Waterfront is a precious resource in urban ecological construction,and also a key section for ecological protection,so ecological planning of urban waterfront has far-reaching influence on the whole region.This study ...Waterfront is a precious resource in urban ecological construction,and also a key section for ecological protection,so ecological planning of urban waterfront has far-reaching influence on the whole region.This study explored ecological planning and design of waterfront from the perspective of landscape security pattern,analyzed current waterfront in Xianghe County and construction of landscape security pattern for waterfront,provided a basis for the ecological planning and design of landscape.展开更多
We find that a conserved mutation residue Glu to residue Asp （E303D）, which both have the same polar and charged properties, makes Kit2.1 protein lose its function. To understand the mechanism, we identify three int...We find that a conserved mutation residue Glu to residue Asp （E303D）, which both have the same polar and charged properties, makes Kit2.1 protein lose its function. To understand the mechanism, we identify three interactions which control the conformation change and maintain the function of the Kit2.1 protein by combining homology modeling and molecular dynamics with targeted molecular dynamics. We find that the E303D mutation weakens these interactions and results in the loss of the related function. Our data indicate that not only the amino residues but also the interactions determine the function of proteins.展开更多
基金Supported by National Natural Science Foundation(51208338)Research Funds of Humanities and Social Sciences of Ministry of Education(10YJCZH144)
文摘Waterfront is a precious resource in urban ecological construction,and also a key section for ecological protection,so ecological planning of urban waterfront has far-reaching influence on the whole region.This study explored ecological planning and design of waterfront from the perspective of landscape security pattern,analyzed current waterfront in Xianghe County and construction of landscape security pattern for waterfront,provided a basis for the ecological planning and design of landscape.
基金Supported by the National Natural Science Foundation of China under Grant Nos 11247010,11175055,11475053 and 11347017the Natural Science Foundation of Hebei Province under Grant Nos C2012202079 and C201400305
文摘We find that a conserved mutation residue Glu to residue Asp （E303D）, which both have the same polar and charged properties, makes Kit2.1 protein lose its function. To understand the mechanism, we identify three interactions which control the conformation change and maintain the function of the Kit2.1 protein by combining homology modeling and molecular dynamics with targeted molecular dynamics. We find that the E303D mutation weakens these interactions and results in the loss of the related function. Our data indicate that not only the amino residues but also the interactions determine the function of proteins.
