The efficiency of devices for bioelectronic applications,including cell and tissue stimulation,is heavily dependent on the scale and the performance level.With miniaturization of stimulation electrodes,achieving a suf...The efficiency of devices for bioelectronic applications,including cell and tissue stimulation,is heavily dependent on the scale and the performance level.With miniaturization of stimulation electrodes,achieving a sufficiently high current pulse to elicit action potentials becomes an issue.Herein we report on our approach of vertically stacking organic p-n junctions to create highlyefficient multilayered organic semiconductor(MOS)photostimulation device.A tandem arrangement substantially increases the photovoltage and charge density without sacrificing lateral area,while not exceeding 200-500 nm of thickness.These devices generate 4 times higher voltages and at least double the charge densities over single p-n junction devices,which allow using lower light intensities for stimulation.MOS devices show an outstanding stability in the electrolyte that is extremely important for forthcoming in vivo experiments.Finally,we have validated MOS devices performance by photostimulating fibroblasts and neuroblasts,and found that using tandem devices leads to more effective action potential generation.As a result,we obtained up to 4 times enhanced effect in cell growth density using 3 p-n layered devices.These results corroborate the conclusion that MOS technology not only can achieve parity with state-of-the-art silicon devices,but also can exceed them in miniaturization and performance for biomedical applications.展开更多
Ferritin has been widely used in drug delivery in recent years due to its unique spherical nanocage structure.In addition,the natural targeting and good biocompatibility of ferritin make it an excellent drug delivery ...Ferritin has been widely used in drug delivery in recent years due to its unique spherical nanocage structure.In addition,the natural targeting and good biocompatibility of ferritin make it an excellent drug delivery system.Therefore,ferritin has shown a broad application prospect in the field of nanomedicine.In this perspective,we will describe ferritin-based drug delivery system,ferritin-based drug delivery system for tumor treatment,and future challenges in ferritin development.Hopefully,this perspective may inspire the future development of ferritin-based drug delivery systems for tumor treatment.展开更多
Intelligent drug delivery system based on “stimulus-response”mode emerging a promising perspective in next generation lipidbased nanoparticle.Here,we classify signal sources into physical and physiological stimulati...Intelligent drug delivery system based on “stimulus-response”mode emerging a promising perspective in next generation lipidbased nanoparticle.Here,we classify signal sources into physical and physiological stimulation according to their origin.展开更多
基金funded by the Ministry of Science and Higher Education of the Russian Federation(No.075-15-2021-596).
文摘The efficiency of devices for bioelectronic applications,including cell and tissue stimulation,is heavily dependent on the scale and the performance level.With miniaturization of stimulation electrodes,achieving a sufficiently high current pulse to elicit action potentials becomes an issue.Herein we report on our approach of vertically stacking organic p-n junctions to create highlyefficient multilayered organic semiconductor(MOS)photostimulation device.A tandem arrangement substantially increases the photovoltage and charge density without sacrificing lateral area,while not exceeding 200-500 nm of thickness.These devices generate 4 times higher voltages and at least double the charge densities over single p-n junction devices,which allow using lower light intensities for stimulation.MOS devices show an outstanding stability in the electrolyte that is extremely important for forthcoming in vivo experiments.Finally,we have validated MOS devices performance by photostimulating fibroblasts and neuroblasts,and found that using tandem devices leads to more effective action potential generation.As a result,we obtained up to 4 times enhanced effect in cell growth density using 3 p-n layered devices.These results corroborate the conclusion that MOS technology not only can achieve parity with state-of-the-art silicon devices,but also can exceed them in miniaturization and performance for biomedical applications.
基金Ministry of Science and Higher Education of the Russian Federation,Grant/Award Number:075-15-2021-596Science Fund for Creative Research Groups of Nature Science Foundation of Hebei Province,Grant/Award Number:B2021201038+3 种基金National Key Research&Development Program of China,Grant/Award Numbers:2021YFA1201000,2018YFE0117800the Beijing-Tianjin-Hebei Basic Research Cooperation Project,Grant/Award Number:19JCZDJC64100NSFC international collaboration,Grant/Award Number:51861135103National Natural Science Foundation of China,Grant/Award Numbers:32030060,82202336。
文摘Ferritin has been widely used in drug delivery in recent years due to its unique spherical nanocage structure.In addition,the natural targeting and good biocompatibility of ferritin make it an excellent drug delivery system.Therefore,ferritin has shown a broad application prospect in the field of nanomedicine.In this perspective,we will describe ferritin-based drug delivery system,ferritin-based drug delivery system for tumor treatment,and future challenges in ferritin development.Hopefully,this perspective may inspire the future development of ferritin-based drug delivery systems for tumor treatment.
基金This work was supported by Beijing Natural Science Foundation(7214283)the National Key Research&Development Program of China(grant Nos.2021YFA1201000 and 2018YFE0117800)+3 种基金National Natural Science Foundation of China(NSFC)Key Project(grant No.32030060)NSFC International CollaborationKey Project(grant No.51861135103)The authors also appreciate the support by the Beijing-Tianjin-Hebei Basic Research Cooperation Project(19JCZDJC64100)This study was also supported by the Science and Technology Development Fund,Macao SAR(File no.0124/2019/A3).
文摘Intelligent drug delivery system based on “stimulus-response”mode emerging a promising perspective in next generation lipidbased nanoparticle.Here,we classify signal sources into physical and physiological stimulation according to their origin.
