Convenient,rapid,and accurate detection of cardiac troponin I(cTnI)is crucial in early diagnosis of acute myocardial infarction(AMI).A paper-based electrochemical immunosensor is a promising choice in this field,becau...Convenient,rapid,and accurate detection of cardiac troponin I(cTnI)is crucial in early diagnosis of acute myocardial infarction(AMI).A paper-based electrochemical immunosensor is a promising choice in this field,because of the flexibility,porosity,and cost-efficacy of the paper.However,paper is poor in electronic conductivity and surface functionality.Herein,we report a paper-based electrochemical immunosensor for the label-free detection of cTnI with the working electrode modified by MXene(Ti_(3)C_(2))nanosheets.In order to immobilize the bio-receptor(anti-cTnI)on the MXene-modified working electrode,the MXene nanosheets were functionalized by aminosilane,and the functionalized MXene was immobilized onto the surface of the working electrode through Nafion.The large surface area of the MXene nanosheets facilitates the immobilization of antibodies,and the excellent conductivity facilitates the electron transfer between the electrochemical species and the underlying electrode surface.As a result,the paper-based immunosensor could detect cTnI within a wide range of 5-100 ng/mL with a detection limit of 0.58 ng/mL.The immunosensor also shows outstanding selectivity and good repeatability.Our MXene-modified paper-based electrochemical immunosensor enables fast and sensitive detection of cTnI,which may be used in real-time and cost-efficient monitoring of AMI diseases in clinics.展开更多
Recently perovskite solar cells(PSCs),as photoelectric conversion devices,exhibit excellent power conversion efficiency(PCE)and low-processing cost,and have become one of the most promising devices to replace conventi...Recently perovskite solar cells(PSCs),as photoelectric conversion devices,exhibit excellent power conversion efficiency(PCE)and low-processing cost,and have become one of the most promising devices to replace conventional silicon-based solar cells and address current pressing energy issues.Among them,the flexible PSCs are especially more widely applicable and may propel the rapid advancements of wearable electronics,causing a significant paradigm shift in consumer electronics.Current flexible PSCs use non-biodegradable petroleum-based polymer substrates,discarding of which will aggravate“white pollution”.Therefore,development of green,biodegradable and low-cost flexible substrates will provide a great alternative to flexible PSCs.Here we have developed transparent nanocellulose paper(NCP)with coating of acrylic resin as substrates to fabricate flexible PSCs,which are biodegradable and easily disposable.The PCE of these NCP-based PSCs reached 4.25%,while the power per weight(the ratio of power to device weight)was as high as 0.56 W g^(–1).The flexible PSCs also showed good stability,retaining>80%of original efficiency after 50 times of bending.The NCP-based substrates can also be applied to other electronic systems,which may prosper next-generation green flexible electronics.展开更多
基金financially supported by the National Key R&D Program of China(2017YFA0204700)the Joint Research Funds of Department of Science&Technology of Shaanxi Province and Northwestern Polytechnical University(2020GXLH-Z-021)+1 种基金the China-Sweden Joint Mobility Project(51811530018)the Fundamental Research Funds for the Central Universities.
文摘Convenient,rapid,and accurate detection of cardiac troponin I(cTnI)is crucial in early diagnosis of acute myocardial infarction(AMI).A paper-based electrochemical immunosensor is a promising choice in this field,because of the flexibility,porosity,and cost-efficacy of the paper.However,paper is poor in electronic conductivity and surface functionality.Herein,we report a paper-based electrochemical immunosensor for the label-free detection of cTnI with the working electrode modified by MXene(Ti_(3)C_(2))nanosheets.In order to immobilize the bio-receptor(anti-cTnI)on the MXene-modified working electrode,the MXene nanosheets were functionalized by aminosilane,and the functionalized MXene was immobilized onto the surface of the working electrode through Nafion.The large surface area of the MXene nanosheets facilitates the immobilization of antibodies,and the excellent conductivity facilitates the electron transfer between the electrochemical species and the underlying electrode surface.As a result,the paper-based immunosensor could detect cTnI within a wide range of 5-100 ng/mL with a detection limit of 0.58 ng/mL.The immunosensor also shows outstanding selectivity and good repeatability.Our MXene-modified paper-based electrochemical immunosensor enables fast and sensitive detection of cTnI,which may be used in real-time and cost-efficient monitoring of AMI diseases in clinics.
基金This work was financially supported by the National Natural Science Foundation of China(Grants 21675085,51602149,61705102,and 91733302)the National Key R&D Program of China(Grant 2017YFA0204700)+3 种基金the National Basic Research Program of China,Fundamental Studies of Perovskite Solar Cells(Grant 2015CB932200)the Natural Science Foundation of Jiangsu Province for Distinguished Young Scholars(Grant BK20170042)the Natural Science Foundation of Jiangsu Province(Grants BK20161011 and BK20161010)Young 1000 Talents Global Recruitment Program of China,Jiangsu Specially-Appointed Professor Program,and“Six Talent Peaks”Project in Jiangsu Province,China.
文摘Recently perovskite solar cells(PSCs),as photoelectric conversion devices,exhibit excellent power conversion efficiency(PCE)and low-processing cost,and have become one of the most promising devices to replace conventional silicon-based solar cells and address current pressing energy issues.Among them,the flexible PSCs are especially more widely applicable and may propel the rapid advancements of wearable electronics,causing a significant paradigm shift in consumer electronics.Current flexible PSCs use non-biodegradable petroleum-based polymer substrates,discarding of which will aggravate“white pollution”.Therefore,development of green,biodegradable and low-cost flexible substrates will provide a great alternative to flexible PSCs.Here we have developed transparent nanocellulose paper(NCP)with coating of acrylic resin as substrates to fabricate flexible PSCs,which are biodegradable and easily disposable.The PCE of these NCP-based PSCs reached 4.25%,while the power per weight(the ratio of power to device weight)was as high as 0.56 W g^(–1).The flexible PSCs also showed good stability,retaining>80%of original efficiency after 50 times of bending.The NCP-based substrates can also be applied to other electronic systems,which may prosper next-generation green flexible electronics.
