon the elastic wave celerities, and (2) the effect of thermoelastic coupling on the thermal wavecelerities. With small wavenumbers, the adiabatic solution for Fourier helical strands is recovered.However, with large wavenumbers, the solutions behave differently depending on the thermalrelaxation and chirality. Due to thermoelastic coupling, the thermal wave celerity deviates from theclassical result of the speed of second sound.展开更多
An elastic-viscoplastic model is used on the finite element package Abaqus to simulate the thermal and mechanical behavior of bloom casting strand and predict the location and scale of centerline cracks. The formation...An elastic-viscoplastic model is used on the finite element package Abaqus to simulate the thermal and mechanical behavior of bloom casting strand and predict the location and scale of centerline cracks. The formation of centerline cracks can be investigated by the application of this model, which is of benefit to the improvement of processing.展开更多
The current research on self-resonating cavitating waterjet（SRCW） mainly focuses on the generation mechanism and structure optimization.Researches relating to the influences of disturbances at nozzle inlet on the ch...The current research on self-resonating cavitating waterjet（SRCW） mainly focuses on the generation mechanism and structure optimization.Researches relating to the influences of disturbances at nozzle inlet on the characteristics of the jet are rarely available.In order to further improve the performance of SRCW,effects of area discontinuity（enlargement and contraction） are experimentally investigated using three organ-pipe nozzles.Axial pressure oscillation peak and amplitude as well as aggressive erosion intensity of the jet are used to evaluate the effects.The results reveal that area enlargement and contraction affect the peak differently,depending on the inlet pressure,nozzle geometry,and standoff distance;while area contraction always improves the amplitude regardless of these factors.At inlet pressures of 10 MPa and 20 MPa,area discontinuity improves the peak at almost all the testing standoff distances,while this only happens at smaller standoff distances with the inlet pressure increased to 30 MPa.The capability of area discontinuity for improving the amplitude is enhancing with increasing inlet pressure.Moreover,the cavitation erosion ability of the jet can be largely enhanced around the optimum standoff distance,depending on the type of area discontinuity and nozzle geometry.A preliminary analysis of the influence of area discontinuity on the disturbance waves in the flow is also performed.The proposed research provides a new method for effectively enhancing the performance of SRCW.展开更多
Introduction Cells can sense and respond to the mechanical microenvironment by converting forces into biochemical signals inside the cells,i.e.mechanotransduction<sup>[1-3]</sup>.Focal adhesions are the ma...Introduction Cells can sense and respond to the mechanical microenvironment by converting forces into biochemical signals inside the cells,i.e.mechanotransduction<sup>[1-3]</sup>.Focal adhesions are the major sites of interaction between a cell and its extracellular matrix（ECM）microenvironment,thus outside mechanical signals can be sensed at focal adhesions through transmembrane receptor integrins.In particular,it has been shown that matrix elasticity can control the cell fate<sup>[4]</sup>by modulating the interactions between ECM proteins and their receptor integrins<sup>[5,6]</sup>.For example,different rigidity of polyacrylamide（PA）gels can lead to different density of ECM ancho-展开更多
Self-sensing multifunctional composite has sensing function using electrical resistance changes. Carbon Fiber Reinforced Polymer (CFRP) composite is one of the self-sensing multifunctional composites. For the reliabil...Self-sensing multifunctional composite has sensing function using electrical resistance changes. Carbon Fiber Reinforced Polymer (CFRP) composite is one of the self-sensing multifunctional composites. For the reliability of the self-sensing, electrical contact between the lead wire and the carbon fibers is the most important issue. The present study focuses on the effect of the cyclic loading of lower applied strain range than the fatigue damage level. As a result, the electrical contact resistance at the copper electrode increased with the increase of cycles. That means that the electrical change at the electrodes must be considered for the long-term self-sensing monitoring system. When a four-probe method is used to measure the electrical resistance, the contact resistance effect is minimized. Moreover, angle-ply laminates have plastic deformation caused by shear loading, and that causes electrical resistance decrease during the cyclic loading. Cross-ply laminates of CFRP composites have no electrical resistance increase without damage. Quasi-isotropic laminates of CFRP composites, however, have electrical resistance decrease with the increase of the number of cycles because of the plastic deformation of the angle-ply laminates.展开更多
基金the National Natural Science Foundation of China(Grant No.11832008 and 11772073)by the Program of the Postgraduate Tutor Team,Chongqing Education Commission(2018).
文摘Cross-talk between tumor cells and mechanical stress in the tumor microenvironment has been shown to be involved in carcinogenesis.High mechanical stress in tumors can alter the metabolism and behaviors of cancer cells and cause cancer cells to attain cancer stem-like cell properties,thus driving tumor progression and promoting metastasis.The mechanical signal is converted into a biochemical signal that activates tumorigenic signaling pathways through mechanotransduction.Herein,we describe the physical changes occurring during reprogramming of cancer cell metabolism,which regulate cancer stem cell functions and promote tumor progression and aggression.Furthermore,we highlight emerging therapeutic strategies targeting mechanotransduction signaling pathways.
基金supported by National Hi-tech Research and Development Program of China (863 Program,Grant No. 2006AA110101)"111 Program" of Ministry of Education and State Administration of Foreign Experts Affairs of China (Grant No. 111-2-11)+1 种基金General Motors Research and Development Center (Grant No. RD-209)Project of State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body,Hunan University,China (Grant No. 60870004)
文摘Lower limb injures are frequently observed in passenger car traffic accidents.Previous studies of the injuries focus on long bone fractures by using either cadaver component tests or simulations of the long bone kinematics,which lack in-depth study on the fractures in stress analysis.This paper aims to investigate lower limb impact biomechanics in real-world car to pedestrian accidents and to predict fractures of long bones in term of stress parameter for femur,tibia,and fibula.For the above purposes,a 3D finite element(FE) model of human body lower limb(HBM-LL) is developed based on human anatomy.The model consists of the pelvis,femur,tibia,fibula,patella,foot bones,primary tendons,knee joint capsule,meniscus,and ligaments.The FE model is validated by comparing the results from a lateral impact between simulations and tests with cadaver lower limb specimens.Two real-world accidents are selected from an in-depth accident database with detailed information about the accident scene,car impact speed,damage to the car,and pedestrian injuries.Multi-body system(MBS) models are used to reconstruct the kinematics of the pedestrians in the two accidents and the impact conditions are calculated for initial impact velocity and orientations of the car and pedestrian during the collision.The FE model is used to perform injury reconstructions and predict the fractures by using physical parameters,such as von Mises stress of long bones.The calculated failure level of the long bones is correlated with the injury outcomes observed from the two accident cases.The reconstruction result shows that the HBM-LL FE model has acceptable biofidelity and can be applied to predict the risk of long bone fractures.This study provides an efficient methodology to investigate the long bone fracture suffered from vehicle traffic collisions.
基金the National Natural Science Foundation of China (10672017 and 10632020)
文摘In this paper, the elastic wave propagation in a two-dimensional piezoelectric phononic crystal is studied by considering the mechanic-electric coupling. The generalized eigenvalue equation is obtained by the relation of the mechanic and electric fields as well as the Bloch-Floquet theorem. The band structures of both the in-plane and anti-plane modes are calculated for a rectangular lattice by the planewave expansion method. The effects of the lattice constant ratio and the piezoelectricity with different filling fractions are analyzed. The results show that the largest gap width is not always obtained for a square lattice. In some situations, a rectangular lattice may generate larger gaps. The band gap characteristics are influenced obviously by the piezoelectricity with the larger lattice constant ratios and the filling fractions.
文摘Evolution of eukaryotes from simple cells to complex multicellular organisms remains a mystery. Our postulate is that cytoskeletal stiffening is a necessary condition for evolution of complex multicellular organisms from early simple eukaryotes. Recent findings show that embryonic stem cells are as soft as primitive eukaryotes-amoebae and that differentiated tissue cells can be two orders of magnitude stiffer than embryonic stem cells. Soft embryonic stem cells become stiff as they differentiate into tissue cells of the complex multicellular organisms to match their microenvironment stiffness. We perhaps see in differentiation of embryonic stem cells (derived from inner cell mass cells) the echo of those early evolutionary events. Early soft unicellular organisms might have evolved to stiffen their cytoskeleton to protect their structural integrity from external mechanical stresses while being able to maintain form, to change shape, and to move.
基金Projects(51776016,51606006) supported by the National Natural Science Foundation of ChinaProjects(3172025,3182030) supported by Beijing Natural Science Foundation,China+4 种基金Project(2017YFB0103401) supported by National Key Research and Development ProgramProject(NELMS2017A10) funded by the National Engineering Laboratory for Mobile Source Emission Control Technology,ChinaProject(2018RC017) supported by the Talents Foundation of Beijing Jiaotong University,ChinaProject(DE-EE0006864) supported by the Department of EnergyProject(201507090044) supported by China Scholarship Council
文摘Effects of butanol isomers on characteristics of combustion and emission were studied on PFI SI engine. Experiments were operated under the condition of 3 and 5 bar brake mean effective pressure (BMEP) engine loads and different equivalence ratios (φ=0.83-1.25) with engine speed of 1200 r/min using blends made of 70 vol.% gasoline and 30 vol.% butanol isomers (N30, S30, I30 and T30). The results indicated that compared with gasoline, all butanol isomer blends have higher cylinder pressure. N30 has the highest and most advanced peak pressure, and T30 shows a higher brake specific fuel consumption (BSFC) and lower brake thermal efficiency (BTE). N30 presents a lower UHC emissions and I30 has slightly higher CO emissions than other blends. For unregulated emissions, compared with gasoline, butanol isomer blends have higher acetaldehyde, and N30 produces a higher emission of 1,3-butadiene than other blends. A reduction in benzene, toluene, ethylbenzene and xylene (BTEX) has been found with butanol isomer blends.
文摘Recently novel mechanisms with compact size and without many mechanical elements such as bearing are strongly required for medical devices such as surgical operation devices. This paper describes analysis and synthesis of elastic link mechanisms of a single spring beam which can be manufactured by NC coiling machines. These mechanisms are expected as disposable micro forceps. Smooth Curvature Model（SCM） with 3rd order Legendre polynomial curvature functions is applied to calculate large deformation of a curved cantilever beam by taking account of the balance between external and internal elastic forces and moments. SCM is then extended to analyze large deformation of a closed-loop curved elastic beam which is composed of multiple free curved beams. A closed-loop elastic link is divided into two free curved cantilever beams each of which is assumed as serially connected free curved cantilever beams described with SCM. The sets of coefficients of Legendre polynomials of SCM in all free curved cantilever beams are determined by taking account of the force and moment balance at connecting point where external input force is applied. The sets of coefficients of Legendre polynomials of a nonleaded closed-loop elastic link are optimized to design a link mechanism which can generate specified output motion due to input force applied at the assumed dividing point. For example, two planar micro grippers with a single pulling input force are analyzed and designed. The elastic deformation analyzed with proposed method agrees very well with that calculated with FEM. The designed micro gripper can generate the desired pinching motion. The proposed method can contribute to design compact and simple elastic mechanisms without high calculation costs.
基金supported by the Department of Mechanical Science and Engineering at the University of Illinois.
文摘Wind-tunnel experiments were performed to study the effect of favorable and adverse constant pressure gradients(PG)from local changes in the topography right downwind of a model wind turbine.Particle image velocimetry was used to characterize the near and intermediate wake regions.We explored five scenarios,two favorable,two adverse PG,and a case with negligible PG.Results show that the PGs induce a wake deflection and modulate the wake.They imposed a relatively small impact on the turbulence kinetic energy and kinematic shear stress but a comparatively dominant effect on the bulk flow on the flow recovery.Based on this,a simple formulation is used to describe the impact of PG on the wake.We modeled the base flow through a linearized perturbation method;the wake is obtained by solving a simplified,integrated streamwise momentum equation.This approach reasonably estimated the flow profile and PG-induced power output variations.
文摘It is well-known that optimizing the wheel system of lunar rovers is essential.However,this is a difficult task due to the complex terrain of the moon and limited resources onboard lunar rovers.In this study,an experimental prototype was set up to analyze the existing mechanical design of a lunar rover and improve its performance.First,a new vane-telescopic walking wheel was proposed for the lunar rover with a positive and negative quadrangle suspension,considering the complex terrain of the moon.Next,the performance was optimized under the limitations of preserving the slope passage and minimizing power consumption.This was achieved via analysis of the wheel force during movement.Finally,the effectiveness of the proposed method was demonstrated by several simulation experiments.The newly designed wheel can protrude on demand and reduce energy consumption;it can be used as a reference for lunar rover development engineering in China.
基金ONR Composites for Marine Structures Program(grant N00014-01-1-0205,Program Manager Dr.Y.D.S.Rajapakse)the National Basic Research Program of China(973 Program,2007CB936803)+1 种基金the NSFCMinistry of Education of China
文摘The nonlinear atomistic interactions usually involve softening behavior. Instability resulting directly from this softening are called the material instability, while those unrelated to this softening are called the structural instability. We use the finite-deformation shell theory based on the interatomic potential to show that the tension instability of single-wall carbon nanotubes is the material instability, while the compression and torsion instabilities are structural instability.
基金supported by the funds from Huazhong University of Science and TechnologyUS NIH grant GM072744
文摘Despite significant progress in cancer research during the past decades,yet there are no major breakthroughs that can be translated into major benefits for the general public in terms of treatment or therapy for the complex neoplastic diseases,especially for the malignant solid tumors.This depressing but indisputable fact leads to a call for new ideas to target tumor metastasis by editors of Nature Medicine<sup>[1]</sup>.The real problems are that the fundamental issues of transformation and malignancy in vivo are poorly understood.In a recent review on cancer,
文摘A novel extended methodology for chatter suppression in milling process by applying external forced vibrations to the workpiece in two orthogonal directions which are the feed and cross-feed directions.Both the regenerative and forced chatter suppression during the milling process of flexible workpieces are investigated.Here,the workpiece is subject to a sinusoidal periodic force in the feed direction to disrupt the regenerative effect.Additionally,to minimize the forced chatter,the workpiece is subject to the periodic excitation force in cross-feed direction.This force is proportional to the magnitude of the estimated cutting force in cross-feed direction and has a phase opposite to the cutting force to minimize the vibration amplitudes.The effectiveness of the proposed method is evaluated numerically and experimentally,for the spindle speed located in both the local minima and local maxima of the stability lobe diagram.The numerical simulations indicate significant suppression effect in terms of vibration amplitudes,resulting in suppression of both the regenerative chatter and the forced chatter.Experiments were conducted by using a workpiece-mounted active stage composed of flexure hinges and driven by piezoelectric actuators.The experimental results agree qualitatively with the numerical simulations.The proposed method indicates a remarkable vibration reduction effect for both regenerative and forced chatters.
文摘We studied consecutive impact loading on woven high-modulus polyethylene rope, which is used in robotics fields. An impact tester was developed to conduct the experiments. Five consecutive impact loads (five drops) were applied to the rope and the stiffness of the loading part that corresponds to each drop was evaluated. The stiffness of the woven ropes was affected strongly by consecutive impact loading. The change in stiffness is undesirable in some applications such as in robotic fields. Therefore, we have proposed a method that can optimize changes in stiffness by applying a preload before impact testing (preload treatment). The experimental results show that preload is an efficient way to reduce changing rope stiffness. We have also proposed an empirical equation that can estimate the rope stiffness after arbitrary preload treatment, and this equation is a function of the number of drops and the static preload level. The equation can be used to determine the preload treatment conditions to stabilize the stiffness of the woven ropes before they are used in engineering fields.
文摘A new simultaneous measurement method for the measurement of the three thermoelectric properties with a film-type thermocouple probe was proposed. Seebeck coefficient was measured using the steady-state condi-tion of the differential method. The electrical resistivity was measured us-ing the four-probe method and the thermal diffusivity is measured using the periodic heating method. The effectiveness of the proposed method was verified using constantan as a reference material. After describing the effectiveness of the method, the measurement of three thermoelectric properties of Bi0.3Sb1.7Te3, which is a thermoelectric material, was per-formed.
基金supported by the National Natural Science Foundation of China(Grant Nos.10672017 and 10632020)the China Postdoctoral Science Foundation,Heilongjiang Province Postdoctoral Science Foundation Japan Society for the Promotion of Science(JSPS) to perform research work at Tokyo Institute of Technology,Japan.
文摘The elastic wave localization in disordered periodic piezoelectric rods with initial stress is studied using the transfer matrix and Lyapunov exponent method. The electric field is approximated as quasi-static. The effects of the initial stress on the band gap characteristics are investigated. The numerical calculations of localization factors and localization lengths are performed. It can be observed from the results that the band structures can be tuned by exerting the suitable initial stress. For different values of the piezoelectric rod length and the elastic constant, the band structures and the localization phenomena are very different. Larger disorder degree can lead to more obvious localization phenomenon.
基金Project(10772061) supported by the National Natural Science Foundation of ChinaProject(A200907) supported by the Natural Science Foundation of Heilongjiang Province, China Project(20092322120001) supported by the PhD Programs Foundations of Ministry of Education of China
文摘In order to eliminate noise interference of metal magnetic memory signal in early diagnosis of stress concentration zones and metal defects, the empirical mode decomposition method combined with the magnetic field gradient characteristic was proposed. A compressive force periodically acting upon a casing pipe led to appreciable deformation, and magnetic signals were measured by a magnetic indicator TSC-1M-4. The raw magnetic memory signal was first decomposed into different intrinsic mode functions and a residue, and the magnetic field gradient distribution of the subsequent reconstructed signal was obtained. The experimental results show that the gradient around 350 mm represents the maximum value ignoring the marginal effect, and there is a good correlation between the real maximum field gradient and the stress concentration zone. The wavelet transform associated with envelop analysis also exhibits this gradient characteristic, indicating that the proposed method is effective for early identifying critical zones.
基金supported by the National Science Foundation of United States (Grants IIP-1362146 and CMMI-1462749)
文摘Harmonic thermoelastic waves in helical strands with Maxwell–Cattaneo heat conduction areinvestigated analytically and numerically. The corresponding dispersion relation is a sixth-orderalgebraic equation, governed by six non-dimensional parameters: two thermoelastic couplingconstants, one chirality parameter, the ratio between extensional and torsional moduli, the Fouriernumber, and the dimensionless thermal relaxation. The behavior of the solutions is discussedfrom two perspectives with an asymptotic-numerical approach: (1) the effect of thermal relaxationon the elastic wave celerities, and (2) the effect of thermoelastic coupling on the thermal wavecelerities. With small wavenumbers, the adiabatic solution for Fourier helical strands is recovered.However, with large wavenumbers, the solutions behave differently depending on the thermalrelaxation and chirality. Due to thermoelastic coupling, the thermal wave celerity deviates from theclassical result of the speed of second sound.
文摘An elastic-viscoplastic model is used on the finite element package Abaqus to simulate the thermal and mechanical behavior of bloom casting strand and predict the location and scale of centerline cracks. The formation of centerline cracks can be investigated by the application of this model, which is of benefit to the improvement of processing.
基金Supported by National Key Basic Research Program of China(973 Program,Grant No.2014CB239203)National Natural Science Foundation of China(Grant No.51474158)China Scholarship Council(Grant No.201406270047)
文摘The current research on self-resonating cavitating waterjet（SRCW） mainly focuses on the generation mechanism and structure optimization.Researches relating to the influences of disturbances at nozzle inlet on the characteristics of the jet are rarely available.In order to further improve the performance of SRCW,effects of area discontinuity（enlargement and contraction） are experimentally investigated using three organ-pipe nozzles.Axial pressure oscillation peak and amplitude as well as aggressive erosion intensity of the jet are used to evaluate the effects.The results reveal that area enlargement and contraction affect the peak differently,depending on the inlet pressure,nozzle geometry,and standoff distance;while area contraction always improves the amplitude regardless of these factors.At inlet pressures of 10 MPa and 20 MPa,area discontinuity improves the peak at almost all the testing standoff distances,while this only happens at smaller standoff distances with the inlet pressure increased to 30 MPa.The capability of area discontinuity for improving the amplitude is enhancing with increasing inlet pressure.Moreover,the cavitation erosion ability of the jet can be largely enhanced around the optimum standoff distance,depending on the type of area discontinuity and nozzle geometry.A preliminary analysis of the influence of area discontinuity on the disturbance waves in the flow is also performed.The proposed research provides a new method for effectively enhancing the performance of SRCW.
基金supported in part by NIH HL098472NSF CBET0846429
文摘Introduction Cells can sense and respond to the mechanical microenvironment by converting forces into biochemical signals inside the cells,i.e.mechanotransduction<sup>[1-3]</sup>.Focal adhesions are the major sites of interaction between a cell and its extracellular matrix（ECM）microenvironment,thus outside mechanical signals can be sensed at focal adhesions through transmembrane receptor integrins.In particular,it has been shown that matrix elasticity can control the cell fate<sup>[4]</sup>by modulating the interactions between ECM proteins and their receptor integrins<sup>[5,6]</sup>.For example,different rigidity of polyacrylamide（PA）gels can lead to different density of ECM ancho-
文摘Self-sensing multifunctional composite has sensing function using electrical resistance changes. Carbon Fiber Reinforced Polymer (CFRP) composite is one of the self-sensing multifunctional composites. For the reliability of the self-sensing, electrical contact between the lead wire and the carbon fibers is the most important issue. The present study focuses on the effect of the cyclic loading of lower applied strain range than the fatigue damage level. As a result, the electrical contact resistance at the copper electrode increased with the increase of cycles. That means that the electrical change at the electrodes must be considered for the long-term self-sensing monitoring system. When a four-probe method is used to measure the electrical resistance, the contact resistance effect is minimized. Moreover, angle-ply laminates have plastic deformation caused by shear loading, and that causes electrical resistance decrease during the cyclic loading. Cross-ply laminates of CFRP composites have no electrical resistance increase without damage. Quasi-isotropic laminates of CFRP composites, however, have electrical resistance decrease with the increase of the number of cycles because of the plastic deformation of the angle-ply laminates.
