At present,the total production output of agricultural and livestock products is constantly increasing and the total market demand is also increasing substantially. This will increase trade volume of agricultural and ...At present,the total production output of agricultural and livestock products is constantly increasing and the total market demand is also increasing substantially. This will increase trade volume of agricultural and livestock products and also bring about rise of talent demand.It is necessary and feasible to add new discipline of special trade economics in Southwest University Rongchang Campus. This meets social demands for special trade economic talents,especially agricultural and livestock product trade economic talents.展开更多
Through field investigation and comprehensive analysis, this paper classified green space system on campus of Southwest University of Science & Technology into points, lines and surfaces, and used basic theories o...Through field investigation and comprehensive analysis, this paper classified green space system on campus of Southwest University of Science & Technology into points, lines and surfaces, and used basic theories of ecology, botany, garden aesthetics, and plant landscape assessment to analyze ornamental characteristics, seasonal changes, spatial layers and cultural connotations of its typical plant landscapes, so as to assess campus plant landscape comprehensively in the near future.展开更多
Digitization of education is an important component of Digital China Strategy. China is deeply implementing the digitalization of education strategy, promoting educational reform and innovation, and accelerating the c...Digitization of education is an important component of Digital China Strategy. China is deeply implementing the digitalization of education strategy, promoting educational reform and innovation, and accelerating the construction of a learning society and a learning country where everyone can learn, learn everywhere, and learn at all times [1]. As the cradle and gathering place of talent cultivation, universities should be at the forefront of educational informatization construction. As a comprehensive energy university in the northeastern region of Sichuan, the Nanchong Campus of Southwest Petroleum University plays an irreplaceable role in the local economic development. This article summarizes the current situation of educational informatization construction on this campus and proposes suggestions for its improvement path, providing constructive reference opinions for the development of similar universities.展开更多
On October 19-22,2018,the 13th China-Japan-Korea Joint Conference on Geography was held at Southwest University,Chongqing,China.The conference was sponsored by the Geographical Society of China and Southwest Universit...On October 19-22,2018,the 13th China-Japan-Korea Joint Conference on Geography was held at Southwest University,Chongqing,China.The conference was sponsored by the Geographical Society of China and Southwest University,co-sponsored by Association of Japanese Geographers and Korean Geographical Society.It was hosted by the School of Geographical Sciences,Southwest University and the Geography Society of Chongqing,and co-organized by the Key Laboratory of Environment Change and Resources Use in Beibu Gulf of Guangxi Teachers Education University.This conference also gained the support from National Natural Science Foundation of China.More than 300 geographers from 100 universities and research institutions of the three countries participated in this conference.A series of academic reports,scientific sessions,and a field trip in downtown Chongqing were carried out around the theme of the "Urbanization and Sustainable Development of Mountain Areas".展开更多
With an increasingly number of cars on campus, the campus is faced with challenges of traffic order and safety. This paper, based on traffic calming and practical experience, took the Xipu campus of Southwest Jiaotong...With an increasingly number of cars on campus, the campus is faced with challenges of traffic order and safety. This paper, based on traffic calming and practical experience, took the Xipu campus of Southwest Jiaotong University as an example. Grounded on the traffic situation and characteristics of Xipu campus, the study analyzed the concept of traffic calming and its engineering measures, put forward traffic calming design scheme for Qiuhua Road on the Xipu campus with practical application of campus traffic characteristics, and stated the significance of campus traffic calming for its driving effect in creating an atmosphere of "environment cultivation" on campus. Finally, this paper discussed the development and application of traffic calming in China.展开更多
As one of the oldest universities of modern China, Southwest Jiaotong University has experienced its grand journey transcending 3 centuries, witnessing 18 relocations. Known as ＂the Cornell of the East＂ and the birt...As one of the oldest universities of modern China, Southwest Jiaotong University has experienced its grand journey transcending 3 centuries, witnessing 18 relocations. Known as ＂the Cornell of the East＂ and the birthplace of China＇s modern education in transportation, mining and metallurgy and civil engineering, the university is now on the list of China＇s ＂211 Project＂, ＂985 Project Innovation Platform＂ and ＂2011 Plan＂. As the front-runner of rail transportation, Southwest Jiaotong University is now playing its active role in facilitating the globalization of China＇s high-speed railway.展开更多
"With copper as a mirror,you can wear a crown;with history as a mirror,you can know the rise and fall."This paper takes the 70-year development process of Southwest Minzu University as the carrier,the castin..."With copper as a mirror,you can wear a crown;with history as a mirror,you can know the rise and fall."This paper takes the 70-year development process of Southwest Minzu University as the carrier,the casting of the Chinese national community as the main line while tracing back to the source,adopts the recording method of"oral history of the school,"interviews witnesses to the development of Southwest Minzu University,including school leaders,teachers,alumni,and other representative figures,records the memories of these parties on the practices of Southwest Minzu University in different periods to cast the awareness of the Chinese national community,and collates them into a text.From the perspective of students,it is important to understand the history of the Chinese national community in the past 70 years since the establishment of Southwest Minzu University,collect and sort out the historical memories of Southwest Minzu University for the education of the Chinese national community,supplement and confirm the school's historical documents,preserve the history,make up for the gap in the history of the school,and at the same time provide a realistic basis for Southwest Minzu University to formulate future development strategies.展开更多
The high and steep slopes along a high-speed railway in the mountainous area of Southwest China are mostly composed of loose accumulations of debris with large internal pores and poor stability,which can easily induce...The high and steep slopes along a high-speed railway in the mountainous area of Southwest China are mostly composed of loose accumulations of debris with large internal pores and poor stability,which can easily induce adverse geological disasters under rainfall conditions.To ensure the smooth construction of the high-speed railway and the subsequent safe operation,it is necessary to master the stability evolution process of the loose accumulation slope under rainfall.This article simulates rainfall using the finite element analysis software’s hydromechanical coupling module.The slope stability under various rainfall situations is calculated and analysed based on the strength reduction method.To validate the simulation results,a field monitoring system is established to study the deformation characteristics of the slope under rainfall.The results show that rainfall duration is the key factor affecting slope stability.Given a constant amount of rainfall,the stability of the slope decreases with increasing duration of rainfall.Moreover,when the amount and duration of rainfall are constant,continuous rainfall has a greater impact on slope stability than intermittent rainfall.The setting of the field retaining structures has a significant role in improving slope stability.The field monitoring data show that the slope is in the initial deformation stage and has good stability,which verifies the rationality of the numerical simulation method.The research results can provide some references for understanding the influence of rainfall on the stability of loose accumulation slopes along high-speed railways and establishing a monitoring system.展开更多
To analyze the episodic alteration of Middle Permian carbonate reservoirs by complex hydrothermal fluid in southwestern Sichuan Basin,petrology,geochemistry,fluid inclusion and U-Pb dating researches are conducted.The...To analyze the episodic alteration of Middle Permian carbonate reservoirs by complex hydrothermal fluid in southwestern Sichuan Basin,petrology,geochemistry,fluid inclusion and U-Pb dating researches are conducted.The fractures and vugs of Middle Permian Qixia–Maokou formations are filled with multi-stage medium-coarse saddle dolomites and associated hydrothermal minerals,which indicates that the early limestone/dolomite episodic alteration was caused by the large-scale,high-temperature,deep magnesium-rich brine along flowing channels such as basement faults or associated fractures under the tectonic compression and napping during the Indosinian.The time of magnesium-rich hydrothermal activity was from the Middle Triassic to the Late Triassic.The siliceous and calcite fillings were triggered by hydrothermal alteration in the Middle and Late Yanshanian Movement and Himalayan Movement.Hydrothermal dolomitization is controlled by fault,hydrothermal property,flowing channel and surrounding rock lithology,which occur as equilibrium effect of porosity and permeability.The thick massive grainstone/dolomites were mainly altered by modification such as hydrothermal dolomitization/recrystallization,brecciation and fracture-vugs filling.Early thin-medium packstones were mainly altered by dissolution and infilling of fracturing,bedding dolomitization,dissolution and associated mineral fillings.The dissolved vugs and fractures are the main reservoir space under hydrothermal conditions,and the connection of dissolved vugs and network fractures is favorable for forming high-quality dolomite reservoir.Hydrothermal dolomite reservoirs are developed within a range of 1 km near faults,with a thickness of 30–60 m.Hydrothermal dolomite reservoirs with local connected pore/vugs and fractures have exploration potential.展开更多
The role of university English instructors has evolved significantly over the years,encompassing various aspects.This paper explores the evolution of the role of university English instructors and examines the current...The role of university English instructors has evolved significantly over the years,encompassing various aspects.This paper explores the evolution of the role of university English instructors and examines the current challenges and opportunities they face in today’s educational landscape.It delves into the multifaceted nature of their responsibilities and discusses the importance of continuous professional development to meet the evolving needs of students and the demands of the profession.展开更多
Neuronal growth, extension, branching, and formation of neural networks are markedly influenced by the extracellular matrix—a complex network composed of proteins and carbohydrates secreted by cells. In addition to p...Neuronal growth, extension, branching, and formation of neural networks are markedly influenced by the extracellular matrix—a complex network composed of proteins and carbohydrates secreted by cells. In addition to providing physical support for cells, the extracellular matrix also conveys critical mechanical stiffness cues. During the development of the nervous system, extracellular matrix stiffness plays a central role in guiding neuronal growth, particularly in the context of axonal extension, which is crucial for the formation of neural networks. In neural tissue engineering, manipulation of biomaterial stiffness is a promising strategy to provide a permissive environment for the repair and regeneration of injured nervous tissue. Recent research has fine-tuned synthetic biomaterials to fabricate scaffolds that closely replicate the stiffness profiles observed in the nervous system. In this review, we highlight the molecular mechanisms by which extracellular matrix stiffness regulates axonal growth and regeneration. We highlight the progress made in the development of stiffness-tunable biomaterials to emulate in vivo extracellular matrix environments, with an emphasis on their application in neural repair and regeneration, along with a discussion of the current limitations and future prospects. The exploration and optimization of the stiffness-tunable biomaterials has the potential to markedly advance the development of neural tissue engineering.展开更多
An efficient copper-catalyzed regioselective acyloxy-trifluoromethylation of allenamides using Togni'sⅡreagent as the source of both the trifluoromethyl and acyloxy moieties was developed to create a workable rou...An efficient copper-catalyzed regioselective acyloxy-trifluoromethylation of allenamides using Togni'sⅡreagent as the source of both the trifluoromethyl and acyloxy moieties was developed to create a workable route to CF_(3)-substituted allylic esters.The reaction exhibited good functional group tolerance and high efficiency,affording the products in moderate to good yields.Mechanistic investigations indicated a radical process was likely involved in this transformation.展开更多
BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after ESD....BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after ESD.AIM To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus post-ESD.METHODS Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential ESD.Endoscopic examinations occurred on days 7 and 21 post-ESD.In vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was assessed.Profibrotic signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after ESD.After treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal layer.Additionally,the expression of fibrotic effector molecules was notably inhibited.Mechanistically,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/3.In vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen I.The 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated pEsF.CONCLUSION KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.展开更多
To improve the catalytic performance of La_(0.6)Sr_(0.4)Co_(0.2)Fe_(0.8)O_(3)(LSCF)towards carbon soot,we utilized the impregnation method to incorporate Ag into the prepared LSCF catalyst.We conducted a series of cha...To improve the catalytic performance of La_(0.6)Sr_(0.4)Co_(0.2)Fe_(0.8)O_(3)(LSCF)towards carbon soot,we utilized the impregnation method to incorporate Ag into the prepared LSCF catalyst.We conducted a series of characterization tests and evaluated the soot catalytic activity of the composite catalyst by comparing it with the LaCoO_(3) group,LaFeO_(3) group,and catalyst-free group.The results indicate that the Ag-LSCF composite catalyst exhibits the highest soot catalytic activity,with the characteristic temperature values of 376.3,431.1,and 473.9℃at 10%,50%,and 90%carbon soot conversion,respectively.These values are 24.8,20.2,and 23.1℃lower than those of the LSCF group.This also shows that LSCF can improve the catalytic activity of soot after compounding with Ag,and reflects the necessity of using catalysts in soot combustion reaction.XPS characterization and BET test show that Ag-LSCF has more abundant surface-adsorbed oxygen species,larger specific surface area and pore volume than LSCF,which also proves that Ag-LSCF has higher soot catalytic activity.展开更多
The onset and progression of type 2 diabetes mellitus(T2DM)are strongly associated with imbalances in gut bacteria,making the gut microbiome a new potential therapeutic focus.This commentary examines the recent public...The onset and progression of type 2 diabetes mellitus(T2DM)are strongly associated with imbalances in gut bacteria,making the gut microbiome a new potential therapeutic focus.This commentary examines the recent publication in World Journal of Diabetes.The article explores the association between T2DM and gut microbiota,with a focus on the pathophysiological changes related to dysbiosis.It proposes innovative microbiome-targeted therapeutic strategies and evaluates the challenges and future directions of such approaches.This editorial summarizes the key points of their discussion of the role of the gut microbiome in T2DM and elaborates on the influence of specific gut microbial species on the disease through the host–microbiota metabolic axis.It provides new insights for future research on gut-microbiota-based interventions for T2DM.展开更多
The lattice parameter,measured with sufficient accuracy,can be utilized to evaluate the quality of single crystals and to determine the equation of state for materials.We propose an iterative method for obtaining more...The lattice parameter,measured with sufficient accuracy,can be utilized to evaluate the quality of single crystals and to determine the equation of state for materials.We propose an iterative method for obtaining more precise lattice parameters using the interaction points for the pseudo-Kossel pattern obtained from laser-induced X-ray diffraction(XRD).This method has been validated by the analysis of an XRD experiment conducted on iron single crystals.Furthermore,the method was used to calculate the compression ratio and rotated angle of an LiF sample under high pressure loading.This technique provides a robust tool for in-situ characterization of structural changes in single crystals under extreme conditions.It has significant implications for studying the equation of state and phase transitions.展开更多
Surrounding rock deterioration and large deformation have always been a significant difficulty in designing and constructing tunnels in soft rock.The key lies in real-time perception and quantitative assessment of the...Surrounding rock deterioration and large deformation have always been a significant difficulty in designing and constructing tunnels in soft rock.The key lies in real-time perception and quantitative assessment of the damaged area around the tunnel.An in situ microseismic(MS)monitoring system is established in the plateau soft tock tunnel.This technique facilitates spatiotemporal monitoring of the rock mass's fracturing expansion and squeezing deformation,which agree well with field convergence deformation results.The formation mechanisms of progressive failure evolution of soft rock tunnels were discussed and analyzed with MS data and numerical results.The results demonstrate that:(1)Localized stress concentration and layered rock result in significant asymmetry in micro-fractures propagation in the tunnel radial section.As excavation continues,the fracture extension area extends into the deep surrounding rockmass on the east side affected by the weak bedding;(2)Tunnel excavation and long-term deformation can induce tensile shear action on the rock mass,vertical tension fractures(account for 45%)exist in deep rockmass,which play a crucial role in controlling the macroscopic failure of surrounding rock;and(3)Based on the radiated MS energy,a three-dimensional model was created to visualize the damage zone of the tunnel surrounding rock.The model depicted varying degrees of damage,and three high damage zones were identified.Generally,the depth of high damage zone ranged from 4 m to 12 m.This study may be a valuable reference for the warning and controlling of large deformations in similar projects.展开更多
Pu-erh tea has been shown to reduce gut inflammation in dextran sulfate sodium(DSS)-induced mice.Also,we found abnormal liver cholesterol metabolism in DSS-induced mice.However,it's not clear how Pu-erh tea improv...Pu-erh tea has been shown to reduce gut inflammation in dextran sulfate sodium(DSS)-induced mice.Also,we found abnormal liver cholesterol metabolism in DSS-induced mice.However,it's not clear how Pu-erh tea improves DSS-induced impaired liver cholesterol metabolism.Here,we established the DSS-induced model and clarified that DSS exacerbated gut inflammation accompanied by disorders of liver cholesterol metabolism.Pu-erh tea reshaped gut microbes,limited gut oxidative stress and inflammation(nicotinamide adenine dinucleotide phosphate oxidase 2/reactive oxygen species/myeloid differentiation primary response protein 88/nuclear factor kappa-B,24.97%-52.89%),reduced gut bile acid reabsorption(up-regulation of farnesoid X receptor(FXR)/fibroblast growth factor 15,24.53%-55.91%),and promoted liver bile acid synthesis(up-regulation of peroxisome proliferator-activated receptor-α/cholesterol 7-alpha hydroxylase,34.65%-79.14%),thereby partly restoring liver cholesterol metabolism(regulated FXR/small heterodimer partner/sterol-regulatory element binding proteins,53.19%-95.40%).Altered bile acid metabolic profiles(increased chenodeoxycholic acid,ursodeoxycholic acid,lithocholic acid,etc.)may also improve liver cholesterol metabolism by altering gut and liver inflammation.Thus,gut microbial reshaping and altered bile acid metabolism may be key targets of Pu-erh tea for improving DSS-induced liver cholesterol metabolism disorders via the gut-gut microbe-bile acid-liver axis.展开更多
In this review,the advantages and advances in applying high-throughput sequencing(HTS)in the management of viral diseases in citrus,along with some challenges,are discussed to provide perspectives on future prospects....In this review,the advantages and advances in applying high-throughput sequencing(HTS)in the management of viral diseases in citrus,along with some challenges,are discussed to provide perspectives on future prospects.Since the initial implementation of HTS in citrus virology,a substantial number of citrus viruses have been identified,with a notable increase in the last 7 years.The acquisition of viral genomes and various HTS-based omics analyses serve as crucial pillars for advancing research in the etiology,epidemiology,pathology,evolution,ecology,and biotechnology of citrus viruses.HTS has notably contributed to disease diagnosis,such as the diagnoses of concave gum and impietratura,as well as to the surveillance of new virus risks and the preparation of virus-free materials.However,certain inherent defects in HTS and coupled bioinformatics analysis,such as challenges with sequence assembly and the detection of viral dark matter,require improvement to enhance practical efficiency.In addition,the utilization of HTS for the systematic management of citrus viral diseases remains limited,and drawing insights from other virus-plant pathosystems while integrating emerging compatible techniques and ideas may broaden its specific applications.展开更多
基金Supported by Project of Business Management Cultivation Discipline in Department of Business and Trade,Southwest University Rongchang Campus(R CQG207001)
文摘At present,the total production output of agricultural and livestock products is constantly increasing and the total market demand is also increasing substantially. This will increase trade volume of agricultural and livestock products and also bring about rise of talent demand.It is necessary and feasible to add new discipline of special trade economics in Southwest University Rongchang Campus. This meets social demands for special trade economic talents,especially agricultural and livestock product trade economic talents.
文摘Through field investigation and comprehensive analysis, this paper classified green space system on campus of Southwest University of Science & Technology into points, lines and surfaces, and used basic theories of ecology, botany, garden aesthetics, and plant landscape assessment to analyze ornamental characteristics, seasonal changes, spatial layers and cultural connotations of its typical plant landscapes, so as to assess campus plant landscape comprehensively in the near future.
文摘Digitization of education is an important component of Digital China Strategy. China is deeply implementing the digitalization of education strategy, promoting educational reform and innovation, and accelerating the construction of a learning society and a learning country where everyone can learn, learn everywhere, and learn at all times [1]. As the cradle and gathering place of talent cultivation, universities should be at the forefront of educational informatization construction. As a comprehensive energy university in the northeastern region of Sichuan, the Nanchong Campus of Southwest Petroleum University plays an irreplaceable role in the local economic development. This article summarizes the current situation of educational informatization construction on this campus and proposes suggestions for its improvement path, providing constructive reference opinions for the development of similar universities.
基金National Natural Science Foundation of China(No.41842002).
文摘On October 19-22,2018,the 13th China-Japan-Korea Joint Conference on Geography was held at Southwest University,Chongqing,China.The conference was sponsored by the Geographical Society of China and Southwest University,co-sponsored by Association of Japanese Geographers and Korean Geographical Society.It was hosted by the School of Geographical Sciences,Southwest University and the Geography Society of Chongqing,and co-organized by the Key Laboratory of Environment Change and Resources Use in Beibu Gulf of Guangxi Teachers Education University.This conference also gained the support from National Natural Science Foundation of China.More than 300 geographers from 100 universities and research institutions of the three countries participated in this conference.A series of academic reports,scientific sessions,and a field trip in downtown Chongqing were carried out around the theme of the "Urbanization and Sustainable Development of Mountain Areas".
基金Sponsored by Study on Synergetic Planning and Spatial Optimization of Urban Comprehensive Passenger Transportation Hub and Its Adjacent Area(51478388)
文摘With an increasingly number of cars on campus, the campus is faced with challenges of traffic order and safety. This paper, based on traffic calming and practical experience, took the Xipu campus of Southwest Jiaotong University as an example. Grounded on the traffic situation and characteristics of Xipu campus, the study analyzed the concept of traffic calming and its engineering measures, put forward traffic calming design scheme for Qiuhua Road on the Xipu campus with practical application of campus traffic characteristics, and stated the significance of campus traffic calming for its driving effect in creating an atmosphere of "environment cultivation" on campus. Finally, this paper discussed the development and application of traffic calming in China.
文摘As one of the oldest universities of modern China, Southwest Jiaotong University has experienced its grand journey transcending 3 centuries, witnessing 18 relocations. Known as ＂the Cornell of the East＂ and the birthplace of China＇s modern education in transportation, mining and metallurgy and civil engineering, the university is now on the list of China＇s ＂211 Project＂, ＂985 Project Innovation Platform＂ and ＂2011 Plan＂. As the front-runner of rail transportation, Southwest Jiaotong University is now playing its active role in facilitating the globalization of China＇s high-speed railway.
基金The 2021 Special Fund for Basic Scientific Research Business Expenses of Central Universities“Special Project for Serving the Society”(Grant Number:2021SYYXSS55)。
文摘"With copper as a mirror,you can wear a crown;with history as a mirror,you can know the rise and fall."This paper takes the 70-year development process of Southwest Minzu University as the carrier,the casting of the Chinese national community as the main line while tracing back to the source,adopts the recording method of"oral history of the school,"interviews witnesses to the development of Southwest Minzu University,including school leaders,teachers,alumni,and other representative figures,records the memories of these parties on the practices of Southwest Minzu University in different periods to cast the awareness of the Chinese national community,and collates them into a text.From the perspective of students,it is important to understand the history of the Chinese national community in the past 70 years since the establishment of Southwest Minzu University,collect and sort out the historical memories of Southwest Minzu University for the education of the Chinese national community,supplement and confirm the school's historical documents,preserve the history,make up for the gap in the history of the school,and at the same time provide a realistic basis for Southwest Minzu University to formulate future development strategies.
基金supported by the National Natural Science Foundation of China (No.51978588).
文摘The high and steep slopes along a high-speed railway in the mountainous area of Southwest China are mostly composed of loose accumulations of debris with large internal pores and poor stability,which can easily induce adverse geological disasters under rainfall conditions.To ensure the smooth construction of the high-speed railway and the subsequent safe operation,it is necessary to master the stability evolution process of the loose accumulation slope under rainfall.This article simulates rainfall using the finite element analysis software’s hydromechanical coupling module.The slope stability under various rainfall situations is calculated and analysed based on the strength reduction method.To validate the simulation results,a field monitoring system is established to study the deformation characteristics of the slope under rainfall.The results show that rainfall duration is the key factor affecting slope stability.Given a constant amount of rainfall,the stability of the slope decreases with increasing duration of rainfall.Moreover,when the amount and duration of rainfall are constant,continuous rainfall has a greater impact on slope stability than intermittent rainfall.The setting of the field retaining structures has a significant role in improving slope stability.The field monitoring data show that the slope is in the initial deformation stage and has good stability,which verifies the rationality of the numerical simulation method.The research results can provide some references for understanding the influence of rainfall on the stability of loose accumulation slopes along high-speed railways and establishing a monitoring system.
基金Supported by the National Science and Technology Major Project(2016ZX05007004-001)Innovation Fund Project of CNPC Carbonate Rock Key Laboratory(RIPED-HZDZY-2019-JS-695).
文摘To analyze the episodic alteration of Middle Permian carbonate reservoirs by complex hydrothermal fluid in southwestern Sichuan Basin,petrology,geochemistry,fluid inclusion and U-Pb dating researches are conducted.The fractures and vugs of Middle Permian Qixia–Maokou formations are filled with multi-stage medium-coarse saddle dolomites and associated hydrothermal minerals,which indicates that the early limestone/dolomite episodic alteration was caused by the large-scale,high-temperature,deep magnesium-rich brine along flowing channels such as basement faults or associated fractures under the tectonic compression and napping during the Indosinian.The time of magnesium-rich hydrothermal activity was from the Middle Triassic to the Late Triassic.The siliceous and calcite fillings were triggered by hydrothermal alteration in the Middle and Late Yanshanian Movement and Himalayan Movement.Hydrothermal dolomitization is controlled by fault,hydrothermal property,flowing channel and surrounding rock lithology,which occur as equilibrium effect of porosity and permeability.The thick massive grainstone/dolomites were mainly altered by modification such as hydrothermal dolomitization/recrystallization,brecciation and fracture-vugs filling.Early thin-medium packstones were mainly altered by dissolution and infilling of fracturing,bedding dolomitization,dissolution and associated mineral fillings.The dissolved vugs and fractures are the main reservoir space under hydrothermal conditions,and the connection of dissolved vugs and network fractures is favorable for forming high-quality dolomite reservoir.Hydrothermal dolomite reservoirs are developed within a range of 1 km near faults,with a thickness of 30–60 m.Hydrothermal dolomite reservoirs with local connected pore/vugs and fractures have exploration potential.
文摘The role of university English instructors has evolved significantly over the years,encompassing various aspects.This paper explores the evolution of the role of university English instructors and examines the current challenges and opportunities they face in today’s educational landscape.It delves into the multifaceted nature of their responsibilities and discusses the importance of continuous professional development to meet the evolving needs of students and the demands of the profession.
基金supported by the Natio`nal Natural Science Foundation of China,No. 81801241a grant from Sichuan Science and Technology Program,No. 2023NSFSC1578Scientific Research Projects of Southwest Medical University,No. 2022ZD002 (all to JX)。
文摘Neuronal growth, extension, branching, and formation of neural networks are markedly influenced by the extracellular matrix—a complex network composed of proteins and carbohydrates secreted by cells. In addition to providing physical support for cells, the extracellular matrix also conveys critical mechanical stiffness cues. During the development of the nervous system, extracellular matrix stiffness plays a central role in guiding neuronal growth, particularly in the context of axonal extension, which is crucial for the formation of neural networks. In neural tissue engineering, manipulation of biomaterial stiffness is a promising strategy to provide a permissive environment for the repair and regeneration of injured nervous tissue. Recent research has fine-tuned synthetic biomaterials to fabricate scaffolds that closely replicate the stiffness profiles observed in the nervous system. In this review, we highlight the molecular mechanisms by which extracellular matrix stiffness regulates axonal growth and regeneration. We highlight the progress made in the development of stiffness-tunable biomaterials to emulate in vivo extracellular matrix environments, with an emphasis on their application in neural repair and regeneration, along with a discussion of the current limitations and future prospects. The exploration and optimization of the stiffness-tunable biomaterials has the potential to markedly advance the development of neural tissue engineering.
文摘An efficient copper-catalyzed regioselective acyloxy-trifluoromethylation of allenamides using Togni'sⅡreagent as the source of both the trifluoromethyl and acyloxy moieties was developed to create a workable route to CF_(3)-substituted allylic esters.The reaction exhibited good functional group tolerance and high efficiency,affording the products in moderate to good yields.Mechanistic investigations indicated a radical process was likely involved in this transformation.
基金Supported by Science and Technology Department of Sichuan Province,No.2020YFS0376National Natural Science Foundation of China,No.81900599Science and Technology Program of Hospital of TCM,Southwest Medical University,No.2022-CXTD-01.
文摘BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after ESD.AIM To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus post-ESD.METHODS Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential ESD.Endoscopic examinations occurred on days 7 and 21 post-ESD.In vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was assessed.Profibrotic signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after ESD.After treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal layer.Additionally,the expression of fibrotic effector molecules was notably inhibited.Mechanistically,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/3.In vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen I.The 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated pEsF.CONCLUSION KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.
文摘To improve the catalytic performance of La_(0.6)Sr_(0.4)Co_(0.2)Fe_(0.8)O_(3)(LSCF)towards carbon soot,we utilized the impregnation method to incorporate Ag into the prepared LSCF catalyst.We conducted a series of characterization tests and evaluated the soot catalytic activity of the composite catalyst by comparing it with the LaCoO_(3) group,LaFeO_(3) group,and catalyst-free group.The results indicate that the Ag-LSCF composite catalyst exhibits the highest soot catalytic activity,with the characteristic temperature values of 376.3,431.1,and 473.9℃at 10%,50%,and 90%carbon soot conversion,respectively.These values are 24.8,20.2,and 23.1℃lower than those of the LSCF group.This also shows that LSCF can improve the catalytic activity of soot after compounding with Ag,and reflects the necessity of using catalysts in soot combustion reaction.XPS characterization and BET test show that Ag-LSCF has more abundant surface-adsorbed oxygen species,larger specific surface area and pore volume than LSCF,which also proves that Ag-LSCF has higher soot catalytic activity.
文摘The onset and progression of type 2 diabetes mellitus(T2DM)are strongly associated with imbalances in gut bacteria,making the gut microbiome a new potential therapeutic focus.This commentary examines the recent publication in World Journal of Diabetes.The article explores the association between T2DM and gut microbiota,with a focus on the pathophysiological changes related to dysbiosis.It proposes innovative microbiome-targeted therapeutic strategies and evaluates the challenges and future directions of such approaches.This editorial summarizes the key points of their discussion of the role of the gut microbiome in T2DM and elaborates on the influence of specific gut microbial species on the disease through the host–microbiota metabolic axis.It provides new insights for future research on gut-microbiota-based interventions for T2DM.
基金National Natural Science Foundation of China(12102410)Fund of National Key Laboratory of Shock Wave and Detonation Physics(JCKYS2022212005)。
文摘The lattice parameter,measured with sufficient accuracy,can be utilized to evaluate the quality of single crystals and to determine the equation of state for materials.We propose an iterative method for obtaining more precise lattice parameters using the interaction points for the pseudo-Kossel pattern obtained from laser-induced X-ray diffraction(XRD).This method has been validated by the analysis of an XRD experiment conducted on iron single crystals.Furthermore,the method was used to calculate the compression ratio and rotated angle of an LiF sample under high pressure loading.This technique provides a robust tool for in-situ characterization of structural changes in single crystals under extreme conditions.It has significant implications for studying the equation of state and phase transitions.
基金the funding support from the National Natural Science Foundation of China(Grant Nos.U23A2060,42177143 and 42277461).
文摘Surrounding rock deterioration and large deformation have always been a significant difficulty in designing and constructing tunnels in soft rock.The key lies in real-time perception and quantitative assessment of the damaged area around the tunnel.An in situ microseismic(MS)monitoring system is established in the plateau soft tock tunnel.This technique facilitates spatiotemporal monitoring of the rock mass's fracturing expansion and squeezing deformation,which agree well with field convergence deformation results.The formation mechanisms of progressive failure evolution of soft rock tunnels were discussed and analyzed with MS data and numerical results.The results demonstrate that:(1)Localized stress concentration and layered rock result in significant asymmetry in micro-fractures propagation in the tunnel radial section.As excavation continues,the fracture extension area extends into the deep surrounding rockmass on the east side affected by the weak bedding;(2)Tunnel excavation and long-term deformation can induce tensile shear action on the rock mass,vertical tension fractures(account for 45%)exist in deep rockmass,which play a crucial role in controlling the macroscopic failure of surrounding rock;and(3)Based on the radiated MS energy,a three-dimensional model was created to visualize the damage zone of the tunnel surrounding rock.The model depicted varying degrees of damage,and three high damage zones were identified.Generally,the depth of high damage zone ranged from 4 m to 12 m.This study may be a valuable reference for the warning and controlling of large deformations in similar projects.
基金supported by the National Natural Science Foundation of China funded project(32172627)Chongqing Modern Tea Technology System for Efficient Agriculture in Mountainous Areas 2022[8]the Germplasm Creation Research Program of Southwest University。
文摘Pu-erh tea has been shown to reduce gut inflammation in dextran sulfate sodium(DSS)-induced mice.Also,we found abnormal liver cholesterol metabolism in DSS-induced mice.However,it's not clear how Pu-erh tea improves DSS-induced impaired liver cholesterol metabolism.Here,we established the DSS-induced model and clarified that DSS exacerbated gut inflammation accompanied by disorders of liver cholesterol metabolism.Pu-erh tea reshaped gut microbes,limited gut oxidative stress and inflammation(nicotinamide adenine dinucleotide phosphate oxidase 2/reactive oxygen species/myeloid differentiation primary response protein 88/nuclear factor kappa-B,24.97%-52.89%),reduced gut bile acid reabsorption(up-regulation of farnesoid X receptor(FXR)/fibroblast growth factor 15,24.53%-55.91%),and promoted liver bile acid synthesis(up-regulation of peroxisome proliferator-activated receptor-α/cholesterol 7-alpha hydroxylase,34.65%-79.14%),thereby partly restoring liver cholesterol metabolism(regulated FXR/small heterodimer partner/sterol-regulatory element binding proteins,53.19%-95.40%).Altered bile acid metabolic profiles(increased chenodeoxycholic acid,ursodeoxycholic acid,lithocholic acid,etc.)may also improve liver cholesterol metabolism by altering gut and liver inflammation.Thus,gut microbial reshaping and altered bile acid metabolism may be key targets of Pu-erh tea for improving DSS-induced liver cholesterol metabolism disorders via the gut-gut microbe-bile acid-liver axis.
基金supported by National Natural Science Foundation of China(Grant Nos.32370005,32072389)Chongqing Science Funds for Distinguished Young Scientists(Grant No.CSTB2022NSCQ-JQX0027)+3 种基金Innovation Research 2035 Pilot Plan of Southwest University(Grant Nos.SWU-XDPY22002,SWUXDZD22002)Special Fund for Youth Team of Southwest University(Grant No.SWU-XJLJ202310)Chongqing Talents of Exceptional Young Talents Project(Grant No.cstc2022ycjh-bgzxm0143)Chongqing Municipal Training Program of Innovation and Entrepreneurship for Undergraduates(Grant No.S202310635160)。
文摘In this review,the advantages and advances in applying high-throughput sequencing(HTS)in the management of viral diseases in citrus,along with some challenges,are discussed to provide perspectives on future prospects.Since the initial implementation of HTS in citrus virology,a substantial number of citrus viruses have been identified,with a notable increase in the last 7 years.The acquisition of viral genomes and various HTS-based omics analyses serve as crucial pillars for advancing research in the etiology,epidemiology,pathology,evolution,ecology,and biotechnology of citrus viruses.HTS has notably contributed to disease diagnosis,such as the diagnoses of concave gum and impietratura,as well as to the surveillance of new virus risks and the preparation of virus-free materials.However,certain inherent defects in HTS and coupled bioinformatics analysis,such as challenges with sequence assembly and the detection of viral dark matter,require improvement to enhance practical efficiency.In addition,the utilization of HTS for the systematic management of citrus viral diseases remains limited,and drawing insights from other virus-plant pathosystems while integrating emerging compatible techniques and ideas may broaden its specific applications.
